LOCUS       NM_006187               6599 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens 2'-5'-oligoadenylate synthetase 3 (OAS3), transcript
            variant 1, mRNA.
ACCESSION   NM_006187
VERSION     NM_006187.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6599)
  AUTHORS   Benmansour,R., Tagajdid,M.R., El Hamzaoui,H., Fjouji,S., Doghmi,N.,
            Houba,A., Belbacha,I., Elkochri,S., Aabi,R., Elannaz,H.,
            Laraqui,A., El Mchichi,B., Chmitah,T., Touil,N., Ennibi,K.,
            Eljaoudi,R., Elmir,E., Amine Lahlou,I. and Oumzil,H.
  TITLE     TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among
            severe COVID-19 ICU patients in Morocco
  JOURNAL   Int J Immunopathol Pharmacol 38, 3946320241257241 (2024)
   PUBMED   38760017
  REMARK    GeneRIF: TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide
            polymorphisms among severe COVID-19 ICU patients in Morocco.
REFERENCE   2  (bases 1 to 6599)
  AUTHORS   Gupta,S., Singh,P., Tasneem,A., Almatroudi,A., Rahmani,A.H.,
            Dohare,R. and Parveen,S.
  TITLE     Integrative Multiomics and Regulatory Network Analyses Uncovers the
            Role of OAS3, TRAFD1, miR-222-3p, and miR-125b-5p in Hepatitis E
            Virus Infection
  JOURNAL   Genes (Basel) 14 (1), 42 (2022)
   PUBMED   36672782
  REMARK    GeneRIF: Integrative Multiomics and Regulatory Network Analyses
            Uncovers the Role of OAS3, TRAFD1, miR-222-3p, and miR-125b-5p in
            Hepatitis E Virus Infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6599)
  AUTHORS   Zheng,B., Zhou,X., Tian,L., Wang,J. and Zhang,W.
  TITLE     IFN-beta1b induces OAS3 to inhibit EV71 via IFN-beta1b/JAK/STAT1
            pathway
  JOURNAL   Virol Sin 37 (5), 676-684 (2022)
   PUBMED   35934228
  REMARK    GeneRIF: IFN-beta1b induces OAS3 to inhibit EV71 via
            IFN-beta1b/JAK/STAT1 pathway.
REFERENCE   4  (bases 1 to 6599)
  AUTHORS   Huang,Y.Z., Zheng,Y.X., Zhou,Y., Xu,F., Cui,Y.Z., Chen,X.Y.,
            Wang,Z.Y., Yan,B.X., Zheng,M. and Man,X.Y.
  TITLE     OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte
            Proliferation by Regulating Cell Cycle and Augmenting IFN-1-Induced
            Jak1-Signal Transducer and Activator of Transcription 1
            Phosphorylation in Psoriasis
  JOURNAL   J Invest Dermatol 142 (10), 2635-2645 (2022)
   PUBMED   35305973
  REMARK    GeneRIF: OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte
            Proliferation by Regulating Cell Cycle and Augmenting IFN-1Induced
            Jak1Signal Transducer and Activator of Transcription 1
            Phosphorylation in Psoriasis.
REFERENCE   5  (bases 1 to 6599)
  AUTHORS   Whelan,J.N., Parenti,N.A., Hatterschide,J., Renner,D.M., Li,Y.,
            Reyes,H.M., Dong,B., Perez,E.R., Silverman,R.H. and Weiss,S.R.
  TITLE     Zika virus employs the host antiviral RNase L protein to support
            replication factory assembly
  JOURNAL   Proc Natl Acad Sci U S A 118 (22) (2021)
   PUBMED   34031250
  REMARK    GeneRIF: Zika virus employs the host antiviral RNase L protein to
            support replication factory assembly.
REFERENCE   6  (bases 1 to 6599)
  AUTHORS   Rebouillat,D., Hovnanian,A., Marie,I. and Hovanessian,A.G.
  TITLE     The 100-kDa 2',5'-oligoadenylate synthetase catalyzing
            preferentially the synthesis of dimeric pppA2'p5'A molecules is
            composed of three homologous domains
  JOURNAL   J Biol Chem 274 (3), 1557-1565 (1999)
   PUBMED   9880533
REFERENCE   7  (bases 1 to 6599)
  AUTHORS   Hovnanian,A., Rebouillat,D., Mattei,M.G., Levy,E.R., Marie,I.,
            Monaco,A.P. and Hovanessian,A.G.
  TITLE     The human 2',5'-oligoadenylate synthetase locus is composed of
            three distinct genes clustered on chromosome 12q24.2 encoding the
            100-, 69-, and 40-kDa forms
  JOURNAL   Genomics 52 (3), 267-277 (1998)
   PUBMED   9790745
REFERENCE   8  (bases 1 to 6599)
  AUTHORS   Marie,I., Blanco,J., Rebouillat,D. and Hovanessian,A.G.
  TITLE     69-kDa and 100-kDa isoforms of interferon-induced
            (2'-5')oligoadenylate synthetase exhibit differential catalytic
            parameters
  JOURNAL   Eur J Biochem 248 (2), 558-566 (1997)
   PUBMED   9346316
REFERENCE   9  (bases 1 to 6599)
  AUTHORS   Silverman,R.H. and Sengupta,D.N.
  TITLE     Translational regulation by HIV leader RNA, TAT, and
            interferon-inducible enzymes
  JOURNAL   J Exp Pathol 5 (2), 69-77 (1990)
   PUBMED   1708818
REFERENCE   10 (bases 1 to 6599)
  AUTHORS   Hovanessian,A.G., Laurent,A.G., Chebath,J., Galabru,J., Robert,N.
            and Svab,J.
  TITLE     Identification of 69-kd and 100-kd forms of 2-5A synthetase in
            interferon-treated human cells by specific monoclonal antibodies
  JOURNAL   EMBO J 6 (5), 1273-1280 (1987)
   PUBMED   2440675
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC113746.1, AB044545.1,
            AC004551.1 and AF063613.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006187.3.
            
            Summary: This gene encodes an enzyme included in the 2', 5'
            oligoadenylate synthase family.  This enzyme is induced by
            interferons and catalyzes the 2', 5' oligomers of adenosine in
            order to bind and activate RNase L.  This enzyme family plays a
            significant role in the inhibition of cellular protein synthesis
            and viral infection resistance. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB044545.1, AF063613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000228928.12/ ENSP00000228928.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1199              BC113746.1         17-1215
            1200-1370           AB044545.1         1322-1492
            1371-1371           AC004551.1         91087-91087         c
            1372-2595           BC113746.1         1388-2611
            2596-3750           AF063613.1         2573-3727
            3751-6261           AC004551.1         67319-69829         c
            6262-6597           AB044545.1         6374-6709
            6598-6599           AC004551.1         66981-66982         c
FEATURES             Location/Qualifiers
     source          1..6599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..6599
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /note="2'-5'-oligoadenylate synthetase 3"
                     /db_xref="GeneID:4940"
                     /db_xref="HGNC:HGNC:8088"
                     /db_xref="MIM:603351"
     exon            1..234
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..3321
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /EC_number="2.7.7.84"
                     /note="isoform 1 is encoded by transcript variant 1;
                     2'-5'oligoadenylate synthetase p100; 2'-5'-oligoadenylate
                     synthase 3; p100 OAS; 2-5A synthetase 3; (2-5')oligo(A)
                     synthetase 3; 2-5A synthase 3; (2-5')oligo(A) synthase 3;
                     2'-5'-oligoadenylate synthetase 3, 100kDa"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase 3 isoform 1"
                     /protein_id="NP_006178.2"
                     /db_xref="CCDS:CCDS44981.1"
                     /db_xref="GeneID:4940"
                     /db_xref="HGNC:HGNC:8088"
                     /db_xref="MIM:603351"
                     /translation="MDLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERG
                     GRLGAAAPRVLKTVKGGSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMR
                     ASLESWWQNPVPGLRLTFPEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGV
                     KPKPQVYSTLLNSGCQGGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGL
                     WKETLPPVYALELLTIFAWEQGCKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFE
                     DPAVGQFLQRQLKRPRPVILDPADPTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMG
                     DPVQSWKGPGLPRAGCSGLGHPIQLDPNQKTPENSKSLNAVYPRAGSKPPSCPAPGPT
                     GAASIVPSVPGMALDLSQIPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHENCV
                     HKASRVSKGGSFGRGTDLRDGCDVELIIFLNCFTDYKDQGPRRAEILDEMRAQLESWW
                     QDQVPSLSLQFPEQNVPEALQFQLVSTALKSWTDVSLLPAFDAVGQLSSGTKPNPQVY
                     SRLLTSGCQEGEHKACFAELRRNFMNIRPVKLKNLILLVKHWYRQVAAQNKGKGPAPA
                     SLPPAYALELLTIFAWEQGCRQDCFNMAQGFRTVLGLVQQHQQLCVYWTVNYSTEDPA
                     MRMHLLGQLRKPRPLVLDPADPTWNVGHGSWELLAQEAAALGMQACFLSRDGTSVQPW
                     DVMPALLYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTICSFLKENCFRNSPIKVIK
                     VVKGGSSAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEIISEIRAQLEACQQERQF
                     EVKFEVSKWENPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLVSGSRPSSQVYVDLI
                     HSYSNAGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKISKGRGSLPPQHGL
                     ELLTVYAWEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKDKTVGDFLKQQ
                     LQKPRPIILDPADPTGNLGHNARWDLLAKEAAACTSALCCMGRNGIPIQPWPVKAAV"
     exon            235..517
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            518..693
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            694..932
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1086
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1431
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1714
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1890
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2141
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2286
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2460
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2746
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2922
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3161
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3309
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..6599
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6579..6584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /note="hexamer: TATAAA"
     polyA_site      6599
                     /gene="OAS3"
                     /gene_synonym="p100; p100OAS"
                     /note="major polyA site"
ORIGIN      
        1 agaaatccga aggccgcgcc agagccctgc ttccccttgc acctgcgccg ggcggccatg
       61 gacttgtaca gcaccccggc cgctgcgctg gacaggttcg tggccagaag gctgcagccg
      121 cggaaggagt tcgtagagaa ggcgcggcgc gctctgggcg ccctggccgc tgccctgagg
      181 gagcgcgggg gccgcctcgg tgctgctgcc ccgcgggtgc tgaaaactgt caagggaggc
      241 tcctcgggcc ggggcacagc tctcaagggt ggctgtgatt ctgaacttgt catcttcctc
      301 gactgcttca agagctatgt ggaccagagg gcccgccgtg cagagatcct cagtgagatg
      361 cgggcatcgc tggaatcctg gtggcagaac ccagtccctg gtctgagact cacgtttcct
      421 gagcagagcg tgcctggggc cctgcagttc cgcctgacat ccgtagatct tgaggactgg
      481 atggatgtta gcctggtgcc tgccttcaat gtcctgggtc aggccggctc cggcgtcaaa
      541 cccaagccac aagtctactc taccctcctc aacagtggct gccaaggggg cgagcatgcg
      601 gcctgcttca cagagctgcg gaggaacttt gtgaacattc gcccagccaa gttgaagaac
      661 ctaatcttgc tggtgaagca ctggtaccac caggtgtgcc tacaggggtt gtggaaggag
      721 acgctgcccc cggtctatgc cctggaattg ctgaccatct tcgcctggga gcagggctgt
      781 aagaaggatg ctttcagcct agccgaaggc ctccgaactg tcctgggcct gatccaacag
      841 catcagcacc tgtgtgtttt ctggactgtc aactatggct tcgaggaccc tgcagttggg
      901 cagttcttgc agcggcagct taagagaccc aggcctgtga tcctggaccc agctgacccc
      961 acatgggacc tggggaatgg ggcagcctgg cactgggatt tgctagccca ggaggcagca
     1021 tcctgctatg accacccatg ctttctgagg gggatggggg acccagtgca gtcttggaag
     1081 gggccgggcc ttccacgtgc tggatgctca ggtttgggcc accccatcca gctagaccct
     1141 aaccagaaga cccctgaaaa cagcaagagc ctcaatgctg tgtacccaag agcagggagc
     1201 aaacctccct catgcccagc tcctggcccc actggggcag ccagcatcgt cccctctgtg
     1261 ccgggaatgg ccttggacct gtctcagatc cccaccaagg agctggaccg cttcatccag
     1321 gaccacctga agccgagccc ccagttccag gagcaggtga aaaaggccat tgacatcatc
     1381 ttgcgctgcc tccatgagaa ctgtgttcac aaggcctcaa gagtcagtaa agggggctca
     1441 tttggccggg gcacagacct aagggatggc tgtgatgttg aactcatcat cttcctcaac
     1501 tgcttcacgg actacaagga ccaggggccc cgccgcgcag agatccttga tgagatgcga
     1561 gcgcagctag aatcctggtg gcaggaccag gtgcccagcc tgagccttca gtttcctgag
     1621 cagaatgtgc ctgaggctct gcagttccag ctggtgtcca cagccctgaa gagctggacg
     1681 gatgttagcc tgctgcctgc cttcgatgct gtggggcagc tcagttctgg caccaaacca
     1741 aatccccagg tctactcgag gctcctcacc agtggctgcc aggagggcga gcataaggcc
     1801 tgcttcgcag agctgcggag gaacttcatg aacattcgcc ctgtcaagct gaagaacctg
     1861 attctgctgg tgaagcactg gtaccgccag gttgcggctc agaacaaagg aaaaggacca
     1921 gcccctgcct ctctgccccc agcctatgcc ctggagctcc tcaccatctt tgcctgggag
     1981 cagggctgca ggcaggattg tttcaacatg gcccaaggct tccggacggt gctggggctc
     2041 gtgcaacagc atcagcagct ctgtgtctac tggacggtca actatagcac tgaggaccca
     2101 gccatgagaa tgcaccttct tggccagctt cgaaaaccca gacccctggt cctggacccc
     2161 gctgatccca cctggaacgt gggccacggt agctgggagc tgttggccca ggaagcagca
     2221 gcgctgggga tgcaggcctg ctttctgagt agagacggga catctgtgca gccctgggat
     2281 gtgatgccag ccctccttta ccaaacccca gctggggacc ttgacaagtt catcagtgaa
     2341 tttctccagc ccaaccgcca gttcctggcc caggtgaaca aggccgttga taccatctgt
     2401 tcatttttga aggaaaactg cttccggaat tctcccatca aagtgatcaa ggtggtcaag
     2461 ggtggctctt cagccaaagg cacagctctg cgaggccgct cagatgccga cctcgtggtg
     2521 ttcctcagct gcttcagcca gttcactgag cagggcaaca agcgggccga gatcatctcc
     2581 gagatccgag cccagctgga ggcatgtcaa caggagcggc agttcgaggt caagtttgaa
     2641 gtctccaaat gggagaatcc ccgcgtgctg agcttctcac tgacatccca gacgatgctg
     2701 gaccagagtg tggactttga tgtgctgcca gcctttgacg ccctaggcca gctggtctct
     2761 ggctccaggc ccagctctca agtctacgtc gacctcatcc acagctacag caatgcgggc
     2821 gagtactcca cctgcttcac agagctacaa cgggacttca tcatctctcg ccctaccaag
     2881 ctgaagagcc tgatccggct ggtgaagcac tggtaccagc agtgtaccaa gatctccaag
     2941 gggagaggct ccctaccccc acagcacggg ctggaactcc tgactgtgta tgcctgggag
     3001 cagggcggga aggactccca gttcaacatg gctgagggct tccgcacggt cctggagctg
     3061 gtcacccagt accgccagct ctgtatctac tggaccatca actacaacgc caaggacaag
     3121 actgttggag acttcctgaa acagcagctt cagaagccca ggcctatcat cctggatccg
     3181 gctgacccga caggcaacct gggccacaat gcccgctggg acctgctggc caaggaagct
     3241 gcagcctgca catctgccct gtgctgcatg ggacggaatg gcatccccat ccagccatgg
     3301 ccagtgaagg ctgctgtgtg aagttgagaa aatcagcggt cctactggat gaagagaaga
     3361 tggacaccag ccctcagcat gaggaaattc agggtcccct accagatgag agagattgtg
     3421 tacatgtgtg tgtgagcaca tgtgtgcatg tgtgtgcaca cgtgtgcatg tgtgtgtttt
     3481 agtgaatctg ctctcccagc tcacacactc ccctgcctcc catggcttac acactaggat
     3541 ccagactcca tggtttgaca ccagcctgcg tttgcagctt ctctgtcact tccatgactc
     3601 tatcctcata ccaccactgc tgcttcccac ccagctgaga atgccccctc ctccctgact
     3661 cctctctgcc catgcaaatt agctcacatc tttcctcctg ctgcaatcca tcccttcctc
     3721 ccattggcct ctccttgcca aatctaaata gtttatatag ggatggcaga gagttcccat
     3781 ctcatctgtc agccacagtc atttggtact ggctacctgg agccttatct tctgaagggt
     3841 tttaaagaat ggccaattag ctgagaagaa ttatctaatc aattagtgat gtctgccatg
     3901 gatgcagtag aggaaagtgg tggtacaagt gccatgattg attagcaatg tctgcactgg
     3961 atacggaaaa aagaaggtgc ttgcaggttt acagtgtata tgtgggctat tgaagagccc
     4021 tctgagctcg gttgctagca ggagagcatg cccatattgg cttactttgt ctgccacaga
     4081 cacagacaga gggagttggg acatgcatgc tatggggacc ctcttgttgg acacctaatt
     4141 ggatgcctct tcatgagagg cctccttttc ttcacctttt atgctgcact cctcccctag
     4201 tttacacatc ttgatgctgt ggctcagttt gccttcctga atttttattg ggtccctgtt
     4261 ttctctccta acatgctgag attctgcatc cccacagcct aaactgagcc agtggccaaa
     4321 caaccgtgct cagcctgttt ctctctgccc tctagagcaa ggcccaccag gtccatccag
     4381 gaggctctcc tgacctcaag tccaacaaca gtgtccacac tagtcaaggt tcagcccaga
     4441 aaacagaaag cactctagga atcttaggca gaaagggatt ttatctaaat cactggaaag
     4501 gctggaggag cagaaggcag aggccaccac tggactattg gtttcaatat tagaccactg
     4561 tagccgaatc agaggccaga gagcagccac tgctactgct aatgccacca ctacccctgc
     4621 catcactgcc ccacatggac aaaactggag tcgagaccta ggttagattc ctgcaaccac
     4681 aaacatccat cagggatggc cagctgccag agctgcggga agacggatcc cacctccctt
     4741 tcttagcaga atctaaatta cagccagacc tctggctgca gaggagtctg agacatgtat
     4801 gattgaatgg gtgccaagtg ccagggggcg gagtccccag cagatgcatc ctggccatct
     4861 gttgcgtgga tgagggagtg ggtctatctc agaggaagga acaggaaaca aagaaaggaa
     4921 gccactgaac atcccttctc tgctccacag gagtgcctta gacagcctga ctctccacaa
     4981 accactgtta aaacttacct gctaggaatg ctagattgaa tgggatggga agagccttcc
     5041 ctcattattg tcattcttgg agagaggtga gcaaccaagg gaagctcctc tgattcacct
     5101 agaacctgtt ctctgccgtc tttggctcag cctacagaga ctagagtagg tgaagggaca
     5161 gaggacaggg cttctaatac ctgtgccata ttgacagcct ccatccctgt cccccatctt
     5221 ggtgctgaac caacgctaag ggcaccttct tagactcacc tcatcgatac tgcctggtaa
     5281 tccaaagcta gaactctcag gaccccaaac tccacctctt ggattggccc tggctgctgc
     5341 cacacacata tccaagagct cagggccagt tctggtgggc agcagagacc tgctctgcca
     5401 agttgtccag cagcagagtg gccctggcct gggcatcaca agccagtgat gctcctggga
     5461 agaccaggtg gcaggtcgca gttgggtacc ttccattccc accacacaga ctctgggcct
     5521 ccccgcaaaa tggctccaga attagagtaa ttatgagatg gtgggaacca gagcaactca
     5581 ggtgcatgat acaaggagag gttgtcatct gggtagggca gagaggaggg cttgctcatc
     5641 tgaacagggg tgtatttcat tccaggccct cagtctttgg caatggccac cctggtgttg
     5701 gcatattggc cccactgtaa cttttggggg cttcccggtc tagccacacc ctcggatgga
     5761 aagacttgac tgcataaaga tgtcagttct ccctgagttg attgataggc ttaatggtca
     5821 ccctaaaaac acccacatat gcttttcgat ggaaccaggt aagttgacgc taaagttctt
     5881 atggaaaaat acacacgcaa tagctaggaa aacacaggga aagaagagtt ctgagcaggg
     5941 cctagtctta gccaatatta aaacatacta tgaagcctct gatacttaaa cagcatggcg
     6001 ctggtacgta aatagaccaa tgcagttagg tggctctttc caagactctg gggaaaaaag
     6061 tagtaaaaag ctaaatgcaa tcaatcagca attgaaagct aagtgagaga gccagagggc
     6121 ctccttggtg gtaaaagagg gttgcatttc ttgcagccag aaggcagaga aagtgaagac
     6181 caagtccaga actgaatcct aagaaatgca ggactgcaaa gaaattggtg tgtgtgtgtg
     6241 tgtgtgtgtg tgtgtgtgtg tttaattttt aaaaagtttt tattgagata caagtcaata
     6301 ccataaagct ctcacccttc taaagtgtac aattcagtgg tgtgagtata ttcataagat
     6361 ttatacttgg tgtctattca taagacttat atccagcata ttcataacta gagccatatc
     6421 acagatgcat tcatcataat aattccagac attttcatca ccctaaaagg aaaccctgaa
     6481 acccattagc agtcattccc cattcctcca acccattctc tccctaatcc ctagaaacca
     6541 ccaatctgct gtgtatttca tctattgcca acatttcata taaatggcat catacaata
//
