LOCUS       NP_056126               1896 aa            linear   PRI 08-OCT-2024
DEFINITION  obscurin-like protein 1 isoform 1 precursor [Homo sapiens].
ACCESSION   NP_056126 XP_001128426 XP_001131592 XP_051017 XP_943597
VERSION     NP_056126.1
DBSOURCE    REFSEQ: accession NM_015311.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1896)
  AUTHORS   Tuysuz,B., Alp Unkar,Z., Turan,H., Gezdirici,A., Uludag Alkaya,D.,
            Kasap,B., Yesil,G., Vural,M. and Ercan,O.
  TITLE     Natural history of facial and skeletal features from neonatal
            period to adulthood in a 3M syndrome cohort with biallelic CUL7 or
            OBSL1 variants
  JOURNAL   Eur J Med Genet 64 (12), 104346 (2021)
   PUBMED   34597859
  REMARK    GeneRIF: Natural history of facial and skeletal features from
            neonatal period to adulthood in a 3M syndrome cohort with biallelic
            CUL7 or OBSL1 variants.
REFERENCE   2  (residues 1 to 1896)
  AUTHORS   Isik,E., Arican,D., Atik,T., Ooi,J.E., Darcan,S., Ozen,S., Simsek
            Kiper,P.O., Utine,E., Cogulu,O. and Ozkinay,F.
  TITLE     A rare cause of syndromic short stature: 3M syndrome in three
            families
  JOURNAL   Am J Med Genet A 185 (2), 461-468 (2021)
   PUBMED   33258289
  REMARK    GeneRIF: A rare cause of syndromic short stature: 3M syndrome in
            three families.
REFERENCE   3  (residues 1 to 1896)
  AUTHORS   Jacob,P. and Girisha,K.M.
  TITLE     Three M syndrome 2 in two Indian patients
  JOURNAL   Am J Med Genet A 185 (2), 614-616 (2021)
   PUBMED   33135300
  REMARK    GeneRIF: Three M syndrome 2 in two Indian patients.
REFERENCE   4  (residues 1 to 1896)
  AUTHORS   Simsek-Kiper,P.O., Taskiran,E., Kosukcu,C., Arslan,U.E.,
            Cormier-Daire,V., Gonc,N., Ozon,A., Alikasifoglu,A., Kandemir,N.,
            Utine,G.E., Alanay,Y., Alikasifoglu,M. and Boduroglu,K.
  TITLE     Further expanding the mutational spectrum and investigation of
            genotype-phenotype correlation in 3M syndrome
  JOURNAL   Am J Med Genet A 179 (7), 1157-1172 (2019)
   PUBMED   30980518
  REMARK    GeneRIF: The mutational spectrum of CUL7, OBSL1, and investigation
            of genotype-phenotype correlation in 3M syndrome has been reported.
REFERENCE   5  (residues 1 to 1896)
  AUTHORS   Pernigo,S., Fukuzawa,A., Beedle,A.E.M., Holt,M., Round,A.,
            Pandini,A., Garcia-Manyes,S., Gautel,M. and Steiner,R.A.
  TITLE     Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band
            Provides a Strategy for Isoform-Specific Mechanical Protection
  JOURNAL   Structure 25 (1), 107-120 (2017)
   PUBMED   27989621
  REMARK    GeneRIF: Crystal structure of the obscurin(-like-1):myomesin
            complex reveals a trans-complementation mechanism whereby an
            incomplete immunoglobulin-like domain assimilates an
            isoform-specific myomesin interdomain sequence.
REFERENCE   6  (residues 1 to 1896)
  AUTHORS   Hanson,D., Murray,P.G., Sud,A., Temtamy,S.A., Aglan,M.,
            Superti-Furga,A., Holder,S.E., Urquhart,J., Hilton,E., Manson,F.D.,
            Scambler,P., Black,G.C. and Clayton,P.E.
  TITLE     The primordial growth disorder 3-M syndrome connects ubiquitination
            to the cytoskeletal adaptor OBSL1
  JOURNAL   Am J Hum Genet 84 (6), 801-806 (2009)
   PUBMED   19481195
  REMARK    GeneRIF: Loss of OBSL1 leads to downregulation of CUL7 and results
            in primordial growth disorder 3-M syndrome.
REFERENCE   7  (residues 1 to 1896)
  AUTHORS   Fukuzawa,A., Lange,S., Holt,M., Vihola,A., Carmignac,V.,
            Ferreiro,A., Udd,B. and Gautel,M.
  TITLE     Interactions with titin and myomesin target obscurin and
            obscurin-like 1 to the M-band: implications for hereditary
            myopathies
  JOURNAL   J Cell Sci 121 (11), 1841-1851 (2008)
   PUBMED   18477606
  REMARK    GeneRIF: N-terminal Ig-domains of Obsl1 and Obscurin (Obsc) bind to
            titin-M10 and myomesin. Titin mutations, linked to limb-girdle
            muscular dystrophy 2J (LGMD2J) or Salih myopathy, weaken or
            abrogate titin-Obsc and titin-Obsl1 binding.
REFERENCE   8  (residues 1 to 1896)
  AUTHORS   Geisler,S.B., Robinson,D., Hauringa,M., Raeker,M.O., Borisov,A.B.,
            Westfall,M.V. and Russell,M.W.
  TITLE     Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to
            obscurin
  JOURNAL   Genomics 89 (4), 521-531 (2007)
   PUBMED   17289344
  REMARK    GeneRIF: report the cloning and characterization of OBSL1; OBSL1 is
            located on human chromosome 2q35 within 100 kb of SPEG, another
            gene related to obscurin
REFERENCE   9  (residues 1 to 1896)
  AUTHORS   Lanfranchi,G., Muraro,T., Caldara,F., Pacchioni,B., Pallavicini,A.,
            Pandolfo,D., Toppo,S., Trevisan,S., Scarso,S. and Valle,G.
  TITLE     Identification of 4370 expressed sequence tags from a
            3'-end-specific cDNA library of human skeletal muscle by DNA
            sequencing and filter hybridization
  JOURNAL   Genome Res 6 (1), 35-42 (1996)
   PUBMED   8681137
REFERENCE   10 (residues 1 to 1896)
  AUTHORS   Irving,M. and Holder-Espinasse,M.
  TITLE     Three M Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301654
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB475523.1, CK904385.1,
            EF063638.1 and F30329.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Apr 9, 2007 this sequence version replaced
            XP_001131592.1, XP_051017.6, XP_001128426.1, XP_943597.2.
            
            Summary: Cytoskeletal adaptor proteins function in linking the
            internal cytoskeleton of cells to the cell membrane. This gene
            encodes a cytoskeletal adaptor protein, which is a member of the
            Unc-89/obscurin family. The protein contains multiple N- and
            C-terminal immunoglobulin (Ig)-like domains and a central
            fibronectin type 3 domain. Mutations in this gene cause 3M syndrome
            type 2. Alternatively spliced transcript variants encoding
            different isoforms have been found in this gene. [provided by
            RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) is the longest transcript and
            encodes the longest isoform (1, also known as isoform A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF063638.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404537.6/ ENSP00000385636.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1896
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     Protein         1..1896
                     /product="obscurin-like protein 1 isoform 1 precursor"
                     /EC_number="2.7.11.18"
                     /note="obscurin-like protein 1; obscurin like 1"
                     /calculated_mol_wt=203918
     sig_peptide     1..29
                     /calculated_mol_wt=3048
     Site            10
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O75147.4)"
     Region          12..88
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          17..19
                     /region_name="Interaction with TTN"
                     /note="propagated from UniProtKB/Swiss-Prot (O75147.4)"
     Region          29..33
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     mat_peptide     30..1896
                     /product="obscurin-like protein 1 isoform 1"
                     /calculated_mol_wt=203918
     Region          42..46
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          67..71
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          81..86
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          85..94
                     /region_name="Interaction with TTN"
                     /note="propagated from UniProtKB/Swiss-Prot (O75147.4)"
     Region          106..127
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O75147.4)"
     Region          134..226
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          145..149
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          158..162
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..196
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          206..211
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          219..222
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          257..336
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          263..267
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          276..280
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          302..306
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          316..321
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          329..332
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          342..426
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          358..362
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          371..374
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          395..399
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..426
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          518..602
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(518,584,599)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          736..801
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          746..750
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          771..775
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          785..790
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          794..797
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          827..892
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          837..841
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          862..866
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          876..881
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          885..888
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          918..983
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          928..932
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          953..957
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          967..972
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          976..979
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1009..1074
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1019..1023
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1044..1048
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1058..1063
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1067..1070
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1097..1164
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1099..1103
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1111..1115
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1136..1140
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1150..1155
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1159..1162
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1178..1265
                     /region_name="Ig_Semaphorin_C"
                     /note="Immunoglobulin (Ig)-like domain at the C-terminus
                     of semaphorins; cd04979"
                     /db_xref="CDD:409368"
     Region          1178..1184
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409368"
     Region          1188..1196
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409368"
     Site            order(1190,1233)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:409368"
     Region          1202..1208
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409368"
     Region          1210..1213
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409368"
     Region          1218..1222
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409368"
     Region          1228..1235
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409368"
     Region          1241..1250
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409368"
     Region          1252..1265
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409368"
     Region          1273..1354
                     /region_name="IgI_C2_MyBP-C-like"
                     /note="Domain C2 of human cardiac Myosin Binding Protein C
                     and similar domains; a member of the I-set of IgSF
                     domains; cd20967"
                     /db_xref="CDD:409559"
     Region          1273..1275
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409559"
     Region          1278..1282
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409559"
     Region          1286..1292
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409559"
     Region          1299..1304
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409559"
     Region          1307..1310
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409559"
     Region          1315..1320
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409559"
     Region          1323..1328
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409559"
     Region          1337..1343
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409559"
     Region          1346..1354
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409559"
     Region          1361..1444
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1377..1381
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1389..1393
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1414..1418
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1428..1433
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1437..1440
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1451..1522
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1466..1470
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1480..1484
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1505..1509
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1519..1524
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1528..1531
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1541..1624
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1557..1561
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1569..1573
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1594..1598
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1608..1613
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1617..1620
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1631..1714
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1646..1650
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1658..1662
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1683..1687
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1697..1702
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1725..1803
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1736..1740
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1749..1752
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1773..1777
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1815..1893
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          1838..1842
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1863..1867
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1877..1882
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..1896
                     /gene="OBSL1"
                     /coded_by="NM_015311.3:308..5998"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS46520.1"
                     /db_xref="GeneID:23363"
                     /db_xref="HGNC:HGNC:29092"
                     /db_xref="MIM:610991"
ORIGIN      
        1 mkassgdqgs ppcflrfprp vrvvsgaeae lkcvvlgepp pvvvwekggq qlaaserlsf
       61 padgaehgll ltaalptdag vyvcrarnaa geayaaaavt vleppasdpe lqpaerplps
      121 pgsgegapvf ltgprsqwvl rgaevvltcr agglpeptly wekdgmalde vwdsshfalq
      181 pgraedgpga slalrilaar lpdsgvyvch arnahghaqa gallqvhqpp esppadpdea
      241 papvveplkc apktfwvneg khakfrcyvm gkpepeiewh wegrpllpdr rrlmyrdrdg
      301 gfvlkvlycq akdrglyvca arnsagqtls avqlhvkepr lrftrplqdv egrehgiavl
      361 eckvpnsrip tawfredqrl lpcrkyeqie egtvrrliih rlkadddgiy lcemrgrvrt
      421 vanvtvkgpi lkrlprkldv legenavllv etleagvegr wsrdgeelpv icqsssghmh
      481 alvlpgvtre dagevtfslg nsrtttllrv kcvkhsppgp pilaemfkgh kntvlltwkp
      541 pepapetpfi yrlerqevgs edwiqcfsie kagavevpgd cvpsegdyrf rictvsghgr
      601 sphvvfhgsa hlvptarlva gledvqvydg edavfsldls tiiqgtwfln geelksnepe
      661 gqvepgalry rieqkglqhr lilhavkhqd sgalvgfscp gvqdsaalti qespvhilsp
      721 qdrvsltftt servvltcel srvdfpatwy kdgqkveese llvvkmdgrk hrlilpeakv
      781 qdsgefecrt egvsaffgvt vqdppvhivd prehvfvhai tsecvmlace vdredapvrw
      841 ykdgqevees dfvvlenegp hrrlvlpatq psdggefqcv agdecayftv titdvsswiv
      901 ypsgkvyvaa vrlervvltc elcrpwaevr wtkdgeevve spalllqked tvrrlvlpav
      961 qledsgeylc eiddesasft vtvteppvri iyprdevtli avtlecvvlm celsredapv
     1021 rwykdgleve esealvlerd gprcrlvlpa aqpedggefv cdagddsaff tvtvtapper
     1081 ivhpaarsld lhfgapgrve lrcevapags qvrwykdgle veasdalqlg aegptrtltl
     1141 phaqpedage yvcetrheai tfnvilaepp vqflalettp splcvapgep vvlscelsra
     1201 gapvvwshng rpvqegegle lhaegprrvl ciqaagpaha glytcqsgaa pgapslsftv
     1261 qvaeppvrvv apeaaqtrvr stpggdlelv vhlsgpggpv rwykdgerla sqgrvqleqa
     1321 garqvlrvqg arsgdageyl cdapqdsrif lvsveepllv klvseltplt vhegddatfr
     1381 cevsppdadv twlrngavvt pgpqvemaqn gssriltlrg cqlgdagtvt lragstatsa
     1441 rlhvretell flrrlqdvra eegqdvclev etgrvgaaga vrwvrggqpl phdsrlsmaq
     1501 dghihrlfih gviladqgty gceshhdrtl arlsvrprql rvlrpledvt iseggsatfq
     1561 lelsqegvtg ewarggvqly pgpkchihsd ghrhrlvlng lgladsgcvs ftadslrcaa
     1621 rlivrevpvt ivrgphdlev tegdtatfec elsqaladvt wekdgnaltp sprlrlqalg
     1681 trrllqlrrc gpsdagtysc avgtaragpv rltvrertva vlselrsvsa regdgatfec
     1741 tvsevettgr welggrplrp garvrirqeg kkhilvlsel raedagevrf qagpaqslal
     1801 levealplqm crhpprektv lvgrravlev tvsrsgghvc wlregaelcp gdkyemrshg
     1861 pthslvihdv rpedqgtycc qagqdsthtr llvegn
//
