LOCUS       NM_152745               3265 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens neurexophilin 1 (NXPH1), mRNA.
ACCESSION   NM_152745
VERSION     NM_152745.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3265)
  AUTHORS   Wang,M., Li,Z. and Zuo,Q.
  TITLE     miR-194-5p inhibits LPS-induced astrocytes activation by directly
            targeting neurexophilin 1
  JOURNAL   Mol Cell Biochem 471 (1-2), 203-213 (2020)
   PUBMED   32533463
  REMARK    GeneRIF: miR-194-5p inhibits LPS-induced astrocytes activation by
            directly targeting neurexophilin 1.
REFERENCE   2  (bases 1 to 3265)
  AUTHORS   Vallee Marcotte,B., Guenard,F., Cormier,H., Lemieux,S., Couture,P.,
            Rudkowska,I. and Vohl,M.C.
  TITLE     Plasma Triglyceride Levels May Be Modulated by Gene Expression of
            IQCJ, NXPH1, PHF17 and MYB in Humans
  JOURNAL   Int J Mol Sci 18 (2), 257 (2017)
   PUBMED   28134766
  REMARK    GeneRIF: A genome-wide association study (GWAS) identified loci
            associated with the plasma triglyceride (TG) response to omega-3
            fatty acid (FA) supplementation in IQCJ, NXPH1, PHF17 and MYB.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3265)
  AUTHORS   Jin,J.S. and Tsai,W.C.
  TITLE     The detection of tumor location and lymph node metastasis by
            aberrant NXPH1 and NXPH2 expressions in pancreatic ductal
            adenocarcinomas
  JOURNAL   Chin J Physiol 59 (6), 348-354 (2016)
   PUBMED   27817196
  REMARK    GeneRIF: expression inversely correlated with N stage in pancreatic
            ductal adenocarcinoma
REFERENCE   4  (bases 1 to 3265)
  AUTHORS   Vallee Marcotte,B., Cormier,H., Guenard,F., Rudkowska,I.,
            Lemieux,S., Couture,P. and Vohl,M.C.
  TITLE     Novel Genetic Loci Associated with the Plasma Triglyceride Response
            to an Omega-3 Fatty Acid Supplementation
  JOURNAL   J Nutrigenet Nutrigenomics 9 (1), 1-11 (2016)
   PUBMED   27160456
  REMARK    GeneRIF: identification of SNPs within the IQCJ, NXPH1, PHF17 and
            MYB genes partly explaining the large interindividual variability
            observed in plasma triglyceride levels in response to an n-3 fatty
            acid supplementation
REFERENCE   5  (bases 1 to 3265)
  AUTHORS   Gareeva,A.E., Traks,T., Koks,S. and Khusnutdinova,E.K.
  TITLE     [The Role of Neurotrophins and Neurexins Genes in the Risk of
            Paranoid Schizophrenia in Russians and Tatars]
  JOURNAL   Genetika 51 (7), 799-811 (2015)
   PUBMED   26410934
  REMARK    GeneRIF: The role of NXPH1 in in paranoid schizophrenia development
            in Russians.
REFERENCE   6  (bases 1 to 3265)
  AUTHORS   Ohira,M., Morohashi,A., Nakamura,Y., Isogai,E., Furuya,K.,
            Hamano,S., Machida,T., Aoyama,M., Fukumura,M., Miyazaki,K.,
            Suzuki,Y., Sugano,S., Hirato,J. and Nakagawara,A.
  TITLE     Neuroblastoma oligo-capping cDNA project: toward the understanding
            of the genesis and biology of neuroblastoma
  JOURNAL   Cancer Lett 197 (1-2), 63-68 (2003)
   PUBMED   12880961
  REMARK    Review article
REFERENCE   7  (bases 1 to 3265)
  AUTHORS   Clarris,H.J., McKeown,S. and Key,B.
  TITLE     Expression of neurexin ligands, the neuroligins and the
            neurexophilins, in the developing and adult rodent olfactory bulb
  JOURNAL   Int J Dev Biol 46 (4), 649-652 (2002)
   PUBMED   12141453
  REMARK    GeneRIF: In rat, the secreted ligand for alpha-neurexin,
            neurexophilin 1, is expressed in the postnatal olfactory bulb.
REFERENCE   8  (bases 1 to 3265)
  AUTHORS   Missler,M., Hammer,R.E. and Sudhof,T.C.
  TITLE     Neurexophilin binding to alpha-neurexins. A single LNS domain
            functions as an independently folding ligand-binding unit
  JOURNAL   J Biol Chem 273 (52), 34716-34723 (1998)
   PUBMED   9856994
REFERENCE   9  (bases 1 to 3265)
  AUTHORS   Missler,M. and Sudhof,T.C.
  TITLE     Neurexophilins form a conserved family of neuropeptide-like
            glycoproteins
  JOURNAL   J Neurosci 18 (10), 3630-3638 (1998)
   PUBMED   9570794
REFERENCE   10 (bases 1 to 3265)
  AUTHORS   Petrenko,A.G., Ullrich,B., Missler,M., Krasnoperov,V., Rosahl,T.W.
            and Sudhof,T.C.
  TITLE     Structure and evolution of neurexophilin
  JOURNAL   J Neurosci 16 (14), 4360-4369 (1996)
   PUBMED   8699246
  REMARK    GeneRIF: In rat, neurexophilin 1 forms a very tight complex with
            neurexin I alpha.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004861.1, AB047362.1,
            AC004613.1, AA575925.1 and BX107562.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152745.2.
            
            Summary: This gene is a member of the neurexophilin family and
            encodes a secreted protein with a variable N-terminal domain, a
            highly conserved, N-glycosylated central domain, a short linker
            region, and a cysteine-rich C-terminal domain. This protein forms a
            very tight complex with alpha neurexins, a group of proteins that
            promote adhesion between dendrites and axons. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB073665.1, SRR1660805.179279.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405863.6/ ENSP00000384551.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               AC004861.1         53533-53878
            347-2291            AB047362.1         1-1945
            2292-2293           AC004613.1         110021-110022
            2294-2821           AB047362.1         1948-2475
            2822-3263           AA575925.1         1-442               c
            3264-3265           BX107562.1         661-662
FEATURES             Location/Qualifiers
     source          1..3265
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.3"
     gene            1..3265
                     /gene="NXPH1"
                     /gene_synonym="Nbla00697; NPH1"
                     /note="neurexophilin 1"
                     /db_xref="GeneID:30010"
                     /db_xref="HGNC:HGNC:20693"
                     /db_xref="MIM:604639"
     exon            1..1147
                     /gene="NXPH1"
                     /gene_synonym="Nbla00697; NPH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1311
                     /gene="NXPH1"
                     /gene_synonym="Nbla00697; NPH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1258..2073
                     /gene="NXPH1"
                     /gene_synonym="Nbla00697; NPH1"
                     /codon_start=1
                     /product="neurexophilin-1 precursor"
                     /protein_id="NP_689958.1"
                     /db_xref="CCDS:CCDS47540.1"
                     /db_xref="GeneID:30010"
                     /db_xref="HGNC:HGNC:20693"
                     /db_xref="MIM:604639"
                     /translation="MQAACWYVLFLLQPTVYLVTCANLTNGGKSELLKSGSSKSTLKH
                     IWTESSKDLSISRLLSQTFRGKENDTDLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRP
                     RAKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQ
                     GNVSVSLVPPTKIVEFDLAQQTVIDAKDSKSFNCRIEYEKVDKATKNTLCNYDPSKTC
                     YQEQTQSHVSWLCSKPFKVICIYISFYSTDYKLVQKVCPDYNYHSDTPYFPSG"
     exon            1312..3265
                     /gene="NXPH1"
                     /gene_synonym="Nbla00697; NPH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3239..3244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXPH1"
                     /gene_synonym="Nbla00697; NPH1"
                     /note="hexamer: AATAAA"
     polyA_site      3265
                     /gene="NXPH1"
                     /gene_synonym="Nbla00697; NPH1"
                     /note="major polyA site"
ORIGIN      
        1 agtcctctcg gctgtctcga gctgaatggc tggcagtctg cggctccccc gcctccggcc
       61 cggcagccac aggtcggagg cgcccggcgt cggcgctcga ggccggcagg ggcgccctgc
      121 accctcccgc gcccttcccc gccctacgcg actcccggct gctcttcccg ccactcccct
      181 gggctttgcg atcttcccta cgccccccgg gaagggggcg ctgcggccac cgaagacacc
      241 gcgggagcca cttgtccctg tgggcccagc ccgcgagagc ctgagagccg gatctgttta
      301 cacagggtac taattagtct ttgaggaatc attcacccac gtgccaaagt aattgtccgt
      361 gtcaggaagg taggcgtgcc aagccgcggc tctgcggaga aaccacgacc accgcggccg
      421 ccggaaaccc aaagcgctcc agagcgtccc cgggtggccg ggcagcacca gggacagcgc
      481 ccgggactcc actggggacc ggctcctggg cttcccagcg tcgcgggtag aggtacagct
      541 gctccgtgtg ccgcaggctc cagattctcg ccaccccacc cctccctcag aaactcggac
      601 tgctctcgtc tgccgtgtgg ttctcttttc ttccgaaagg ccagtgtctt atctctccac
      661 ttcaagtcca gaggacttgc tcagtctcct ccccttaagt catttccacc atcctcaggc
      721 agctgtggga agccgagagt cctggactgt tcgtccgggt gccagcgctg gcagtcccag
      781 tccgtccggt gcagcagccc ggcgcattcc cctctctccc tccctcttgc tctccctccc
      841 tttctgtctt cctctctttc ctcctctact gctccctccc tctcttgcct cttaagtttc
      901 ctgcaccgtg aatccaactg tgccaagcct tggctcccgc gaaccaatcc tgagcgcgac
      961 ccgggcactg ggacggcgac tccgccaaag ctggacgagg cagccggacc cgtctgcgct
     1021 cgagcatgga gacggagcgc ctgggagggc acgtccgggg cgctggagac gccaggcccg
     1081 agtagcttct ccatggagcc tgcccagagc ggtcccttct cgcaggattc gccccaagtc
     1141 ctgtgcggct gctgagagcg ctccttgctc tgtaaagtgg atgtcaggtg gatctatgtt
     1201 tctgaaggaa caaagactca aagaaggcac cgccaaggaa gtttgagacg cgggagaatg
     1261 caggctgcgt gctggtacgt gcttttcctc ctgcagccca ccgtctactt ggtcacatgt
     1321 gccaatttaa cgaacggtgg aaagtcagaa cttctgaaat caggaagcag caaatccaca
     1381 ctaaagcaca tatggacaga aagcagcaaa gacttgtcta tcagccgact cctgtcacag
     1441 acttttcgtg gcaaagagaa tgatacagat ttggacctga gatatgacac cccagaacct
     1501 tattctgagc aagacctctg ggactggctg aggaactcca cagaccttca agagcctcgg
     1561 cccagggcca agagaaggcc cattgttaaa acgggcaagt ttaagaaaat gtttggatgg
     1621 ggcgattttc attccaacat caaaacagtg aagctgaacc tgttgataac tgggaaaatt
     1681 gtagatcatg gcaatgggac atttagtgtt tatttcaggc ataattcaac tggtcaaggg
     1741 aatgtatctg tcagcttggt accccctaca aaaatcgtgg aatttgactt ggcacaacaa
     1801 accgtgattg atgccaaaga ttccaagtct tttaattgtc gcattgaata tgaaaaggtt
     1861 gacaaggcta ccaagaacac actctgcaac tatgaccctt caaaaacctg ttaccaggag
     1921 caaacccaaa gtcatgtatc ctggctctgc tccaagccct ttaaggtgat ctgtatttac
     1981 atttcctttt atagtacaga ttataaactg gtacagaaag tgtgccctga ctacaactac
     2041 cacagtgaca caccttactt tccctcggga tgaaggtgaa catgggggtg agactgaagc
     2101 ctgaggaatt aaaggtcata tgacagggct gttacctcaa agaagaaggt cacatctgtt
     2161 gcctggaatg tgtctacact gctgctcttg tcaactggct gcaaaataca ctagtggaaa
     2221 acactctgat gtaatttctg cccagtcagc ttcatccctc agtataattg taaatcatca
     2281 cagattttga attcacacct gaagacatgc tctcacatat agaggtacac aaacacaccg
     2341 tcatgcacat ttcagcttgc gtctatcatg attcctgttg agagggcttt cattgtctga
     2401 ctcataatgg ttcaggatca actatcatca aacggaagga ttaactagac agagaatgtt
     2461 tctaacagtt gctgttatgg aaatctcttt taaagtcttg agtacatgct aatcaataat
     2521 ctccactcat gcattcctac tgcttggagt agctgtactg gtaaatacta ctgtaggagt
     2581 atctgcttgt taaaatggaa aaatgtgtct ttagagctca gtattcttta ttttacaaac
     2641 acaacaaaat gtagtaactt ttttccagca tacagtaggc acattcaaag tggtccaaga
     2701 tggctctttt ttctttgaaa ggggcctgtt ctcagtaaag atgagcaaac atttggaatt
     2761 tacatgtggg cagacattgg gataacaact ttcatcacca atcattggac ttttgtgaag
     2821 ttgacaccag ctaaggctgc ttaaaataag ttctgatcat tatataagaa gggaaatgcc
     2881 tggcagacac catgtaagtt ataagtgtct gtcttatctt tactacacat attgtaacaa
     2941 attcaatatc ctagtcttca tttgtatgaa tggtttgtat tgtacatagt ttaaccaagt
     3001 gttatttgag ctgcttatta atattaactt gtacttgtct ctctgcttgt tattggttaa
     3061 gaaaaaagga tatgaggaat tcattttatc aatgtagctg tgaaggccat taaaaagaca
     3121 aacttaatgt acagagcatt tattcagatc aagtattgtt gaaagctata catatacaac
     3181 attacagtct gtctgtattt agatatttta tttctggaaa aaatgaaatg tacataaaaa
     3241 taaaacactt aaagttgagt ttcaa
//
