LOCUS       NM_007224               1805 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens neurexophilin 4 (NXPH4), mRNA.
ACCESSION   NM_007224 XM_290582
VERSION     NM_007224.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1805)
  AUTHORS   Sun,X., Xin,S., Jin,L., Zhang,Y. and Ye,L.
  TITLE     Neurexophilin 4 is a prognostic biomarker correlated with immune
            infiltration in bladder cancer
  JOURNAL   Bioengineered 13 (5), 13986-13999 (2022)
   PUBMED   35758021
  REMARK    GeneRIF: Neurexophilin 4 is a prognostic biomarker correlated with
            immune infiltration in bladder cancer.
REFERENCE   2  (bases 1 to 1805)
  AUTHORS   Yang,Z., Wei,B., Qiao,A., Yang,P., Chen,W., Zhen,D. and Qiu,X.
  TITLE     A novel EZH2/NXPH4/CDKN2A axis is involved in regulating the
            proliferation and migration of non-small cell lung cancer cells
  JOURNAL   Biosci Biotechnol Biochem 86 (3), 340-350 (2022)
   PUBMED   34919637
  REMARK    GeneRIF: A novel EZH2/NXPH4/CDKN2A axis is involved in regulating
            the proliferation and migration of non-small cell lung cancer
            cells.
REFERENCE   3  (bases 1 to 1805)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   4  (bases 1 to 1805)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 1805)
  AUTHORS   Missler,M. and Sudhof,T.C.
  TITLE     Neurexophilins form a conserved family of neuropeptide-like
            glycoproteins
  JOURNAL   J Neurosci 18 (10), 3630-3638 (1998)
   PUBMED   9570794
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137834.9.
            
            On Nov 23, 2018 this sequence version replaced NM_007224.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053581.1, AY358614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349394.6/ ENSP00000333593.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AC137834.9         75383-75615         c
            234-1805            AC137834.9         65960-67531         c
FEATURES             Location/Qualifiers
     source          1..1805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..1805
                     /gene="NXPH4"
                     /gene_synonym="NPH4"
                     /note="neurexophilin 4"
                     /db_xref="GeneID:11247"
                     /db_xref="HGNC:HGNC:8078"
                     /db_xref="MIM:604637"
     exon            1..233
                     /gene="NXPH4"
                     /gene_synonym="NPH4"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1103
                     /gene="NXPH4"
                     /gene_synonym="NPH4"
                     /note="alternative protein NXPH4"
                     /codon_start=1
                     /product="neurexophilin-4 precursor"
                     /protein_id="NP_009155.1"
                     /db_xref="CCDS:CCDS8933.1"
                     /db_xref="GeneID:11247"
                     /db_xref="HGNC:HGNC:8078"
                     /db_xref="MIM:604637"
                     /translation="MRLLPEWFLLLFGPWLLRKAVSAQIPESGRPQYLGLRPAAAGAG
                     APGQQLPEPRSSDGLGVGRAWSWAWPTNHTGALARAGAAGALPAQRTKRKPSIKAARA
                     KKIFGWGDFYFRVHTLKFSLLVTGKIVDHVNGTFSVYFRHNSSSLGNLSVSIVPPSKR
                     VEFGGVWLPGPVPHPLQSTLALEGVLPGLGPPLGMAAAAAGPGLGGSLGGALAGPLGG
                     ALGVPGAKESRAFNCHVEYEKTNRARKHRPCLYDPSQVCFTEHTQSQAAWLCAKPFKV
                     ICIFVSFLSFDYKLVQKVCPDYNFQSEHPYFG"
     exon            234..1805
                     /gene="NXPH4"
                     /gene_synonym="NPH4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1785..1790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXPH4"
                     /gene_synonym="NPH4"
                     /note="hexamer: AATAAA"
     polyA_site      1805
                     /gene="NXPH4"
                     /gene_synonym="NPH4"
                     /note="major polyA site"
ORIGIN      
        1 agcgccggct ccgcgcctcg cgcccagtcc gcgggccgcg ccgccgctcc cgccgctccc
       61 gccgctcccg ccgctcccgc agccgccccg ccgcccgccc ggagccccgc gtccctaggc
      121 ctggctcccg cctgcccgag acccgcccag cctgccccgc tcagccgcca gagaagatgc
      181 ggctgctccc ggaatggttc ctcttgctct ttggcccgtg gctccttagg aaggccgtca
      241 gtgcccagat accagagtcc ggaaggccgc agtacctggg gctgcgcccc gccgcggccg
      301 gagcgggtgc ccccggccag cagctcccag agccaaggtc ttcggacggc ctaggcgtgg
      361 gccgcgcctg gagctgggcc tggccgacca accacacggg ggcgctggcc cgggcagggg
      421 cagccggggc gttgcccgcg cagcgcacca agaggaagcc gtccatcaag gcggcgcgcg
      481 ccaaaaagat cttcggctgg ggggacttct actttcgggt gcataccctc aagttttcgc
      541 tgctggtgac cggcaagatc gtggaccatg tgaacggtac cttcagtgtg tatttccgcc
      601 acaactcgtc cagcctgggc aacctcagtg tcagcatcgt gccgccctcc aagcgtgtcg
      661 agttcggagg agtctggctg cccgggcctg tcccccaccc tctgcagtct acgctcgccc
      721 tggagggggt gcttcctggg ctggggcccc cgctggggat ggcagcagca gcggcggggc
      781 ccgggcttgg gggctccctc gggggcgcac tggcggggcc gcttgggggc gcgttgggag
      841 tgcctggggc caaagagtca cgcgctttca attgccacgt ggagtatgag aagacaaacc
      901 gcgcgcgcaa gcaccgaccg tgcctgtacg acccgtcgca ggtgtgcttc accgagcaca
      961 cgcagagcca ggccgcctgg ctctgtgcca agcccttcaa agtcatctgt atcttcgtct
     1021 ctttcctcag ctttgactac aaactggtgc agaaggtgtg cccagactat aacttccaga
     1081 gtgagcaccc ctacttcgga tagcgcccct ccccagccag tcctgagcct cccgccaaat
     1141 cccagcctca ctaggtggga cccccttccc agtgttctgc cgctcctgtg gccatgtcgc
     1201 ccactccttc cactctgggg gcggagggga atggcttctc gggaccctca gctagcgtgg
     1261 gtgccctttt ccttatgcgg agtgcccgca aggctggggt agccccctcc agtacacccc
     1321 aaagtgaaag ggataagagt gcagccccag aataggcggg gcttggaggc ggtcccaatg
     1381 tcccctgggt ccacagtggg tccccttttc acccttggcg ctaggctgcg cactcccttt
     1441 ccccgcagct ttaataactc ctggcctggc accctcaccc caccctgact ttcccatccc
     1501 ccagcgcttg tcctgcttca ccctaccccg cctaagactg taaaggccta aaaacctcgg
     1561 cctgtcctcc caccattctg cctgccatat gcctgtcccc ttttcctcca aaccctatta
     1621 gggtaccgga agcagaaccc ctgggctgag gccctggccc tgcccccggc ccctgcccct
     1681 gcccgccccc ctccagtcca ggcagtcgag ctccacctgc cctctcctgc tgcttcctct
     1741 cggtgatatt ttttctacgc caaaacagac gggaaaggga acaaaataaa gtgaaatcca
     1801 ataca
//
