LOCUS       NM_014582                702 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens odorant binding protein 2A (OBP2A), transcript variant
            1, mRNA.
ACCESSION   NM_014582
VERSION     NM_014582.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 702)
  AUTHORS   Qin,X., Tan,Y., Ren,W., Zhou,W., Niu,R., Liang,L., Li,J., Cao,K.,
            Wei,G., Zhu,X. and Huang,M.
  TITLE     Elevated expression of LCN13 through FXR activation ameliorates
            hepatocellular lipid accumulation and inflammation
  JOURNAL   Int Immunopharmacol 131, 111812 (2024)
   PUBMED   38493698
  REMARK    GeneRIF: Elevated expression of LCN13 through FXR activation
            ameliorates hepatocellular lipid accumulation and inflammation.
REFERENCE   2  (bases 1 to 702)
  AUTHORS   Jeong,J.H., Zhong,S., Li,F., Huang,C., Chen,X., Liu,Q., Peng,S.,
            Park,H., Lee,Y.M., Dhillon,J. and Luo,J.L.
  TITLE     Tumor-derived OBP2A promotes prostate cancer castration resistance
  JOURNAL   J Exp Med 220 (3) (2023)
   PUBMED   36547668
  REMARK    GeneRIF: Tumor-derived OBP2A promotes prostate cancer castration
            resistance.
REFERENCE   3  (bases 1 to 702)
  AUTHORS   Sollai,G., Melis,M., Tomassini Barbarossa,I. and Crnjar,R.
  TITLE     A polymorphism in the human gene encoding OBPIIa affects the
            perceived intensity of smelled odors
  JOURNAL   Behav Brain Res 427, 113860 (2022)
   PUBMED   35341882
  REMARK    GeneRIF: A polymorphism in the human gene encoding OBPIIa affects
            the perceived intensity of smelled odors.
REFERENCE   4  (bases 1 to 702)
  AUTHORS   Sollai,G., Melis,M., Mastinu,M., Paduano,D., Chicco,F., Magri,S.,
            Usai,P., Hummel,T., Barbarossa,I.T. and Crnjar,R.
  TITLE     Olfactory Function in Patients with Inflammatory Bowel Disease
            (IBD) Is Associated with Their Body Mass Index and Polymorphism in
            the Odor Binding-Protein (OBPIIa) Gene
  JOURNAL   Nutrients 13 (2), 703 (2021)
   PUBMED   33671721
  REMARK    GeneRIF: Olfactory Function in Patients with Inflammatory Bowel
            Disease (IBD) Is Associated with Their Body Mass Index and
            Polymorphism in the Odor Binding-Protein (OBPIIa) Gene.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 702)
  AUTHORS   Melis,M., Pintus,S., Mastinu,M., Fantola,G., Moroni,R., Pepino,M.Y.
            and Barbarossa,I.T.
  TITLE     Changes of Taste, Smell and Eating Behavior in Patients Undergoing
            Bariatric Surgery: Associations with PROP Phenotypes and
            Polymorphisms in the Odorant-Binding Protein OBPIIa and CD36
            Receptor Genes
  JOURNAL   Nutrients 13 (1), 250 (2021)
   PUBMED   33467165
  REMARK    GeneRIF: Changes of Taste, Smell and Eating Behavior in Patients
            Undergoing Bariatric Surgery: Associations with PROP Phenotypes and
            Polymorphisms in the Odorant-Binding Protein OBPIIa and CD36
            Receptor Genes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 702)
  AUTHORS   Breustedt,D.A., Schonfeld,D.L. and Skerra,A.
  TITLE     Comparative ligand-binding analysis of ten human lipocalins
  JOURNAL   Biochim Biophys Acta 1764 (2), 161-173 (2006)
   PUBMED   16461020
REFERENCE   7  (bases 1 to 702)
  AUTHORS   Matarazzo,V., Zsurger,N., Guillemot,J.C., Clot-Faybesse,O.,
            Botto,J.M., Dal Farra,C., Crowe,M., Demaille,J., Vincent,J.P.,
            Mazella,J. and Ronin,C.
  TITLE     Porcine odorant-binding protein selectively binds to a human
            olfactory receptor
  JOURNAL   Chem Senses 27 (8), 691-701 (2002)
   PUBMED   12379593
REFERENCE   8  (bases 1 to 702)
  AUTHORS   Briand,L., Eloit,C., Nespoulous,C., Bezirard,V., Huet,J.C.,
            Henry,C., Blon,F., Trotier,D. and Pernollet,J.C.
  TITLE     Evidence of an odorant-binding protein in the human olfactory
            mucus: location, structural characterization, and odorant-binding
            properties
  JOURNAL   Biochemistry 41 (23), 7241-7252 (2002)
   PUBMED   12044155
  REMARK    GeneRIF: hOBPIIa(alpha) is expressed in the nasal mucus covering
            the olfactory cleft and is able to bind numerous odorants of
            diverse chemical structures, with a higher affinity for aldehydes
            and large fatty acids.
REFERENCE   9  (bases 1 to 702)
  AUTHORS   Tegoni,M., Pelosi,P., Vincent,F., Spinelli,S., Campanacci,V.,
            Grolli,S., Ramoni,R. and Cambillau,C.
  TITLE     Mammalian odorant binding proteins
  JOURNAL   Biochim Biophys Acta 1482 (1-2), 229-240 (2000)
   PUBMED   11058764
  REMARK    Review article
REFERENCE   10 (bases 1 to 702)
  AUTHORS   Lacazette,E., Gachon,A.M. and Pitiot,G.
  TITLE     A novel human odorant-binding protein gene family resulting from
            genomic duplicons at 9q34: differential expression in the oral and
            genital spheres
  JOURNAL   Hum Mol Genet 9 (2), 289-301 (2000)
   PUBMED   10607840
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161452.19, AJ251021.1 and
            AI219510.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_014582.2.
            
            Summary: This gene encodes a small extracellular protein belonging
            to the lipocalin superfamily. The protein is thought to transport
            small, hydrophobic, volatile molecules or odorants through the
            nasal mucus to olfactory receptors, and may also function as a
            scavenger of highly concentrated or toxic odors. The protein is
            expressed as a monomer in the nasal mucus, and can bind diverse
            types of odorants with a higher affinity for aldehydes and fatty
            acids. This gene and a highly similar family member are located in
            a cluster of lipocalin genes on chromosome 9. Alternatively spliced
            transcript variants have been described, but their biological
            validity has not been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ251021.1, BC069563.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371776.6/ ENSP00000360841.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL161452.19        12759-12771         c
            14-689              AJ251021.1         1-676
            690-702             AI219510.1         3-15                c
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..702
                     /gene="OBP2A"
                     /gene_synonym="hOBPIIa; LCN13; OBP; OBP2C; OBPIIa"
                     /note="odorant binding protein 2A"
                     /db_xref="GeneID:29991"
                     /db_xref="HGNC:HGNC:23380"
                     /db_xref="MIM:164320"
     exon            1..127
                     /gene="OBP2A"
                     /gene_synonym="hOBPIIa; LCN13; OBP; OBP2C; OBPIIa"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..568
                     /gene="OBP2A"
                     /gene_synonym="hOBPIIa; LCN13; OBP; OBP2C; OBPIIa"
                     /note="isoform alpha precursor is encoded by transcript
                     variant 1; putative odorant-binding protein 2c;
                     odorant-binding protein IIa"
                     /codon_start=1
                     /product="odorant-binding protein 2a isoform alpha
                     precursor"
                     /protein_id="NP_055397.1"
                     /db_xref="CCDS:CCDS6992.1"
                     /db_xref="GeneID:29991"
                     /db_xref="HGNC:HGNC:23380"
                     /db_xref="MIM:164320"
                     /translation="MKTLFLGVTLGLAAALSFTLEEEDITGTWYVKAMVVDKDFPEDR
                     RPRKVSPVKVTALGGGNLEATFTFMREDRCIQKKILMRKTEEPGKFSAYGGRKLIYLQ
                     ELPGTDDYVFYCKDQRRGGLRYMGKLVGRNPNTNLEALEEFKKLVQHKGLSEEDIFMP
                     LQTGSCVLEH"
     exon            128..261
                     /gene="OBP2A"
                     /gene_synonym="hOBPIIa; LCN13; OBP; OBP2C; OBPIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            262..332
                     /gene="OBP2A"
                     /gene_synonym="hOBPIIa; LCN13; OBP; OBP2C; OBPIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            333..443
                     /gene="OBP2A"
                     /gene_synonym="hOBPIIa; LCN13; OBP; OBP2C; OBPIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            444..545
                     /gene="OBP2A"
                     /gene_synonym="hOBPIIa; LCN13; OBP; OBP2C; OBPIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            546..569
                     /gene="OBP2A"
                     /gene_synonym="hOBPIIa; LCN13; OBP; OBP2C; OBPIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            570..702
                     /gene="OBP2A"
                     /gene_synonym="hOBPIIa; LCN13; OBP; OBP2C; OBPIIa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      683..688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OBP2A"
                     /gene_synonym="hOBPIIa; LCN13; OBP; OBP2C; OBPIIa"
                     /note="hexamer: AATAAA"
     polyA_site      702
                     /gene="OBP2A"
                     /gene_synonym="hOBPIIa; LCN13; OBP; OBP2C; OBPIIa"
                     /note="major polyA site"
ORIGIN      
        1 agccttgttc agacgcccag tgacctgccg aggtcggcag cacagagctc tggagatgaa
       61 gaccctgttc ctgggtgtca cgctcggcct ggccgctgcc ctgtccttca ccctggagga
      121 ggaggatatc acagggacct ggtacgtgaa ggccatggtg gtcgataagg actttccgga
      181 ggacaggagg cccaggaagg tgtccccagt gaaggtgaca gccctgggcg gtgggaactt
      241 ggaagccacg ttcaccttca tgagggagga tcggtgcatc cagaagaaaa tcctgatgcg
      301 gaagacggag gagcctggca aattcagcgc ctatgggggc aggaagctca tatacctgca
      361 ggagctgccc gggacggacg actacgtctt ttactgcaaa gaccagcgcc gtgggggcct
      421 gcgctacatg ggaaagcttg tgggtaggaa tcctaatacc aacctggagg ccctggaaga
      481 atttaagaaa ttggtgcagc acaagggact ctcggaggag gacattttca tgcccctgca
      541 gacgggaagc tgcgttctcg aacactaggc agcccccggg tctgcacctc cagagcccac
      601 cctaccacca gacacagagc ccggaccacc tggacctacc ctccagccat gacccttccc
      661 tgctcccacc cacctgactc caaataaaga gcttctcccc ca
//
