LOCUS       NM_016816               1631 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens 2'-5'-oligoadenylate synthetase 1 (OAS1), transcript
            variant 1, mRNA.
ACCESSION   NM_016816
VERSION     NM_016816.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1631)
  AUTHORS   Wang,L., Gao,L., Ding,F., Gao,K., Liu,Q. and Yin,X.
  TITLE     Prognostic value and molecular mechanisms of OAS1 in lung
            adenocarcinoma
  JOURNAL   BMC Pulm Med 24 (1), 473 (2024)
   PUBMED   39334033
  REMARK    GeneRIF: Prognostic value and molecular mechanisms of OAS1 in lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1631)
  AUTHORS   Yousfi,F.Z.E., Haroun,A.E., Nebhani,C., Belayachi,J., Askander,O.,
            Fahime,E.E., Fares,H., Ennibi,K., Abouqal,R., Razine,R. and
            Bouhouche,A.
  TITLE     Prevalence of the protective OAS1 rs10774671-G allele against
            severe COVID-19 in Moroccans: implications for a North African
            Neanderthal connection
  JOURNAL   Arch Virol 169 (5), 109 (2024)
   PUBMED   38658463
  REMARK    GeneRIF: Prevalence of the protective OAS1 rs10774671-G allele
            against severe COVID-19 in Moroccans: implications for a North
            African Neanderthal connection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1631)
  AUTHORS   Kjaer,K.H., Pahus,J., Hansen,M.F., Poulsen,J.B., Christensen,E.I.,
            Justesen,J. and Martensen,P.M.
  TITLE     Mitochondrial localization of the OAS1 p46 isoform associated with
            a common single nucleotide polymorphism
  JOURNAL   BMC Cell Biol 15, 33 (2014)
   PUBMED   25205466
  REMARK    GeneRIF: The OAS1 p46 isoform localizes to the mitochondria.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1631)
  AUTHORS   Noguchi,S., Hamano,E., Matsushita,I., Hijikata,M., Ito,H.,
            Nagase,T. and Keicho,N.
  TITLE     Differential effects of a common splice site polymorphism on the
            generation of OAS1 variants in human bronchial epithelial cells
  JOURNAL   Hum Immunol 74 (3), 395-401 (2013)
   PUBMED   23220500
  REMARK    GeneRIF: Findings provide insights into the potential role of OAS1
            polymorphisms in respiratory infection.
REFERENCE   5  (bases 1 to 1631)
  AUTHORS   Kristiansen,H., Gad,H.H., Eskildsen-Larsen,S., Despres,P. and
            Hartmann,R.
  TITLE     The oligoadenylate synthetase family: an ancient protein family
            with multiple antiviral activities
  JOURNAL   J Interferon Cytokine Res 31 (1), 41-47 (2011)
   PUBMED   21142819
  REMARK    Review article
REFERENCE   6  (bases 1 to 1631)
  AUTHORS   Bonnevie-Nielsen,V., Field,L.L., Lu,S., Zheng,D.J., Li,M.,
            Martensen,P.M., Nielsen,T.B., Beck-Nielsen,H., Lau,Y.L. and
            Pociot,F.
  TITLE     Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS)
            enzyme activity is controlled by a single-nucleotide polymorphism
            at a splice-acceptor site in the OAS1 gene
  JOURNAL   Am J Hum Genet 76 (4), 623-633 (2005)
   PUBMED   15732009
  REMARK    GeneRIF: This genetic polymorphism makes OAS1 an excellent
            candidate for a human gene that influences host susceptibility to
            viral infection.
REFERENCE   7  (bases 1 to 1631)
  AUTHORS   Aissouni,Y., Perez,C., Calmels,B. and Benech,P.D.
  TITLE     The cleavage/polyadenylation activity triggered by a U-rich motif
            sequence is differently required depending on the poly(A) site
            location at either the first or last 3'-terminal exon of the 2'-5'
            oligo(A) synthetase gene
  JOURNAL   J Biol Chem 277 (39), 35808-35814 (2002)
   PUBMED   12082089
  REMARK    GeneRIF: sequence motifs in OAS1 regulate polyadenylation
REFERENCE   8  (bases 1 to 1631)
  AUTHORS   Ghosh,S.K., Kusari,J., Bandyopadhyay,S.K., Samanta,H., Kumar,R. and
            Sen,G.C.
  TITLE     Cloning, sequencing, and expression of two murine
            2'-5'-oligoadenylate synthetases. Structure-function relationships
  JOURNAL   J Biol Chem 266 (23), 15293-15299 (1991)
   PUBMED   1651324
REFERENCE   9  (bases 1 to 1631)
  AUTHORS   Benech,P., Vigneron,M., Peretz,D., Revel,M. and Chebath,J.
  TITLE     Interferon-responsive regulatory elements in the promoter of the
            human 2',5'-oligo(A) synthetase gene
  JOURNAL   Mol Cell Biol 7 (12), 4498-4504 (1987)
   PUBMED   2830497
REFERENCE   10 (bases 1 to 1631)
  AUTHORS   Benech,P., Mory,Y., Revel,M. and Chebath,J.
  TITLE     Structure of two forms of the interferon-induced (2'-5') oligo A
            synthetase of human cells based on cDNAs and gene sequences
  JOURNAL   EMBO J 4 (9), 2249-2256 (1985)
   PUBMED   2416561
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB112445.1, AJ629455.1 and
            AK225384.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016816.3.
            
            Summary: This interferon-induced gene encodes a protein that
            synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key
            role in innate cellular antiviral response, and has been implicated
            in other cellular processes like cell growth and apoptosis.
            Alternative splicing results in multiple transcript variants with
            different enzymatic activities. Polymorphisms in this gene have
            been associated with susceptibility to viral infection, including
            SARS-CoV-2, and diabetes mellitus, type 1. This gene is located in
            a cluster of related genes on chromosome 12. [provided by RefSeq,
            May 2022].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. It encodes isoform 1 (also known as E18 and p46). This
            variant is produced in individuals with a G allele at a polymorphic
            splice acceptor site in the 3' most intron(PMID:15732009).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.754483.1,
                                           SRR1163655.42488.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related                :: involved in immune response
                                                  or antiviral activity
            gene product(s) localized to mito. :: PMID: 25205466
            MANE Ensembl match                 :: ENST00000202917.10/
                                                  ENSP00000202917.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                CB112445.1         186-230
            46-596              AJ629455.1         1-551
            597-1631            AK225384.1         582-1616
FEATURES             Location/Qualifiers
     source          1..1631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..1631
                     /gene="OAS1"
                     /gene_synonym="E18/E16; IFI-4; IMD100; OIAS; OIASI"
                     /note="2'-5'-oligoadenylate synthetase 1"
                     /db_xref="GeneID:4938"
                     /db_xref="HGNC:HGNC:8086"
                     /db_xref="MIM:164350"
     exon            1..258
                     /gene="OAS1"
                     /gene_synonym="E18/E16; IFI-4; IMD100; OIAS; OIASI"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1281
                     /gene="OAS1"
                     /gene_synonym="E18/E16; IFI-4; IMD100; OIAS; OIASI"
                     /EC_number="2.7.7.84"
                     /note="isoform 1 is encoded by transcript variant 1; E16
                     (2'-5') oligo A synthetase; 2'-5'-oligoadenylate
                     synthetase 1, 40/46kDa; 2'-5'-oligoisoadenylate synthetase
                     1; 2',5'-oligo A synthetase 1; 2-5A synthetase 1;
                     2'-5'-oligoadenylate synthase 1; 2-5A synthase 1;
                     (2-5')oligo(A) synthase 1; 2'-5'-oligoadenylate synthase 1
                     isoform p42"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase 1 isoform 1"
                     /protein_id="NP_058132.2"
                     /db_xref="CCDS:CCDS41838.1"
                     /db_xref="GeneID:4938"
                     /db_xref="HGNC:HGNC:8086"
                     /db_xref="MIM:164350"
                     /translation="MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKER
                     CFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEI
                     RRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLT
                     GGYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQN
                     CKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYY
                     DFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKN
                     WDGSPVSSWILLAESNSADDETDDPRRYQKYGYIGTHEYPHFSHRPSTLQAASTPQAE
                     EDWTCTIL"
     exon            259..547
                     /gene="OAS1"
                     /gene_synonym="E18/E16; IFI-4; IMD100; OIAS; OIASI"
                     /inference="alignment:Splign:2.1.0"
     exon            548..732
                     /gene="OAS1"
                     /gene_synonym="E18/E16; IFI-4; IMD100; OIAS; OIASI"
                     /inference="alignment:Splign:2.1.0"
     exon            733..962
                     /gene="OAS1"
                     /gene_synonym="E18/E16; IFI-4; IMD100; OIAS; OIASI"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1116
                     /gene="OAS1"
                     /gene_synonym="E18/E16; IFI-4; IMD100; OIAS; OIASI"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1631
                     /gene="OAS1"
                     /gene_synonym="E18/E16; IFI-4; IMD100; OIAS; OIASI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1610..1615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OAS1"
                     /gene_synonym="E18/E16; IFI-4; IMD100; OIAS; OIASI"
                     /note="hexamer: AATAAA"
     polyA_site      1631
                     /gene="OAS1"
                     /gene_synonym="E18/E16; IFI-4; IMD100; OIAS; OIASI"
                     /note="major polyA site"
ORIGIN      
        1 agtccaagct cagtcagcag aagagataaa agcaaacagg tctgggaggc agttctgttg
       61 ccactctctc tcctgtcaat gatggatctc agaaataccc cagccaaatc tctggacaag
      121 ttcattgaag actatctctt gccagacacg tgtttccgca tgcaaatcaa ccatgccatt
      181 gacatcatct gtgggttcct gaaggaaagg tgcttccgag gtagctccta ccctgtgtgt
      241 gtgtccaagg tggtaaaggg tggctcctca ggcaagggca ccaccctcag aggccgatct
      301 gacgctgacc tggttgtctt cctcagtcct ctcaccactt ttcaggatca gttaaatcgc
      361 cggggagagt tcatccagga aattaggaga cagctggaag cctgtcaaag agagagagca
      421 ttttccgtga agtttgaggt ccaggctcca cgctggggca acccccgtgc gctcagcttc
      481 gtactgagtt cgctccagct cggggagggg gtggagttcg atgtgctgcc tgcctttgat
      541 gccctgggtc agttgactgg cggctataaa cctaaccccc aaatctatgt caagctcatc
      601 gaggagtgca ccgacctgca gaaagagggc gagttctcca cctgcttcac agaactacag
      661 agagacttcc tgaagcagcg ccccaccaag ctcaagagcc tcatccgcct agtcaagcac
      721 tggtaccaaa attgtaagaa gaagcttggg aagctgccac ctcagtatgc cctggagctc
      781 ctgacggtct atgcttggga gcgagggagc atgaaaacac atttcaacac agcccaggga
      841 tttcggacgg tcttggaatt agtcataaac taccagcaac tctgcatcta ctggacaaag
      901 tattatgact ttaaaaaccc cattattgaa aagtacctga gaaggcagct cacgaaaccc
      961 aggcctgtga tcctggaccc ggcggaccct acaggaaact tgggtggtgg agacccaaag
     1021 ggttggaggc agctggcaca agaggctgag gcctggctga attacccatg ctttaagaat
     1081 tgggatgggt ccccagtgag ctcctggatt ctgctggctg aaagcaacag tgcagacgat
     1141 gagaccgacg atcccaggag gtatcagaaa tatggttaca ttggaacaca tgagtaccct
     1201 catttctctc atagacccag cacactccag gcagcatcca ccccacaggc agaagaggac
     1261 tggacctgca ccatcctctg aatgccagtg catcttgggg gaaagggctc cagtgttatc
     1321 tggaccagtt ccttcatttt caggtgggac tcttgatcca gagaggacaa agctcctcag
     1381 tgagctggtg tataatccag gacagaaccc aggtctcctg actcctggcc ttctatgccc
     1441 tctatcctat catagataac attctccaca gcctcacttc attccaccta ttctctgaaa
     1501 atattccctg agagagaaca gagagattta gataagagaa tgaaattcca gccttgactt
     1561 tcttctgtgc acctgatggg agggtaatgt ctaatgtatt atcaataaca ataaaaataa
     1621 agcaaatacc a
//
