LOCUS       NM_024546               3507 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ORC ubiquitin ligase 1 (OBI1), mRNA.
ACCESSION   NM_024546
VERSION     NM_024546.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3507)
  AUTHORS   Li,X.D., Zhong,Q.L., Luo,D.J., Liang,Q.F., Qiu,J.Q., Du,Q.H.,
            Xiao,L., Zhou,Y.H., Long,Y.B., Liu,W.Q. and Li,J.
  TITLE     RNF219 Promotes Nasopharyngeal Carcinoma Progression by Activating
            the NF-kappaB Pathway
  JOURNAL   Mol Biotechnol 65 (8), 1318-1326 (2023)
   PUBMED   36512252
  REMARK    GeneRIF: RNF219 Promotes Nasopharyngeal Carcinoma Progression by
            Activating the NF-kappaB Pathway.
REFERENCE   2  (bases 1 to 3507)
  AUTHORS   Poetz,F., Corbo,J., Levdansky,Y., Spiegelhalter,A., Lindner,D.,
            Magg,V., Lebedeva,S., Schweiggert,J., Schott,J., Valkov,E. and
            Stoecklin,G.
  TITLE     RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT
            complex-mediated deadenylation
  JOURNAL   Nat Commun 12 (1), 7175 (2021)
   PUBMED   34887419
  REMARK    GeneRIF: RNF219 attenuates global mRNA decay through inhibition of
            CCR4-NOT complex-mediated deadenylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3507)
  AUTHORS   Fu,G.H., Chen,W., Li,H.M., Wang,Y.F., Liu,L. and Qian,Q.J.
  TITLE     A potential association of RNF219-AS1 with ADHD: Evidence from
            categorical analysis of clinical phenotypes and from quantitative
            exploration of executive function and white matter microstructure
            endophenotypes
  JOURNAL   CNS Neurosci Ther 27 (5), 603-616 (2021)
   PUBMED   33644999
  REMARK    GeneRIF: A potential association of RNF219-AS1 with ADHD: Evidence
            from categorical analysis of clinical phenotypes and from
            quantitative exploration of executive function and white matter
            microstructure endophenotypes.
REFERENCE   4  (bases 1 to 3507)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3507)
  AUTHORS   Coulombe,P., Nassar,J., Peiffer,I., Stanojcic,S., Sterkers,Y.,
            Delamarre,A., Bocquet,S. and Mechali,M.
  TITLE     The ORC ubiquitin ligase OBI1 promotes DNA replication origin
            firing
  JOURNAL   Nat Commun 10 (1), 2426 (2019)
   PUBMED   31160578
  REMARK    GeneRIF: RNF219 silencing result in defective replication origin
            firing, as shown by reduced CDC45/MCM2-7/GINS complex formation,
            without affecting pre-replicative complex establishment. RNF219
            catalyses the multi-mono-ubiquitylation of a subset of
            chromatin-bound ORC3 and ORC5 during S-phase.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3507)
  AUTHORS   Dichgans,M., Malik,R., Konig,I.R., Rosand,J., Clarke,R.,
            Gretarsdottir,S., Thorleifsson,G., Mitchell,B.D., Assimes,T.L.,
            Levi,C., O'Donnell,C.J., Fornage,M., Thorsteinsdottir,U.,
            Psaty,B.M., Hengstenberg,C., Seshadri,S., Erdmann,J., Bis,J.C.,
            Peters,A., Boncoraglio,G.B., Marz,W., Meschia,J.F., Kathiresan,S.,
            Ikram,M.A., McPherson,R., Stefansson,K., Sudlow,C., Reilly,M.P.,
            Thompson,J.R., Sharma,P., Hopewell,J.C., Chambers,J.C., Watkins,H.,
            Rothwell,P.M., Roberts,R., Markus,H.S., Samani,N.J., Farrall,M. and
            Schunkert,H.
  CONSRTM   METASTROKE Consortium; CARDIoGRAM Consortium; C4D Consortium;
            International Stroke Genetics Consortium
  TITLE     Shared genetic susceptibility to ischemic stroke and coronary
            artery disease: a genome-wide analysis of common variants
  JOURNAL   Stroke 45 (1), 24-36 (2014)
   PUBMED   24262325
  REMARK    Review article
REFERENCE   7  (bases 1 to 3507)
  AUTHORS   Barber,M.J., Mangravite,L.M., Hyde,C.L., Chasman,D.I., Smith,J.D.,
            McCarty,C.A., Li,X., Wilke,R.A., Rieder,M.J., Williams,P.T.,
            Ridker,P.M., Chatterjee,A., Rotter,J.I., Nickerson,D.A.,
            Stephens,M. and Krauss,R.M.
  TITLE     Genome-wide association of lipid-lowering response to statins in
            combined study populations
  JOURNAL   PLoS One 5 (3), e9763 (2010)
   PUBMED   20339536
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3507)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   9  (bases 1 to 3507)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC028586.1, BI550796.1, AK023511.1 and BM674566.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024546.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.252175.1,
                                           SRR1803613.258641.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282003.7/ ENSP00000282003.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               BC028586.1         30-179
            151-673             BI550796.1         93-615
            674-1874            BC028586.1         703-1903
            1875-2508           AK023511.1         1088-1721
            2509-3148           BC028586.1         2539-3178
            3149-3507           BM674566.1         22-380              c
FEATURES             Location/Qualifiers
     source          1..3507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q31.1"
     gene            1..3507
                     /gene="OBI1"
                     /gene_synonym="C13orf7; RNF219"
                     /note="ORC ubiquitin ligase 1"
                     /db_xref="GeneID:79596"
                     /db_xref="HGNC:HGNC:20308"
                     /db_xref="MIM:615906"
     exon            1..107
                     /gene="OBI1"
                     /gene_synonym="C13orf7; RNF219"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2216
                     /gene="OBI1"
                     /gene_synonym="C13orf7; RNF219"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 219"
                     /codon_start=1
                     /product="ORC ubiquitin ligase 1"
                     /protein_id="NP_078822.3"
                     /db_xref="CCDS:CCDS31997.1"
                     /db_xref="GeneID:79596"
                     /db_xref="HGNC:HGNC:20308"
                     /db_xref="MIM:615906"
                     /translation="MAQTVQNVTLSLTLPITCHICLGKVRQPVICINNHVFCSICIDL
                     WLKNNSQCPACRVPITPENPCKEIIGGTSESEPMLSHTVRKHLRKTRLELLHKEYEDE
                     IDCLQKEVEELKSKNLSLESQIKTILDPLTLVQGNQNEDKHLVTDNPSKINPETVAEW
                     KKKLRTANEIYEKVKDDVDKLKEANKKLKLENGGLVRENLRLKAEVDNRSPQKFGRFA
                     VAALQSKVEQYERETNRLKKALERSDKYIEELESQVAQLKNSSEEKEAMNSICQTALS
                     ADGKGSKGSEEDVVSKNQGDSARKQPGSSTSSSSHLAKPSSSRLCDTSSARQESTSKA
                     DLNCSKNKDLYQEQVEVMLDVTDTSMDTYLEREWGNKPSDCVPYKDEELYDLPAPCTP
                     LSLSCLQLSTPENRESSVVQAGGSKKHSNHLRKLVFDDFCDSSNVSNKDSSEDDISRS
                     ENEKKSECFSSPKTGFWDCCSTSYAQNLDFESSEGNTIANSVGEISSKLSEKSGLCLS
                     KRLNSIRSFEMNRTRTSSEASMDAAYLDKISELDSMMSESDNSKSPCNNGFKSLDLDG
                     LSKSSQGSEFLEEPDKLEEKTELNLSKGSLTNDQLENGSEWKPTSFFLLSPSDQEMNE
                     DFSLHSSSCPVTNEIKPPSCLFQTEFSQGILLSSSHRLFEDQRFGSSLFKMSSEMHSL
                     HNHLQSPWSTSFVPEKRNKNVNQSTKRKIQSSLSSASPSKATKS"
     exon            108..243
                     /gene="OBI1"
                     /gene_synonym="C13orf7; RNF219"
                     /inference="alignment:Splign:2.1.0"
     exon            244..335
                     /gene="OBI1"
                     /gene_synonym="C13orf7; RNF219"
                     /inference="alignment:Splign:2.1.0"
     exon            336..584
                     /gene="OBI1"
                     /gene_synonym="C13orf7; RNF219"
                     /inference="alignment:Splign:2.1.0"
     exon            585..673
                     /gene="OBI1"
                     /gene_synonym="C13orf7; RNF219"
                     /inference="alignment:Splign:2.1.0"
     exon            674..3507
                     /gene="OBI1"
                     /gene_synonym="C13orf7; RNF219"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3483..3488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OBI1"
                     /gene_synonym="C13orf7; RNF219"
                     /note="hexamer: AATAAA"
     polyA_site      3507
                     /gene="OBI1"
                     /gene_synonym="C13orf7; RNF219"
                     /note="major polyA site"
ORIGIN      
        1 gggacttccg tgttggcggg attctgaacg ctgccatggc tcagaccgtg cagaatgtta
       61 cattgtcgct cactctgccc atcacgtgcc acatttgctt ggggaaggta cgtcagcctg
      121 tcatatgcat caacaaccat gtattttgtt cgatttgtat tgatttgtgg ttgaagaata
      181 atagccagtg tccagcttgc agagtcccca tcactcctga aaatccttgc aaagaaatta
      241 taggaggaac aagtgaaagt gaacctatgc taagccatac ggtcaggaag catcttcgga
      301 aaactagact tgaattacta cacaaagaat atgaggacga aatagattgt ttacagaaag
      361 aagtagaaga gcttaagagt aaaaatctca gcttggagtc acagatcaaa actattctgg
      421 atcctttaac cttggtgcag ggcaaccaaa atgaagacaa acatctagtc acagataatc
      481 caagtaaaat taacccagaa actgtagcag agtggaagaa aaaactcaga acagctaatg
      541 aaatctatga aaaagtgaaa gatgatgtgg ataagctaaa ggaggcaaat aaaaaattga
      601 aattggaaaa tggtggtctg gtgagggaga atttacgact gaaggctgaa gttgataaca
      661 gatcacctca aaagtttgga aggtttgcag ttgctgctct tcagtccaaa gtagaacagt
      721 atgagcgtga aaccaatcgc ctcaagaaag ccctggaacg aagtgataag tatatagagg
      781 aactagaatc tcaagttgca cagctaaaaa attcaagtga agagaaagaa gctatgaatt
      841 ccatttgcca gacagcactt tctgcagatg gcaaagggag caaaggcagt gaggaggatg
      901 tggtgtcaaa gaatcaaggc gatagtgcca gaaagcagcc tggctcatcc acctccagtt
      961 cttctcacct agcgaagcct tccagcagca gactgtgtga caccagttct gcaaggcagg
     1021 aaagtaccag caaagcagac cttaactgtt ctaagaacaa agacctatat caagaacagg
     1081 tagaagtaat gttagatgtg acagatacaa gtatggatac ttatttggaa agagaatggg
     1141 ggaataaacc aagtgactgt gtaccctaca aagatgaaga actttatgat cttccagctc
     1201 cttgtactcc tttgtccctt agttgccttc agctcagtac tccagaaaat agagagagct
     1261 ctgtggtcca agcaggaggt tccaaaaagc actcaaacca tctcagaaaa ttggtgtttg
     1321 atgatttttg tgattcttca aatgtttcta ataaagattc ttcagaagat gatataagta
     1381 gaagtgaaaa tgaaaagaaa tcagaatgtt tttcttcccc aaagacagga ttttgggact
     1441 gttgttccac aagctatgcc caaaacttag attttgaaag ttcagagggg aacacgatag
     1501 caaattctgt tggagaaata tcttcaaaat tgagtgagaa atcaggctta tgtttatcca
     1561 aaaggttgaa ttctattcgc tcttttgaaa tgaaccggac aagaacatcc agtgaagcat
     1621 cgatggatgc tgcttacctt gacaaaatct ctgagttgga ttcaatgatg tcagagtcag
     1681 acaacagcaa gagcccttgt aataacggtt ttaagtcact ggatttggat gggttatcaa
     1741 agtcatctca aggcagtgaa tttcttgagg aacctgataa gttggaagaa aaaactgagc
     1801 taaacctttc caaaggttct ctaactaatg atcagttaga aaatggaagt gaatggaaac
     1861 ccacttcttt ttttctcctc tctccatctg accaagaaat gaatgaagat ttttcactcc
     1921 attccagttc ttgtccagta actaatgaaa tcaaaccccc aagctgcttg tttcagacag
     1981 agttttccca gggcattttg ttaagcagtt cacatcgact atttgaagat caaagatttg
     2041 ggtcatcttt gtttaagatg tcctcagaga tgcacagtct tcataaccac cttcagtctc
     2101 cttggtctac ttcctttgtg cctgaaaaga ggaataaaaa tgtgaatcaa tcaacaaaaa
     2161 gaaaaatcca gagcagcctt tccagtgcca gcccatcaaa agcaactaaa agttgactca
     2221 ttagaaaggt gtcatttgtg gttttgtcct gagagaaata gaaaagttgt taaagttacc
     2281 ttttttcctc ataaaagttc tatacaaatt ggaattgata atctttagtc aagtatcaag
     2341 tcaggatggt ggattaacct gtacccagaa tacttattgt tcattttgaa aagactttgt
     2401 tcttttcatt tttatttggg agtctttgtg accagagaag ttagggagga ggttattttt
     2461 gtgttttggg gttggttggt tggttggttt tgtttttggt tttgtttttt tactgaattt
     2521 gatatgtatc tcggttggat atacattgtt tttttaaaaa atgttattta actgttagat
     2581 acagtggcct gttgataagc cccacttgtc ttcagaactt ggatttctta aataaaactt
     2641 ttagtgttgt ctatacactg ctcaataaga cacttgagtt taagcttttc ccagggtgga
     2701 aattatttta cctgtccctt tttatttatg tttagtgatg gcctagtttt tctgcagggc
     2761 catgatggag aaatagcact ctagccttag tccaatattg atttactttc tttttttagg
     2821 ttttatgtat atgtttgcat tttttagcat tgtgttttgt ccagttttgt gaaaatgttc
     2881 tgctagtatg aaagaaaaca ttttctatat gaagacattt gttttatgtt aggtagctta
     2941 cattttctcc tctgcgtgtg tgtgtatgtg tgtaaaatca gaaatttagc atactatgga
     3001 aagaaggcat ggagcacttg ggtttagagg aacctaaaac atcatagctt cattgttcca
     3061 gatgtaacag gtttgaaaga gctcatcgcc aagttcttga tccacttgca ttccagggga
     3121 gttttctttt gagtagtatg tttcttgttt gcatgttcct gttctttgtg gaaactatgc
     3181 atggtagcat ttttgcttgc tgtgttttcc atacttaaga aaaagaggtt tcagttggct
     3241 gatagaatat cttttatgta ggacaaaact tttctgtgaa gagtgttgag ggggtgaaga
     3301 taggtaagag gtaagcacaa tttttaattt aggctctgaa aaagtgtatt gttctaaacg
     3361 tatttggtat gcctatatag gtctttaaaa atgggtatgt atgctgttta atgtgcactg
     3421 aacattttac attaatattg tactgtttta cattaatact gcatgctttt ctatgtgaat
     3481 tgaataaaga atgtcataag cactgtg
//
