LOCUS       NM_016178                901 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ornithine decarboxylase antizyme 3 (OAZ3), transcript
            variant 1, mRNA.
ACCESSION   NM_016178
VERSION     NM_016178.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 901)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 901)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 901)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 901)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 901)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   6  (bases 1 to 901)
  AUTHORS   Christensen,G.L., Ivanov,I.P., Wooding,S.P., Atkins,J.F.,
            Mielnik,A., Schlegel,P.N. and Carrell,D.T.
  TITLE     Identification of polymorphisms and balancing selection in the male
            infertility candidate gene, ornithine decarboxylase antizyme 3
  JOURNAL   BMC Med Genet 7, 27 (2006)
   PUBMED   16542438
  REMARK    GeneRIF: Mutations in the OAZ3 gene are not a common cause of male
            infertility.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 901)
  AUTHORS   Zhang,J., Wang,Y., Zhou,Y., Cao,Z., Huang,P. and Lu,B.
  TITLE     Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are
            potential interaction partners of testicular germ cell-specific
            protein GGN1
  JOURNAL   FEBS Lett 579 (2), 559-566 (2005)
   PUBMED   15642376
REFERENCE   8  (bases 1 to 901)
  AUTHORS   Mangold,U. and Leberer,E.
  TITLE     Regulation of all members of the antizyme family by antizyme
            inhibitor
  JOURNAL   Biochem J 385 (Pt 1), 21-28 (2005)
   PUBMED   15355308
REFERENCE   9  (bases 1 to 901)
  AUTHORS   Ivanov,I.P., Rohrwasser,A., Terreros,D.A., Gesteland,R.F. and
            Atkins,J.F.
  TITLE     Discovery of a spermatogenesis stage-specific ornithine
            decarboxylase antizyme: antizyme 3
  JOURNAL   Proc Natl Acad Sci U S A 97 (9), 4808-4813 (2000)
   PUBMED   10781085
  REMARK    GeneRIF: antizyme expression requires programmed, ribosomal
            frameshifting
REFERENCE   10 (bases 1 to 901)
  AUTHORS   Coffino,P.
  TITLE     Polyamines in spermiogenesis: not now, darling
  JOURNAL   Proc Natl Acad Sci U S A 97 (9), 4421-4423 (2000)
   PUBMED   10781034
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF175296.1 and BC073949.1.
            
            On Nov 30, 2007 this sequence version replaced NM_016178.1.
            
            Summary: The protein encoded by this gene belongs to the ornithine
            decarboxylase antizyme family, which plays a role in cell growth
            and proliferation by regulating intracellular polyamine levels.
            Expression of antizymes requires +1 ribosomal frameshifting, which
            is enhanced by high levels of polyamines. Antizymes in turn bind to
            and inhibit ornithine decarboxylase (ODC), the key enzyme in
            polyamine biosynthesis; thus, completing the auto-regulatory
            circuit. This gene encodes antizyme 3, the third member of the
            antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC
            activity and polyamine uptake; however, it does not stimulate ODC
            degradation. Also, while antizymes 1 and 2 have broad tissue
            distribution, expression of antizyme 3 is restricted to haploid
            germ cells in testis, suggesting a distinct role for this antizyme
            in spermiogenesis. Antizyme 3 gene knockout studies showed that
            homozygous mutant male mice were infertile, and indicated the
            likely role of this antizyme in the formation of a rigid connection
            between the sperm head and tail during spermatogenesis.
            Alternatively spliced transcript variants encoding different
            isoforms, including one resulting from the use of non-AUG (CUG)
            translation initiation codon, have been found for this gene.
            [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) initiates translation from a
            non-AUG (CUG) start codon, and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF175296.1, ERR279830.4026.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on conservation, expression,
                                        longest protein
            ribosomal slippage       :: inferred from conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-882               AF175296.1         1-882
            883-901             BC073949.1         847-865
FEATURES             Location/Qualifiers
     source          1..901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..901
                     /gene="OAZ3"
                     /gene_synonym="AZ3; OAZ-t; TISP15"
                     /note="ornithine decarboxylase antizyme 3"
                     /db_xref="GeneID:51686"
                     /db_xref="HGNC:HGNC:8097"
                     /db_xref="MIM:605138"
     exon            1..234
                     /gene="OAZ3"
                     /gene_synonym="AZ3; OAZ-t; TISP15"
                     /inference="alignment:Splign:2.1.0"
     CDS             join(68..295,297..776)
                     /gene="OAZ3"
                     /gene_synonym="AZ3; OAZ-t; TISP15"
                     /ribosomal_slippage
                     /note="protein translation is dependent on +1 ribosomal
                     frameshift; isoform 1 is encoded by transcript variant 1;
                     non-AUG (CUG) translation initiation codon; antizyme 3;
                     ODC-Az 3; testicular secretory protein Li 31"
                     /codon_start=1
                     /product="ornithine decarboxylase antizyme 3 isoform 1"
                     /protein_id="NP_057262.2"
                     /db_xref="CCDS:CCDS81378.1"
                     /db_xref="GeneID:51686"
                     /db_xref="HGNC:HGNC:8097"
                     /db_xref="MIM:605138"
                     /translation="MPCKRCRPSVYSLSYIKRGKTRNYLYPIWSPYAYYLYCYKYRIT
                     LREKMLPRCYKSITYKEEEDLTLQPRSCLQCSESLVGLQEGKSTEQGNHDQLKELYSA
                     GNLTVLATDPLLHQDPVQLDFHFRLTSQTSAHWHGLLCDRRLFLDIPYQALDQGNRES
                     LTATLEYVEEKTNVDSVFVNFQNDRNDRGALLRAFSYMGFEVVRPDHPALPPLDNVIF
                     MVYPLERDVGHLPSEPP"
     exon            235..371
                     /gene="OAZ3"
                     /gene_synonym="AZ3; OAZ-t; TISP15"
                     /inference="alignment:Splign:2.1.0"
     exon            372..547
                     /gene="OAZ3"
                     /gene_synonym="AZ3; OAZ-t; TISP15"
                     /inference="alignment:Splign:2.1.0"
     exon            548..633
                     /gene="OAZ3"
                     /gene_synonym="AZ3; OAZ-t; TISP15"
                     /inference="alignment:Splign:2.1.0"
     exon            634..887
                     /gene="OAZ3"
                     /gene_synonym="AZ3; OAZ-t; TISP15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      868..873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OAZ3"
                     /gene_synonym="AZ3; OAZ-t; TISP15"
                     /note="hexamer: AATAAA"
     polyA_site      887
                     /gene="OAZ3"
                     /gene_synonym="AZ3; OAZ-t; TISP15"
                     /note="major polyA site"
ORIGIN      
        1 gttgcctaaa cctctgccac ccacctgtga acttcacttt gccacaggga ggcactgaac
       61 tgaaaaactg ccttgtaaga ggtgtcgccc ctctgtctac tccctttctt atatcaagag
      121 gggaaaaaca cgtaactacc tctacccgat ctggtcacca tacgcctatt acctttactg
      181 ttacaagtac cggatcactc tccgggagaa gatgctgcct cgttgttata aaagcatcac
      241 ttataaggaa gaggaggact tgacactcca gccccgttcc tgcctccagt gctcctgagt
      301 ccctagtagg cctccaggag ggcaaaagca ccgagcaggg taaccacgac cagcttaaag
      361 aactgtattc ggctgggaac ttgacggtgc tggctactga ccccctgctc caccaggacc
      421 cagtacagtt agactttcac ttccgcctta cctcccagac ctctgcccat tggcacggcc
      481 ttctctgtga ccgtcgactc ttcctggata tcccatatca ggccttggat caaggcaacc
      541 gggaaagttt gactgcaacc ctggagtacg tggaagagaa gacaaatgtg gactctgtgt
      601 ttgtgaactt ccagaatgat cggaacgaca gaggtgccct gctgcgggcc ttcagctaca
      661 tgggctttga ggtggtcaga ccagatcacc ctgccctccc tcccttggac aatgtcatct
      721 ttatggtgta tccccttgaa agggatgttg gccacctgcc cagtgagcct ccttgaacat
      781 gcttattcca acgctttgag gggctggaag ccttgacaca tggaatcagg ggcccgggat
      841 gtgattcagg acactttcca tcctaggaat aaagggtagt gcaatcaaaa aaaaaaaaaa
      901 a
//
