LOCUS       NM_013248               1062 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens nuclear transport factor 2 like export factor 1
            (NXT1), mRNA.
ACCESSION   NM_013248
VERSION     NM_013248.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1062)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1062)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1062)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1062)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1062)
  AUTHORS   Chutiwitoonchai,N. and Aida,Y.
  TITLE     NXT1, a Novel Influenza A NP Binding Protein, Promotes the Nuclear
            Export of NP via a CRM1-Dependent Pathway
  JOURNAL   Viruses 8 (8), 209 (2016)
   PUBMED   27483302
  REMARK    GeneRIF: Here, the authors identify cellular nuclear transport
            factor 2 (NTF2)-like export protein 1 (NXT1) as a novel binding
            partner of nucleoprotein (NP) that stimulates NP-mediated nuclear
            export via the CRM1-dependent pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1062)
  AUTHORS   Black,B.E., Holaska,J.M., Levesque,L., Ossareh-Nazari,B.,
            Gwizdek,C., Dargemont,C. and Paschal,B.M.
  TITLE     NXT1 is necessary for the terminal step of Crm1-mediated nuclear
            export
  JOURNAL   J Cell Biol 152 (1), 141-155 (2001)
   PUBMED   11149927
REFERENCE   7  (bases 1 to 1062)
  AUTHORS   Herold,A., Suyama,M., Rodrigues,J.P., Braun,I.C., Kutay,U.,
            Carmo-Fonseca,M., Bork,P. and Izaurralde,E.
  TITLE     TAP (NXF1) belongs to a multigene family of putative RNA export
            factors with a conserved modular architecture
  JOURNAL   Mol Cell Biol 20 (23), 8996-9008 (2000)
   PUBMED   11073998
REFERENCE   8  (bases 1 to 1062)
  AUTHORS   Ossareh-Nazari,B., Maison,C., Black,B.E., Levesque,L., Paschal,B.M.
            and Dargemont,C.
  TITLE     RanGTP-binding protein NXT1 facilitates nuclear export of different
            classes of RNA in vitro
  JOURNAL   Mol Cell Biol 20 (13), 4562-4571 (2000)
   PUBMED   10848583
REFERENCE   9  (bases 1 to 1062)
  AUTHORS   Black,B.E., Levesque,L., Holaska,J.M., Wood,T.C. and Paschal,B.M.
  TITLE     Identification of an NTF2-related factor that binds Ran-GTP and
            regulates nuclear protein export
  JOURNAL   Mol Cell Biol 19 (12), 8616-8624 (1999)
   PUBMED   10567585
REFERENCE   10 (bases 1 to 1062)
  AUTHORS   Katahira,J., Strasser,K., Podtelejnikov,A., Mann,M., Jung,J.U. and
            Hurt,E.
  TITLE     The Mex67p-mediated nuclear mRNA export pathway is conserved from
            yeast to human
  JOURNAL   EMBO J 18 (9), 2593-2609 (1999)
   PUBMED   10228171
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC003410.1.
            
            On Nov 23, 2018 this sequence version replaced NM_013248.2.
            
            Summary: The protein encoded by this gene is located in the nuclear
            envelope. It has protein similarity to nuclear transport factor 2.
            This protein functions as a nuclear export factor in both RAN
            (Ras-related nuclear protein)- and CRM1 (required for chromosome
            region maintenance)-dependent pathways. It is found to stimulate
            the export of U1 snRNA in RAN- and CRM1-dependent pathways and the
            export of tRNA and mRNA in a CRM1-independent pathway. The encoded
            protein heterodimerizes with Tap protein and may regulate the
            ability of Tap protein to mediate nuclear mRNA export. The use of
            alternate polyadenylation sites has been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003410.1, SRR5189661.8840.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254998.3/ ENSP00000254998.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1062              BC003410.1         56-1117
FEATURES             Location/Qualifiers
     source          1..1062
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..1062
                     /gene="NXT1"
                     /gene_synonym="MTR2; P15"
                     /note="nuclear transport factor 2 like export factor 1"
                     /db_xref="GeneID:29107"
                     /db_xref="HGNC:HGNC:15913"
                     /db_xref="MIM:605811"
     exon            1..271
                     /gene="NXT1"
                     /gene_synonym="MTR2; P15"
                     /inference="alignment:Splign:2.1.0"
     exon            272..1062
                     /gene="NXT1"
                     /gene_synonym="MTR2; P15"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..755
                     /gene="NXT1"
                     /gene_synonym="MTR2; P15"
                     /note="NTX2-like export factor1; NUTF-like export factor
                     1; protein p15; NTF2-like export factor 1"
                     /codon_start=1
                     /product="NTF2-related export protein 1"
                     /protein_id="NP_037380.1"
                     /db_xref="CCDS:CCDS13150.1"
                     /db_xref="GeneID:29107"
                     /db_xref="HGNC:HGNC:15913"
                     /db_xref="MIM:605811"
                     /translation="MASVDFKTYVDQACRAAEEFVNVYYTTMDKRRRLLSRLYMGTAT
                     LVWNGNAVSGQESLSEFFEMLPSSEFQISVVDCQPVHDEATPSQTTVLVVICGSVKFE
                     GNKQRDFNQNFILTAQASPSNTVWKIASDCFRFQDWAS"
     regulatory      973..978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXT1"
                     /gene_synonym="MTR2; P15"
                     /note="hexamer: AGTAAA"
     polyA_site      994
                     /gene="NXT1"
                     /gene_synonym="MTR2; P15"
                     /note="major polyA site"
     regulatory      1044..1049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXT1"
                     /gene_synonym="MTR2; P15"
                     /note="hexamer: AATACA"
     polyA_site      1062
                     /gene="NXT1"
                     /gene_synonym="MTR2; P15"
                     /note="major polyA site"
ORIGIN      
        1 gcgtctgcgt ggagaccggc tggccgcgcg cgggaagccg cggaactgcg ccggaaagtc
       61 ccccggctct ggggccccgg tgacccagag taagcctcca agaaggagga ggaggagaga
      121 aaggcggctc ttcccgtgcc cctaccagag gcttcggtgg gcccaccttg tgacctccgc
      181 ggccggcccc tcagtggaac tgcgtcccac gcggggggcg tcccgaccgt gggggccgcg
      241 gcccgcgctg accctggacg tcgccgcgca gcccctggtt ccccaaggca gaggaaatac
      301 cctggtggag ccctccttcc atagaaccag agatggcatc tgtggatttc aagacctatg
      361 tggatcaggc ctgcagagct gctgaggagt ttgtcaatgt ctactacacc accatggata
      421 agcggcggcg tttgctgtcc cgcctgtaca tgggcacagc caccctggtc tggaatggca
      481 atgctgtttc aggacaagaa tccttgagtg agttttttga aatgttgcct tccagcgagt
      541 tccaaatcag cgtggtagac tgccagcctg ttcatgatga agccacacca agccagacca
      601 cggtccttgt tgtcatctgt ggatcagtga agtttgaggg gaacaaacaa cgggacttca
      661 accagaactt catcctgacc gcccaggcct cacccagcaa cacagtgtgg aagatcgcaa
      721 gtgactgctt ccgcttccag gactgggcca gctagtgggg gtggcagagg tctctttgct
      781 tcattcagcc ctagctctgt agagaaatgc aaacctcgac tctcaaggat gtgaggaaca
      841 caagttcatt tctgttgttg cggagacact gcagactcca ctgtgccgag gttgaactct
      901 tttttgttgc tcaagttcta ggagtccctt tcctgaatat atacttgttt gtcatagttt
      961 ccttttcaaa gtagtaaact tttctatttt tctacttgcc cagtagagac tctgattctg
     1021 gaaattctga caaataattt aataatacac atgttgcttc tt
//
