LOCUS       NM_007226               2709 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens neurexophilin 2 (NXPH2), mRNA.
ACCESSION   NM_007226 XM_371573
VERSION     NM_007226.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2709)
  AUTHORS   Jin,J.S. and Tsai,W.C.
  TITLE     The detection of tumor location and lymph node metastasis by
            aberrant NXPH1 and NXPH2 expressions in pancreatic ductal
            adenocarcinomas
  JOURNAL   Chin J Physiol 59 (6), 348-354 (2016)
   PUBMED   27817196
  REMARK    GeneRIF: expression inversely correlated with N stage in pancreatic
            ductal adenocarcinoma
REFERENCE   2  (bases 1 to 2709)
  AUTHORS   Zuo,L., Gelernter,J., Zhang,C.K., Zhao,H., Lu,L., Kranzler,H.R.,
            Malison,R.T., Li,C.S., Wang,F., Zhang,X.Y., Deng,H.W.,
            Krystal,J.H., Zhang,F. and Luo,X.
  TITLE     Genome-wide association study of alcohol dependence implicates
            KIAA0040 on chromosome 1q
  JOURNAL   Neuropsychopharmacology 37 (2), 557-566 (2012)
   PUBMED   21956439
  REMARK    Erratum:[Neuropsychopharmacology. 2012 Jan;37(2):581-2]
REFERENCE   3  (bases 1 to 2709)
  AUTHORS   Aston,K.I. and Carrell,D.T.
  TITLE     Genome-wide study of single-nucleotide polymorphisms associated
            with azoospermia and severe oligozoospermia
  JOURNAL   J Androl 30 (6), 711-725 (2009)
   PUBMED   19478329
REFERENCE   4  (bases 1 to 2709)
  AUTHORS   Missler,M. and Sudhof,T.C.
  TITLE     Neurexophilins form a conserved family of neuropeptide-like
            glycoproteins
  JOURNAL   J Neurosci 18 (10), 3630-3638 (1998)
   PUBMED   9570794
REFERENCE   5  (bases 1 to 2709)
  AUTHORS   Petrenko,A.G., Ullrich,B., Missler,M., Krasnoperov,V., Rosahl,T.W.
            and Sudhof,T.C.
  TITLE     Structure and evolution of neurexophilin
  JOURNAL   J Neurosci 16 (14), 4360-4369 (1996)
   PUBMED   8699246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092837.5, BC101462.1 and AC092620.2.
            
            On Nov 23, 2018 this sequence version replaced NM_007226.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.44898.1,
                                           SRR1803614.175146.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272641.4/ ENSP00000272641.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC092837.5         74920-75068         c
            150-367             BC101462.1         1-218
            368-2709            AC092620.2         21029-23370
FEATURES             Location/Qualifiers
     source          1..2709
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.1"
     gene            1..2709
                     /gene="NXPH2"
                     /gene_synonym="NPH2"
                     /note="neurexophilin 2"
                     /db_xref="GeneID:11249"
                     /db_xref="HGNC:HGNC:8076"
                     /db_xref="MIM:604635"
     exon            1..200
                     /gene="NXPH2"
                     /gene_synonym="NPH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..944
                     /gene="NXPH2"
                     /gene_synonym="NPH2"
                     /codon_start=1
                     /product="neurexophilin-2 precursor"
                     /protein_id="NP_009157.1"
                     /db_xref="CCDS:CCDS46421.1"
                     /db_xref="GeneID:11249"
                     /db_xref="HGNC:HGNC:8076"
                     /db_xref="MIM:604635"
                     /translation="MRLRPLPLVVVPGLLQLLFCDSKEVVHATEGLDWEDKDAPGTLV
                     GNVVHSRIISPLRLFVKQSPVPKPGPMAYADSMENFWDWLANITEIQEPLARTKRRPI
                     VKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGLGNVSVSL
                     VPPSKVVEFEVSPQSTLETKESKSFNCRIEYEKTDRAKKTALCNFDPSKICYQEQTQS
                     HVSWLCSKPFKVICIYIAFYSVDYKLVQKVCPDYNYHSETPYLSSG"
     exon            201..2709
                     /gene="NXPH2"
                     /gene_synonym="NPH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2677..2682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXPH2"
                     /gene_synonym="NPH2"
                     /note="hexamer: AATAAA"
     polyA_site      2709
                     /gene="NXPH2"
                     /gene_synonym="NPH2"
                     /note="major polyA site"
ORIGIN      
        1 agagctgcgc ggcacggcgc agcgctcgga ttccgggagg gaagcgccgc gctgtgtccc
       61 tggcgtcctc agtcctgccc cgcgaagtgg agatgcgcga gaggcaggcg agggcgcgca
      121 gctcgtgaaa agccgcgcca gccggcacca tgcgcctgcg gccgctgccc ctcgtggtgg
      181 tccctggctt gctgcagctg ctattttgtg acagtaagga agtggtgcat gccacggagg
      241 ggctggattg ggaagacaaa gatgctccag ggacgttggt cggcaacgtg gtgcactcaa
      301 ggatcatcag tcccctgcgc ctgtttgtta aacagtctcc ggtgcccaag cccggcccca
      361 tggcgtacgc agacagcatg gaaaactttt gggattggct ggccaacatc acggagattc
      421 aggagccatt ggcaagaact aaacggaggc caatagtaaa aacaggaaaa tttaagaaaa
      481 tgtttggatg gggtgacttt cattccaaca ttaaaactgt caaactcaat ctcctcatca
      541 cagggaaaat tgttgaccat ggaaatggaa ccttcagtgt gtatttccga cataattcaa
      601 caggcctggg caatgtttca gtgagcttgg taccaccctc caaggtggtg gaatttgaag
      661 tttcccccca gtctaccttg gagaccaagg aatccaaatc tttcaattgt cgcattgagt
      721 atgaaaaaac agatcgggcg aaaaagaccg ccctgtgcaa ctttgaccca tccaagatct
      781 gctaccagga gcagactcag agccatgtgt cttggttgtg ctccaagccc ttcaaggtca
      841 tttgcattta cattgccttt tacagtgttg attataaact cgtgcaaaag gtgtgccctg
      901 actacaatta ccatagtgag accccatact tatcttctgg ctgatcttcc tgctgtggtg
      961 gaaatgaggg atacatatgt atttgattag aatgacaaag aaacaagccc agctctttat
     1021 gataaaggat cccttttgtt tctggcagtg aacaatagtt ccctatcagg ttttcaaatt
     1081 taaaaaaaga aaaagagaca tctttaagtg tgaaatttgt ttctttctat cgtaggtacc
     1141 tttatctaaa aagttaaact gtttatgaaa ccatcacttt catgcaagat gactaagttc
     1201 tagaaatctt attgtttctc tgaaagaaac atcaatgata gcaatatgtg acaagaagga
     1261 acaaaattat gcatgtgaca aacattgctc ttgaaatgag cctgcctttg aaatatgttt
     1321 tggaaggtta ccgcagaaac agcagatgcg gtaaaggaaa agattgtatt tgatagatga
     1381 attgtgtttt tgacattgga cccttttttt tatatttcta tcttttcccc catccatctg
     1441 tgctgttatt gatatgagag aaaaaaaggt aaaatttgtt tcaaaattca tgtgtgaagt
     1501 tacagtgcca cagtggaacc aagttcctta tcatctgagc tacagttgcg tggaatgtga
     1561 tttgagcact tagccctgtg ttggtcacca ttcttatgat tccccctgag tttgaatact
     1621 gatgtaatgg gaaagcaaat ctgagaataa gtttgttgaa cgataacaaa aatcatgatg
     1681 tttttagact cttctgataa attcaaatgc tgtggaatta atcaaaaaat gacaaaattt
     1741 gtatgcatcc tatagcttag agctttattc aattcattcg atagtgtgat tctttacaca
     1801 tgtgtagaac agctctgaag ttgagtgaaa gtgcttgttt cctagactag aatagaaaac
     1861 aaaagtggga agtagaggga ggaaatttca ggattatgga ttcattattt ctagcctccc
     1921 agattaagtt ccccttgcat ttagttaata tttgaataag agatcaaact ctatgtggaa
     1981 atagagagtt atatttaaac atttctaatt attaagtgct gacaaccaag atacctggct
     2041 taccagactt ttgaaatgac tttcaaatta atgtcacttc acagtcagtg cccttctcat
     2101 cttccctgtg ggggtgaata gcagtcctat atggtagaac tgaatgatca ttaaattaga
     2161 acagaaacag gggtctggtt ggccaagaaa aaggcttcta gaactcagga cgctcatgga
     2221 atggtcactc cttttacaat agatgttaac ttctttctcc cttcttatct gtaaaatatt
     2281 aattaaagta aaacattaaa ttgaggacta aaggaagaga agtcctaaac aacaagaaat
     2341 actcttacca cactgttcaa aaaaccaaga gctctgttct ctatcttcat ttctttcctt
     2401 ttaccggtaa tatctgcagt gttcaatttt tgtcttttgt aaaaattgta ctaagcttag
     2461 tgtgtggtag tacaggcttg aagttcttgc tctgagttca ccacatgttt ttgtaatttt
     2521 gtggttggtg attaatattt tgaaacatct ttttattttc acctagaaac aagagtaaaa
     2581 tattatttat tgtaaaatat gtgggaatca tatatctata tatatatact tagaattttc
     2641 tgtgtacaga gaaagtatgt gtacacattt tatgtaaata aaaagaattt gctagatctg
     2701 tcacattaa
//
