LOCUS       NM_001329686            3184 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens O-acyl-ADP-ribose deacylase 1 (OARD1), transcript
            variant 3, mRNA.
ACCESSION   NM_001329686
VERSION     NM_001329686.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3184)
  AUTHORS   Tromans-Coia,C., Sanchi,A., Moeller,G.K., Timinszky,G., Lopes,M.
            and Ahel,I.
  TITLE     TARG1 protects against toxic DNA ADP-ribosylation
  JOURNAL   Nucleic Acids Res 49 (18), 10477-10492 (2021)
   PUBMED   34508355
  REMARK    GeneRIF: TARG1 protects against toxic DNA ADP-ribosylation.
REFERENCE   2  (bases 1 to 3184)
  AUTHORS   Zaja,R., Aydin,G., Lippok,B.E., Feederle,R., Luscher,B. and
            Feijs,K.L.H.
  TITLE     Comparative analysis of MACROD1, MACROD2 and TARG1 expression,
            localisation and interactome
  JOURNAL   Sci Rep 10 (1), 8286 (2020)
   PUBMED   32427867
  REMARK    GeneRIF: Comparative analysis of MACROD1, MACROD2 and TARG1
            expression, localisation and interactome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3184)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3184)
  AUTHORS   Butepage,M., Preisinger,C., von Kriegsheim,A., Scheufen,A.,
            Lausberg,E., Li,J., Kappes,F., Feederle,R., Ernst,S., Eckei,L.,
            Krieg,S., Muller-Newen,G., Rossetti,G., Feijs,K.L.H., Verheugd,P.
            and Luscher,B.
  TITLE     Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA
            damage-induced poly-ADP-ribosylation and by nucleolar transcription
  JOURNAL   Sci Rep 8 (1), 6748 (2018)
   PUBMED   29712969
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3184)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    GeneRIF: Studies indicate that poly (ADP-ribose) glycohydrolase
            (PARG) and terminal ADP-ribose glycohydrolase 1 (TARG1) are key
            enzymes in poly(ADP-ribose) polymerases (PARPs)-mediated
            ADP-ribosylation.
            Review article
REFERENCE   6  (bases 1 to 3184)
  AUTHORS   Sharifi,R., Morra,R., Appel,C.D., Tallis,M., Chioza,B.,
            Jankevicius,G., Simpson,M.A., Matic,I., Ozkan,E., Golia,B.,
            Schellenberg,M.J., Weston,R., Williams,J.G., Rossi,M.N.,
            Galehdari,H., Krahn,J., Wan,A., Trembath,R.C., Crosby,A.H.,
            Ahel,D., Hay,R., Ladurner,A.G., Timinszky,G., Williams,R.S. and
            Ahel,I.
  TITLE     Deficiency of terminal ADP-ribose protein glycohydrolase
            TARG1/C6orf130 in neurodegenerative disease
  JOURNAL   EMBO J 32 (9), 1225-1237 (2013)
   PUBMED   23481255
  REMARK    GeneRIF: C6orf130 enzymatic activity has a role in the turnover and
            recycling of protein ADP-ribosylation in neurodegenerative disease.
REFERENCE   7  (bases 1 to 3184)
  AUTHORS   Rosenthal,F., Feijs,K.L., Frugier,E., Bonalli,M., Forst,A.H.,
            Imhof,R., Winkler,H.C., Fischer,D., Caflisch,A., Hassa,P.O.,
            Luscher,B. and Hottiger,M.O.
  TITLE     Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases
  JOURNAL   Nat Struct Mol Biol 20 (4), 502-507 (2013)
   PUBMED   23474714
REFERENCE   8  (bases 1 to 3184)
  AUTHORS   Peterson,F.C., Chen,D., Lytle,B.L., Rossi,M.N., Ahel,I., Denu,J.M.
            and Volkman,B.F.
  TITLE     Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose
            deacylase: solution structure and catalytic properties
  JOURNAL   J Biol Chem 286 (41), 35955-35965 (2011)
   PUBMED   21849506
  REMARK    GeneRIF: Orphan macrodomain protein (human C6orf130) is an
            O-acyl-ADP-ribose deacylase: solution structure and catalytic
            properties.
REFERENCE   9  (bases 1 to 3184)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031778.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001329686.1.
            
            Summary: The protein encoded by this gene is a deacylase that can
            convert O-acetyl-ADP-ribose to ADP-ribose and acetate,
            O-propionyl-ADP-ribose to ADP-ribose and propionate, and
            O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose
            product is able to inhibit these reactions through a competitive
            feedback loop. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (3), along with variants 1, 2, 4,
            and 5, encodes isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.209738.1,
                                           SRR1803616.117683.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424266.7/ ENSP00000416829.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AL031778.1         117844-117964       c
            122-201             AL031778.1         117204-117283       c
            202-346             AL031778.1         116740-116884       c
            347-405             AL031778.1         115684-115742       c
            406-518             AL031778.1         114449-114561       c
            519-3184            AL031778.1         110380-113045       c
FEATURES             Location/Qualifiers
     source          1..3184
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..3184
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /note="O-acyl-ADP-ribose deacylase 1"
                     /db_xref="GeneID:221443"
                     /db_xref="HGNC:HGNC:21257"
                     /db_xref="MIM:614393"
     exon            1..121
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /inference="alignment:Splign:2.1.0"
     exon            122..201
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..621
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /EC_number="3.5.1.-"
                     /note="isoform a is encoded by transcript variant 3;
                     O-acetyl-ADP-ribose deacetylase C6orf130;
                     O-acetyl-ADP-ribose deacetylase 1; terminal ADP-ribose
                     protein glycohydrolase 1; [Protein ADP-ribosylglutamate]
                     hydrolase OARD1; ADP-ribose glycohydrolase OARD1"
                     /codon_start=1
                     /product="ADP-ribose glycohydrolase OARD1 isoform a"
                     /protein_id="NP_001316615.1"
                     /db_xref="CCDS:CCDS34445.1"
                     /db_xref="GeneID:221443"
                     /db_xref="HGNC:HGNC:21257"
                     /db_xref="MIM:614393"
                     /translation="MASSLNEDPEGSRITYVKGDLFACPKTDSLAHCISEDCRMGAGI
                     AVLFKKKFGGVQELLNQQKKSGEVAVLKRDGRYIYYLITKKRASHKPTYENLQKSLEA
                     MKSHCLKNGVTDLSMPRIGCGLDRLQWENVSAMIEEVFEATDIKITVYTL"
     exon            202..346
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..405
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..518
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..3184
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1096..1101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /note="hexamer: ATTAAA"
     polyA_site      1122
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /note="major polyA site"
     regulatory      1145..1150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /note="hexamer: AATAAA"
     polyA_site      1168
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /note="major polyA site"
     regulatory      1464..1469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /note="hexamer: AATAAA"
     polyA_site      1486
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /note="major polyA site"
     regulatory      3154..3159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
                     /note="hexamer: AATAAA"
     polyA_site      3184
                     /gene="OARD1"
                     /gene_synonym="C6orf130; dJ34B21.3; TARG1"
ORIGIN      
        1 caaacaaccg actcctttcc aggtgaaggg tgacttgggt acgttggggc tttgagcgag
       61 cctccccgca ccctcccata ggaccccagg acagactgcg tcctcgctga cccgccctag
      121 gctgaagaaa cacttaaatt ctggaaatag cgactcagta tcatggccag cagccttaat
      181 gaagatccag aaggaagcag aatcacttat gtgaaaggag acctttttgc atgcccgaaa
      241 acagactctt tagcccactg tatcagtgag gattgtcgca tgggcgctgg gatagctgtc
      301 ctctttaaga agaaatttgg aggggtgcaa gaacttttaa atcaacaaaa gaaatctgga
      361 gaagtggctg ttctgaagag agatgggcga tatatatatt acttgattac aaagaaaagg
      421 gcttcgcaca agccaactta tgaaaactta cagaagagtt tagaggcaat gaagtctcat
      481 tgtctgaaga atggagtcac tgacctctcc atgcccagga ttggatgtgg tcttgatcgt
      541 ctgcaatggg aaaatgtatc tgcgatgatc gaggaggtat ttgaggcaac agacatcaaa
      601 attactgtgt acacactctg aaccagtgaa cattttggat gtttccgtgt tctcctgtgt
      661 catctctact gggccatagg accgggcaaa cctaccttaa aataggcaga ggaaagtttc
      721 atgagaagta gtgtgtttaa caagacagac tttggttgct gtattcaagt atttggatta
      781 tgactgtgga ggagggcttg cttaagatat gtggttgtgt ttttttgtgg aaaagtaagg
      841 agttaggtgg cttgataata ggcagggaaa ccagattgtc gggactatga cctttttctc
      901 cagtatgcta cctgatttgt ttggctggcc actaggtggc agcattggtt ctacttctct
      961 gctttttaag agaaatttca ggaaggatga tcattccagt tagtttggca ttttttgtcg
     1021 tttgtgcaca taacttggtg ttatccttat gtcatcagat tcctcctagg ggagagtttt
     1081 tgttttaatt acaaaattaa attctacatt gttaccaaga aatttgtggt gataaaaatg
     1141 gaaaaataaa aatttgggga gttagtgagg ttctgtgctt atgtctattt gttctggaca
     1201 tgggtaatgg agggttcacc tgcaacttaa tttcaaacag tcagacaaag ggtccaagcg
     1261 ggaggagaag caaagtgaga aataagagat aaaaatagac aagtcaaaag gcaggttttt
     1321 agaatctcct catggtgaac tttttctctc ttttgtccac tgcatggttt ctgtgattga
     1381 acctgcctga atttaatcat gaaaacaagt gaaataatgt atgttaaatg cctggcagag
     1441 tacttagcac agactagtga cccaataaat cagtgattgt caaaaatcct tatgagtctt
     1501 ctttaaaaaa ataaaggcca cttcctctca aaaaattctc atacctgtca tctcagcact
     1561 ttgagaggct gagactggag gatgacttga gcccaggagt ttgagacaaa cctggttaac
     1621 atagcgagac cctgtctcta caaaaaaaaa agaaattaaa aattagctgg gcctggtggt
     1681 gcaggcctgt agttccagct actctagagg ttgaggcggg aggatggctt gagcctggga
     1741 ggttgaagtt gcattgagct gtgattgtgc cactgcactc cagtgtgggc aacagagcaa
     1801 gaccctatct caattaaaaa aaaaaatttg gtggtggagt gggatggcca cttttgtgtt
     1861 tttaacctcc atagaagatt tggatgtgca gccagctggg gtctaaatat tagtcctctt
     1921 ttcttccgaa gctgcaaaga ccagtcgtct attgtggtca tggtaggaaa ataaagttca
     1981 tggatttagc caatggttca gtatcagagc tattcgggaa actagacatt ttcttgtttt
     2041 cccttacagt ggtgttgaga gttaaaacag ccagacttgc tattgatttt ctccctagag
     2101 tgactttggg tctgtcacag gacttgctgc tttcccaagt ataaaagaac aactgtattt
     2161 tagaaggggc tggttaaaac accaggaaag tactggttaa atataatctt tgtactttag
     2221 actgtgttct tatcacatat cagcctgata agaggcaaca gtttcaaaaa agtatttcac
     2281 ttttgtattt ctaggtggaa cagacaagtt cttcatgttg ttggggtagg ggcagtggag
     2341 ggtcaagttc attatcaaac ttttagattg aggcttttct tgaagcattg cttttgtcca
     2401 cataaagttg aagggaaaaa ggaaggagag attatctaaa tacacaaaat tgaaagtgag
     2461 agtgggggat aagaaactta aagaaactta aaatattttg cttaactctg caattacaga
     2521 tgctcctcaa cttaggtcta tgtctgggta accccatctt aagttgagtt cagttgaagg
     2581 gtgtactgaa tgtgtatggc ttttgcaccg ttgtaaagtc caaaaattgc aagacaaacc
     2641 attgtaaatt gagtaccatc tgtaaacctt aacacaagtc aaaacatgga ttttctaggc
     2701 ttcctttact tttaaagaga ttatggttat tattattatt tttttcttgg cgtttgagcc
     2761 ttgattcttt agacaaaacc tagtctcatt caggattggc tgtaagtgga attctgggac
     2821 ttagcaggaa tgtgataaag cactttgtca tttgccgata gtagtcttgg gtcaaattcc
     2881 gacgacttat cacacttgaa gcctgaggaa aggaggcatg ccctggtaat cagagtgaac
     2941 acattattcc tggaaaccta gttagagttt ggcaaacacc cggaaattca cctgtgaatt
     3001 tttgcttcca cataggactc aaacaaacct ttaaaaaaaa aaaaagagag acttgacatc
     3061 atcctgccat taccatcaaa caccatgtat tgaatacttt taaatgattg tatatctgaa
     3121 cattaaacta ctacttttca cccgctcctc tctaataaag aagctagttg cttattaact
     3181 ggca
//
