LOCUS       NM_182495               1868 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens neurexophilin and PC-esterase domain family member 2
            (NXPE2), mRNA.
ACCESSION   NM_182495 XM_001725616 XM_001725952 XM_001725989
VERSION     NM_182495.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1868)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1868)
  AUTHORS   Ivarsson,Y., Arnold,R., McLaughlin,M., Nim,S., Joshi,R., Ray,D.,
            Liu,B., Teyra,J., Pawson,T., Moffat,J., Li,S.S., Sidhu,S.S. and
            Kim,P.M.
  TITLE     Large-scale interaction profiling of PDZ domains through proteomic
            peptide-phage display using human and viral phage peptidomes
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), 2542-2547 (2014)
   PUBMED   24550280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002774.3.
            
            On May 17, 2019 this sequence version replaced NM_182495.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1968832 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389586.6/ ENSP00000374237.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AP002774.3         32130-32204
            76-181              AP002774.3         33260-33365
            182-915             AP002774.3         51648-52381
            916-977             AP002774.3         57594-57655
            978-1193            AP002774.3         59384-59599
            1194-1729           AP002774.3         59998-60533
            1730-1868           AP002774.3         60534-60672
FEATURES             Location/Qualifiers
     source          1..1868
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.2-q23.3"
     gene            1..1868
                     /gene="NXPE2"
                     /gene_synonym="FAM55B"
                     /note="neurexophilin and PC-esterase domain family member
                     2"
                     /db_xref="GeneID:120406"
                     /db_xref="HGNC:HGNC:26331"
     exon            1..75
                     /gene="NXPE2"
                     /gene_synonym="FAM55B"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1729
                     /gene="NXPE2"
                     /gene_synonym="FAM55B"
                     /note="protein FAM55B; family with sequence similarity 55,
                     member B"
                     /codon_start=1
                     /product="NXPE family member 2"
                     /protein_id="NP_872301.2"
                     /db_xref="CCDS:CCDS44738.1"
                     /db_xref="GeneID:120406"
                     /db_xref="HGNC:HGNC:26331"
                     /translation="MVEKILIHRILTLFPNAIARKLLLMLTFILIFWIIYLASKDHTK
                     FSFNLENHIILNQGNIFKKYSHSETPLCPAVSPKETELRIKDIMEKLDQQIPPRPFTH
                     VNTTTSATHSTATILNPQDTYCRGDQLDILLEVRDHLGHRKQYGGDFLRARMYSTALM
                     AGASGKVTDFNNGTYLVSFTLFWEGQVSLSLLLIHPSEGVSALWRARNQGCDRIIFTG
                     LFANRSSNVFTECGLTLNTNAELCQYMDDRDQEAFYCVRPQHMPCEALTHMTTRTRNI
                     SYLSKEEWRLFHRSNIGVEMMKNFTPIEVIPCNKSENIKKNCQIGMKTPFPSGYTLKK
                     MWITAFCKQIKFNETKNINDCLERKLIYLMGDSTLHQWIYYLQKAVKTLKYFDHHGAG
                     IFKTHVLLDVERHILIQWKKHGHPFVTKKLFSVKDENYIPREIDQVAGDKNTAIVITL
                     GQHFRPFPINIFIRRAINIQKAIERLFLRSPETKVILKTENTREIEQNAEMFSDFHGY
                     IQNLIIRDIFVDLNVGIIDAWDMTIAYCTNNAHPPDYVIQNQIGMFLNYIC"
     exon            76..181
                     /gene="NXPE2"
                     /gene_synonym="FAM55B"
                     /inference="alignment:Splign:2.1.0"
     exon            182..915
                     /gene="NXPE2"
                     /gene_synonym="FAM55B"
                     /inference="alignment:Splign:2.1.0"
     exon            916..977
                     /gene="NXPE2"
                     /gene_synonym="FAM55B"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1193
                     /gene="NXPE2"
                     /gene_synonym="FAM55B"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1868
                     /gene="NXPE2"
                     /gene_synonym="FAM55B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatcaaggag agtctctgga cactataatt cctgtgagaa cacgagaaga tggtggagaa
       61 aatactcatc cataggatac tcactttgtt tccaaatgcc atagctcgaa aattactgct
      121 gatgttgaca tttatcttaa ttttctggat catttacttg gcttcaaaag accacacaaa
      181 gttctcgttc aacttggaaa accatattat cctgaaccaa gggaacatct tcaaaaaata
      241 ttcacactct gaaacaccac tgtgtccagc agtttcacca aaagagactg aacttagaat
      301 aaaggacatt atggagaaac tagaccagca gatcccaccc agacctttca cccatgtgaa
      361 taccaccacc agtgccacac acagcacagc caccatcctc aaccctcaag atacgtactg
      421 caggggggat cagctggaca tccttctgga ggtgagggac cacttgggac acaggaagca
      481 atatggtggg gatttcctga gggccaggat gtactccaca gcactaatgg caggtgcttc
      541 aggaaaggtg actgacttca acaacggcac ctacctggtc agcttcactc tgttctggga
      601 gggccaggtt tccctgtctc tgctgctcat ccaccccagt gaaggggtat cagctctctg
      661 gagggcaagg aaccaaggat gtgataggat catcttcact ggcctgtttg ccaacagaag
      721 ctccaatgtc ttcactgaat gtggcctgac cctaaacaca aatgctgaac tgtgccagta
      781 catggatgac agagaccaag aagccttcta ctgtgtgagg cctcaacata tgccctgtga
      841 ggccttgacc cacatgacca ctaggacaag aaatatttcc tatcttagca aggaagaatg
      901 gaggcttttc cacaggtcca acataggagt tgaaatgatg aagaacttta cccccattga
      961 ggtcatacca tgcaacaaga gcgagaacat aaaaaagaac tgccagattg gaatgaagac
     1021 tcctttcccc agtggttata ctttgaaaaa aatgtggatt acagcatttt gtaaacagat
     1081 caagttcaat gaaacaaaaa atataaatga ctgcttggaa agaaaactta tttatctcat
     1141 gggagattca acactgcatc agtggattta ctacttacaa aaagctgtga aaaccctaaa
     1201 atattttgat catcatggag ctgggatctt taaaacacat gttcttctgg atgttgaaag
     1261 acatattttg attcagtgga aaaaacatgg tcatccattt gttaccaaaa aattattctc
     1321 agtgaaagat gaaaactata tcccacggga aattgaccag gtagcaggag acaaaaacac
     1381 agccattgtc attaccctcg gccaacactt cagacccttt cccatcaaca ttttcatccg
     1441 tagggccatc aatattcaaa aggccattga acgtctattc ttgcgaagcc cggagaccaa
     1501 ggtgatactt aaaactgaaa acaccagaga gatagaacaa aatgcagaga tgttcagtga
     1561 ctttcatggc tatattcaga atcttatcat aagagatatt tttgtggatc ttaatgtggg
     1621 tattattgat gcctgggaca tgacgattgc atattgcacc aacaatgccc atccaccgga
     1681 ttatgtgatt caaaatcaga ttggcatgtt cttaaactac atttgttaga ggaaaaatac
     1741 aaaaatagca ctagccactt tctatagatg atctcacata tacagcgaag atagtttaat
     1801 gcaatccaag ttttgaggaa actaaatttg aaaaagttct attaaagtta aatatatgta
     1861 acataaca
//
