LOCUS       NM_178507               2262 bp    mRNA    linear   PRI 22-JAN-2025
DEFINITION  Homo sapiens out at first homolog (OAF), mRNA.
ACCESSION   NM_178507
VERSION     NM_178507.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2262)
  AUTHORS   Sanchez-Pulido,L. and Ponting,C.P.
  TITLE     OAF: a new member of the BRICHOS family
  JOURNAL   Bioinform Adv 2 (1), vbac087 (2022)
   PUBMED   36699367
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2262)
  AUTHORS   Lu,Q., Liu,J., Yu,Y., Liang,H.F., Zhang,S.Q., Li,Z.B., Chen,J.X.,
            Xu,Q.G. and Li,J.C.
  TITLE     ALB, HP, OAF and RBP4 as novel protein biomarkers for identifying
            cured patients with pulmonary tuberculosis by DIA
  JOURNAL   Clin Chim Acta 535, 82-91 (2022)
   PUBMED   35964702
  REMARK    GeneRIF: ALB, HP, OAF and RBP4 as novel protein biomarkers for
            identifying cured patients with pulmonary tuberculosis by DIA.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB480792.1, BC047726.1, AI733095.1, AA902624.1 and AP000679.7.
            
            On Nov 23, 2018 this sequence version replaced NM_178507.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047726.1, ERR279833.8880.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328965.9/ ENSP00000332613.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DB480792.1         58-64
            8-1869              BC047726.1         1-1862
            1870-2091           AI733095.1         187-408             c
            2092-2260           AA902624.1         18-186              c
            2261-2262           AP000679.7         117925-117926
FEATURES             Location/Qualifiers
     source          1..2262
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..2262
                     /gene="OAF"
                     /gene_synonym="NS5ATP13TP2"
                     /note="out at first homolog"
                     /db_xref="GeneID:220323"
                     /db_xref="HGNC:HGNC:28752"
                     /db_xref="MIM:621070"
     exon            1..479
                     /gene="OAF"
                     /gene_synonym="NS5ATP13TP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1070
                     /gene="OAF"
                     /gene_synonym="NS5ATP13TP2"
                     /note="out at first protein homolog; HCV
                     NS5A-transactivated protein 13 target protein 2; OAF
                     homolog"
                     /codon_start=1
                     /product="out at first protein homolog precursor"
                     /protein_id="NP_848602.1"
                     /db_xref="CCDS:CCDS8430.1"
                     /db_xref="GeneID:220323"
                     /db_xref="HGNC:HGNC:28752"
                     /db_xref="MIM:621070"
                     /translation="MRLPGVPLARPALLLLLPLLAPLLGTGAPAELRVRVRLPDGQVT
                     EESLQADSDADSISLELRKPDGTLVSFTADFKKDVKVFRALILGELEKGQSQFQALCF
                     VTQLQHNEIIPSEAMAKLRQKNPRAVRQAEEVRGLEHLHMDVAVNFSQGALLSPHLHN
                     VCAEAVDAIYTRQEDVRFWLEQGVDSSVFEALPKASEQAELPRCRQVGDHGKPCVCRY
                     GLSLAWYPCMLKYCHSRDRPTPYKCGIRSCQKSYSFDFYVPQRQLCLWDEDPYPG"
     exon            480..614
                     /gene="OAF"
                     /gene_synonym="NS5ATP13TP2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..795
                     /gene="OAF"
                     /gene_synonym="NS5ATP13TP2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..2262
                     /gene="OAF"
                     /gene_synonym="NS5ATP13TP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1844..1849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OAF"
                     /gene_synonym="NS5ATP13TP2"
                     /note="hexamer: AATAAA"
     polyA_site      1869
                     /gene="OAF"
                     /gene_synonym="NS5ATP13TP2"
                     /note="major polyA site"
     regulatory      2241..2246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OAF"
                     /gene_synonym="NS5ATP13TP2"
                     /note="hexamer: TATAAA"
     polyA_site      2262
                     /gene="OAF"
                     /gene_synonym="NS5ATP13TP2"
ORIGIN      
        1 gctggagccc ggggccgcgg agccgggccg gggcagcgcc gtctccgcct cggggccgcc
       61 gggggcgccc tgctgagcgc tacccacgtg cgtccgcgcc acctcgcggg cgaccccgcg
      121 gccaaggccc ccggcggagc ggctcccggg cgccccgaac tagcccccaa ctttgggcga
      181 agtttgcctg cgcctctccc cgcccccacg cggcgcgccg gggccgcgga cggcagcggc
      241 ccccggggat gcgccttccc ggggtacccc tggcgcgccc tgcgctgctg ctgctgctgc
      301 cgctgctcgc gccgctgctg ggaacgggtg cgccggccga gctgcgggtc cgcgtgcggc
      361 tgccggacgg ccaggtgacc gaggagagcc tgcaggcgga cagcgacgcg gacagcatca
      421 gcctcgagct gcgcaagccc gacggcaccc tcgtctcctt caccgccgac ttcaagaagg
      481 atgtgaaggt cttccgggcc ctgatcctgg gggagctgga gaaggggcag agtcagttcc
      541 aggccctctg ctttgtcacc cagctgcagc acaatgagat catccccagt gaggccatgg
      601 ccaagctccg gcagaaaaat ccccgggcag tgcggcaggc ggaggaggtt cggggtctgg
      661 agcatctgca catggatgtc gctgtcaact tcagccaggg ggccctgctg agcccccatc
      721 tccacaacgt gtgtgccgag gccgtggatg ccatctacac ccgccaggag gatgtccggt
      781 tctggctgga gcaaggtgtg gacagttctg tgttcgaggc tctgcccaag gcctcagagc
      841 aggcggagct gcctcgctgc aggcaggtgg gggaccacgg gaagccctgc gtctgccgct
      901 atggcctgag cctggcctgg tacccctgca tgctcaagta ctgccacagc cgcgaccggc
      961 ccacgcccta caagtgtggc atccgcagct gccagaagag ctacagcttc gacttctacg
     1021 tgccccagag gcagctgtgt ctctgggatg aggatcccta cccaggctag ggtgggagca
     1081 acctggcggg tggctgctct gggcccactg ctcttcacca gccactagag ggggtggcaa
     1141 cccccacctg aggccttatt tccctccctc cccactcccc tggccctaga gcctgggccc
     1201 ctctggcccc atctcacatg actgtgaagg gggtgtggca tggcaggggg tctcatgaag
     1261 gcacccccat tcccaccctg tgccttcctt gcgggcagag agggagagaa gggctcccca
     1321 gatctacacc cctccctcct gcatctcccc tggagtgttc acttgcaagc tgccaaaaca
     1381 tgatggcctc tggttgttct gttgaactcc ttgaacgttt agaccctaaa aggagtctat
     1441 acctggacac ccacctcccc agacacaact cccttcccca tgcacacatc tggaaggagc
     1501 tggcccctca gtcccttcct actccccaac aaggggctca ctatccccaa agaaggagct
     1561 gttggggacc cacgacgcag cccctgtact ggattacagc atattctcat ctctggcccc
     1621 gaggctgcct gtggggcgag tggagacctc ccatcactga gacagatcac agaccacgag
     1681 tgcctttccc ggacctggac gttgcctcca gagcaggcac cagctctttc cctctctaca
     1741 cagaaatatt tttgtaaggt tctggggcag ggagggagca tgaagtacga ggaaaacttg
     1801 aattccagat ttttagtgca aagtatttat catttctacc agaaataaac gttttaagtt
     1861 tttacttgac taatgagacc cagagtttgg agaaaacttt tggccaatgc tgccacctga
     1921 tgtcagaaag tgtccccaca ccctagcagt ggcctatctt ggaacaagaa cttcgaaagc
     1981 acctactgtg tgctcagcca tttgaggaag gaaggaggag aaggaagatg ttactaggga
     2041 aggatgagat aaaacttctg cacccaagac aatgagacag acatagctgc aaccgtagta
     2101 agccagtcag aaatagccag cgcgaaggca agagatgggg tggagattgg aaccccgctt
     2161 cagatctggg ctcggctact tacctgctgt gcagccatgg gtcaagttgc ttgacctctc
     2221 tgtgcctcca ctcccttagc tataaaatga gcttacttaa ga
//
