LOCUS       NM_014581                698 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens odorant binding protein 2B (OBP2B), transcript variant
            alpha, mRNA.
ACCESSION   NM_014581
VERSION     NM_014581.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 698)
  AUTHORS   Sano,R., Takahashi,Y., Fukuda,H., Harada,M., Hayakawa,A., Okawa,T.,
            Kubo,R., Takeshita,H., Tsukada,J. and Kominato,Y.
  TITLE     A cell-specific regulatory region of the human ABO blood group gene
            regulates the neighborhood gene encoding odorant binding protein 2B
  JOURNAL   Sci Rep 11 (1), 7325 (2021)
   PUBMED   33795748
  REMARK    GeneRIF: A cell-specific regulatory region of the human ABO blood
            group gene regulates the neighborhood gene encoding odorant binding
            protein 2B.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 698)
  AUTHORS   Desch,K.C., Ozel,A.B., Siemieniak,D., Kalish,Y., Shavit,J.A.,
            Thornburg,C.D., Sharathkumar,A.A., McHugh,C.P., Laurie,C.C.,
            Crenshaw,A., Mirel,D.B., Kim,Y., Cropp,C.D., Molloy,A.M.,
            Kirke,P.N., Bailey-Wilson,J.E., Wilson,A.F., Mills,J.L.,
            Scott,J.M., Brody,L.C., Li,J.Z. and Ginsburg,D.
  TITLE     Linkage analysis identifies a locus for plasma von Willebrand
            factor undetected by genome-wide association
  JOURNAL   Proc Natl Acad Sci U S A 110 (2), 588-593 (2013)
   PUBMED   23267103
REFERENCE   3  (bases 1 to 698)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   4  (bases 1 to 698)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 698)
  AUTHORS   Briand,L., Eloit,C., Nespoulous,C., Bezirard,V., Huet,J.C.,
            Henry,C., Blon,F., Trotier,D. and Pernollet,J.C.
  TITLE     Evidence of an odorant-binding protein in the human olfactory
            mucus: location, structural characterization, and odorant-binding
            properties
  JOURNAL   Biochemistry 41 (23), 7241-7252 (2002)
   PUBMED   12044155
REFERENCE   6  (bases 1 to 698)
  AUTHORS   Lacazette,E., Gachon,A.M. and Pitiot,G.
  TITLE     A novel human odorant-binding protein gene family resulting from
            genomic duplicons at 9q34: differential expression in the oral and
            genital spheres
  JOURNAL   Hum Mol Genet 9 (2), 289-301 (2000)
   PUBMED   10607840
REFERENCE   7  (bases 1 to 698)
  AUTHORS   Pevsner,J., Reed,R.R., Feinstein,P.G. and Snyder,S.H.
  TITLE     Molecular cloning of odorant-binding protein: member of a ligand
            carrier family
  JOURNAL   Science 241 (4863), 336-339 (1988)
   PUBMED   3388043
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY046406.1, AY358981.1 and AI251747.1.
            
            On Aug 13, 2020 this sequence version replaced NM_014581.3.
            
            Transcript Variant: This variant (alpha, PMID:10607840) differs in
            the 3' UTR, compared to variant 1. Variants 1 and alpha encode the
            same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358981.1, AJ251026.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372034.8/ ENSP00000361104.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 HY046406.1         1-7
            8-267               AY358981.1         1-260
            268-698             AI251747.1         11-441              c
FEATURES             Location/Qualifiers
     source          1..698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..698
                     /gene="OBP2B"
                     /gene_synonym="LCN14; OBPIIb"
                     /note="odorant binding protein 2B"
                     /db_xref="GeneID:29989"
                     /db_xref="HGNC:HGNC:23381"
                     /db_xref="MIM:604606"
     exon            1..123
                     /gene="OBP2B"
                     /gene_synonym="LCN14; OBPIIb"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..564
                     /gene="OBP2B"
                     /gene_synonym="LCN14; OBPIIb"
                     /note="odorant-binding protein IIb; odorant-binding
                     protein 2b"
                     /codon_start=1
                     /product="odorant-binding protein 2b precursor"
                     /protein_id="NP_055396.1"
                     /db_xref="CCDS:CCDS6961.1"
                     /db_xref="GeneID:29989"
                     /db_xref="HGNC:HGNC:23381"
                     /db_xref="MIM:604606"
                     /translation="MKTLFLGVTLGLAAALSFTLEEEDITGTWYVKAMVVDKDFPEDR
                     RPRKVSPVKVTALGGGKLEATFTFMREDRCIQKKILMRKTEEPGKYSAYGGRKLMYLQ
                     ELPRRDHYIFYCKDQHHGGLLHMGKLVGRNSDTNREALEEFKKLVQRKGLSEEDIFTP
                     LQTGSCVPEH"
     exon            124..257
                     /gene="OBP2B"
                     /gene_synonym="LCN14; OBPIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            258..328
                     /gene="OBP2B"
                     /gene_synonym="LCN14; OBPIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            329..439
                     /gene="OBP2B"
                     /gene_synonym="LCN14; OBPIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            440..541
                     /gene="OBP2B"
                     /gene_synonym="LCN14; OBPIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            542..565
                     /gene="OBP2B"
                     /gene_synonym="LCN14; OBPIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            566..698
                     /gene="OBP2B"
                     /gene_synonym="LCN14; OBPIIb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      679..684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OBP2B"
                     /gene_synonym="LCN14; OBPIIb"
                     /note="hexamer: AATAAA"
     polyA_site      698
                     /gene="OBP2B"
                     /gene_synonym="LCN14; OBPIIb"
                     /note="major polyA site"
ORIGIN      
        1 ttgttcagac gcccagtgac ctgccgaggt cggcagcaca gagctctgga gatgaagacc
       61 ctgttcctgg gtgtcacgct cggcctggcc gctgccctgt ccttcaccct ggaggaggag
      121 gatatcacag ggacctggta cgtgaaggcc atggtggtcg ataaggactt tccggaggac
      181 aggaggccca ggaaggtgtc cccagtgaag gtgacagccc tgggcggtgg gaagttggaa
      241 gccacgttca ccttcatgag ggaggatagg tgcatccaga agaaaatcct gatgcggaag
      301 acggaggagc ctggcaaata cagcgcctat gggggcagga agctcatgta cctgcaggag
      361 ctgcccagga gggaccacta catcttttac tgcaaagacc agcaccatgg gggcctgctc
      421 cacatgggaa agcttgtggg taggaattct gataccaacc gggaggccct ggaagaattt
      481 aagaaattgg tgcagcgcaa gggactctcg gaggaggaca ttttcacgcc cctgcagacg
      541 ggaagctgcg ttcccgaaca ctaggcagcc cccgggtctg cacctccaga gcccacccta
      601 ccaccagaca cagagcctgg accacctgga cctaccctcc agccatgacc cttccctgct
      661 cccacccacc tgactccaaa taaagtcctt ctccccca
//
