LOCUS       NM_001080399            1788 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens otoconin 90 (OC90), mRNA.
ACCESSION   NM_001080399 XM_001129959
VERSION     NM_001080399.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1788)
  AUTHORS   Aygun,D., Dumur,S., Elgormus,M.N., Alpaslan,M.S. and Uzun,H.
  TITLE     Serum Otoconin-90 and Otolin-1 Concentrations in Benign Paroxysmal
            Positional Vertigo
  JOURNAL   Biomolecules 14 (10), 1279 (2024)
   PUBMED   39456211
  REMARK    GeneRIF: Serum Otoconin-90 and Otolin-1 Concentrations in Benign
            Paroxysmal Positional Vertigo.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1788)
  AUTHORS   Moreland,K.T., Hong,M., Lu,W., Rowley,C.W., Ornitz,D.M., De
            Yoreo,J.J. and Thalmann,R.
  TITLE     In vitro calcite crystal morphology is modulated by otoconial
            proteins otolin-1 and otoconin-90
  JOURNAL   PLoS One 9 (4), e95333 (2014)
   PUBMED   24748133
  REMARK    GeneRIF: calcium carbonate crystal growth data demonstrate that
            Otolin-1 and OC90 modulate in vitro calcite crystal morphology but
            neither protein is sufficient to produce the shape of otoconia
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1788)
  AUTHORS   Zeng,Z., Feingold,E., Wang,X., Weeks,D.E., Lee,M., Cuenco,D.T.,
            Broffitt,B., Weyant,R.J., Crout,R., McNeil,D.W., Levy,S.M.,
            Marazita,M.L. and Shaffer,J.R.
  TITLE     Genome-wide association study of primary dentition pit-and-fissure
            and smooth surface caries
  JOURNAL   Caries Res 48 (4), 330-338 (2014)
   PUBMED   24556642
REFERENCE   4  (bases 1 to 1788)
  AUTHORS   Kowalski,P.E., Freeman,J.D. and Mager,D.L.
  TITLE     Intergenic splicing between a HERV-H endogenous retrovirus and two
            adjacent human genes
  JOURNAL   Genomics 57 (3), 371-379 (1999)
   PUBMED   10329003
REFERENCE   5  (bases 1 to 1788)
  AUTHORS   Wang,Y., Kowalski,P.E., Thalmann,I., Ornitz,D.M., Mager,D.L. and
            Thalmann,R.
  TITLE     Otoconin-90, the mammalian otoconial matrix protein, contains two
            domains of homology to secretory phospholipase A2
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15345-15350 (1998)
   PUBMED   9860971
REFERENCE   6  (bases 1 to 1788)
  AUTHORS   Feuchter-Murthy,A.E., Freeman,J.D. and Mager,D.L.
  TITLE     Splicing of a human endogenous retrovirus to a novel phospholipase
            A2 related gene
  JOURNAL   Nucleic Acids Res 21 (1), 135-143 (1993)
   PUBMED   8382789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100868.2, AK297911.1 and AC092817.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001080399.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK297911.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2142853,
                                           SAMEA2149178 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254627.4/ ENSP00000254627.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC100868.2         121868-121869       c
            3-47                AK297911.1         1-45
            48-48               AC100868.2         117555-117555       c
            49-518              AK297911.1         47-516
            519-528             AC100868.2         103549-103558       c
            529-1784            AK297911.1         527-1782
            1785-1788           AC092817.2         1554-1557
FEATURES             Location/Qualifiers
     source          1..1788
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.22"
     gene            1..1788
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /note="otoconin 90"
                     /db_xref="GeneID:729330"
                     /db_xref="HGNC:HGNC:8100"
                     /db_xref="MIM:601658"
     exon            1..42
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            43..135
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1523
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /note="phospholipase A2 homolog"
                     /codon_start=1
                     /product="otoconin-90 precursor"
                     /protein_id="NP_001073868.2"
                     /db_xref="CCDS:CCDS47919.1"
                     /db_xref="GeneID:729330"
                     /db_xref="HGNC:HGNC:8100"
                     /db_xref="MIM:601658"
                     /translation="MIAFLLTSVLMIPHAGGHPLDTPHLPQELPPGLPNNINITFFSG
                     MFKNVESVAEIFDCLGPHFTWLQAVFTNFPVLIQFVNGMKCVAGLCPRDFEDYGCTCR
                     FEMEGLPVDESDSCCFQHRRCYEEAAEMDCLQDPAKLSTEVNCVSKKIICESKDNCEH
                     LLCTCDKAAIECLARSSLNSSLNLLDTSFCLAQTPETTIKEDLTTLLPRVVPVEPTDT
                     SLTALSGEEAGHDQEGVGAARATSPPGSAEIVATRVTAKIVTLVPAGIKSLGLAVSSV
                     ENDPEETTEKACDRFTFLHLGSGDNMQVMPQLGEMLFCLTSRCPEEFESYGCYCGQEG
                     RGEPRDDLDRCCLSHHCCLEQVRRLGCLLERLPWSPVVCVDHTPKCGGQSLCEKLLCA
                     CDQTAAECMTSASFNQSLKSPSRLGCPGQPAACEDSLHPVPAAPTLGSSSEEDSEEDP
                     PQEDLGRAKRFLRKSLGPLGIGPLHGR"
     exon            136..201
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            202..258
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            259..433
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            434..546
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            547..675
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            676..717
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            718..768
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            769..822
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            823..948
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1120
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1227
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1788
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1769..1774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /note="hexamer: AATAAA"
     polyA_site      1786
                     /gene="OC90"
                     /gene_synonym="PLA2L"
                     /note="major polyA site"
ORIGIN      
        1 ctagcatcat tcatccagct gcactccagt ggagccttca cggagtccgt tccagttgct
       61 gcctaagccc catcctttgt tctcctgcta tgattgcgtt tctcctcacc agtgtgctga
      121 tgatccccca tgccggaggc catcctctgg acactccaca tcttccacag gagctgcctc
      181 caggactccc aaacaatatc aatatcactt tcttcagtgg gatgtttaaa aatgtggaaa
      241 gtgtggctga aatttttgat tgcctgggcc cccacttcac ctggctgcag gctgtcttca
      301 ccaatttccc tgtgctgatc cagtttgtca atggtatgaa gtgtgtggct ggtctctgcc
      361 cccgagactt tgaagactat ggttgcacct gcaggtttga gatggaaggg ttgcctgtgg
      421 atgaatctga cagctgctgc ttccagcacc gcaggtgcta tgaggaggcc gctgagatgg
      481 actgtctcca agaccccgcc aaacttagca cagaggtcaa ttgtgtcagc aagaagatca
      541 tatgtgagtc caaggacaac tgtgagcacc tgctgtgtac ctgtgataag gctgccatag
      601 agtgcttggc tcgatccagc ctcaactctt ccctgaacct tctggacacc tccttctgcc
      661 tggctcagac tccagagaca accatcaagg aagacttgac aacacttctg cccagagtgg
      721 ttcctgtgga gcccacagac accagcctga cagccctttc aggagaagaa gcaggccacg
      781 atcaggaagg agtgggagct gctagggcta cgtcccctcc aggatctgca gagatagttg
      841 caacaagggt tacagctaaa attgtaaccc ttgtccctgc tggcattaaa tctctggggc
      901 tggcagtgtc atctgttgaa aatgatcctg aggagaccac tgaaaaagcc tgtgacagat
      961 tcaccttcct gcacctggga agtggggaca acatgcaggt gatgccacag cttggagaga
     1021 tgctcttttg tctgacatcc cggtgcccgg aggaatttga gtcttatggc tgttactgtg
     1081 gacaagaagg aagaggcgag ccaagggatg acctagacag gtgctgcttg tcccatcact
     1141 gctgcctaga gcaagtgaga aggctgggct gcctgcttga gaggcttcct tggtcaccgg
     1201 tggtgtgtgt ggatcatacg cccaagtgtg ggggccaaag cctgtgtgag aagttgctct
     1261 gtgcctgtga ccagacggca gctgagtgca tgacctctgc ctcctttaac caaagcctca
     1321 agtccccaag cagactcggg tgccctgggc agccagcagc ctgtgaagac agcctgcacc
     1381 ctgtgcccgc agcccccacc ctgggctcca gctctgagga ggacagcgag gaggaccctc
     1441 cacaggagga cctcggcaga gccaagaggt ttctgcggaa gtcactgggt cccttgggga
     1501 tcgggcctct tcatggaaga tagatgccca gagaaaatgg ctaacacctt cagtagcgtg
     1561 gctcctgctc caccttcagc tctttatctc tcagcctcct ctgtcccttg gagccttctt
     1621 cccttccttt aactcagagg cggggaggga acagaggccg tgagccctgc ccatgcctca
     1681 tcagctgtgg tcacctcaca agccaatgta cacttggaga aggcacacca tggtacctcc
     1741 atgctccttt agtgcactgt ggaagctcaa taaatactcc aatcaaca
//
