LOCUS       NM_173564               3584 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens neuronal tyrosine phosphorylated
            phosphoinositide-3-kinase adaptor 1 (NYAP1), mRNA.
ACCESSION   NM_173564 XM_351734 XM_353650
VERSION     NM_173564.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3584)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 3584)
  AUTHORS   Arking,D.E., Pulit,S.L., Crotti,L., van der Harst,P., Munroe,P.B.,
            Koopmann,T.T., Sotoodehnia,N., Rossin,E.J., Morley,M., Wang,X.,
            Johnson,A.D., Lundby,A., Gudbjartsson,D.F., Noseworthy,P.A.,
            Eijgelsheim,M., Bradford,Y., Tarasov,K.V., Dorr,M.,
            Muller-Nurasyid,M., Lahtinen,A.M., Nolte,I.M., Smith,A.V.,
            Bis,J.C., Isaacs,A., Newhouse,S.J., Evans,D.S., Post,W.S.,
            Waggott,D., Lyytikainen,L.P., Hicks,A.A., Eisele,L., Ellinghaus,D.,
            Hayward,C., Navarro,P., Ulivi,S., Tanaka,T., Tester,D.J.,
            Chatel,S., Gustafsson,S., Kumari,M., Morris,R.W., Naluai,A.T.,
            Padmanabhan,S., Kluttig,A., Strohmer,B., Panayiotou,A.G.,
            Torres,M., Knoflach,M., Hubacek,J.A., Slowikowski,K.,
            Raychaudhuri,S., Kumar,R.D., Harris,T.B., Launer,L.J.,
            Shuldiner,A.R., Alonso,A., Bader,J.S., Ehret,G., Huang,H.,
            Kao,W.H., Strait,J.B., Macfarlane,P.W., Brown,M., Caulfield,M.J.,
            Samani,N.J., Kronenberg,F., Willeit,J., Smith,J.G., Greiser,K.H.,
            Meyer Zu Schwabedissen,H., Werdan,K., Carella,M., Zelante,L.,
            Heckbert,S.R., Psaty,B.M., Rotter,J.I., Kolcic,I., Polasek,O.,
            Wright,A.F., Griffin,M., Daly,M.J., Arnar,D.O., Holm,H.,
            Thorsteinsdottir,U., Denny,J.C., Roden,D.M., Zuvich,R.L.,
            Emilsson,V., Plump,A.S., Larson,M.G., O'Donnell,C.J., Yin,X.,
            Bobbo,M., D'Adamo,A.P., Iorio,A., Sinagra,G., Carracedo,A.,
            Cummings,S.R., Nalls,M.A., Jula,A., Kontula,K.K., Marjamaa,A.,
            Oikarinen,L., Perola,M., Porthan,K., Erbel,R., Hoffmann,P.,
            Jockel,K.H., Kalsch,H., Nothen,M.M., den Hoed,M., Loos,R.J.,
            Thelle,D.S., Gieger,C., Meitinger,T., Perz,S., Peters,A.,
            Prucha,H., Sinner,M.F., Waldenberger,M., de Boer,R.A., Franke,L.,
            van der Vleuten,P.A., Beckmann,B.M., Martens,E., Bardai,A.,
            Hofman,N., Wilde,A.A., Behr,E.R., Dalageorgou,C., Giudicessi,J.R.,
            Medeiros-Domingo,A., Barc,J., Kyndt,F., Probst,V., Ghidoni,A.,
            Insolia,R., Hamilton,R.M., Scherer,S.W., Brandimarto,J.,
            Margulies,K., Moravec,C.E., del Greco,M. F, Fuchsberger,C.,
            O'Connell,J.R., Lee,W.K., Watt,G.C., Campbell,H., Wild,S.H., El
            Mokhtari,N.E., Frey,N., Asselbergs,F.W., Mateo Leach,I., Navis,G.,
            van den Berg,M.P., van Veldhuisen,D.J., Kellis,M., Krijthe,B.P.,
            Franco,O.H., Hofman,A., Kors,J.A., Uitterlinden,A.G.,
            Witteman,J.C., Kedenko,L., Lamina,C., Oostra,B.A., Abecasis,G.R.,
            Lakatta,E.G., Mulas,A., Orru,M., Schlessinger,D., Uda,M.,
            Markus,M.R., Volker,U., Snieder,H., Spector,T.D., Arnlov,J.,
            Lind,L., Sundstrom,J., Syvanen,A.C., Kivimaki,M., Kahonen,M.,
            Mononen,N., Raitakari,O.T., Viikari,J.S., Adamkova,V., Kiechl,S.,
            Brion,M., Nicolaides,A.N., Paulweber,B., Haerting,J.,
            Dominiczak,A.F., Nyberg,F., Whincup,P.H., Hingorani,A.D.,
            Schott,J.J., Bezzina,C.R., Ingelsson,E., Ferrucci,L., Gasparini,P.,
            Wilson,J.F., Rudan,I., Franke,A., Muhleisen,T.W., Pramstaller,P.P.,
            Lehtimaki,T.J., Paterson,A.D., Parsa,A., Liu,Y., van Duijn,C.M.,
            Siscovick,D.S., Gudnason,V., Jamshidi,Y., Salomaa,V., Felix,S.B.,
            Sanna,S., Ritchie,M.D., Stricker,B.H., Stefansson,K., Boyer,L.A.,
            Cappola,T.P., Olsen,J.V., Lage,K., Schwartz,P.J., Kaab,S.,
            Chakravarti,A., Ackerman,M.J., Pfeufer,A., de Bakker,P.I. and
            Newton-Cheh,C.
  CONSRTM   CARe Consortium; COGENT Consortium; DCCT/EDIC; eMERGE Consortium;
            HRGEN Consortium
  TITLE     Genetic association study of QT interval highlights role for
            calcium signaling pathways in myocardial repolarization
  JOURNAL   Nat Genet 46 (8), 826-836 (2014)
   PUBMED   24952745
REFERENCE   3  (bases 1 to 3584)
  AUTHORS   Yokoyama,K., Tezuka,T., Kotani,M., Nakazawa,T., Hoshina,N.,
            Shimoda,Y., Kakuta,S., Sudo,K., Watanabe,K., Iwakura,Y. and
            Yamamoto,T.
  TITLE     NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling
            in neurons
  JOURNAL   EMBO J 30 (23), 4739-4754 (2011)
   PUBMED   21946561
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK124773.1, AC069281.6 and AA737804.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173564.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK124773.1, SRR7410571.143326.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153980, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300179.7/ ENSP00000300179.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2717              AK124773.1         1-2717
            2718-3536           AC069281.6         108413-109231       c
            3537-3584           AA737804.1         29-76               c
FEATURES             Location/Qualifiers
     source          1..3584
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..3584
                     /gene="NYAP1"
                     /gene_synonym="C7orf51"
                     /note="neuronal tyrosine phosphorylated
                     phosphoinositide-3-kinase adaptor 1"
                     /db_xref="GeneID:222950"
                     /db_xref="HGNC:HGNC:22009"
                     /db_xref="MIM:615477"
     exon            1..75
                     /gene="NYAP1"
                     /gene_synonym="C7orf51"
                     /inference="alignment:Splign:2.1.0"
     exon            76..227
                     /gene="NYAP1"
                     /gene_synonym="C7orf51"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2685
                     /gene="NYAP1"
                     /gene_synonym="C7orf51"
                     /codon_start=1
                     /product="neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adapter 1"
                     /protein_id="NP_775835.2"
                     /db_xref="CCDS:CCDS5696.1"
                     /db_xref="GeneID:222950"
                     /db_xref="HGNC:HGNC:22009"
                     /db_xref="MIM:615477"
                     /translation="MNLLYRKTKLEWRQHKEEEAKRSSSKEVAPAGSAGPAAGQGPGV
                     RVRDIASLRRSLRMGFMTMPASQEHTPHPCRSAMAPRSLSCHSVGSMDSVGGGPGGAS
                     GGLTEDSSTRRPPAKPRRHPSTKLSMVGPGSGAETPPSKKAGSQKPTPEGRESSRKVP
                     PQKPRRSPNTQLSVSFDESCPPGPSPRGGNLPLQRLTRGSRVAGDPDVGAQEEPVYIE
                     MVGDVFRGGGRSGGGLAGPPLGGGGPTPPAGADSDSEESEAIYEEMKYPLPEEAGEGR
                     ANGPPPLTATSPPQQPHALPPHAHRRPASALPSRRDGTPTKTTPCEIPPPFPNLLQHR
                     PPLLAFPQAKSASRTPGDGVSRLPVLCHSKEPAGSTPAPQVPARERETPPPPPPPPAA
                     NLLLLGPSGRARSHSTPLPPQGSGQPRGERELPNSHSMICPKAAGAPAAPPAPAALLP
                     GPPKDKAVSYTMVYSAVKVTTHSVLPAGPPLGAGEPKTEKEISVLHGMLCTSSRPPVP
                     GKTSPHGGAMGAAAGVLHHRGCLASPHSLPDPTVGPLTPLWTYPATAAGLKRPPAYES
                     LKAGGVLNKGCGVGAPSPMVKIQLQEQGTDGGAFASISCAHVIASAGTPEEEEEEVGA
                     ATFGAGWALQRKVLYGGRKAKELDKVEDGARAWNGSAEGPGKVEREDRGPGTSGIPVR
                     SQGAEGLLARIHHGDRGGSRTALPIPCQTFPACHRNGDFTGGYRLGRSASTSGVRQVV
                     LHTPRPCSQPRDALSQPHPALPLPLPLPPQPARERDGKLLEVIERKRCVCKEIKARHR
                     PDRGLCKQESMPILPSWRRGPEPRKSGTPPCRRQHTVLWDTAI"
     exon            228..589
                     /gene="NYAP1"
                     /gene_synonym="C7orf51"
                     /inference="alignment:Splign:2.1.0"
     exon            590..2104
                     /gene="NYAP1"
                     /gene_synonym="C7orf51"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2317
                     /gene="NYAP1"
                     /gene_synonym="C7orf51"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2427
                     /gene="NYAP1"
                     /gene_synonym="C7orf51"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..3584
                     /gene="NYAP1"
                     /gene_synonym="C7orf51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3562..3567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NYAP1"
                     /gene_synonym="C7orf51"
                     /note="hexamer: ATTAAA"
     polyA_site      3584
                     /gene="NYAP1"
                     /gene_synonym="C7orf51"
                     /note="major polyA site"
ORIGIN      
        1 gtctctgtct ctcctcctcc ctcctcctgc tccgggcgga gcccggcatg ggggggccgg
       61 cgcccggcag gccagtggat ccgggaccca gggagggccg ccccccgggc ctggtggcac
      121 tgagcagggc cccccagccc ccacctcctg ccccacgaga tgaacctcct ctaccgaaaa
      181 accaagctgg agtggaggca gcacaaggaa gaggaggcca agaggagctc cagtaaggag
      241 gtggcccccg ctggctcggc tgggcccgcg gccggccagg ggcctggggt ccgcgtgcgg
      301 gacatcgcct cgctgcggcg ctccctcagg atgggtttca tgacgatgcc cgcctcccag
      361 gagcacaccc cgcacccctg ccgcagcgcc atggccccac gctccctctc ctgccactcg
      421 gtgggcagca tggacagtgt cgggggtggc cctggcgggg ccagtggggg cctcacagag
      481 gacagcagca cccgaagacc ccctgccaag ccccggagac accccagcac caagctcagc
      541 atggtggggc ctgggtctgg ggcagagacg ccccccagca agaaagcagg ctcacagaag
      601 ccaaccccag agggccgaga gtccagccgg aaggttcctc cgcagaagcc caggcgaagc
      661 cctaacaccc agctctctgt ctccttcgat gagtcctgcc ccccaggccc ctctcctcga
      721 ggggggaacc tgcctcttca gcgcctcact agggggtccc gagtagctgg ggaccctgat
      781 gtgggtgccc aggaagagcc tgtgtacatt gagatggtgg gggacgtctt taggggagga
      841 ggacgaagtg gaggaggcct ggctgggccc cctcttgggg gtgggggccc gacccctcca
      901 gcgggcgccg actcggactc tgaagagagt gaggccatct atgaagagat gaagtacccg
      961 ctgccggaag aggctgggga aggccgggcc aatggccctc caccattgac ggcaacatcc
     1021 ccgccacaac agcctcacgc ccttccgccc catgcccacc gccgcccagc ttcagccctc
     1081 ccgagccgga gggacgggac gcccaccaag accactcctt gtgaaatccc cccgcccttc
     1141 cccaacctcc ttcagcaccg gcctccactc ctggccttcc cccaagccaa gtctgcttcc
     1201 cgaacccctg gcgatggggt ctcaaggcta cctgtcctct gccactccaa ggagccagcc
     1261 ggctccaccc cagctcccca agtgcctgca cgggagcggg agacgcctcc cccaccgcct
     1321 ccacctcctg ctgccaacct gctgctgctg ggaccatcgg gccgggcccg gagccactcg
     1381 acaccgttgc caccccaggg ctctggccag ccccgggggg agcgggagct ccccaactcc
     1441 cacagcatga tctgccctaa ggcggcgggg gcgccggcag ccccccctgc cccggccgcc
     1501 ttgctccccg gcccccccaa ggacaaggcc gtgtcttaca ccatggtgta ctcggcggtc
     1561 aaggtgacca cgcactctgt cctgccagct ggtccacccc tgggtgctgg ggagccaaag
     1621 acggagaagg agatctcggt cctccatggg atgctgtgta ccagctcaag gccccctgtg
     1681 ccagggaaga ccagccccca cggtggggcc atgggcgcag cagctggggt cctccaccac
     1741 cgcggctgcc tggcctcccc ccacagcctt ccggacccaa ctgtaggccc cctgaccccg
     1801 ctgtggacct acccagccac agcagctggg ctcaagagac cccctgccta tgagagcctc
     1861 aaggctgggg gggtgctgaa taagggctgt ggtgtggggg ccccatcccc catggtcaag
     1921 atccagctgc aggagcaagg gaccgatggg ggtgcttttg ccagcatctc ctgtgcccac
     1981 gtcatcgcca gcgcagggac accagaggag gaagaagagg aggtgggcgc cgcgacattt
     2041 ggggcaggct gggccctgca gaggaaggtc ctctatggag ggagaaaagc aaaggagttg
     2101 gacaaggtcg aggacggtgc ccgggcctgg aatggcagtg ccgagggtcc aggcaaggtg
     2161 gagcgtgagg acaggggccc tgggacatcg gggatcccag tgagaagcca gggggcagag
     2221 ggactgctgg ccaggatcca ccatggagac cgaggaggga gccgcaccgc gctgcccatt
     2281 ccctgccaga ccttccccgc ctgccaccgc aatggagact tcacgggagg ctaccgcctg
     2341 gggcgctccg cctccacctc cggagtccgg caggtcgtgc tccacacacc ccggccctgc
     2401 agccagccca gggatgccct gagccagccc caccccgcgc tgccgctgcc tctgcccctg
     2461 ccgccccagc cggcccgcga gcgtgacggg aagctgctgg aggtgatcga gcgcaagcgc
     2521 tgcgtgtgca aggagatcaa ggcgcgccac cgcccggacc gaggcctctg caagcaggag
     2581 agcatgccca tcctccccag ctggcggcgg ggacccgagc cccgcaagtc cggcaccccg
     2641 ccctgccgcc ggcagcacac ggtcctctgg gacaccgcca tctgaggcgg gcgggggggt
     2701 accggggcgc ctggactggg gagggggcgg gcacgcctgg ctctcccggg agcctcgcct
     2761 tgagagacat tgaaagacta cgtgggagag tgccagggag aacccctgcc ctccaaccta
     2821 ccccccggga tggggagagt ctgccaggcc cattgggctt aggatgccaa cagcgctgct
     2881 gagaaacgga ggaggaggag ggtttgcttg aggttggggc gagagtcgct ctggctgttc
     2941 ttcccgctgg gcgttgtaca cccctcctcc tgaaccaagc cagaggtcag catggggaag
     3001 ggaggaagga agggatggga ggaagagggg ggtgggtgag ctgaaagaga gggactagag
     3061 tgccagatgg aggagctctt ttctagagag ccgggagttg gggagggggt atttattttg
     3121 ttatttattt cagtctggag ggcgattctg ggcctttctg acctactcct gagctaggag
     3181 tggagaatca gggccaagtt tgcactctcc ccaatgccaa tgcctaaagg ccccgccgtc
     3241 catgccaccc cacagccaag gaggggtctg catggggagt ggaccgagag aagaaggggc
     3301 ccagggaagc agagggccca agaccattca cagtatttac aatttgccag aatttggtag
     3361 tcagtgtggc ctgctctgaa tcaggcatct tatttagttc tggggtgagg gtctagtgcc
     3421 agggatgggc aggatgatgg gggaggagga gggaaatttt agcgggtgga gggggtgggc
     3481 agggtattta tttaaattaa aaaacaaaac agaagagatg tcaggaactt ttttttaatt
     3541 cctttctttt cagaataata tattaaaaga ctcatgatcc taaa
//
