LOCUS       NM_001161625            1154 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens nucleoredoxin like 2 (NXNL2), transcript variant 1,
            mRNA.
ACCESSION   NM_001161625
VERSION     NM_001161625.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1154)
  AUTHORS   Li,W. and Zou,C.
  TITLE     NXNL2 Promotes Colon Cancer Proliferation and Metastasis by
            Regulating AKT Pathway
  JOURNAL   Appl Biochem Biotechnol 195 (12), 7685-7696 (2023)
   PUBMED   37084033
  REMARK    GeneRIF: NXNL2 Promotes Colon Cancer Proliferation and Metastasis
            by Regulating AKT Pathway.
REFERENCE   2  (bases 1 to 1154)
  AUTHORS   Elachouri,G., Lee-Rivera,I., Clerin,E., Argentini,M., Fridlich,R.,
            Blond,F., Ferracane,V., Yang,Y., Raffelsberger,W., Wan,J.,
            Bennett,J., Sahel,J.A., Zack,D.J. and Leveillard,T.
  TITLE     Thioredoxin rod-derived cone viability factor protects against
            photooxidative retinal damage
  JOURNAL   Free Radic Biol Med 81, 22-29 (2015)
   PUBMED   25596499
REFERENCE   3  (bases 1 to 1154)
  AUTHORS   Jaillard,C., Mouret,A., Niepon,M.L., Clerin,E., Yang,Y.,
            Lee-Rivera,I., Ait-Ali,N., Millet-Puel,G., Cronin,T., Sedmak,T.,
            Raffelsberger,W., Kinzel,B., Trembleau,A., Poch,O., Bennett,J.,
            Wolfrum,U., Lledo,P.M., Sahel,J.A. and Leveillard,T.
  TITLE     Nxnl2 splicing results in dual functions in neuronal cell survival
            and maintenance of cell integrity
  JOURNAL   Hum Mol Genet 21 (10), 2298-2311 (2012)
   PUBMED   22343139
REFERENCE   4  (bases 1 to 1154)
  AUTHORS   Lambard,S., Reichman,S., Berlinicke,C., Niepon,M.L., Goureau,O.,
            Sahel,J.A., Leveillard,T. and Zack,D.J.
  TITLE     Expression of rod-derived cone viability factor: dual role of CRX
            in regulating promoter activity and cell-type specificity
  JOURNAL   PLoS One 5 (10), e13075 (2010)
   PUBMED   20949100
  REMARK    GeneRIF: regulation of the Nucleoredoxin-like genes involves a CRX
            responsive element that can act as both as a positive regulator of
            promoter activity and as a modulator of cell-type specificity
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1154)
  AUTHORS   Chalmel,F., Leveillard,T., Jaillard,C., Lardenois,A., Berdugo,N.,
            Morel,E., Koehl,P., Lambrou,G., Holmgren,A., Sahel,J.A. and Poch,O.
  TITLE     Rod-derived Cone Viability Factor-2 is a novel
            bifunctional-thioredoxin-like protein with therapeutic potential
  JOURNAL   BMC Mol Biol 8, 74 (2007)
   PUBMED   17764561
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1154)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162729.8.
            
            On Oct 23, 2020 this sequence version replaced NM_001161625.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.376005.1,
                                           SRR14038195.118260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375854.8/ ENSP00000365014.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               AL162729.8         15823-16381
            560-1154            AL162729.8         25024-25618
FEATURES             Location/Qualifiers
     source          1..1154
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.1"
     gene            1..1154
                     /gene="NXNL2"
                     /gene_synonym="C9orf121; RDCVF2; RdCVF2L"
                     /note="nucleoredoxin like 2"
                     /db_xref="GeneID:158046"
                     /db_xref="HGNC:HGNC:30482"
                     /db_xref="MIM:615299"
     exon            1..559
                     /gene="NXNL2"
                     /gene_synonym="C9orf121; RDCVF2; RdCVF2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..728
                     /gene="NXNL2"
                     /gene_synonym="C9orf121; RDCVF2; RdCVF2L"
                     /EC_number="1.8.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleoredoxin-like protein 2; rod-derived cone viability
                     factor 2"
                     /codon_start=1
                     /product="nucleoredoxin-like protein 2 isoform 1"
                     /protein_id="NP_001155097.1"
                     /db_xref="CCDS:CCDS55325.1"
                     /db_xref="GeneID:158046"
                     /db_xref="HGNC:HGNC:30482"
                     /db_xref="MIM:615299"
                     /translation="MVDILGERHLVTCKGATVEAEAALQNKVVALYFAAARCAPSRDF
                     TPLLCDFYTALVAEARRPAPFEVVFVSADGSSQEMLDFMRELHGAWLALPFHDPYRHE
                     LRKRYNVTAIPKLVIVKQNGEVITNKGRKQIRERGLACFQDWVEAADIFQNFSV"
     exon            560..1154
                     /gene="NXNL2"
                     /gene_synonym="C9orf121; RDCVF2; RdCVF2L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1127..1132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXNL2"
                     /gene_synonym="C9orf121; RDCVF2; RdCVF2L"
                     /note="hexamer: AATAAA"
     polyA_site      1154
                     /gene="NXNL2"
                     /gene_synonym="C9orf121; RDCVF2; RdCVF2L"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgggt gccgcgctgt cgcccaggta tctggggtct ctggtgtctg agtgtctcat
       61 tgtcggcgcg aacacaattg ctccagccac aggcgaggcc tggccaaggt gtgggcgcat
      121 ctggggcagg tcttgagagg tccagcgccc ggtggtgcgg acagaggcgg ggcaccgcgg
      181 cgctcgccgc cgcctccccg caggtgatca tcctcctgca ggtgtcctcg ggtctcaggt
      241 ggctgcgtgt ctgcgccatg gttgacattc tgggcgagcg gcacctggtg acctgtaagg
      301 gcgcgacggt ggaggccgag gcggcgctgc agaacaaggt ggtggcactg tacttcgcgg
      361 cggcccggtg cgcgccgagc cgcgacttca cgccgctgct ctgcgacttc tatacggcgc
      421 tggtggccga ggcgcggcgg cccgcgccct tcgaagtggt cttcgtgtca gccgacggca
      481 gctcccagga gatgctggac ttcatgcgcg agctgcatgg cgcctggctg gcgctgccct
      541 tccacgaccc ctaccggcat gagctgagga agaggtacaa cgtcacagcc atccccaagc
      601 ttgtgattgt gaaacaaaat ggggaggtca tcaccaacaa agggcggaag cagatccggg
      661 aacgggggtt ggcctgcttc caggactggg tggaggcggc cgatatcttc cagaatttct
      721 ccgtttgaag tgggagggac ctcagagggc caggacaggt gctgcttctc cagcaccgac
      781 gctggggcaa agaggagcat gttgggttcc ttcctctgtt ggtgtgattt cattgtattt
      841 cagagcagaa gcactaagct gtggtcaaaa agcaactatt gctcaggaaa taatacactc
      901 catattttga tcatgcaggc tgtttgtatt atagttattt ttgttattct ttgcatacct
      961 ttatccacct gtgcttaagg aaggatcctc atatgttcat actgagctgt tggaaatcta
     1021 tgcaagacat ttatttgtac aagtctcttc aggtaaaata atatatttat tgataacatt
     1081 ttctggcgat ctgtttattt taatggtatg ctttcacaac tatcttaata aagtttgcaa
     1141 gctgtgtact ttaa
//
