LOCUS       NM_004152               1195 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ornithine decarboxylase antizyme 1 (OAZ1), transcript
            variant 1, mRNA.
ACCESSION   NM_004152
VERSION     NM_004152.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1195)
  AUTHORS   Li,D., Neo,S.P., Gunaratne,J. and Sabapathy,K.
  TITLE     EPLIN-beta is a novel substrate of ornithine decarboxylase antizyme
            1 and mediates cellular migration
  JOURNAL   J Cell Sci 136 (12) (2023)
   PUBMED   37325974
  REMARK    GeneRIF: EPLIN-beta is a novel substrate of ornithine decarboxylase
            antizyme 1 and mediates cellular migration.
REFERENCE   2  (bases 1 to 1195)
  AUTHORS   Oguro,A., Shigeta,T., Machida,K., Suzuki,T., Iwamoto,T.,
            Matsufuji,S. and Imataka,H.
  TITLE     Translation efficiency affects the sequence-independent +1
            ribosomal frameshifting by polyamines
  JOURNAL   J Biochem 168 (2), 139-149 (2020)
   PUBMED   32181810
  REMARK    GeneRIF: Translation efficiency affects the sequence-independent +1
            ribosomal frameshifting by polyamines.
REFERENCE   3  (bases 1 to 1195)
  AUTHORS   Rasila,T., Saavalainen,O., Attalla,H., Lankila,P., Haglund,C.,
            Holtta,E. and Andersson,L.C.
  TITLE     Astroprincin (FAM171A1, C10orf38): A Regulator of Human Cell Shape
            and Invasive Growth
  JOURNAL   Am J Pathol 189 (1), 177-189 (2019)
   PUBMED   30312582
REFERENCE   4  (bases 1 to 1195)
  AUTHORS   Sokolina,K., Kittanakom,S., Snider,J., Kotlyar,M., Maurice,P.,
            Gandia,J., Benleulmi-Chaachoua,A., Tadagaki,K., Oishi,A., Wong,V.,
            Malty,R.H., Deineko,V., Aoki,H., Amin,S., Yao,Z., Morato,X.,
            Otasek,D., Kobayashi,H., Menendez,J., Auerbach,D., Angers,S.,
            Przulj,N., Bouvier,M., Babu,M., Ciruela,F., Jockers,R., Jurisica,I.
            and Stagljar,I.
  TITLE     Systematic protein-protein interaction mapping for clinically
            relevant human GPCRs
  JOURNAL   Mol Syst Biol 13 (3), 918 (2017)
   PUBMED   28298427
  REMARK    Erratum:[Mol Syst Biol. 2025 Feb;21(2):208-209. doi:
            10.1038/s44320-024-00080-3.. PMID: 39762653]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1195)
  AUTHORS   Gandre,S., Bercovich,Z. and Kahana,C.
  TITLE     Mitochondrial localization of antizyme is determined by
            context-dependent alternative utilization of two AUG initiation
            codons
  JOURNAL   Mitochondrion 2 (4), 245-256 (2003)
   PUBMED   16120325
REFERENCE   6  (bases 1 to 1195)
  AUTHORS   Matsufuji,S., Matsufuji,T., Miyazaki,Y., Murakami,Y., Atkins,J.F.,
            Gesteland,R.F. and Hayashi,S.
  TITLE     Autoregulatory frameshifting in decoding mammalian ornithine
            decarboxylase antizyme
  JOURNAL   Cell 80 (1), 51-60 (1995)
   PUBMED   7813017
  REMARK    GeneRIF: antizyme expression requires programmed, ribosomal
            frameshifting
REFERENCE   7  (bases 1 to 1195)
  AUTHORS   Tewari,D.S., Qian,Y., Thornton,R.D., Pieringer,J., Taub,R.,
            Mochan,E. and Tewari,M.
  TITLE     Molecular cloning and sequencing of a human cDNA encoding ornithine
            decarboxylase antizyme
  JOURNAL   Biochim Biophys Acta 1209 (2), 293-295 (1994)
   PUBMED   7811704
REFERENCE   8  (bases 1 to 1195)
  AUTHORS   Mamroud-Kidron,E., Omer-Itsicovich,M., Bercovich,Z., Tobias,K.E.,
            Rom,E. and Kahana,C.
  TITLE     A unified pathway for the degradation of ornithine decarboxylase in
            reticulocyte lysate requires interaction with the polyamine-induced
            protein, ornithine decarboxylase antizyme
  JOURNAL   Eur J Biochem 226 (2), 547-554 (1994)
   PUBMED   8001569
REFERENCE   9  (bases 1 to 1195)
  AUTHORS   Ichiba,T., Matsufuji,S., Miyazaki,Y., Murakami,Y., Tanaka,K.,
            Ichihara,A. and Hayashi,S.
  TITLE     Functional regions of ornithine decarboxylase antizyme
  JOURNAL   Biochem Biophys Res Commun 200 (3), 1721-1727 (1994)
   PUBMED   8185631
REFERENCE   10 (bases 1 to 1195)
  AUTHORS   Savage,R.E. Jr., Nofzinger,K., Bedell,C., DeAngelo,A.B. and
            Pereira,M.A.
  TITLE     Chloroform-induced multiple forms of ornithine decarboxylase:
            differential sensitivity of forms to enhancement by diethyl maleate
            and inhibition by ODC-antizyme
  JOURNAL   J Toxicol Environ Health 27 (1), 57-64 (1989)
   PUBMED   2724368
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY050868.1 and BC100291.1.
            
            On Jul 10, 2014 this sequence version replaced NM_004152.2.
            
            Summary: The protein encoded by this gene belongs to the ornithine
            decarboxylase antizyme family, which plays a role in cell growth
            and proliferation by regulating intracellular polyamine levels.
            Expression of antizymes requires +1 ribosomal frameshifting, which
            is enhanced by high levels of polyamines. Antizymes in turn bind to
            and inhibit ornithine decarboxylase (ODC), the key enzyme in
            polyamine biosynthesis; thus, completing the auto-regulatory
            circuit. This gene encodes antizyme 1, the first member of the
            antizyme family, that has broad tissue distribution, and negatively
            regulates intracellular polyamine levels by binding to and
            targeting ODC for degradation, as well as inhibiting polyamine
            uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and
            studies in rat suggest that alternative use of the two translation
            initiation sites results in N-terminally distinct protein isoforms
            with different subcellular localization. Alternatively spliced
            transcript variants have also been noted for this gene. [provided
            by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            CCDS Note: The expression of the protein represented in this CCDS
            ID is auto-regulated by polyamine-enhanced translational
            frameshifting. During translation, a +1 frameshift occurs following
            codon 68, just preceding a termination codon, thereby enabling
            translation of the remaining portion of the protein (aa 69-228) in
            a different reading frame, as experimentally shown for the
            conserved rat ortholog (PMID:7813017).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.540760.1,
                                           SRR1163655.641932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ribosomal slippage                 :: inferred from conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                HY050868.1         1-46
            47-1195             BC100291.1         12-1160
FEATURES             Location/Qualifiers
     source          1..1195
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1195
                     /gene="OAZ1"
                     /gene_synonym="AZ1; AZI; OAZ"
                     /note="ornithine decarboxylase antizyme 1"
                     /db_xref="GeneID:4946"
                     /db_xref="HGNC:HGNC:8095"
                     /db_xref="MIM:601579"
     exon            1..259
                     /gene="OAZ1"
                     /gene_synonym="AZ1; AZI; OAZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             join(114..317,319..801)
                     /gene="OAZ1"
                     /gene_synonym="AZ1; AZI; OAZ"
                     /ribosomal_slippage
                     /note="protein translation is dependent on +1
                     polyamine-induced ribosomal frameshift; isoform 1 is
                     encoded by transcript variant 1; antizyme 1; ODC-Az"
                     /codon_start=1
                     /product="ornithine decarboxylase antizyme 1 isoform 1"
                     /protein_id="NP_004143.1"
                     /db_xref="CCDS:CCDS58639.1"
                     /db_xref="GeneID:4946"
                     /db_xref="HGNC:HGNC:8095"
                     /db_xref="MIM:601579"
                     /translation="MVKSSLQRILNSHCFAREKEGDKPSATIHASRTMPLLSLHSRGG
                     SSSESSRVSLHCCSNPGPGPRWCSDAPHPPLKIPGGRGNSQRDHNLSANLFYSDDRLN
                     VTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLL
                     EFAEEQLRADHVFICFHKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTF
                     ERESSGEEEE"
     exon            260..405
                     /gene="OAZ1"
                     /gene_synonym="AZ1; AZI; OAZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      324..376
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="OAZ1"
                     /gene_synonym="AZ1; AZI; OAZ"
                     /note="recoding_pseudoknot"
                     /function="stimulates +1 ribosomal frameshifting"
     exon            406..578
                     /gene="OAZ1"
                     /gene_synonym="AZ1; AZI; OAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            579..664
                     /gene="OAZ1"
                     /gene_synonym="AZ1; AZI; OAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            665..1181
                     /gene="OAZ1"
                     /gene_synonym="AZ1; AZI; OAZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      916..921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OAZ1"
                     /gene_synonym="AZ1; AZI; OAZ"
                     /note="hexamer: AATAAA"
     polyA_site      934
                     /gene="OAZ1"
                     /gene_synonym="AZ1; AZI; OAZ"
                     /note="major polyA site"
     regulatory      1000..1005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OAZ1"
                     /gene_synonym="AZ1; AZI; OAZ"
                     /note="hexamer: AATAAA"
     polyA_site      1018
                     /gene="OAZ1"
                     /gene_synonym="AZ1; AZI; OAZ"
     regulatory      1162..1167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OAZ1"
                     /gene_synonym="AZ1; AZI; OAZ"
                     /note="hexamer: AATAAA"
     polyA_site      1181
                     /gene="OAZ1"
                     /gene_synonym="AZ1; AZI; OAZ"
                     /note="major polyA site"
ORIGIN      
        1 agcatctata aaggcgggcg gcggcagagg cgccattttg cgaacggcga gcagcggcgg
       61 cggcgcggag agacgcagcg gaggttttcc tggtttcgga ccccagcggc cggatggtga
      121 aatcctccct gcagcggatc ctcaatagcc actgcttcgc cagagagaag gaaggggata
      181 aacccagcgc caccatccac gccagccgca ccatgccgct cctaagcctg cacagccgcg
      241 gcggcagcag cagtgagagt tccagggtct ccctccactg ctgtagtaac ccgggtccgg
      301 ggcctcggtg gtgctcctga tgcccctcac ccacccctga agatcccagg tgggcgaggg
      361 aatagtcaga gggatcacaa tctttcagct aacttattct actccgatga tcggctgaat
      421 gtaacagagg aactaacgtc caacgacaag acgaggattc tcaacgtcca gtccaggctc
      481 acagacgcca aacgcattaa ctggcgaaca gtgctgagtg gcggcagcct ctacatcgag
      541 atcccgggcg gcgcgctgcc cgaggggagc aaggacagct ttgcagttct cctggagttc
      601 gctgaggagc agctgcgagc cgaccatgtc ttcatttgct tccacaagaa ccgcgaggac
      661 agagccgcct tgctccgaac cttcagcttt ttgggctttg agattgtgag accggggcat
      721 ccccttgtcc ccaagagacc cgacgcttgc ttcatggcct acacgttcga gagagagtct
      781 tcgggagagg aggaggagta gggccgcctc ggggctgggc atccggcccc tggggccacc
      841 ccttgtcagc cgggtgggta ggaaccgtag actcgctcat ctcgcctggg tttgtccgca
      901 tgttgtaatc gtgcaaataa acgctcactc cgaattagcg gtgtatttct tgaagtttaa
      961 tattgtgttt gtgatactga agtatttgct ttaattctaa ataaaaattt atattttact
     1021 tttttattgc tggtttaaga tgattcagat tatccttgta ctttgaggag aagtttctta
     1081 tttggagtct tttggaaaca gtcttagtct tttaacttgg aaagatgagg tattaatccc
     1141 ctccattgct ctccaaaagc caataaagtg attacacccg aaaaaaaaaa aaaaa
//
