LOCUS       NM_145037               8568 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens neurexophilin and PC-esterase domain family member 3
            (NXPE3), transcript variant 2, mRNA.
ACCESSION   NM_145037
VERSION     NM_145037.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8568)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 8568)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 8568)
  AUTHORS   Yamada,N., Yasui,K., Dohi,O., Gen,Y., Tomie,A., Kitaichi,T.,
            Iwai,N., Mitsuyoshi,H., Sumida,Y., Moriguchi,M., Yamaguchi,K.,
            Nishikawa,T., Umemura,A., Naito,Y., Tanaka,S., Arii,S. and Itoh,Y.
  TITLE     Genome-wide DNA methylation analysis in hepatocellular carcinoma
  JOURNAL   Oncol Rep 35 (4), 2228-2236 (2016)
   PUBMED   26883180
REFERENCE   4  (bases 1 to 8568)
  AUTHORS   Missler,M., Hammer,R.E. and Sudhof,T.C.
  TITLE     Neurexophilin binding to alpha-neurexins. A single LNS domain
            functions as an independently folding ligand-binding unit
  JOURNAL   J Biol Chem 273 (52), 34716-34723 (1998)
   PUBMED   9856994
REFERENCE   5  (bases 1 to 8568)
  AUTHORS   Missler,M. and Sudhof,T.C.
  TITLE     Neurexophilins form a conserved family of neuropeptide-like
            glycoproteins
  JOURNAL   J Neurosci 18 (10), 3630-3638 (1998)
   PUBMED   9570794
REFERENCE   6  (bases 1 to 8568)
  AUTHORS   Petrenko,A.G., Ullrich,B., Missler,M., Krasnoperov,V., Rosahl,T.W.
            and Sudhof,T.C.
  TITLE     Structure and evolution of neurexophilin
  JOURNAL   J Neurosci 16 (14), 4360-4369 (1996)
   PUBMED   8699246
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084198.31 and AC020651.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_145037.3.
            
            Summary: This gene encodes a member of the neurexophilin family of
            neuropeptide-like glycoproteins. The encoded protein contains a
            variable N-terminal domain, a highly conserved neurexophilin and
            PC-esterase (NXPE) central domain, a short linker region, and a
            cysteine-rich C-terminal domain. This protein binds alpha
            neurexins, a group of presynaptic transmembrane receptors that
            promote adhesion between dendrites and axons. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Feb
            2017].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1-8 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.120766.1,
                                           SRR1803613.73081.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273347.10/ ENSP00000273347.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC084198.31        182058-182171
            115-295             AC084198.31        184957-185137
            296-416             AC084198.31        185507-185627
            417-704             AC084198.31        188249-188536
            705-1459            AC020651.19        140765-141519       c
            1460-1533           AC020651.19        135628-135701       c
            1534-1740           AC020651.19        125753-125959       c
            1741-8568           AC020651.19        114523-121350       c
FEATURES             Location/Qualifiers
     source          1..8568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.3"
     gene            1..8568
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /note="neurexophilin and PC-esterase domain family member
                     3"
                     /db_xref="GeneID:91775"
                     /db_xref="HGNC:HGNC:28238"
     exon            1..114
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /inference="alignment:Splign:2.1.0"
     exon            115..295
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /inference="alignment:Splign:2.1.0"
     exon            296..416
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /inference="alignment:Splign:2.1.0"
     exon            417..704
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /inference="alignment:Splign:2.1.0"
     CDS             612..2291
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; family with sequence similarity 55, member C;
                     NXPE family member 3"
                     /codon_start=1
                     /product="NXPE family member 3 isoform 1 precursor"
                     /protein_id="NP_659474.1"
                     /db_xref="CCDS:CCDS2945.1"
                     /db_xref="GeneID:91775"
                     /db_xref="HGNC:HGNC:28238"
                     /translation="MWTNFFKLRLFCCLLAVLMVVVLVINVTQVEYLDHETVSATFID
                     SSGQFVSSQVTGISRNPYCGYDQQTLSSQERMEEDSLLAALHRQVPDVGPVPFVKSTD
                     PSSSYFVILNSAAFFKVGSQLEVLVHVQDFQRKPKKYGGDYLQARIHSLKLQAGAVGR
                     VVDYQNGFYKVFFTLLWPGKVKVSVSLVHPSEGIRVLQRLQEDKPDRVYFKSLFRSGR
                     ISETTECNVCLPGNLPLCNFTDLYTGEPWFCFKPKKLPCSSRITHFKGGYLKGLLTAA
                     ESAFFQSGVNIKMPVNSSGPDWVTVIPRRIKETNSLELSQGSGTFPSGYYYKDQWRPR
                     KFKMRQFNDPDNITECLQRKVVHLFGDSTIRQWFEYLTTFVPDLVEFNLGSPKNVGPF
                     LAVDQKHNILLKYRCHGPPIRFTTVFSNELHYVANELNGIVGGKNTVVAIAVWSHFST
                     FPLEVYIRRLRNIRRAVVRLLDRSPKTVVVIRTANAQELGPEVSLFNSDWYNFQLDTI
                     LRRMFSGVGVYLVDAWEMTLAHYLPHKLHPDEVIVKNQLDMFLSFVCPLET"
     exon            705..1459
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1533
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1740
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..8568
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3136..3141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /note="hexamer: TATAAA"
     polyA_site      3163
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /note="major polyA site"
     regulatory      3248..3253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /note="hexamer: AATAAG"
     polyA_site      3271
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /note="major polyA site"
     regulatory      6855..6860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /note="hexamer: AATAAA"
     polyA_site      6872
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /note="major polyA site"
     regulatory      7394..7399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /note="hexamer: AATAAA"
     polyA_site      7419
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
     regulatory      7709..7714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /note="hexamer: AATAAA"
     polyA_site      7734
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /note="major polyA site"
     regulatory      8547..8552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
                     /note="hexamer: ATTAAA"
     polyA_site      8568
                     /gene="NXPE3"
                     /gene_synonym="FAM55C; MST115; MSTP115"
ORIGIN      
        1 gaggagacgt cgccgggtga ggaagcgggg ggctagcggc ctggcgctgc ggcgaccgac
       61 cggggcgtca ggatccctgg cccccggaga gcgaagggcg ggcgggtccc ggagcaagaa
      121 gaattgtata gaaatgtaaa aaacatttat gtgtgcttca catgtggcat gaaaaaaatg
      181 aggacctctg gtcaaaattg cctgagttca gaatttcatg ctggaaggaa agttagacgt
      241 aacttctaat ttctagttcc agtaagcatc tcttcttgga aaatttccaa aaaagagtcc
      301 tgctctgttg cccaggctgg agtacattgg tgtgatgatc atggttcact gcagcctcga
      361 cctcccaggc tcaagcaatt ctcctacctc agcctcctga gtaactggga ctataggatt
      421 tctttgaaga aaaatgtgct tcttgaatca actgcagtct ctcctctgca taagagctct
      481 taagggtact agcaggatag aagcaaatga aactgaaagc tcatctgcag ctcagaaaag
      541 caaagacatg gaattttaaa gagtgaaggt agcatggtgt cggccatggg tgaacaagac
      601 acagccagac aatgtggacc aatttcttca aactacggct tttctgctgt ctgcttgcag
      661 tgttgatggt ggtggtgctg gtcatcaatg ttactcaggt agagtacttg gaccatgaga
      721 ctgtttcagc cactttcatc gacagcagtg gacagtttgt ttcctcccag gtgacaggaa
      781 ttagccgaaa tccctactgt ggctatgatc agcagaccct gtccagccag gagcgcatgg
      841 aggaggactc cttgctggct gccttgcacc ggcaggttcc tgatgtgggc ccagtcccct
      901 ttgtgaagag cactgaccct tcttccagct actttgtcat cttgaactct gctgccttct
      961 ttaaggtggg aagccagctt gaggtgctgg ttcatgtgca ggattttcaa agaaagccca
     1021 agaagtatgg tggagactac ctgcaggcca gaattcactc cctcaagctg caggctgggg
     1081 ctgtgggcag ggtggtggat taccagaatg ggttttacaa ggttttcttt actttgctat
     1141 ggccaggcaa agttaaagta tccgtatctc tggtccaccc cagtgaaggg atcagagttc
     1201 ttcagcgctt acaggaagat aaaccagaca gggtctattt caagagtctc ttccgttcag
     1261 gaagaatttc tgaaactact gagtgcaacg tgtgtcttcc tgggaatctg cccctgtgta
     1321 actttacaga cctctacact ggggagccct ggttctgctt caaaccaaag aagctccctt
     1381 gcagcagcag aattacccat ttcaaaggtg gatacctgaa aggtctccta accgctgcag
     1441 agagtgcttt cttccagagt ggtgtcaata tcaaaatgcc agtcaactcc agtggacctg
     1501 attgggtaac tgtgattccc aggagaataa aagaaactaa cagtctagaa ctatctcaag
     1561 gctcaggaac ttttccttct gggtattatt ataaagacca gtggaggccc agaaagttta
     1621 agatgcgtca gtttaatgac cctgacaaca ttacagagtg cttacaaaga aaagtggtgc
     1681 atttatttgg tgactcaaca atcaggcaat ggtttgaata ccttactaca tttgttccag
     1741 atttagtgga gtttaacttg ggtagtccca agaatgtggg tcccttcctt gcagtggacc
     1801 agaagcacaa catcctgctc aaataccgct gccatggtcc acccatccgc ttcacgactg
     1861 tctttagcaa tgagctccat tatgtggcga atgagctgaa tggcattgtg ggagggaaga
     1921 acacagtggt tgccatagct gtatggtctc acttcagcac cttccctttg gaagtgtaca
     1981 tccggcggct caggaacatc cgtcgagcag tggttcggct cctcgatcga agcccaaaga
     2041 ccgtggtggt catccggacg gccaacgccc aagagctggg acctgaggtg agccttttca
     2101 acagcgactg gtacaacttt cagctggaca ccatccttcg gaggatgttc tcaggggttg
     2161 gagtatatct cgtcgatgcc tgggagatga ccctggccca ttatctaccg cacaagctgc
     2221 atccagatga agttattgtg aagaaccagc tggacatgtt cttgtccttt gtgtgcccct
     2281 tggaaaccta gcctgtcttg gaagggactg gaggaatcat attcaatgac cttctcaatt
     2341 gacctgagtt acagaaagtg gccccagtga gagatgactg cccttaataa gtataaaatt
     2401 tcaaaaagat ctggacttaa tatgatgact tataaggagc ttagaaaatg caggttacat
     2461 ttatatctac ctataggatt ttatccaatg ttgacttagc catggtagaa ctcttaactg
     2521 catctacaca ctatattgct cttgtaacca aagatgctaa tgagtgtatt tgaattagct
     2581 tctcctagga ggggtgacta ctttgctaaa gagtatgaaa aatgttttga tggaagggac
     2641 aagtttggtt ggtagtagag tgtttgtagc ttatctggta aaggaaattg agtgcatctg
     2701 catgcatagc acaagtaatc catcttctgg cggttaacta gagaaagctt atagtcagag
     2761 gctcttgtga atgcactgaa gactgctgtg tctcaggagt ttctcttgat gatctacctt
     2821 ttctgaatta cttgaaaagg ccaatgtgct tggttcgagt tttttagtga atatttacaa
     2881 tttcctgctt ttatctagaa aagaagcaaa agggaaatat gaaagcagta tatataaaat
     2941 ctgtgctttg gaattgatat ttgcatttgg tgattgtttt ttatttgatt cagctaaatt
     3001 ttatgtgttg aatacttact ctagaataac tacttttgga actggaaggg ggaaatctgt
     3061 aaatggaaat ttatttttat gttctgaaat ttgagggttt aggaattgac ttttgtgtaa
     3121 agaatgctac gatattataa agctgtggaa gttttttcca ctagtttcag gtgttttttt
     3181 ttttgttgtt gttgttgtta ttttgaacta cttaccaaaa ttagaagtta aaatctaatt
     3241 agaaattaat aagatactaa aattcatgac agttttttgt ttgtttgttt gtttgttttt
     3301 tggtatttct tgatttgggc ataaaaggca cacccattct ctcatgcttg gaagaagctg
     3361 ctattcctac tggctatcta agaagaatgg aattattaat tttatttgac ttattaattt
     3421 taaacgagtt taatttggga tcatttagta agtactcttt tctttttgag ctgtgataga
     3481 ttatagtcta gtttaagttg ctcctaagta gacagatgaa gaaactaggg aggctttaga
     3541 gaggaagaca gatgcttgaa gtatgaacaa tatataccct tagaagaatg ggtcaaataa
     3601 tttgggtttt taatttaaaa taggagggcc ccagatctta ctttcctgtc cttgaggaac
     3661 accttcaagt ttttaaagta ttttaggggg aaagaagatt tttaattgtt tctgagccta
     3721 atgaggtaat aaaatatatt aaaatagttt aattttaatg gtccttacgc tttacagtac
     3781 ctaaggatca cttgtagtat ctgacaaaaa tgcagaatta aagagtcatg gcagggtgtg
     3841 gtagctcaag cctgtaatcc cagcactttg ggaggccagg caggaggatt gcttgaggcc
     3901 aggagtttga gaccagcctg ggcaacatag taagacctca tctctacaaa aaataaaaaa
     3961 ttatccaggt gtgggccgac agtcccagct actagggagg ctaaggcagg gtgattgatt
     4021 gagcccagta gtttgaggct gcagtgagtt atgattgcgc cactacactc ccacttgggc
     4081 aacagacaag agatcttatc tctaaaaaat ttttgttaaa taataaaaga attaaggcca
     4141 gggatgttgg ctcacatctg taatcccagc agggattata gtctcgggag gctgaggtgg
     4201 gcggattgct tgagcccgga aggtcaagac cagcctgggt gccatggtga aaccccatct
     4261 ctacaaaaaa atacaaaaac tagctgggtg tggtggcacc acctgtagtc cccgctactt
     4321 aggaggctga ggtgggagga ttgcttgagc ccaggaggca gaaggttgca gaggttgcag
     4381 tgagccttga ttgtgccact gtactccagt ctgggcaaca gggcaagacc ctgtctctaa
     4441 aaaaaaaaaa aaaaaaaaaa gagggaccat gatgcctctg ggatttatga aaccaacctt
     4501 tgtggcgagt gctcagtgat tctgatgcaa tggtggtatt ccacactgtg agaaacacta
     4561 agagaagagg taagatagaa tgagggaata aacatggctt gtttattatt ttgggggatt
     4621 taccaataac tggtttaatt ctgttcatga tccaatagta ttggtgatat tagctccatt
     4681 ttatagatga ggaactcatg tttagatctg aaataaggta tgtgagagtc catatctctt
     4741 ttcagctaaa cttgtgagac tttcgtaaag aagcgtttgt atttatttat ttgtttttga
     4801 gacagggtct tgctcttttg cccaggctgg agtgcagtgg catgatatgg ctcactgcag
     4861 ccttgacttc ctgggctcaa gggatccttc tgcctcagcc tcctgagtag ctgggactac
     4921 aggtatgtac caccatgccc agctaatttt tgtatctttt tgtagagact acattttgcc
     4981 atgttgtcca ggctggtctt aaactcctga gctcaagcat ctgcccacct cagcttccca
     5041 aagtgctggg attacaggtg tgagccactg tgcccagctg agagtttttc ttgtcgtgaa
     5101 agaacttgac atttcctcaa ggatttataa aggaggctga ggagtaattt tcccaggaga
     5161 attttaaaaa gaaagcgggc attgctcctc cagtggtttg gaatgatgcc acttgattgt
     5221 gcaaatgatt tcttatgatc ttgtctggtt ttctgttatt ttttgatttg gtgacatagc
     5281 tctcaaagat ttggtgacac agcttcttga gtcactttca tctctcttaa aaaaattttt
     5341 tttttaacaa cttttaagtt caggggtaca tgtgccagtt tgtttcatag gtaaacttac
     5401 gtcatggggg tttgttgtat agatgatttc atcacccagg tgttaagcct agtacccatt
     5461 agtaattttt cctgatcctc tccctcctcc taccctccac cctccaatag accccagtgt
     5521 gtgttgttgc cctttatgtg tccatgtgtt ctcatcattt agctctcact tatcagtgag
     5581 aacaactttc atcccacatc taatttgtct ttcttcactc tggtgtggaa attttgatag
     5641 agattccaat atcacttaaa cgtttcccag aatatttaga tagaataatt tagtttcttc
     5701 tgaaaagttt attttaggct agtgccacat ggttgtgaat attagcatgg tagccaaata
     5761 atagtttgtt taaatgtata tttcccaata taaatataag gggcatcata atttttaaaa
     5821 actataaaat ctagaagaaa aatctatgga taaaatccat aattctatca tctgaatgca
     5881 atgaacatta gcatttaggt atattttctt gcaggttttt taaccatata cttatagaga
     5941 atatgtaatt tgggtctgtg ttttttacat ataaatattt ttctatgtta aatagtcttc
     6001 ataagttaat tataaagatc tgcttaatag ttctgctact gcagttttca ttattagata
     6061 agttggtcat tatagttgga catttaggtt tacaatatta aagcagtggt ttatatcaat
     6121 ttcagtggtt taaaatatga atttctattt tggaatgaaa gtattaattt aatgtagtga
     6181 atctcatatt ccagaactga gatgattgat ttgatgctat ttgtgacaga cagaacccat
     6241 aataaagcct ttctatgcaa gttacatttt atagaattat cctactaaaa gtaacctttc
     6301 ttcagcgaat gcaaaacaga cctttggtgt tccagtatga ttcattttgc cattctgaac
     6361 aactatcatt ttaattaaga ccatttaact gacacttcct ggattcagtt attaagtttc
     6421 agattgaaac ttgatccagt ttaataactg aatccagttt cacatttatc aatctgaaaa
     6481 cttagtttgc agattggtaa atcagggtac ttgacaagaa taaatatggt acgcctttat
     6541 atattcatgt gttacatgcc agaaatgagt ctgtttctgg accctgttca aggaaatagt
     6601 gatgactgag agaggtacag ggaaataaac acccaaggga aacaacagaa ataagcctcc
     6661 ccaactttct aaaaaactgc tcagcattat ctctgtggat tctgggtaaa ttcagctttt
     6721 taacatcagc tagtcactaa tgccagaaat tccacttcaa gtgtatttat tttcttgtgt
     6781 taagcattat tctacctggt ttatgtctac aatgtagtat tagtgtactt aggattcttg
     6841 acacctcagt gtgcaataaa taaaattttg aagttgttgt ttttcatttg aaggtgagac
     6901 cacagcccct gagtgctaag gggacctggg aatcctaggg gaatggaggt ggtggacgat
     6961 aagaggatgg ttgagggcag gagtttaaag gacacagaag ctaggagagc agaaaatgta
     7021 ctccaccacc ttctgtctaa cttgtctctt aaaagtgctt ttacatttta actttttaaa
     7081 aaaatgtggg ccgggcatag tggctcatgc ctgtaatccc agcactttgg gaggccgagg
     7141 tgggcggatc acctgaggtc aagagttcaa gaccagcctg accaatatga tgaaacccca
     7201 tctctactaa aaatacaaaa atagccaggt gtggtggcac atgcctgtca tcccagctac
     7261 tcaggaggct gaggtgggag aatcgcttga acccgggagg tggaggttgc agtgagccga
     7321 gatcatgcca ttgcactcta gcctgggcaa cgagagtgaa actctgtctc aataaataaa
     7381 taaataaata aaaaataaaa aagtgtgaac ttaaatatat ttatatgtgt gtacatatat
     7441 tttctttttt aatattctgg ttaaatgaga ggccatcggg cctcttttta agagtctaat
     7501 gatgtgtata tctaatgccc attccagctg gattgtaaca ctgcttgggg aagataactt
     7561 aaaaaaaagt agtaccgaga ttacagcagc tagtgtccta aatggaaaag aagtgaaact
     7621 aaatgtcata ggagaaatcc tttcagtttt gtgcagtggt tcatttgctg ttaaatctac
     7681 cccattacca ttccccttac tccttgaaaa taaagtgatc ttcatgttac aggaccattg
     7741 ctttatttat gtcacagatt tcttgtcctt taattagtca gtgaaggcac atgattgcga
     7801 tactactttt tgattgccgt attgtaaaag ctatatggta aaaggtaact ccctccaccc
     7861 gcccactgca ccctcacgtt taggggccac acagaaaaag cgaaataaga tgaggtgaat
     7921 ctaatgagaa ggcaactcta atgcccatca ggagattcac taggacattt taaaaggacg
     7981 tctttaagga aaaagttttg tttgtagatg ttgcctctga ttcctccctg cggctccagt
     8041 ccaggtcttg gagccggccc tcgaggggaa tgtccgggac tcgggtcggt acctttttgg
     8101 tctgggaatt tccagtgtgc agaaaaaaaa tccacaaatc taggcctcgc tgccccctcc
     8161 ctgcctcctc tggccctcct cagtgcccac gcaacccggt tcgaaagaga ggatgaccgt
     8221 attctgcatt ttagaaaaca ggctcttagc ttcccccgcc cccgtcctca ctagagtgga
     8281 gaactgaaag cgaacgctat aaagggcgcc agtgagaggg gctggcctcc tcttgccacg
     8341 aggtcagacg gcgagttctt agagaaaaag gctgcttagc tgctgcttat catgtaacct
     8401 caaaaggaaa ctgatcgtct ttctcatgct gtcacgtact tgggttatta tcgctgatta
     8461 cagctggaaa caattgattt gctcttacgt atttgtgtga cttgactctt caaacacaaa
     8521 ggtatatttt tattatctga tattttatta aaatatctta aatggtaa
//
