LOCUS       NM_001077639            2187 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens neurexophilin and PC-esterase domain family member 4
            (NXPE4), transcript variant 1, mRNA.
ACCESSION   NM_001077639
VERSION     NM_001077639.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2187)
  AUTHORS   Liu,Y.R., Hu,Y., Zeng,Y., Li,Z.X., Zhang,H.B., Deng,J.L. and
            Wang,G.
  TITLE     Neurexophilin and PC-esterase domain family member 4 (NXPE4) and
            prostate androgen-regulated mucin-like protein 1 (PARM1) as
            prognostic biomarkers for colorectal cancer
  JOURNAL   J Cell Biochem 120 (10), 18041-18052 (2019)
   PUBMED   31297877
  REMARK    GeneRIF: Neurexophilin and PC-esterase domain family member 4
            (NXPE4) and prostate androgen-regulated mucin-like protein 1
            (PARM1) as prognostic biomarkers for colorectal cancer.
REFERENCE   2  (bases 1 to 2187)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   3  (bases 1 to 2187)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     Novel eukaryotic enzymes modifying cell-surface biopolymers
  JOURNAL   Biol Direct 5, 1 (2010)
   PUBMED   20056006
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2187)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 2187)
  AUTHORS   Solmi,R., De Sanctis,P., Zucchini,C., Ugolini,G., Rosati,G., Del
            Governatore,M., Coppola,D., Yeatman,T.J., Lenzi,L., Caira,A.,
            Zanotti,S., Taffurelli,M., Carinci,P., Valvassori,L. and
            Strippoli,P.
  TITLE     Search for epithelial-specific mRNAs in peripheral blood of
            patients with colon cancer by RT-PCR
  JOURNAL   Int J Oncol 25 (4), 1049-1056 (2004)
   PUBMED   15375555
REFERENCE   6  (bases 1 to 2187)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020549.4, DA428771.1, AY358805.1 and AK000134.1.
            
            On May 17, 2019 this sequence version replaced NM_001077639.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138528.205481.1, AY358805.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2156266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375478.4/ ENSP00000364627.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC020549.4         94201-94224         c
            25-110              DA428771.1         1-86
            111-1846            AY358805.1         3-1738
            1847-2187           AK000134.1         1348-1688
FEATURES             Location/Qualifiers
     source          1..2187
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.2-q23.3"
     gene            1..2187
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /note="neurexophilin and PC-esterase domain family member
                     4"
                     /db_xref="GeneID:54827"
                     /db_xref="HGNC:HGNC:23117"
                     /db_xref="MIM:618133"
     exon            1..195
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /inference="alignment:Splign:2.1.0"
     exon            196..301
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1840
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein FAM55D; family with sequence similarity
                     55, member D; NXPE family member 4"
                     /codon_start=1
                     /product="NXPE family member 4 isoform 1 precursor"
                     /protein_id="NP_001071107.1"
                     /db_xref="CCDS:CCDS41718.1"
                     /db_xref="GeneID:54827"
                     /db_xref="HGNC:HGNC:23117"
                     /db_xref="MIM:618133"
                     /translation="MKISMINYKSLLALLFILASWIIFTVFQNSTKVWSALNLSISLH
                     YWNNSTKSLFPKTPLISLKPLTETELRIKEIIEKLDQQIPPRPFTHVNTTTSATHSTA
                     TILNPRDTYCRGDQLHILLEVRDHLGRRKQYGGDFLRARMSSPALMAGASGKVTDFNN
                     GTYLVSFTLFWEGQVSLSLLLIHPSEGVSALWSARNQGYDRVIFTGQFVNGTSQVHSE
                     CGLILNTNAELCQYLDNRDQEGFYCVRPQHMPCAALTHMYSKNKKVSYLSKQEKSLFE
                     RSNVGVEIMEKFNTISVSKCNKETVAMKEKCKFGMTSTIPSGHVWRNTWNPVSCSLAT
                     VKMKECLRGKLIYLMGDSTIRQWMEYFKASINTLKSVDLHESGKLQHQLAVDLDRNIN
                     IQWQKYCYPLIGSMTYSVKEMEYLTRAIDRTGGEKNTVIVISLGQHFRPFPIDVFIRR
                     ALNVHKAIQHLLLRSPDTMVIIKTENIREMYNDAERFSDFHGYIQYLIIKDIFQDLSV
                     SIIDAWDITIAYGTNNVHPPQHVVGNQINILLNYIC"
     exon            302..1035
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1097
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1304
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..2187
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttctgtct tagctgaaac aagcagaagg ttgtgaatcc atgctaaagg taaacaaact
       61 gcaacttata tctgcaattt attttggtat agacaagagg tatgccagta gcacactggt
      121 ggcttcagaa gaaattctca acacctagct cgccagagag tctatgtatg ggattgaaca
      181 atctgtaaac taaaggatcc taatcatgaa aataagtatg ataaattata agtcactatt
      241 ggcactgttg tttatattag cctcctggat catttttaca gttttccaga actccacaaa
      301 ggtttggtct gctctaaact tatccatctc cctccattac tggaacaact ccacaaagtc
      361 cttattccct aaaacaccac tgatatcatt aaagccacta acagagactg aactcagaat
      421 aaaggaaatc atagagaaac tagatcagca gatcccaccc agacctttca cccacgtgaa
      481 caccaccacc agcgccacac atagcacagc caccatcctc aaccctcgag atacgtactg
      541 caggggagac cagctgcaca tcctgctgga ggtgagggac cacttgggac gcaggaagca
      601 atatggcggg gatttcctga gggccaggat gtcttcccca gcgctgatgg caggtgcttc
      661 aggaaaggtg actgacttca acaacggcac ctacctggtc agcttcactc tgttctggga
      721 gggccaggtc tctctgtctc tgctgctcat ccaccccagt gaaggggtgt cagctctctg
      781 gagtgcaagg aaccaaggct atgacagggt gatcttcact ggccagtttg tcaatggcac
      841 ttcccaagtc cactctgaat gtggcctgat cctaaacaca aatgctgaat tgtgccagta
      901 cctggacaac agagaccaag aaggcttcta ctgtgtgagg cctcaacaca tgccctgtgc
      961 tgcactcact cacatgtatt ctaagaacaa gaaagtttct tatcttagca aacaagaaaa
     1021 gagcctcttt gaaaggtcaa atgtgggtgt agagattatg gaaaaattca atacaattag
     1081 tgtctccaaa tgcaacaaag aaacagttgc aatgaaagag aaatgcaagt ttggaatgac
     1141 atccacaatc cccagtgggc atgtctggag aaacacatgg aatcctgtct cctgtagttt
     1201 ggctacagtc aaaatgaagg aatgcctgag aggaaaactc atatacctaa tgggagattc
     1261 cacgatccgc cagtggatgg aatacttcaa agccagtatc aacacactga agtcagtgga
     1321 tctgcatgaa tctggaaaat tgcaacacca gcttgctgtg gatttggata ggaacatcaa
     1381 catccagtgg caaaaatatt gttatccctt gataggatca atgacctatt cagtcaaaga
     1441 gatggagtac ctcacccggg ccattgacag aactggagga gaaaaaaata ctgtcattgt
     1501 tatttccctg ggccagcatt tcagaccctt tcccattgat gtttttatcc gaagggccct
     1561 caatgtccac aaagccattc agcatcttct tctgagaagc ccagacacta tggttatcat
     1621 caaaacagaa aacatcaggg agatgtacaa tgatgcagaa agatttagtg actttcatgg
     1681 ttacattcaa tatctcatca taaaggacat tttccaggat ctcagtgtga gtatcattga
     1741 tgcctgggat ataacaattg catatggcac aaataatgta cacccacctc aacatgtagt
     1801 cggaaatcag attaatatat tattaaacta tatttgttaa ataacacaaa agtctgaaat
     1861 tcattcactt aagtaaaaaa atttattgac tgtctactag caggccagat gctgtgtttg
     1921 gctctgaatt cccaactagc aagagcagag aatctacatt atggctgatc cataagccac
     1981 caattcagct aaatgagatg tttctaatct gggcttccac ttaaaaataa aactaaaaat
     2041 actcatgaaa agagcctacc cttcttgatc agagccatac ccctcttcac caatgggaag
     2101 tcaagacacc tatgggtaaa agttctctct gatgcatgaa aactcagagt gataaagtaa
     2161 ttttaaaata aaaatttgga gaaagca
//
