LOCUS       NM_007225               5635 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens neurexophilin 3 (NXPH3), mRNA.
ACCESSION   NM_007225
VERSION     NM_007225.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5635)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   2  (bases 1 to 5635)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   3  (bases 1 to 5635)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   4  (bases 1 to 5635)
  AUTHORS   Missler,M., Hammer,R.E. and Sudhof,T.C.
  TITLE     Neurexophilin binding to alpha-neurexins. A single LNS domain
            functions as an independently folding ligand-binding unit
  JOURNAL   J Biol Chem 273 (52), 34716-34723 (1998)
   PUBMED   9856994
REFERENCE   5  (bases 1 to 5635)
  AUTHORS   Missler,M. and Sudhof,T.C.
  TITLE     Neurexophilins form a conserved family of neuropeptide-like
            glycoproteins
  JOURNAL   J Neurosci 18 (10), 3630-3638 (1998)
   PUBMED   9570794
REFERENCE   6  (bases 1 to 5635)
  AUTHORS   Petrenko,A.G., Ullrich,B., Missler,M., Krasnoperov,V., Rosahl,T.W.
            and Sudhof,T.C.
  TITLE     Structure and evolution of neurexophilin
  JOURNAL   J Neurosci 16 (14), 4360-4369 (1996)
   PUBMED   8699246
REFERENCE   7  (bases 1 to 5635)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006487.9, AB032985.1 and AA325150.1.
            
            On Dec 2, 2019 this sequence version replaced NM_007225.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.12949.1,
                                           SRR14372080.812510.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328741.6/ ENSP00000329295.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               AC006487.9         90207-90609
            404-2162            AC006487.9         92932-94690
            2163-2269           AB032985.1         1722-1828
            2270-2270           AA325150.1         196-196
            2271-5618           AB032985.1         1830-5177
            5619-5635           AC006487.9         98147-98163
FEATURES             Location/Qualifiers
     source          1..5635
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..5635
                     /gene="NXPH3"
                     /gene_synonym="NPH3"
                     /note="neurexophilin 3"
                     /db_xref="GeneID:11248"
                     /db_xref="HGNC:HGNC:8077"
                     /db_xref="MIM:604636"
     exon            1..403
                     /gene="NXPH3"
                     /gene_synonym="NPH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..1108
                     /gene="NXPH3"
                     /gene_synonym="NPH3"
                     /codon_start=1
                     /product="neurexophilin-3 precursor"
                     /protein_id="NP_009156.2"
                     /db_xref="CCDS:CCDS11550.1"
                     /db_xref="GeneID:11248"
                     /db_xref="HGNC:HGNC:8077"
                     /db_xref="MIM:604636"
                     /translation="MQLTRCCFVFLVQGSLYLVICGQDDGPPGSEDPERDDHEGQPRP
                     RVPRKRGHISPKSRPMANSTLLGLLAPPGEAWGILGQPPNRPNHSPPPSAKVKKIFGW
                     GDFYSNIKTVALNLLVTGKIVDHGNGTFSVHFQHNATGQGNISISLVPPSKAVEFHQE
                     QQIFIEAKASKIFNCRMEWEKVERGRRTSLCTHDPAKICSRDHAQSSATWSCSQPFKV
                     VCVYIAFYSTDYRLVQKVCPDYNYHSDTPYYPSG"
     exon            404..5635
                     /gene="NXPH3"
                     /gene_synonym="NPH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5597..5602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXPH3"
                     /gene_synonym="NPH3"
                     /note="hexamer: ATTAAA"
     regulatory      5613..5618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXPH3"
                     /gene_synonym="NPH3"
                     /note="hexamer: AATAAA"
     polyA_site      5618
                     /gene="NXPH3"
                     /gene_synonym="NPH3"
                     /note="major polyA site"
     polyA_site      5635
                     /gene="NXPH3"
                     /gene_synonym="NPH3"
ORIGIN      
        1 agcacatctg ggcgagagcg gcgccgctgg agccgagggg ggcgccgagc gcagatctgg
       61 agcagcagag ccacggcgca gctggggccc ttcgaggcgc tcggggcgca catctgggac
      121 ctcgagcggg ggccgtgccg cgcgcagctg gaccagggga ggggggcggc ggctgcacag
      181 ctggaccgaa gggggcgggg tcggccctgg gcgacccgct gaggggaggg ccgcgggccg
      241 ccggggactg gagcatggga cggcgcgcct gaaggagcag gaaggggaag gaggcctggg
      301 accccgaaaa gagaagggga gagcgagggg acgagagcgg aggaggaaga tgcaactgac
      361 tcgctgctgc ttcgtgttcc tggtgcaggg tagcctctat ctggtcatct gtggccagga
      421 tgatggtcct cccggctcag aggaccctga gcgtgatgac cacgagggcc agccccggcc
      481 ccgggtgcct cggaagcggg gccacatctc acctaagtcc cgccccatgg ccaattccac
      541 tctcctaggg ctgctggccc cgcctgggga ggcttggggc attcttgggc agccccccaa
      601 ccgcccgaac cacagccccc caccctcagc caaggtgaag aaaatctttg gctggggcga
      661 cttctactcc aacatcaaga cggtggccct gaacctgctc gtcacaggga agattgtgga
      721 ccatggcaat gggaccttca gcgtccactt ccaacacaat gccacaggcc agggaaacat
      781 ctccatcagc ctcgtgcccc ccagtaaagc tgtagagttc caccaggaac agcagatctt
      841 catcgaagcc aaggcctcca aaatcttcaa ctgccggatg gagtgggaga aggtagaacg
      901 gggccgccgg acctcgcttt gcacccacga cccagccaag atctgctccc gagaccacgc
      961 tcagagctca gccacctgga gctgctccca gcccttcaaa gtcgtctgtg tctacatcgc
     1021 cttctacagc acggactatc ggctggtcca gaaggtgtgc ccagattaca actaccatag
     1081 tgataccccc tactacccat ctgggtgacc cggggcaggc cacagaggcc aggccagggc
     1141 tggaaggaca ggcctgccca tgcaggagac catctggaca ccgggcaggg aaggggttgg
     1201 gcctcaggca gggagggggg tggagacgag gagatgccaa gtggggccag ggccaagtct
     1261 caagtggcag agaaagggtc ccaagtgctg gtcccaacct gaagctgtgg agtgactaga
     1321 tcacaggagc actggaggag gagtgggctc tctgtgcagc ctcacagggc tttgccacgg
     1381 agccacagag agatgctggg tccccgaggc ctgtgggcag gccgatcagt gtggccccag
     1441 atcaagtcat gggaggaagc taagcccttg gttcttgcca tcctgaggaa agatagcaac
     1501 agggaggggg agatttcatc agtgtggaca gcctgtcaac ttaggatgga tggctgagag
     1561 ggcttcctag gagccagtca gcagggtggg gtggggccag aggagctctc cagccctgcc
     1621 tagtgggcgc cctcagcccc ttgtcgtgtg ctgagcatgg catgaggctg aagtggcaac
     1681 cctggggtct ttgatgtctt gacagattga ccatctgtct ccagccaggc cacccctttc
     1741 caaaattccc tcttctgcca gtactccccc tgtaccaccc attgctgatg gcacacccat
     1801 ccttaagcta agacaggacg attgtggtcc tcccacacta aggccacagc ccatccgcgt
     1861 gctgtgtgtc cctcttccac cccaacccct gctggctcct ctgggagcat ccatgtcccg
     1921 gagaggggtc cctcaacagt cagcctcacc tgtcagaccg gggttctccc ggatctggat
     1981 ggcgccgccc tctcagcagc gggcacgggt ggggcggggc cgggccgcag agcatgtgct
     2041 ggatctgttc tgtgtgtctg tctgtgggtg gggggagggg agggaagtct tgtgaaaccg
     2101 ctgattgctg acttttgtgt gaagaatcgt gttcttggag caggaaataa agcttgcccc
     2161 ggggcactgg agtcagagtt gtccaaggaa agggcctcag gcatcccttg gtccaggaag
     2221 aatttctctg atggccgcag gacatttgct tgagacccaa gtggcaggga tccaaccgcc
     2281 cttggcgctg atgtttgctg agggctcagg gcttccctct ccagccccgg ttccaagctg
     2341 tctgatcccc cacgaggaaa cttgagcaaa caccctgggc tcggtgctgg aggagggcgt
     2401 agcatcttca agaacagctc agggagggag agctagcagg tagaatgggc caatgagggt
     2461 gttccttggt gtcctccctg aactgccatc tgcagaccca gcagggtcct agccccgtca
     2521 ttttgctgcg tggccttggc catgtccatt ctcctctctg gctttctttc tttgtttctt
     2581 cctctatgac atgaagggct tgcccagacc aggggttctc aaacgcggat cacccagagg
     2641 gtttgttaac acacagattt ctgggtccta cccacatttc taattcagca ggcctgggtg
     2701 gggcctaaga attagaattt ctaacgagtg cccaggtcta tgctgatgct gctgctccag
     2761 ggcccatgct gggagaccca ctcaaaggac cttgaagttc atctctggct atggctccgc
     2821 aggaggggga gacacctcgg atgtgatttc ccagctgtaa tttccatctg cttctcctgg
     2881 ggaaggggcc tttcagagaa tcggggctat tgtattggat tttcaatctg accacatgcc
     2941 agtgaaggaa caggctggag tggggtgtgg acacagggcc tgcgtcagtc actcccctcc
     3001 tgcagctagt aagaggcctc agaatggcca gctgccagtg gcaccttgtc tgggagttag
     3061 ttgggccctt tgggactctg tgaagggaag acactaccaa ggtcacagtg ccttctggag
     3121 gtcattctaa gtcggctctc ttgggagggc agcactcagg gccctttggg ccctcttgag
     3181 gagaggagag tcctggcagt aaggtaagat gggcttgcca ccccccacct ttcgcccctg
     3241 cccaccagcg ctccgcgcaa actggtcccc tcatactgca gcgcagagtt gggtggggct
     3301 gagaagccat ctggttacag cccaccttgt aggaaatgac ccagcttgtt tcccccacat
     3361 catgcttcca ggggccgtct ctcctgagtg gagatgtgag acacacaccc ctcctccaga
     3421 ccaccctccg ctccccaccc tggaggcttg agactgctgg cactggagca gcccaccaat
     3481 ggacacccac cgtgtgccgt tcagcctccc acagtgctgt ggagactgca ggaaggagga
     3541 ggaagcaatg gggccagagg ccctgggcgc cctccccacc tcccctggct gaactctcag
     3601 caggcactgg gggcactttg acccccctcc tgctcctctc ctcctgtgga gagccagatg
     3661 ctggcgacag ctggagggcc cggccttcct ggcacacagt tctgcctgca ccagggatgg
     3721 attcatttta ataacttcat ttcaccctca tgcacactgc cgcctcatcc ctcctttcca
     3781 ccttccccag tagcctggct gctctcctca gctaggactt cgctaacaga tttcctccca
     3841 aaccttaatt ctttggaata gccctctggt ccctactgtt cttgccagat acttctgtgc
     3901 ccgcttggtc ctcacaaggg caaggggtcc atccaacttc ctctggctaa gaagacgtca
     3961 cctctgcccc attggcgagc agtgtcccca tggtgatgcc cccccaccat cacgacgaag
     4021 tgcgctggcc tcccactctt gccatgcaca cactcacagg agattcctct gaagaaacct
     4081 gtccccactc tgcccagacc ccaaagggcc aggtcctact cacactccaa cccgttgacc
     4141 ttccccatcc actgcccttc aaggcagtct gaaatgccct cagaccgttt agcggtcccg
     4201 tggtcctcca ccctaacccc tcagcccagc tgggggctgc cgggggcctt gtctcctcca
     4261 tcagtggagc ctctgggaca agtttaccag gctgggggtt ctttaaggac acagcttgga
     4321 tctccccatc aggctgggga acacctaggg ccgggggcca tgcctccctc atcagactga
     4381 ggacaccctg atgtcagggg ctggatggcc ccttagactg ggggtccctg agggcagaag
     4441 ctatgcctcc cctcatcaga ctggagtctc cctgagggca agaactgtgc tatggatggg
     4501 agggggacag cttgcctttt cctaggcatc agagcacctg gaggctgcct ctgcccttca
     4561 gctttgctca aaggcgctgt ctgggtctca gcattccttt ctcaagtagg gtgaatctcc
     4621 tagcactctg tgaagctaat aagggggatt acccgttagg tcaactggta gcaatgcccg
     4681 agtctccttc tcgatgaagc ttaaggcaaa agcaaatgaa tatctaggtc ccttcccccc
     4741 cttcccccct tccctttcct gggatgagca agcgggaact gagtcaccct gttccccatc
     4801 cttggcagga atgctggtga ccttgcattg tggcagattc aggtggcgag gcccattgct
     4861 cgagatgcac ctggtgggtg ggtggcaggg atcctggggg agtgtttatg gggacggagg
     4921 cagctgaagg gcagggaggg gtgaccaggt gctgggatca tcgagtgagt atgtgcagga
     4981 gggattgtag agacacaatg aaacagttgc tctgtgttgg gaagtgatcc agtgtcatcg
     5041 ctgggagtgg gagacagaaa tgttacttcc aaagattccg agtcctgtgg tactgccagg
     5101 agaaccgggg gctggggtga tgggtaagga gaggcaccat tagccccgcc aggcagaggc
     5161 aagatggggt gggggcggca cctgccaatt atgccaaagt cttggagtgg cagctggcac
     5221 catcaccaag gcacaaatgc cagcagagac ctggcactca cctgggttgt gattccatag
     5281 ggcccctgtc tcctgttggt ctcccaggct caaaggctga cctgataatt caagtgaagg
     5341 atgcctagtt caaggcctcc cagttcctca tcccaggcca cctggtcagg tggtcccaag
     5401 ggacaagcta ggtcctcctg aactgcagag gctgccaata aactggcaac acaggtgttg
     5461 caggaagata tagctgggtc ctcatcctgg gtctgtaatt tattagacgt gtggctttgg
     5521 acaaatgaca taatttccca gagcctcctt agataaaaaa ctagggcttt gcttaccttg
     5581 gcgtattgtt aggaaaatta aatgagttgc tcaataaatg ttacttcctc ctgtc
//
