LOCUS       NM_003733               3270 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens 2'-5'-oligoadenylate synthetase like (OASL),
            transcript variant 1, mRNA.
ACCESSION   NM_003733
VERSION     NM_003733.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3270)
  AUTHORS   Chen,Q., Jiang,L.Y., Cao,C., Liu,F.Y., Li,D.R., Wu,P.F. and
            Jiang,K.R.
  TITLE     Peptidase inhibitor 16 promotes proliferation of pancreatic ductal
            adenocarcinoma cells through OASL signaling
  JOURNAL   Mol Carcinog 63 (5), 938-950 (2024)
   PUBMED   38353288
  REMARK    GeneRIF: Peptidase inhibitor 16 promotes proliferation of
            pancreatic ductal adenocarcinoma cells through OASL signaling.
REFERENCE   2  (bases 1 to 3270)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3270)
  AUTHORS   Kwock,J.T., Handfield,C., Suwanpradid,J., Hoang,P., McFadden,M.J.,
            Labagnara,K.F., Floyd,L., Shannon,J., Uppala,R., Sarkar,M.K.,
            Gudjonsson,J.E., Corcoran,D.L., Lazear,H.M., Sempowski,G.,
            Horner,S.M. and MacLeod,A.S.
  TITLE     IL-27 signaling activates skin cells to induce innate antiviral
            proteins and protects against Zika virus infection
  JOURNAL   Sci Adv 6 (14), eaay3245 (2020)
   PUBMED   32270034
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3270)
  AUTHORS   Leisching,G., Ali,A., Cole,V. and Baker,B.
  TITLE     2'-5'-Oligoadenylate synthetase-like protein inhibits intracellular
            M. tuberculosis replication and promotes proinflammatory cytokine
            secretion
  JOURNAL   Mol Immunol 118, 73-78 (2020)
   PUBMED   31855809
  REMARK    GeneRIF: OASL regulates pro-inflammatory mediators such as
            cytokines and chemokines which suppress intracellular mycobacterial
            growth and survival.
REFERENCE   5  (bases 1 to 3270)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   6  (bases 1 to 3270)
  AUTHORS   Hovnanian,A., Rebouillat,D., Levy,E.R., Mattei,M.G. and
            Hovanessian,A.G.
  TITLE     The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding
            the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in
            the proximity of the 2',5'-OAS locus
  JOURNAL   Genomics 56 (3), 362-363 (1999)
   PUBMED   10087211
REFERENCE   7  (bases 1 to 3270)
  AUTHORS   Rebouillat,D., Marie,I. and Hovanessian,A.G.
  TITLE     Molecular cloning and characterization of two related and
            interferon-induced 56-kDa and 30-kDa proteins highly similar to
            2'-5' oligoadenylate synthetase
  JOURNAL   Eur J Biochem 257 (2), 319-330 (1998)
   PUBMED   9826176
REFERENCE   8  (bases 1 to 3270)
  AUTHORS   Hartmann,R., Olsen,H.S., Widder,S., Jorgensen,R. and Justesen,J.
  TITLE     p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel
            human gene related to the 2'-5' oligoadenylate synthetase family
  JOURNAL   Nucleic Acids Res 26 (18), 4121-4128 (1998)
   PUBMED   9722630
REFERENCE   9  (bases 1 to 3270)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
REFERENCE   10 (bases 1 to 3270)
  AUTHORS   Mackay,V. and Linn,S.
  TITLE     Selective inhibition of the dnase activity of the recBC enzyme by
            the DNA binding protein from Escherichia coli
  JOURNAL   J Biol Chem 251 (12), 3716-3719 (1976)
   PUBMED   776974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079602.15.
            
            On Jun 30, 2021 this sequence version replaced NM_003733.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ225089.1, BC117408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257570.10/ ENSP00000257570.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-473               AC079602.15        99699-100171
            474-756             AC079602.15        105202-105484
            757-932             AC079602.15        107328-107503
            933-1174            AC079602.15        111128-111369
            1175-1322           AC079602.15        114808-114955
            1323-3270           AC079602.15        117887-119834
FEATURES             Location/Qualifiers
     source          1..3270
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..3270
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
                     /note="2'-5'-oligoadenylate synthetase like"
                     /db_xref="GeneID:8638"
                     /db_xref="HGNC:HGNC:8090"
                     /db_xref="MIM:603281"
     exon            1..473
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1820
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
                     /note="isoform a is encoded by transcript variant 1; 59
                     kDa 2'-5'-oligoadenylate synthetase-like protein; 59 kDa
                     2'-5'-oligoadenylate synthase-like protein; TR-interacting
                     protein 14; thyroid receptor-interacting protein 14;
                     2'-5'-OAS-RP; 2'-5'-OAS-related protein"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase-like protein
                     isoform a"
                     /protein_id="NP_003724.1"
                     /db_xref="CCDS:CCDS9211.1"
                     /db_xref="GeneID:8638"
                     /db_xref="HGNC:HGNC:8090"
                     /db_xref="MIM:603281"
                     /translation="MALMQELYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFL
                     RQEHFQGKRGLDQDVRVLKVVKVGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKHHK
                     DVLRLIWKTMWQSQDLLDLGLEDLRMEQRVPDALVFTIQTRGTAEPITVTIVPAYRAL
                     GPSLPNSQPPPEVYVSLIKACGGPGNFCPSFSELQRNFVKHRPTKLKSLLRLVKHWYQ
                     QYVKARSPRANLPPLYALELLTIYAWEMGTEEDENFMLDEGFTTVMDLLLEYEVICIY
                     WTKYYTLHNAIIEDCVRKQLKKERPIILDPADPTLNVAEGYRWDIVAQRASQCLKQDC
                     CYDNRENPISSWNVKRARDIHLTVEQRGYPDFNLIVNPYEPIRKVKEKIRRTRGYSGL
                     QRLSFQVPGSERQLLSSRCSLAKYGIFSHTHIYLLETIPSEIQVFVKNPDGGSYAYAI
                     NPNSFILGLKQQIEDQQGLPKKQQQLEFQGQVLQDWLGLGIYGIQDSDTLILSKKKGE
                     ALFPAS"
     exon            474..756
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
                     /inference="alignment:Splign:2.1.0"
     exon            757..932
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1174
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1322
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..3270
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2068..2073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
                     /note="hexamer: AATAAA"
     polyA_site      2089
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
                     /note="major polyA site"
     regulatory      2675..2680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
                     /note="hexamer: AATAAA"
     polyA_site      2699
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
                     /note="hexamer: AATAAA"
     polyA_site      2993
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
     regulatory      3245..3250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
                     /note="hexamer: AATAAA"
     polyA_site      3270
                     /gene="OASL"
                     /gene_synonym="OASL1; OASLd; p59 OASL; p59-OASL; p59OASL;
                     TRIP-14; TRIP14"
ORIGIN      
        1 agattgacta gacggccagc ctgttaaggt ggccccagat attccagcct cagcccagag
       61 tcctcctgtg cccctactgc agcaagggtg tctccaagaa gggggacctg gagtcagccc
      121 gtcacacctg gtttcctctc tgctagggtc cctcctccca cagagcactg gagggcagct
      181 gaggaggagc taccttaaaa aaggaggtgt gtgccaggga gctgggtagg agcctggcta
      241 tatatctgcc cagcagcggt actctcggga cagagatggc actgatgcag gaactgtata
      301 gcacaccagc ctccaggctg gactccttcg tggctcagtg gctgcagccc caccgggagt
      361 ggaaggaaga ggtgctagac gctgtgcgga ccgtggagga gtttctgagg caggagcatt
      421 tccaggggaa gcgtgggctg gaccaggatg tgcgggtgct gaaggtagtc aaggtgggct
      481 ccttcgggaa tggcacggtt ctcaggagca ccagagaggt ggagctggtg gcgtttctga
      541 gctgtttcca cagcttccag gaggcagcca agcatcacaa agatgttctg aggctgatat
      601 ggaaaaccat gtggcaaagc caggacctgc tggacctcgg gctcgaggac ctgaggatgg
      661 agcagagagt ccccgatgct ctcgtcttca ccatccagac cagggggact gcggagccca
      721 tcacggtcac cattgtgcct gcctacagag ccctggggcc ttctcttccc aactcccagc
      781 caccccctga ggtctatgtg agcctgatca aggcctgcgg tggtcctgga aatttctgcc
      841 catccttcag cgagctgcag agaaatttcg tgaaacatcg gccaactaag ctgaagagcc
      901 tcctgcgcct ggtgaaacac tggtaccagc agtatgtgaa agccaggtcc cccagagcca
      961 atctgccccc tctctatgct cttgaacttc taaccatcta tgcctgggaa atgggtactg
     1021 aagaagacga gaatttcatg ttggacgaag gcttcaccac tgtgatggac ctgctcctgg
     1081 agtatgaagt catctgtatc tactggacca agtactacac actccacaat gcaatcattg
     1141 aggattgtgt cagaaaacag ctcaaaaaag agaggcccat catcctggat ccggccgacc
     1201 ccaccctcaa cgtggcagaa gggtacagat gggacatcgt tgctcagagg gcctcccagt
     1261 gcctgaaaca ggactgttgc tatgacaaca gggagaaccc catctccagc tggaacgtga
     1321 agagggcacg agacatccac ttgacagtgg agcagagggg ttacccagat ttcaacctca
     1381 tcgtgaaccc ttatgagccc ataaggaagg ttaaagagaa aatccggagg accaggggct
     1441 actctggcct gcagcgtctg tccttccagg ttcctggcag tgagaggcag cttctcagca
     1501 gcaggtgctc cttagccaaa tatgggatct tctcccacac tcacatctat ctgctggaga
     1561 ccatcccctc cgagatccag gtcttcgtga agaatcctga tggtgggagc tacgcctatg
     1621 ccatcaaccc caacagcttc atcctgggtc tgaagcagca gattgaagac cagcaggggc
     1681 ttcctaaaaa gcagcagcag ctggaattcc aaggccaagt cctgcaggac tggttgggtc
     1741 tggggatcta tggcatccaa gacagtgaca ctctcatcct ctcgaagaag aaaggagagg
     1801 ctctgtttcc agccagttag ttttctctgg gagacttctc tgtacatttc tgccatgtac
     1861 tccagaactc atcctgtcaa tcactctgtc ccattgtcta ctgggaaggt cccaggtctt
     1921 caccagtttt acaatgagtt atcccaggcc agacgtggta gctcacacct gtaatcccag
     1981 aactttggga ggccgaggtg ggaggagcgc ttgagccgag gagttcaaga ccagcctggg
     2041 tatcacaggg agaccccgtc tctacaaaat aaaaaaataa ttcactgggt gtggttgtgc
     2101 acatttgtag tctcaggcac tcaagaagct gaggcagaag aatcacttga gcccaggagg
     2161 ctgaagctgc agtgagctgt gatcacaccg ctacactcct gcccaggcca cagagcaaga
     2221 ccctgtgtct aaaaactaaa acataaaaat aagtaaatcc gtttaaaaaa aggattatcc
     2281 cagccctgcc agggggagga tgaggagggg tgtgaggact aaatatacaa ataaatagtg
     2341 tggtcacatg acgcacagca acagaattcg gacccacagc cttctgcagc aatcaacccc
     2401 aaaccatcag gacttgggcg ataactggca gcatctctaa ctccccaccc tactcccatc
     2461 ctgcttccta tttatgacca acccaagaaa cccaaataag ctccccagac caatcacatg
     2521 gttagcccca cttctggtga gtgcacttcc agcttcccca taccaacagc ctcaatcacg
     2581 gcatccctga agccttccca ttttcctgcc tgtctttaaa tctctgtcaa aagcgagaga
     2641 tgggtggctg gttcctttgc tatagcaagt tgggaataaa tcgcctttgt tagttctcat
     2701 ttgggggctg tttatttcca cagggcctaa tgctgtccta atggttattg cttgatcatt
     2761 tgagcttctc aactctaaga aatgaggact ggggaaactg aggcaaaaag agacaaagaa
     2821 tgggagattg aggatgatgc agtgtaaaaa aaaatcacct caactcctaa aacccataca
     2881 caaacagtac ataatagtca ggaaactgta ggaaagtaat agcatcttta ttatcaaagg
     2941 acgtcatgtg atcaggttta ctccaagcaa taaaaagttt ccttttgccc ccctgttttg
     3001 cctagttttc tggtgggcta ctctcctacc atagcataga aaatgcacac tgcaattggt
     3061 tatcaacagc ctctggtcaa tttagcaatc ataatctgtg tatctcccac ctctgtttgc
     3121 cttcagggac agaaaaagtg cctcctttcc aggaggtaga caggctgttc cagtccccat
     3181 ctttgtgtcc ttcataatgc ccagcacagc ccacattgta ggtggtggga aaattcttgt
     3241 ttaaaataaa aaaaagaatg aaaaatgcaa
//
