LOCUS       NM_025081               7635 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens NYN domain and retroviral integrase containing
            (NYNRIN), mRNA.
ACCESSION   NM_025081 XM_370756 XM_940150
VERSION     NM_025081.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7635)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   2  (bases 1 to 7635)
  AUTHORS   Teslovich,T.M., Musunuru,K., Smith,A.V., Edmondson,A.C.,
            Stylianou,I.M., Koseki,M., Pirruccello,J.P., Ripatti,S.,
            Chasman,D.I., Willer,C.J., Johansen,C.T., Fouchier,S.W., Isaacs,A.,
            Peloso,G.M., Barbalic,M., Ricketts,S.L., Bis,J.C., Aulchenko,Y.S.,
            Thorleifsson,G., Feitosa,M.F., Chambers,J., Orho-Melander,M.,
            Melander,O., Johnson,T., Li,X., Guo,X., Li,M., Shin Cho,Y., Jin
            Go,M., Jin Kim,Y., Lee,J.Y., Park,T., Kim,K., Sim,X., Twee-Hee
            Ong,R., Croteau-Chonka,D.C., Lange,L.A., Smith,J.D., Song,K., Hua
            Zhao,J., Yuan,X., Luan,J., Lamina,C., Ziegler,A., Zhang,W.,
            Zee,R.Y., Wright,A.F., Witteman,J.C., Wilson,J.F., Willemsen,G.,
            Wichmann,H.E., Whitfield,J.B., Waterworth,D.M., Wareham,N.J.,
            Waeber,G., Vollenweider,P., Voight,B.F., Vitart,V.,
            Uitterlinden,A.G., Uda,M., Tuomilehto,J., Thompson,J.R., Tanaka,T.,
            Surakka,I., Stringham,H.M., Spector,T.D., Soranzo,N., Smit,J.H.,
            Sinisalo,J., Silander,K., Sijbrands,E.J., Scuteri,A., Scott,J.,
            Schlessinger,D., Sanna,S., Salomaa,V., Saharinen,J., Sabatti,C.,
            Ruokonen,A., Rudan,I., Rose,L.M., Roberts,R., Rieder,M.,
            Psaty,B.M., Pramstaller,P.P., Pichler,I., Perola,M., Penninx,B.W.,
            Pedersen,N.L., Pattaro,C., Parker,A.N., Pare,G., Oostra,B.A.,
            O'Donnell,C.J., Nieminen,M.S., Nickerson,D.A., Montgomery,G.W.,
            Meitinger,T., McPherson,R., McCarthy,M.I., McArdle,W., Masson,D.,
            Martin,N.G., Marroni,F., Mangino,M., Magnusson,P.K., Lucas,G.,
            Luben,R., Loos,R.J., Lokki,M.L., Lettre,G., Langenberg,C.,
            Launer,L.J., Lakatta,E.G., Laaksonen,R., Kyvik,K.O., Kronenberg,F.,
            Konig,I.R., Khaw,K.T., Kaprio,J., Kaplan,L.M., Johansson,A.,
            Jarvelin,M.R., Janssens,A.C., Ingelsson,E., Igl,W., Kees
            Hovingh,G., Hottenga,J.J., Hofman,A., Hicks,A.A., Hengstenberg,C.,
            Heid,I.M., Hayward,C., Havulinna,A.S., Hastie,N.D., Harris,T.B.,
            Haritunians,T., Hall,A.S., Gyllensten,U., Guiducci,C., Groop,L.C.,
            Gonzalez,E., Gieger,C., Freimer,N.B., Ferrucci,L., Erdmann,J.,
            Elliott,P., Ejebe,K.G., Doring,A., Dominiczak,A.F., Demissie,S.,
            Deloukas,P., de Geus,E.J., de Faire,U., Crawford,G., Collins,F.S.,
            Chen,Y.D., Caulfield,M.J., Campbell,H., Burtt,N.P.,
            Bonnycastle,L.L., Boomsma,D.I., Boekholdt,S.M., Bergman,R.N.,
            Barroso,I., Bandinelli,S., Ballantyne,C.M., Assimes,T.L.,
            Quertermous,T., Altshuler,D., Seielstad,M., Wong,T.Y., Tai,E.S.,
            Feranil,A.B., Kuzawa,C.W., Adair,L.S., Taylor,H.A. Jr.,
            Borecki,I.B., Gabriel,S.B., Wilson,J.G., Holm,H.,
            Thorsteinsdottir,U., Gudnason,V., Krauss,R.M., Mohlke,K.L.,
            Ordovas,J.M., Munroe,P.B., Kooner,J.S., Tall,A.R., Hegele,R.A.,
            Kastelein,J.J., Schadt,E.E., Rotter,J.I., Boerwinkle,E.,
            Strachan,D.P., Mooser,V., Stefansson,K., Reilly,M.P., Samani,N.J.,
            Schunkert,H., Cupples,L.A., Sandhu,M.S., Ridker,P.M., Rader,D.J.,
            van Duijn,C.M., Peltonen,L., Abecasis,G.R., Boehnke,M. and
            Kathiresan,S.
  TITLE     Biological, clinical and population relevance of 95 loci for blood
            lipids
  JOURNAL   Nature 466 (7307), 707-713 (2010)
   PUBMED   20686565
REFERENCE   3  (bases 1 to 7635)
  AUTHORS   Marco,A. and Marin,I.
  TITLE     CGIN1: a retroviral contribution to mammalian genomes
  JOURNAL   Mol Biol Evol 26 (10), 2167-2170 (2009)
   PUBMED   19561090
REFERENCE   4  (bases 1 to 7635)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     The NYN domains: novel predicted RNAses with a PIN domain-like fold
  JOURNAL   RNA Biol 3 (1), 18-27 (2006)
   PUBMED   17114934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC065283.1, AB037726.2 and AL132800.4.
            
            On Nov 22, 2018 this sequence version replaced NM_025081.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1968189 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382554.4/ ENSP00000371994.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               BC065283.1         217-554
            339-6027            AB037726.2         1-5689
            6028-7635           AL132800.4         148458-150065       c
FEATURES             Location/Qualifiers
     source          1..7635
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..7635
                     /gene="NYNRIN"
                     /gene_synonym="CGIN1; KIAA1305"
                     /note="NYN domain and retroviral integrase containing"
                     /db_xref="GeneID:57523"
                     /db_xref="HGNC:HGNC:20165"
                     /db_xref="MIM:620129"
     exon            1..84
                     /gene="NYNRIN"
                     /gene_synonym="CGIN1; KIAA1305"
                     /inference="alignment:Splign:2.1.0"
     exon            85..299
                     /gene="NYNRIN"
                     /gene_synonym="CGIN1; KIAA1305"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..5798
                     /gene="NYNRIN"
                     /gene_synonym="CGIN1; KIAA1305"
                     /note="Cousin of GIN1; protein cousin of GIN1; NYN domain
                     and retroviral integrase catalytic domain-containing
                     protein"
                     /codon_start=1
                     /product="protein NYNRIN"
                     /protein_id="NP_079357.2"
                     /db_xref="CCDS:CCDS45090.1"
                     /db_xref="GeneID:57523"
                     /db_xref="HGNC:HGNC:20165"
                     /db_xref="MIM:620129"
                     /translation="MLLSGGDPPAQEWFMVQTKSKPRVQRQRLQVQRIFRVKLNAFQS
                     RPDTPYFWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLFLDCL
                     CWSTLAYLVPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWEAEVT
                     RAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDIIEWLSRFGISDSHSDP
                     EVLICPPQQQKEAPAMVSVGESPGPFVDMGTLQNRGPENSKRLSSLGATGSLITAQST
                     PQEAANQLVRVGSNNQDGMDSAQEEGTVQATSSQDSTNHTQALLKQRQVQKIEDKLLF
                     QPPVSALGVCPPWKAWTPGPAFGPLWPGAIAATFWRINELHSLHLAWLLSQACFNFPF
                     WQRPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLGGEAALQNCPRP
                     EISPKVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGGEPGDQGSMQLDFKGL
                     EEGPAPVLPTGQGKPVAQGGLTDQSVPGAQTVPETLKVPMAAAVPKAENPSRTQVPSA
                     APKLPTSRMMLAVHTEPAAPEVPLAPTKPTAQLMATAQKTVVNQPVLVAQVEPTTPKT
                     PQAQKMPVAKTSPAGPKTPKAQAGPAATVSKAPAASKAPAAPKVPVTPRVSRAPKTPA
                     AQKVPTDAGPTLDVARLLSEVQPTSRASVSLLKGQGQAGRQGPQSSGTLALSSKHQFQ
                     MEGLLGAWEGAPRQPPRHLQANSTVTSFQRYHEALNTPFELNLSGEPGNQGLRRVVID
                     GSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREVTVFVPTWQLKKNRRVRESHFLTKL
                     HSLKMLSITPSQLENGKKITTYDYRFMVKLAEETDGIIVTNEQIHILMNSSKKLMVKD
                     RLLPFTFAGNLFMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKVWKTLPPSSASVT
                     ELSDDADSGPLESLPNMEEVREEKEERQDEEQRQGQGTQKAAEEDDLDSSLASVFRVE
                     CPSLSEEILRCLSLHDPPDGALDIDLLPGAASPYLGIPWDGKAPCQQVLAHLAQLTIP
                     SNFTALSFFMGFMDSHRDAIPDYEALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALV
                     SALCLMAPNSQLPFRLEVTVSHVALTAILHQEHSGRKHPIAYTSKPLLPDEESQGPQS
                     GGDSPYAVAWALKHFSRCIGDTPVVLDLSYASRTTADPEVREGRRVSKAWLIRWSLLV
                     QDKGKRALELALLQGLLGENRLLTPAASMPRFFQVLPPFSDLSTFVCIHMSGYCFYRE
                     DEWCAGFGLYVLSPTSPPVSLSFSCSPYTPTYAHLAAVACGLERFGQSPLPVVFLTHC
                     NWIFSLLWELLPLWRARGFLSSDGAPLPHPSLLSYIISLTSGLSSLPFIYRTSYRGSL
                     FAVTVDTLAKQGAQGGGQWWSLPKDVPAPTVSPHAMGKRPNLLALQLSDSTLADIIAR
                     LQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGDKKPRVWVVPTQLRRDLIFSVHDIP
                     LGAHQRPEETYKKLRLLGWWPGMQEHVKDYCRSCLFCIPRNLIGSELKVIESPWPLRS
                     TAPWSNLQIEVVGPVTISEEGHKHVLIVADPNTRWVEAFPLKPYTHTAVAQVLLQHVF
                     ARWGVPVRLEAAQGPQFARHVLVSCGLALGAQVASLSRDLQFPCLTSSGAYWEFKRAL
                     KEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVLTGGESRLTEPLWWEMSSANIEGL
                     KMDVFLLQLVGELLELHWRVADKASEKAENRRFKRESQEKEWNVGDQVLLLSLPRNGS
                     SAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPSSLMKAFAKSGTPLSFKVLEQ"
     exon            300..958
                     /gene="NYNRIN"
                     /gene_synonym="CGIN1; KIAA1305"
                     /inference="alignment:Splign:2.1.0"
     exon            959..2515
                     /gene="NYNRIN"
                     /gene_synonym="CGIN1; KIAA1305"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2646
                     /gene="NYNRIN"
                     /gene_synonym="CGIN1; KIAA1305"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2743
                     /gene="NYNRIN"
                     /gene_synonym="CGIN1; KIAA1305"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2845
                     /gene="NYNRIN"
                     /gene_synonym="CGIN1; KIAA1305"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2947
                     /gene="NYNRIN"
                     /gene_synonym="CGIN1; KIAA1305"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..7635
                     /gene="NYNRIN"
                     /gene_synonym="CGIN1; KIAA1305"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7616..7621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NYNRIN"
                     /gene_synonym="CGIN1; KIAA1305"
                     /note="hexamer: AATAAA"
     polyA_site      7635
                     /gene="NYNRIN"
                     /gene_synonym="CGIN1; KIAA1305"
                     /note="major polyA site"
ORIGIN      
        1 caaccccggg caggaagagc tcgtcgcggt agcagcggtc gaaggggacc aagctccaga
       61 gggcgggcgc ccgagccgtg cggggagcgg gcggggcagc catgctcctg tctgggggcg
      121 atcctccggc gcaggaatgg ttcatggtgc agacaaaatc gaagcctcgg gtgcagcggc
      181 agcggctgca agtgcagcgc atctttaggg tcaagctgaa cgccttccag agccgcccgg
      241 acacccccta cttctggcta cagctcgagg ggccccgaga gaacatgggc aaagccaagg
      301 aatacctgaa gggcctgtgc agcccagagc tgtggaaaga ggttcgctac ccaccgatcc
      361 tgcactgtgc cttccttggg gcccaaggcc tcttcctgga ctgcctctgc tggagcaccc
      421 ttgcctacct ggtgcctggc ccccctggct ccctgatggt gggcgggctg actgagtctt
      481 tcatcatgac acagaactgg ctggaggagc tggtggggcg actgcgctgg ggccctgccc
      541 ctctgctgac cccccggggg atctgggagg ctgaggtgac ccgggccttt ggggccctgg
      601 tctggatccg tggtgaccag catgcagggg acctactgca gctgccccca gcggtccagg
      661 agctgctgct gagcctggtg cgggatgctg cgggcaagga agacatcatc gagtggctca
      721 gccgcttcgg catctctgac tcccactccg atccggaggt tctaatctgc cctccccagc
      781 agcagaagga agccccagcc atggtgtccg tgggagagag tcctggaccc tttgtggaca
      841 tggggaccct ccagaacagg ggcccagaaa attcaaagag attatctagc ctgggagcca
      901 ctgggtccct gatcacagcc cagagcacac cgcaggaggc agcaaaccag ctggtacggg
      961 tcggttccaa caaccaagat ggtatggaca gtgctcaaga ggaagggaca gtgcaagcca
     1021 ccagcagcca ggactccacg aaccacacac aagccttgtt gaagcaaagg caggtccaga
     1081 agatagaaga taaactcctc ttccaacctc cagtatcagc cctgggtgtg tgcccaccct
     1141 ggaaggcctg gaccccgggg ccagcctttg ggccattgtg gccgggggct attgctgcaa
     1201 ccttctggag gatcaatgag ctgcattctc tacatctggc ctggctcctg tcccaggcgt
     1261 gcttcaattt ccccttctgg cagagacctc tgggccccat tcagttgaag ctgccagggc
     1321 agaatccttt gcccttaaat ctggagtgga agcagaagga gctggctcct ctgcctagtg
     1381 cagaaagccc agctggtaga ccagatgggg ggctgggagg agaagcagcc ctgcagaatt
     1441 gcccaaggcc agagatttcc ccaaaagtta cgagtttatt ggtggtccct gggagctcag
     1501 atgtaaaaga caaagttagc tcggatctcc cacagatagg gccacccttg acctctacac
     1561 cccaactaca ggctggaggt gagccggggg atcaagggag tatgcagtta gattttaagg
     1621 gactggaaga gggacccgct ccagtgctgc caacagggca agggaagccc gtggctcaag
     1681 gggggctgac agatcagtca gtacctggag ctcaaacagt gcctgaaact ctcaaagtgc
     1741 ccatggctgc agcagtgccc aaagctgaaa atccctccag aactcaagtg ccatctgcag
     1801 ctcccaaact gcctacatct cgaatgatgc tggcagtgca cacagagcct gcagctcccg
     1861 aagtgccttt ggctccaaca aagccaacag ctcaactgat ggccacagct caaaaaacag
     1921 ttgtgaatca accagtgttg gtagctcaag tggaacccac aactccaaaa actccccagg
     1981 ctcagaagat gcctgtagca aaaacatcac ctgcaggtcc caaaacaccc aaagctcaag
     2041 ccgggcctgc agctacagtt tccaaagcac ctgcagcttc caaagcacct gcagctccca
     2101 aagtacctgt gacccccaga gtctccagag ctcccaaaac acctgcagct cagaaggtgc
     2161 ccacggatgc agggccaacc ttggatgtag ccagacttct gagtgaggtc cagcctacat
     2221 caagggctag tgtctcctta ctgaagggcc aggggcaggc tggaaggcag ggtccccagt
     2281 ccagtggcac cttggccctc agcagtaagc accagtttca gatggagggg ctcctggggg
     2341 cttgggaggg ggccccaagg cagccacctc gccacctgca agcgaacagc acagtgacca
     2401 gcttccagag gtaccacgag gccctgaata cacccttcga gctgaacctg tcaggggaac
     2461 ctggaaacca ggggttgcgg cgagtggtca tcgatggcag cagtgtggcc atggtgcatg
     2521 gcctgcagca cttcttctcc tgccgaggaa ttgccatggc agtgcagttt ttctggaacc
     2581 ggggacaccg agaggtcact gtgtttgtac ccacctggca gctgaagaag aaccggaggg
     2641 tgagagagag ccactttctg acgaagctac actcgctcaa gatgctttca atcacaccct
     2701 cccagcttga gaatggcaag aagatcacca cctacgatta taggttcatg gtaaagctgg
     2761 cagaggagac agatggcatc attgtcacca atgagcagat tcacatcctg atgaatagtt
     2821 ccaagaaact gatggtcaaa gatcgcttgc tgcctttcac ctttgcgggg aatctcttca
     2881 tggtgcctga tgaccccctg ggccgtgatg gccccacctt ggatgagttt ctgaagaagc
     2941 caaacaggtt ggacactgac attggcaact tcctgaaggt gtggaagacc cttcctccca
     3001 gctcagccag tgtcactgag ctgagtgatg acgctgactc tgggcccctg gagagtctgc
     3061 cgaatatgga agaagtcagg gaagagaagg aggagaggca ggatgaggag cagagacagg
     3121 ggcagggcac acagaaggcg gctgaggagg acgaccttga ctcttcgctg gcgtcagtgt
     3181 tcagggtgga gtgcccgtcc ctttcggagg agatcctgcg gtgcctcagc ctccatgatc
     3241 cccctgatgg ggccctggac atcgacctcc tgccaggggc agcttctccc tacctgggca
     3301 tcccctggga tggaaaggct ccctgccagc aggttcttgc ccacctggcc cagctcacca
     3361 tccccagcaa cttcaccgca ctctccttct tcatgggctt catggactcc cacagggatg
     3421 ccatccctga ctatgaagcc ctagtgggcc ccctgcacag cctcctcaag cagaagcctg
     3481 actggcagtg ggaccaggag catgaggagg ccttcctggc cctgaagcga gccctggtgt
     3541 ctgccctctg cctgatggcc cccaactccc agctgccctt ccgcctggag gtgaccgtga
     3601 gccacgtggc cctgacggcc atcctccatc aggagcactc agggaggaag caccccatag
     3661 cctatacctc aaaacccctc ctccctgatg aggagagcca gggcccccag tcagggggtg
     3721 acagccccta tgctgtggcc tgggccctca agcatttttc ccgctgcatt ggagacaccc
     3781 cggtggtcct ggacctttcc tatgcctccc ggaccactgc ggaccctgag gtgcgggagg
     3841 gccgcagggt ttccaaagct tggttgatcc gatggtccct cttggttcag gacaaaggca
     3901 agagggccct ggaattggcc ctcctccagg gcctgctggg ggagaaccgc ctgctcaccc
     3961 ccgcggcctc catgcctcgc ttcttccagg ttctgccgcc tttctctgac ctgtccacgt
     4021 tcgtctgcat ccacatgtcg ggctactgct tctaccgtga ggatgagtgg tgtgctggct
     4081 ttggtctcta tgttctatcg cccaccagcc cccctgtctc cctttccttc tcctgctccc
     4141 cttacacgcc aacctatgcc cacctggcag ccgtggcctg cggcctggag cgctttggcc
     4201 agtccccact cccagtggtt ttcctcactc actgcaactg gatcttcagc ctcctgtggg
     4261 agctcctgcc cctctggagg gctcggggct tcctctcctc tgatggggct ccactccctc
     4321 acccaagcct gctctcctac attatatccc tcacctctgg cctctcatcc cttccgttta
     4381 tctaccgaac ctcctaccgg ggctctctgt ttgctgtgac agtggacacc ctggccaagc
     4441 agggtgccca ggggggtggg cagtggtgga gtttgccaaa ggatgtgcca gcccctacag
     4501 tgagtcccca tgccatgggc aagaggccca atttgctggc attacagctg agtgacagca
     4561 ccctggccga catcattgcc aggctgcagg ctgggcagaa actgtctggc tcctcaccgt
     4621 ttagttctgc ctttaactca ctcagcctcg acaaggagag tggcctgctt atgttcaagg
     4681 gagataagaa gcccagggtc tgggtagtcc cgacgcaact ccggagggat ctgattttct
     4741 ctgtgcatga cattcccttg ggggcccacc agaggcccga agagacctac aagaagttgc
     4801 gtttgctggg gtggtggcct gggatgcagg agcatgtgaa agattactgc aggagctgct
     4861 tgttctgcat cccccgaaat ctcataggca gcgagttgaa ggttattgag tccccatggc
     4921 ccctcaggtc gaccgccccc tggtcgaacc tgcagatcga ggtggtgggc ccggtcacca
     4981 taagtgagga gggccataag catgtactta ttgtggctga cccaaacacc aggtgggtgg
     5041 aggcattccc cctgaagccc tacacacaca cggctgtggc ccaggtgctg cttcagcatg
     5101 tgtttgcaag gtggggtgtt cctgtgaggc tggaggcagc ccaggggccc cagtttgccc
     5161 ggcacgtcct tgtgagctgt gggctggccc tgggagccca ggtggcctcc ctgagtcggg
     5221 acctccagtt cccctgcctg acgagctcag gggcctactg ggaattcaag agggccctca
     5281 aggagttcat cttcctgcat gggaagaagt gggcggcctc cctgcctttg ctgcacctgg
     5341 ccttcagggc ctcctccact gatgccacac cgttcaaggt cctgaccggg ggtgagtcaa
     5401 ggctcacgga gcccctgtgg tgggagatga gcagcgcaaa cattgaaggg ctcaagatgg
     5461 acgtcttcct gctacagctg gtgggggagc tgctggagct ccactggagg gtggctgaca
     5521 aggcgagtga aaaggccgag aacaggcgtt tcaagcggga gagccaggag aaggagtgga
     5581 atgtgggtga ccaggtcctt ttgctgtccc tccccaggaa tggcagcagt gccaaatggg
     5641 tgggtccctt ctatatcggg gaccggctga gcctgtcact ctataggata tggggcttcc
     5701 caaccccaga gaagctgggg tgcatctatc ccagcagtct gatgaaggcc tttgccaaga
     5761 gtggcacccc gctgtccttc aaggtcttgg agcagtgagc gggagcagcg ggggtgcccc
     5821 ctgccccagg gccgtgggtt tctgctgcta ggcctccccc tgtcccagca gtgctctcag
     5881 tccactgggg gccctcagtt gtgccttttg tagagaactt gcttcataaa gctttgctga
     5941 attgccttga actagggacc agcatcccca tggaaacatc cccagtttgg ggtacttgga
     6001 gaatttgcca aaggctgtca gatatgggtc cctggcagtt ttacactggg aaatggagtg
     6061 ctcctctagg ctataccagg ctcagtgtct tctccccaag tatcctcttt ccccttcaca
     6121 tgtaggtgtg tggtggtgtg cacacacact cacgaaagaa tctatcttgg ccatgaaact
     6181 gtggctgttg accttggaat tggaaccaca gtcctttccc atacagaaac cccaaatgtg
     6241 ggctcctccc tccaacctgt tcttttgggg accctttgcc cttagagctg tcacagatga
     6301 cataagcctg ggcaggctgt ggggaggccg ctgcctccta gcctcacggt cagctttctc
     6361 aagccaggtg tggcctgcac agctctcagg gcagggctgg ccatcctccc aggcctcaag
     6421 ggcagtgtct tggagtggga ggatggccag ccacaagcca ccagcttgtc agcatgggaa
     6481 gggcaagggg gaaatgggtt ggcctacctc atttgactcc agccaatgga gacaattcct
     6541 gacccctgct ttgatggtgt tgaccccaca ggaatcaagg atcttgatgc caagtgtggc
     6601 atctctatct gaagagctgc ttctgttaga cccaggggcc ccggcctctg ttttaagggg
     6661 gcagggcgtc tgcaacagga gtggcacacg gtgaagtgct ggcatggctc tacctcccaa
     6721 cccctcccaa ccccatccca aagcctacag tcctctgctc cttctacctc cactgtatcc
     6781 tgcatcccag accctacaga ttgtgtgatt gcttcatctg tatcaccccc cgagtcctgt
     6841 ggacctgcct tctgtgtaga gcaaaaccca ggctccctca cagccattct ttgcagagat
     6901 cacccttgca gtgagtgtga gttccttcca ggtgtgtgcg cgtacactca ccctctgaat
     6961 tgctgccgct gccaaggaag tgggctccag gtgaaggcca gtgccacgtc actctggctg
     7021 gccttcttag tagtttcatt tctccggaag ctgagccagt ctcctggtct agcccaggtt
     7081 gccagaacgc ttggcattgc agagtgctag agccagtgga gaacttgcca acttgattgt
     7141 tttacagcag aggaaagagg atcacagagg gaaaatgatt cacccaaagt cacacagcaa
     7201 gttcatggct gagctgagac caggattaag cttcctgact cccagttcac catgaaaagg
     7261 gttctggcaa caggttcaag ctggagaatc cttcaaaatg ctacacccac attctctcca
     7321 actcttcatc tccctgatct tccagacaaa ctacctggat gttgccctta aaccatttct
     7381 agctgttaac cctgtccaga aaaatgattg agtgatagct gagaagtgga aagtgtggga
     7441 tttttggcag gtgctctctt tcctccgccc cccgcgccat tctttctctt cctcctctct
     7501 gtaatggtat gtccagcctc actctccctc cctggtgctg tatgcgttcc ccctgttagc
     7561 tacatttgtg atcacatacc cttcttttaa gtgaattttt ttcatttgat ttgtcaataa
     7621 acgaatcaaa ctgga
//
