LOCUS       NM_001395504            4972 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens neurexophilin and PC-esterase domain family member 1
            (NXPE1), transcript variant 3, mRNA.
ACCESSION   NM_001395504 XM_011542595
VERSION     NM_001395504.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4972)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4972)
  AUTHORS   Gremel,G., Wanders,A., Cedernaes,J., Fagerberg,L., Hallstrom,B.,
            Edlund,K., Sjostedt,E., Uhlen,M. and Ponten,F.
  TITLE     The human gastrointestinal tract-specific transcriptome and
            proteome as defined by RNA sequencing and antibody-based profiling
  JOURNAL   J Gastroenterol 50 (1), 46-57 (2015)
   PUBMED   24789573
REFERENCE   3  (bases 1 to 4972)
  AUTHORS   Anderson,C.A., Boucher,G., Lees,C.W., Franke,A., D'Amato,M.,
            Taylor,K.D., Lee,J.C., Goyette,P., Imielinski,M., Latiano,A.,
            Lagace,C., Scott,R., Amininejad,L., Bumpstead,S., Baidoo,L.,
            Baldassano,R.N., Barclay,M., Bayless,T.M., Brand,S., Buning,C.,
            Colombel,J.F., Denson,L.A., De Vos,M., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Fehrmann,R.S., Floyd,J.A., Florin,T.,
            Franchimont,D., Franke,L., Georges,M., Glas,J., Glazer,N.L.,
            Guthery,S.L., Haritunians,T., Hayward,N.K., Hugot,J.P., Jobin,G.,
            Laukens,D., Lawrance,I., Lemann,M., Levine,A., Libioulle,C.,
            Louis,E., McGovern,D.P., Milla,M., Montgomery,G.W., Morley,K.I.,
            Mowat,C., Ng,A., Newman,W., Ophoff,R.A., Papi,L., Palmieri,O.,
            Peyrin-Biroulet,L., Panes,J., Phillips,A., Prescott,N.J.,
            Proctor,D.D., Roberts,R., Russell,R., Rutgeerts,P., Sanderson,J.,
            Sans,M., Schumm,P., Seibold,F., Sharma,Y., Simms,L.A.,
            Seielstad,M., Steinhart,A.H., Targan,S.R., van den Berg,L.H.,
            Vatn,M., Verspaget,H., Walters,T., Wijmenga,C., Wilson,D.C.,
            Westra,H.J., Xavier,R.J., Zhao,Z.Z., Ponsioen,C.Y., Andersen,V.,
            Torkvist,L., Gazouli,M., Anagnou,N.P., Karlsen,T.H., Kupcinskas,L.,
            Sventoraityte,J., Mansfield,J.C., Kugathasan,S., Silverberg,M.S.,
            Halfvarson,J., Rotter,J.I., Mathew,C.G., Griffiths,A.M., Gearry,R.,
            Ahmad,T., Brant,S.R., Chamaillard,M., Satsangi,J., Cho,J.H.,
            Schreiber,S., Daly,M.J., Barrett,J.C., Parkes,M., Annese,V.,
            Hakonarson,H., Radford-Smith,G., Duerr,R.H., Vermeire,S.,
            Weersma,R.K. and Rioux,J.D.
  TITLE     Meta-analysis identifies 29 additional ulcerative colitis risk
            loci, increasing the number of confirmed associations to 47
  JOURNAL   Nat Genet 43 (3), 246-252 (2011)
   PUBMED   21297633
  REMARK    Erratum:[Nat Genet. 2011 Sep;43(9):919]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020549.4.
            
            On Jul 13, 2021 this sequence version replaced XM_011542595.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142348
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000534921.3/ ENSP00000439503.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC020549.4         58236-58319         c
            85-113              AC020549.4         51290-51318         c
            114-225             AC020549.4         50412-50523         c
            226-284             AC020549.4         49821-49879         c
            285-393             AC020549.4         49541-49649         c
            394-1127            AC020549.4         28613-29346         c
            1128-1189           AC020549.4         26278-26339         c
            1190-1402           AC020549.4         21317-21529         c
            1403-4972           AC020549.4         17372-20941         c
FEATURES             Location/Qualifiers
     source          1..4972
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.2"
     gene            1..4972
                     /gene="NXPE1"
                     /gene_synonym="FAM55A"
                     /note="neurexophilin and PC-esterase domain family member
                     1"
                     /db_xref="GeneID:120400"
                     /db_xref="HGNC:HGNC:28527"
     exon            1..84
                     /gene="NXPE1"
                     /gene_synonym="FAM55A"
                     /inference="alignment:Splign:2.1.0"
     exon            85..113
                     /gene="NXPE1"
                     /gene_synonym="FAM55A"
                     /inference="alignment:Splign:2.1.0"
     exon            114..225
                     /gene="NXPE1"
                     /gene_synonym="FAM55A"
                     /inference="alignment:Splign:2.1.0"
     exon            226..284
                     /gene="NXPE1"
                     /gene_synonym="FAM55A"
                     /inference="alignment:Splign:2.1.0"
     exon            285..393
                     /gene="NXPE1"
                     /gene_synonym="FAM55A"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1938
                     /gene="NXPE1"
                     /gene_synonym="FAM55A"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; protein FAM55A; family with sequence similarity
                     55, member A; NXPE family member 1"
                     /codon_start=1
                     /product="NXPE family member 1 isoform 1 precursor"
                     /protein_id="NP_001382433.1"
                     /db_xref="CCDS:CCDS91598.1"
                     /db_xref="GeneID:120400"
                     /db_xref="HGNC:HGNC:28527"
                     /translation="MSSNTMLQKTLLILISFSVVTWMIFIISQNFTKLWSALNLSISV
                     HYWNNSAKSLFPKTSLIPLKPLTETELRIKEIIEKLDQQIPPRPFTHVNTTTSATHST
                     ATILNPRDTYCRGDQLDILLEVRDHLGQRKQYGGDFLRARMSSPALTAGASGKVMDFN
                     NGTYLVSFTLFWEGQVSLSLLLIHPSEGASALWRARNQGYDKIIFKGKFVNGTSHVFT
                     ECGLTLNSNAELCEYLDDRDQEAFYCMKPQHMPCEALTYMTTRNREVSYLTDKENSLF
                     HRSKVGVEMMKDRKHIDVTNCNKREKIEETCQVGMKPPVPGGYTLQGKWITTFCNQVQ
                     LDTIKINGCLKGKLIYLLGDSTLRQWIYYFPKVVKTLKFFDLHETGIFKKHLLLDAER
                     HTQIQWKKHSYPFVTFQLYSLIDHDYIPREIDRLSGDKNTAIVITFGQHFRPFPIDIF
                     IRRAIGVQKAIERLFLRSPATKVIIKTENIREMHIETERFGDFHGYIHYLIMKDIFKD
                     LNVGIIDAWDMTIAYGTDTIHPPDHVIGNQINMFLNYIC"
     exon            394..1127
                     /gene="NXPE1"
                     /gene_synonym="FAM55A"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1189
                     /gene="NXPE1"
                     /gene_synonym="FAM55A"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1402
                     /gene="NXPE1"
                     /gene_synonym="FAM55A"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..4972
                     /gene="NXPE1"
                     /gene_synonym="FAM55A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacatttta cacagccaca agagccagtt aagaactcac aggtactttt ccagccaccc
       61 agataggaga gatcattaaa acagtgcatt ctgtgctacc tgacacctat tggtatctaa
      121 attgctctgc gcatccagat tcaaaacaca gaactttttg gattccacaa aacgaaacca
      181 ctcacacaaa acctttcaca caattgagac ttcactgagg atttgggtcc tggaaggagg
      241 aagcaacaat cctgagtgaa acctcgacaa gaagtatcca ataggacatt cgtcatgtcc
      301 tcaaatacaa tgcttcaaaa aacgctgctg atcttgatct ctttttcagt agtaacctgg
      361 atgattttta taatttctca gaacttcaca aagctttggt ctgctctaaa cttatccatc
      421 tctgtccatt actggaacaa ctccgcaaag tccttattcc ctaaaacatc actgatacca
      481 ttaaagccac taacagagac tgaactcaga ataaaggaaa tcatagagaa actagatcag
      541 cagatcccac ccagaccttt cacccatgtg aacaccacca ccagtgccac acacagcaca
      601 gccaccatcc tcaaccctcg agatacatac tgcaggggag accagctgga catcctactg
      661 gaggtgaggg accacttggg acagaggaag caatatggtg gggatttcct gagggccagg
      721 atgtcctccc cagcactgac ggcaggtgct tcaggaaagg tgatggactt caacaatggc
      781 acctacctgg tcagcttcac tctgttctgg gagggccagg tctccctgtc tctgctgctc
      841 atccacccca gtgaaggggc gtcggctctc tggagggcaa ggaaccaagg ctatgataaa
      901 attattttca aaggcaaatt tgttaatggc acctctcatg tcttcactga atgtggcctg
      961 accctaaact caaatgctga actctgtgaa tatctggatg acagagacca agaagccttc
     1021 tattgtatga agcctcaaca catgccctgt gaggctctga cctacatgac cacccggaat
     1081 agagaggtat cttatcttac agacaaggaa aacagccttt tccacaggtc caaagtggga
     1141 gttgaaatga tgaaggatcg taaacacatt gatgtcacta attgtaacaa gagagaaaaa
     1201 atagaagaga catgccaagt tggaatgaag cctcctgtcc ctggtggtta tactttacaa
     1261 ggaaaatgga taacaacatt ttgcaaccag gttcagttag acacaattaa gataaatggc
     1321 tgtttgaaag gcaaactcat ttacctcctg ggagactcta cactacgtca gtggatctac
     1381 tacttcccca aagttgtaaa aacactgaag ttttttgatc ttcatgaaac tggaatcttt
     1441 aagaaacatt tgcttctgga tgcagaaaga cacactcaga ttcaatggaa aaaacatagc
     1501 tatcccttcg tcactttcca gctctactct ctgatagatc atgattatat ccctcgggaa
     1561 attgaccggc tatcaggtga caaaaacaca gccatcgtca tcacctttgg ccagcacttt
     1621 agaccatttc ccattgacat ttttattcgc agggccatcg gtgttcaaaa ggctattgaa
     1681 agactgttcc taagaagccc agccactaaa gtgattatta agacagaaaa catcagggag
     1741 atgcacatag agacagagag gtttggagac ttccatggtt atattcacta tcttatcatg
     1801 aaggatattt tcaaagacct caacgtgggc atcattgatg cctgggacat gaccattgca
     1861 tatggcactg acactatcca cccacctgat catgtgattg gaaatcagat taacatgttc
     1921 ttaaactaca tttgctaagg gataaatact atacaaaatc actaggaacc aatctctgca
     1981 cataatccca catgtattgt aaagtaagtt ttactcattt taggaactaa ggaaaataaa
     2041 tttaaaagaa tctgtttggg gaggaaggct atgtaaggac aatgacaact gataagggat
     2101 gcaaaaccaa gagaatcatt catgaagaat gactatacca tgcctggttc tgatgctcgt
     2161 ttaaaatatt aaaaaagttt tttaaaagcc atgttattaa gctgatttga aaatatctgt
     2221 acaaattcat gatgctttct atttccaata tagatatttc ctagctctgt ctattgaaaa
     2281 ggcctaggag caatgataac ccattagcaa taatcactcc gagcacccta actgtgatgt
     2341 ctaagaaccc ttcctcaata aaagaaaaga ggcatccttg aagggaaggc tgattccagg
     2401 actggaacag aaaatatgta taccatgagc ctggacatct tgttatgcca gaaagcaaat
     2461 aatcaaagac aaatggaatc atatcatgga acagaggagg taacccaaag gagtctcttc
     2521 attggccata gatagattag ttttagcatc aaaaagacta atgactgcag ttaattgaaa
     2581 tacataatat ataaaatcca tgaggtcata gcaatacaaa aagagacatg caagaataaa
     2641 agcaaaatct ctcatgtgtc gtaagtggag ttgggtaaac ccttattttg aaaattggca
     2701 acaaaaggga aatatatgaa catttatcct ctttcctgtt aaagagaaaa tcaataaccc
     2761 taatagataa aggaaatttc ttctttttgg aagaattaca gctaatgaat acagaaagaa
     2821 cgacagaatt aggaaagcac catttaaaaa cttctactca aataagtaaa taaggcagag
     2881 atcatcagtg aatgaacttt tttaaaaggt ttgattggaa ctttactatg gatatagcag
     2941 gctgtcactt ctgaatccac tgctcaaact tagctttatt aattttaaag ctttgtaaca
     3001 gcaggacaac tggtcattat gtcctacatg atttgatgca atgtaaagta tacaacacca
     3061 cctatgaagg agcgagatct gtaagaaaga tgctcaattt ggaagtcatc attatatata
     3121 ggtgcctgct aaaaatgagg agatggtaat attttcacac acaaagggaa ctctcataca
     3181 ctcttggtgg gaatgtaagt tggtacagcc attatggaaa acagtatggc agttccccta
     3241 aaaacagaac taccatatga cccagcaatc cctctgctga gtatcccaaa ggaaatgaaa
     3301 tcagcacttc atagagatat ctgcattctc atgctcactg cagcattatt cacaatagcc
     3361 aagacagaga aacaacataa gtgcccatca atagatgaac agataaataa tttgcagtat
     3421 atatgtacaa tggaatatca ttcagcctta caaaaggaga tgctgctata tttgcaataa
     3481 catgggtgaa cctggaggac gttacgctaa gtaaaataac aatattgaag gaaagaaata
     3541 atactgaaag aaaaatattg cttgatctca cttatatatg gaacttaaaa actacacata
     3601 gaaacagggt agaatggtag ttatccaggc tgggaggaag agaaaacagg gaggtgtagg
     3661 tcaaagggta caaacttgca gttctattgg atgaatgtct agagagctaa tgtacagcat
     3721 gagaactata gttaatattg tatatggaaa atttgctgag agactagatt ttaggtattc
     3781 tacctcaatt aaaaaggtaa ttgtggccag gcacggtggc ttacgcctgt aatgccagca
     3841 ctttgggagg cctaagcggg aggatcacga ggtcaggaga tcgagaccac agtgaaaccc
     3901 cgtctttact aaaaatacaa aaaaaaatta gcgggcaagc tcgccgagat ggcaccactg
     3961 cactccagac tgggctacag agcgagactc tgtctcaaaa aacaaacaaa caaacaaaag
     4021 gtaattgtgc agtgaggaat atgttaatat actgactaca gtaatcattt cactatgcat
     4081 atgtatatca aaacatcaca ctgtatacct taaatgtatg caataaaaaa taaaagatac
     4141 atacacaaaa ttctttaaat gtcccacaca caagacaaat acgtgttcaa atacatcagt
     4201 ctctgaagcc tctgcaccac tctacacgct gctccttctg actagaatgc cctcctgccc
     4261 ctccttccac ctgtcaaact cccaatcacc ctttaaaacc agattgaatt attttcttct
     4321 gtgaagcttt ccctgacacc ccgggaaaga ataatgtttc cacagtgttt tgtcatttac
     4381 tccataaaag aaacaaaaac atgtattttt aaaagtatct gttatctcta atagcttgta
     4441 aacatcttga ggaaagagac taagttttgc ttctttttcc cccaaagaga actttattaa
     4501 aacatttacc atctctttag agagaggttt taccatctct ttagaaagct ccagaatcta
     4561 caaccaggaa taagtgttaa tgggatagaa ccaatgagag aacagcatat gatagtgaaa
     4621 tgtactttat tattaatacg aattcagtgg gctcacagaa tgaacctttt tgccaaacgg
     4681 ggggaaagca ttttctgtaa agtatcttta gaaaaatatg tataatttga aaaatggtta
     4741 tccaaattta acatttgtca tataaaaggc tcataaaacg tgtgtggctg tgtttctcaa
     4801 aattgtgggg tcaattggtc acattatgcc tagacattct ggttttgttc ttggggttaa
     4861 taatggttgt ggtcttataa gaaaaggaaa tctggaaatc ttgtccctgt tattaataca
     4921 cctgtcatta ctaataaaag tggtttgttg atatgctaaa taggttgaaa aa
//
