LOCUS       NM_001242617            2602 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens nuclear transport factor 2 like export factor 2
            (NXT2), transcript variant 2, mRNA.
ACCESSION   NM_001242617
VERSION     NM_001242617.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2602)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2602)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2602)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2602)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2602)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   6  (bases 1 to 2602)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   7  (bases 1 to 2602)
  AUTHORS   Herold,A., Suyama,M., Rodrigues,J.P., Braun,I.C., Kutay,U.,
            Carmo-Fonseca,M., Bork,P. and Izaurralde,E.
  TITLE     TAP (NXF1) belongs to a multigene family of putative RNA export
            factors with a conserved modular architecture
  JOURNAL   Mol Cell Biol 20 (23), 8996-9008 (2000)
   PUBMED   11073998
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA442845.1, AF201942.1,
            BC014888.1 and AA806876.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001242617.1.
            
            Summary: The protein encoded by this gene contains a nuclear
            transport factor 2 (NTF2) domain, which plays an important role in
            the trafficking of macromolecules, ions, and small molecules
            between the cytoplasm and nucleus. This protein may also have a
            role in mRNA nuclear export. Alternatively spliced transcript
            variants encoding different isoforms have been noted for this gene.
            [provided by RefSeq, Jun 2011].
            
            Transcript Variant: This variant (2) differs at the 5' end compared
            to variant 1. This results in translation initiation from a
            downstream AUG, and an isoform (2, also known as p15-2a) with a
            shorter N-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.257428.1,
                                           SRR1660803.188752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372106.6/ ENSP00000361178.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA442845.1         15-33
            20-907              AF201942.1         1-888
            908-2594            BC014888.1         876-2562
            2595-2602           AA806876.1         8-15                c
FEATURES             Location/Qualifiers
     source          1..2602
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..2602
                     /gene="NXT2"
                     /gene_synonym="P15-2"
                     /note="nuclear transport factor 2 like export factor 2"
                     /db_xref="GeneID:55916"
                     /db_xref="HGNC:HGNC:18151"
                     /db_xref="MIM:300320"
     exon            1..178
                     /gene="NXT2"
                     /gene_synonym="P15-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..592
                     /gene="NXT2"
                     /gene_synonym="P15-2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     NTF2-related export protein 2; protein p15-2"
                     /codon_start=1
                     /product="NTF2-related export protein 2 isoform 2"
                     /protein_id="NP_001229546.1"
                     /db_xref="CCDS:CCDS56605.1"
                     /db_xref="GeneID:55916"
                     /db_xref="HGNC:HGNC:18151"
                     /db_xref="MIM:300320"
                     /translation="MATSLDFKTYVDQACRAAEEFVNIYYETMDKRRRALTRLYLDKA
                     TLIWNGNAVSGLDALNNFFDTLPSSEFQVNMLDCQPVHEQATQSQTTVLVVTSGTVKF
                     DGNKQHFFNQNFLLTAQSTPNNTVWKIASDCFRFQDWSSS"
     exon            179..265
                     /gene="NXT2"
                     /gene_synonym="P15-2"
                     /inference="alignment:Splign:2.1.0"
     exon            266..410
                     /gene="NXT2"
                     /gene_synonym="P15-2"
                     /inference="alignment:Splign:2.1.0"
     exon            411..2602
                     /gene="NXT2"
                     /gene_synonym="P15-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2570..2575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXT2"
                     /gene_synonym="P15-2"
                     /note="hexamer: AATAAA"
     polyA_site      2602
                     /gene="NXT2"
                     /gene_synonym="P15-2"
                     /note="major polyA site"
ORIGIN      
        1 ggaccgagct acttccggga gagaatggga gggtggaaaa ttttgtgcgt ttggcgggtt
       61 tcgctctctt cataagtatt gatcattccg cagccctgcg gaccggacac gtgaggaggt
      121 agtgacgccg acactgccag aacacactgc tacaaggtcc cagatggcca cgtctctgga
      181 ttttaaaact tatgtagatc aggcatgtag agctgctgag gagtttgtca atatttacta
      241 tgagacaatg gataaaagaa gacgggcact aaccaggctg tatctggaca aggccacctt
      301 aatatggaat ggaaatgctg tttcagggct ggatgcccta aataattttt ttgacacatt
      361 gccttctagt gagttccagg tcaatatgtt agattgccaa ccagttcatg agcaagcaac
      421 tcagtcccaa actacagttc ttgttgtgac cagtggaact gtgaagtttg atggaaacaa
      481 acaacatttc ttcaaccaga acttcctgct gactgctcag tccactccca acaatactgt
      541 gtggaagatt gcaagtgatt gcttccgttt tcaagattgg tctagtagtt aaaggggcaa
      601 aagtccattc tcatttggtc cattagttcc agcaattgaa atttatgtga attattttga
      661 ttgtagaagc actataatat gtgctgaaac taaatttctt taatattttc tattcctgtc
      721 agcacctttt ctagcagctg ccagtttgga gcattgccct ctaagagctt taaaactatt
      781 tttttacatg ccttatatac attccactaa tgacattctt ataataatat taaacacatg
      841 atcttggtac taacatactc actgtgaacc cagcctattg caaaaataaa atctttttat
      901 aatattatct atgggatgtc agcacaatat aacactctgg gaagaagtgg agttttttgg
      961 ttattaggtt aattttctag taaaacacgt tgcctgtttt cagttaacac tggtaatgcc
     1021 attttaatat atggcttttt caaatcagtt cagtgaaaat agtacagatt taggtttaca
     1081 taactactct gacatactgg aattgcatat agagatgttc agtggtcgtt tttcatttta
     1141 agtaattttt gttttggcat ttttttgtgt gaagtaaatt aatcaactag agaggtgcaa
     1201 aacgttctca gttgatatct gagtattggg tgcatttggt ggcttaaaag caaagcttcc
     1261 taaaaagatt tttcttggca gctccaggtc tatacattta ggtaatgaat ggtagtagaa
     1321 ctaatagctt taacaggaga atagggaatg agaaatagaa atccaaggct gaagccaaaa
     1381 gtaaggaggg tggccaaatg gtaaactatt ggtacttgtt ttctacctcc taaaaatgta
     1441 gcttattttt aggatttaaa tcactaagta aataagtatc cttgccaagt gatcatgagt
     1501 gtcatttttg ttctaagact aatattttta gatcttttta cttcacctca tacttatcac
     1561 caatgtatat ctccatttat tcaataactt actggggtaa aataacagca ataaacctaa
     1621 ccttttaaca gggtctaaca tgagagttgg agtcaaagcc attgttatct tttggtgaca
     1681 cccttaaatt ttaagtcttc cagtcttcca tgtgaacttt aggcccaaag tttcttatgt
     1741 atcacacatc ccccaaataa gtgatttttt cccagtgctt tgtactgtca actgcattat
     1801 ctttaattat ttaaaggtag aattatttaa ttttgtgatt tgttcttcca tatgacattg
     1861 agcaaataga tctgtttcaa aatatgttcc cgctatgtgg ataactcttc tttttaaaaa
     1921 gaaaatagag aatagcaaat cttcatgata atcctcaaaa gaacaaaatg cttaacttta
     1981 tctcttaatt tctaaaggta aataacctag gttcagcttt tgcttaaaca ttaaatatct
     2041 tttccatttt ttaatgtttg taagctagat atgccagctt tgtttctaca ttgcaaccaa
     2101 aaactgtttc ttttcactta attataaaac cagtaattca tttactcttg cccaaaacta
     2161 tacactgtat ttctgttata gtaacaaaat agagttatgt agaattgtat ggaactcaaa
     2221 tttaaaccat gctttcttgt agtactgatt gaaacttaca cgttttattc tactcatagt
     2281 gagcttattc ttattttgga ttgattttcc aaaaccacag cttcagcagc aacaatcaga
     2341 atgtccaaat gctgtccttt cccttacaga gaagaacaat ggtaactaaa agctgcatat
     2401 aactagcaat aactacattg aacggtgtgc attgttcatg attgttgtgt tttaagactt
     2461 gtatataaac tgctttttcc aaactctgta taacttttaa atggctggaa ctactcgtat
     2521 aaggactaga ctgtattttt gacatgctcc tatttttgta acttgaaaaa ataaaatttt
     2581 gccttgtgac agattttctc aa
//
