LOCUS       NM_002535               4622 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens 2'-5'-oligoadenylate synthetase 2 (OAS2), transcript
            variant 2, mRNA.
ACCESSION   NM_002535
VERSION     NM_002535.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4622)
  AUTHORS   Huang,Y.Z., Zheng,Y.X., Zhou,Y., Xu,F., Cui,Y.Z., Chen,X.Y.,
            Wang,Z.Y., Yan,B.X., Zheng,M. and Man,X.Y.
  TITLE     OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte
            Proliferation by Regulating Cell Cycle and Augmenting IFN-1-Induced
            Jak1-Signal Transducer and Activator of Transcription 1
            Phosphorylation in Psoriasis
  JOURNAL   J Invest Dermatol 142 (10), 2635-2645 (2022)
   PUBMED   35305973
  REMARK    GeneRIF: OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte
            Proliferation by Regulating Cell Cycle and Augmenting IFN-1Induced
            Jak1Signal Transducer and Activator of Transcription 1
            Phosphorylation in Psoriasis.
REFERENCE   2  (bases 1 to 4622)
  AUTHORS   Zhou,H., Jia,X., Yang,F. and Shi,P.
  TITLE     Long noncoding RNA SATB1-AS1 contributes to the chemotherapy
            resistance through the microRNA-580/ 2'-5'-oligoadenylate
            synthetase 2 axis in acute myeloid leukemia
  JOURNAL   Bioengineered 12 (1), 6403-6417 (2021)
   PUBMED   34516354
  REMARK    GeneRIF: Long noncoding RNA SATB1-AS1 contributes to the
            chemotherapy resistance through the microRNA-580/
            2'-5'-oligoadenylate synthetase 2 axis in acute myeloid leukemia.
REFERENCE   3  (bases 1 to 4622)
  AUTHORS   Shaath,H., Vishnubalaji,R., Elkord,E. and Alajez,N.M.
  TITLE     Single-Cell Transcriptome Analysis Highlights a Role for
            Neutrophils and Inflammatory Macrophages in the Pathogenesis of
            Severe COVID-19
  JOURNAL   Cells 9 (11), 2374 (2020)
   PUBMED   33138195
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4622)
  AUTHORS   Zhou,Y., Wang,P., Yan,B.X., Chen,X.Y., Landeck,L., Wang,Z.Y.,
            Li,X.X., Zhang,J., Zheng,M. and Man,X.Y.
  TITLE     Quantitative Proteomic Profile of Psoriatic Epidermis Identifies
            OAS2 as a Novel Biomarker for Disease Activity
  JOURNAL   Front Immunol 11, 1432 (2020)
   PUBMED   32849499
  REMARK    GeneRIF: Quantitative Proteomic Profile of Psoriatic Epidermis
            Identifies OAS2 as a Novel Biomarker for Disease Activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4622)
  AUTHORS   Koul,A., Gemmill,D., Lubna,N., Meier,M., Krahn,N., Booy,E.P.,
            Stetefeld,J., Patel,T.R. and McKenna,S.A.
  TITLE     Structural and Hydrodynamic Characterization of Dimeric Human
            Oligoadenylate Synthetase 2
  JOURNAL   Biophys J 118 (11), 2726-2740 (2020)
   PUBMED   32413313
  REMARK    GeneRIF: Structural and Hydrodynamic Characterization of Dimeric
            Human Oligoadenylate Synthetase 2.
REFERENCE   6  (bases 1 to 4622)
  AUTHORS   Marie,I. and Hovanessian,A.G.
  TITLE     The 69-kDa 2-5A synthetase is composed of two homologous and
            adjacent functional domains
  JOURNAL   J Biol Chem 267 (14), 9933-9939 (1992)
   PUBMED   1577824
REFERENCE   7  (bases 1 to 4622)
  AUTHORS   Marie,I., Svab,J., Robert,N., Galabru,J. and Hovanessian,A.G.
  TITLE     Differential expression and distinct structure of 69- and 100-kDa
            forms of 2-5A synthetase in human cells treated with interferon
  JOURNAL   J Biol Chem 265 (30), 18601-18607 (1990)
   PUBMED   2211721
REFERENCE   8  (bases 1 to 4622)
  AUTHORS   Silverman,R.H. and Sengupta,D.N.
  TITLE     Translational regulation by HIV leader RNA, TAT, and
            interferon-inducible enzymes
  JOURNAL   J Exp Pathol 5 (2), 69-77 (1990)
   PUBMED   1708818
REFERENCE   9  (bases 1 to 4622)
  AUTHORS   Marie,I., Galabru,J., Svab,J. and Hovanessian,A.G.
  TITLE     Preparation and characterization of polyclonal antibodies specific
            for the 69 and 100 k-dalton forms of human 2-5A synthetase
  JOURNAL   Biochem Biophys Res Commun 160 (2), 580-587 (1989)
   PUBMED   2470369
REFERENCE   10 (bases 1 to 4622)
  AUTHORS   Hovanessian,A.G., Laurent,A.G., Chebath,J., Galabru,J., Robert,N.
            and Svab,J.
  TITLE     Identification of 69-kd and 100-kd forms of 2-5A synthetase in
            interferon-treated human cells by specific monoclonal antibodies
  JOURNAL   EMBO J 6 (5), 1273-1280 (1987)
   PUBMED   2440675
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE885222.1, BC049215.1,
            BQ213828.1 and AC004551.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002535.2.
            
            Summary: This gene encodes a member of the 2-5A synthetase family,
            essential proteins involved in the innate immune response to viral
            infection. The encoded protein is induced by interferons and uses
            adenosine triphosphate in 2'-specific nucleotidyl transfer
            reactions to synthesize 2',5'-oligoadenylates (2-5As). These
            molecules activate latent RNase L, which results in viral RNA
            degradation and the inhibition of viral replication. The three
            known members of this gene family are located in a cluster on
            chromosome 12. Alternatively spliced transcript variants encoding
            different isoforms have been described. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) contains an additional segment
            in the 3' coding region, compared to variant 1, which leads to a
            premature stop codon. It encodes isoform 2, also known as p69,
            which has a shorter, distinct C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1711286.1,
                                           SRR1803615.163673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000392583.7/ ENSP00000376362.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               BE885222.1         108-557
            451-842             BC049215.1         402-793
            843-953             BQ213828.1         420-530
            954-2196            BC049215.1         905-2147
            2197-3597           AC004551.1         29534-30934         c
            3598-4622           AC004551.1         28509-29533         c
FEATURES             Location/Qualifiers
     source          1..4622
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..4622
                     /gene="OAS2"
                     /note="2'-5'-oligoadenylate synthetase 2"
                     /db_xref="GeneID:4939"
                     /db_xref="HGNC:HGNC:8087"
                     /db_xref="MIM:603350"
     exon            1..267
                     /gene="OAS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2154
                     /gene="OAS2"
                     /EC_number="2.7.7.84"
                     /note="isoform 2 is encoded by transcript variant 2;
                     (2'-5')oligo(A) synthetase 2; 2'-5'-oligoadenylate
                     synthetase 2, 69/71kDa; p69 OAS / p71 OAS; 2-5A synthase
                     2"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase 2 isoform 2"
                     /protein_id="NP_002526.2"
                     /db_xref="CCDS:CCDS41839.1"
                     /db_xref="GeneID:4939"
                     /db_xref="HGNC:HGNC:8087"
                     /db_xref="MIM:603350"
                     /translation="MGNGESQLSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDV
                     LQEPEQFPLVQGVAIGGSYGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTG
                     DKLKFCLFTKWLKNNFEIQKSLDGFTIQVFTKNQRISFEVLAAFNALSLNDNPSPWIY
                     RELKRSLDKTNASPGEFAVCFTELQQKFFDNRPGKLKDLILLIKHWHQQCQKKIKDLP
                     SLSPYALELLTVYAWEQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETI
                     RNILLHQLQSARPVILDPVDPTNNVSGDKICWQWLKKEAQTWLTSPNLDNELPAPSWN
                     VLPAPLFTTPGHLLDKFIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAKIQIV
                     RGGSTAKGTALKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEEL
                     EVSFEPPKWKAPRVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLID
                     LYKSSDLPGGEFSTCFTVLQRNFIRSRPTKLKDLIRLVKHWYKECERKLKPKGSLPPK
                     YALELLTIYAWEQGSGVPDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFL
                     LSQLQKTRPVILDPAEPTGDVGGGDRWCWHLLAKEAKEWLSSPCFKDGTGNPIPPWKV
                     PVKVI"
     exon            268..538
                     /gene="OAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..717
                     /gene="OAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..953
                     /gene="OAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1098
                     /gene="OAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1269
                     /gene="OAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1558
                     /gene="OAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1746
                     /gene="OAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1985
                     /gene="OAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..4622
                     /gene="OAS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4098..4103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OAS2"
                     /note="hexamer: AATAAA"
     polyA_site      4116
                     /gene="OAS2"
                     /note="major polyA site"
     regulatory      4596..4601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OAS2"
                     /note="hexamer: AATAAA"
     polyA_site      4622
                     /gene="OAS2"
                     /note="major polyA site"
ORIGIN      
        1 agtttcagtt tcctggctct gggcagcagc aagaattcct ctgcctccca tcctaccatt
       61 cactgtcttg ccggcagcca gctgagagca atgggaaatg gggagtccca gctgtcctcg
      121 gtgcctgctc agaagctggg ttggtttatc caggaatacc tgaagcccta cgaagaatgt
      181 cagacactga tcgacgagat ggtgaacacc atctgtgacg tcctgcagga acccgaacag
      241 ttccccctgg tgcagggagt ggccataggt ggctcctatg gacggaaaac agtcttaaga
      301 ggcaactccg atggtaccct tgtcctcttc ttcagtgact taaaacaatt ccaggatcag
      361 aagagaagcc aacgtgacat cctcgataaa actggggata agctgaagtt ctgtctgttc
      421 acgaagtggt tgaaaaacaa tttcgagatc cagaagtccc ttgatgggtt caccatccag
      481 gtgttcacaa aaaatcagag aatctctttc gaggtgctgg ccgccttcaa cgctctgagc
      541 ttaaatgata atcccagccc ctggatctat cgagagctca aaagatcctt ggataagaca
      601 aatgccagtc ctggtgagtt tgcagtctgc ttcactgaac tccagcagaa gttttttgac
      661 aaccgtcctg gaaaactaaa ggatttgatc ctcttgataa agcactggca tcaacagtgc
      721 cagaaaaaaa tcaaggattt accctcgctg tctccgtatg ccctggagct gcttacggtg
      781 tatgcctggg aacaggggtg cagaaaagac aactttgaca ttgctgaagg cgtcagaacc
      841 gtactggagc tgatcaaatg ccaggagaag ctgtgtatct attggatggt caactacaac
      901 tttgaagatg agaccatcag gaacatcctg ctgcaccagc tccaatcagc gaggccagta
      961 atcttggatc cagttgaccc aaccaataat gtgagtggag ataaaatatg ctggcaatgg
     1021 ctgaaaaaag aagctcaaac ctggttgact tctcccaacc tggataatga gttacctgca
     1081 ccatcttgga atgttctgcc tgcaccactc ttcacgaccc caggccacct tctggataag
     1141 ttcatcaagg agtttctcca gcccaacaaa tgcttcctag agcagattga cagtgctgtt
     1201 aacatcatcc gtacattcct taaagaaaac tgcttccgac aatcaacagc caagatccag
     1261 attgtccggg gaggatcaac cgccaaaggc acagctctga agactggctc tgatgccgat
     1321 ctcgtcgtgt tccataactc acttaaaagc tacacctccc aaaaaaacga gcggcacaaa
     1381 atcgtcaagg aaatccatga acagctgaaa gccttttgga gggagaagga ggaggagctt
     1441 gaagtcagct ttgagcctcc caagtggaag gctcccaggg tgctgagctt ctctctgaaa
     1501 tccaaagtcc tcaacgaaag tgtcagcttt gatgtgcttc ctgcctttaa tgcactgggt
     1561 cagctgagtt ctggctccac acccagcccc gaggtttatg cagggctcat tgatctgtat
     1621 aaatcctcgg acctcccggg aggagagttt tctacctgtt tcacagtcct gcagcgaaac
     1681 ttcattcgct cccggcccac caaactaaag gatttaattc gcctggtgaa gcactggtac
     1741 aaagagtgtg aaaggaaact gaagccaaag gggtctttgc ccccaaagta tgccttggag
     1801 ctgctcacca tctatgcctg ggagcagggg agtggagtgc cggattttga cactgcagaa
     1861 ggtttccgga cagtcctgga gctggtcaca caatatcagc agctctgcat cttctggaag
     1921 gtcaattaca actttgaaga tgagaccgtg aggaagtttc tactgagcca gttgcagaaa
     1981 accaggcctg tgatcttgga cccagccgaa cccacaggtg acgtgggtgg aggggaccgt
     2041 tggtgttggc atcttctggc aaaagaagca aaggaatggt tatcctctcc ctgcttcaag
     2101 gatgggactg gaaacccaat accaccttgg aaagtgccgg taaaagtcat ctaaaggagg
     2161 cgttgtctgg aaatagccct gtaacaggct tgaatcaaag aacttctcct actgtagcaa
     2221 cctgaaatta actcagacac aaataaagga aacccagctc acaggagctt aaacagctgg
     2281 tcagccccct aagcccccac tacaagtgat cctcaggcag gtaaccccag attcatgcac
     2341 tgtagggtgc tgcgcagcat ccctagtctc tacccagtag atgccactag ccctcctctc
     2401 ccagtgacaa ccaaaagtct tcagacattg tcaaacgttc ccctgggttc acagatcttt
     2461 ctgcctttgg cttttggctc caccctcttt agctgttaat ttgagtactt atggccctga
     2521 aagcggccac ggtgcctcca gatggcaggt ttgcaatcca agcaggaaga aggaaaagat
     2581 acccaaaggt caagaacaca gtgattttat tagaagtttc atccgcaaat tttcttccat
     2641 ttcattgctc agaaatgtca tgtggctacc tgtaacttga aggtggctac aaagatgact
     2701 gtggacgtgg gttgcactgg ccacccaagg atgtctgcca cacctctcca aagccctccc
     2761 tacctaccaa gatatacctg atatattcca ccaggatatc ctccctccag atatacttgg
     2821 ttctctccac caggttcttt ctttaaagca ggatttctca actttgatac ttactcacat
     2881 ttggggctag acagttcttt gtttggaggc tctcttgtgc attgtaggat gttgagcagc
     2941 atctctggcc tgtacccagt agatgccacc cagttgtgac aattaaaagt gtcttgagac
     3001 tttatcatgt gtcttctgcc ctaggtgaga acccttgcac tagaggaacc ctacacccca
     3061 accctggggg gaatgtaggg aagaggtggc caagccaacc gtggggttag ctctaattat
     3121 taagatatgc attataaata aataccaaaa aattgtctct ggcaatagtt accttcccag
     3181 atacaggtcc cccctttttt cccctaactc ttttaagcaa tgattgtaac tattaggaga
     3241 cattgctctc ccacgtatgt ttttcttttt agacaatgca gacaccagga agttgtggag
     3301 ctaggatcca tcctattgtc aatgagatgt tctcatccag aagccataga atcctgaata
     3361 ataattctaa aagaaacttc tagagatcat ctggcaatcg cttttaaaga ctcggctcac
     3421 cgtgagaaag agtcactcac atccattctt cccttgatgg tccctattcc tccttccctt
     3481 gcttcttgga cttcttgaaa tcaatcaaga ctgcaaaccc tttcataaag tcttgccttg
     3541 ctgaactccc tctctgcagg cagcctgcct ttaaaaatag ttgctgtcat ccactttatg
     3601 tgcatcttat ttctgtcaac ttgtattttt tttcttgtat ttttccaatt agctcctcct
     3661 ttttccttcc agtctaaaaa aggaatcctc tgtgtcttca aagcaaagct ctttactttc
     3721 cccttggttc tcataactct gtgatcttgc tctcggtgct tccaactcat ccacgtcctg
     3781 tctgtttcct ctgtatacaa aaccctttct gcccctgctg acacagacat cctctatgcc
     3841 agcagccagc caaccctttc attagaactt caagctctcc aaaggctcag attataactg
     3901 ttgtcatatt tatatgaggc tgttgtcttt tccttctgag cctgcctttc tcccccccac
     3961 ccaggagtat cctcttgcca aatcaaaaga ctttttcctt gggctttagc cttaaagata
     4021 cttgaaggtc taggtgcttt aacctcacat accctcactt aaacttttat cactgttgca
     4081 tataccagtt gtgatacaat aaagaatgta tctggatttt gtgcctagtt cctagcacac
     4141 agcttcaaaa attctagagt ttcctgatag gagtgtcttt tgtattcata acaagccctt
     4201 ttcacccatg cctgggttta tgctaacaag gttacccatg gtgggccctt agtttcaagg
     4261 aaggagttgg ccaagccaga aagaccaagc atgtggttaa agcattggaa ttttcagccc
     4321 catcccaccc ccaatctcca aggaggtgat ggggctggaa attgagttca attttaacat
     4381 ggccagtgat ttaagcaatg ctgcctatgt aaagaaaccc caataaaaac tctggacagt
     4441 gaggcttggg gagcttcctg attggcagac attccaatgt actaggaagg tagcgcatct
     4501 tgattccaca gggacaaagg ctcctgagct ctgggccctt ccagtgcttg ccaccctaca
     4561 tactctttgt ctggctcttc atttgtattc tttataataa aatggtgatt gtaagtagag
     4621 ca
//
