LOCUS       NM_022052               1956 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nuclear RNA export factor 3 (NXF3), mRNA.
ACCESSION   NM_022052
VERSION     NM_022052.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1956)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1956)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1956)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1956)
  AUTHORS   Zeng,T., Wang,D., Chen,J., Chen,K., Yu,G., Chen,Q., Liu,Y., Yan,S.,
            Zhu,L., Zhou,H., Huang,A. and Tang,H.
  TITLE     AF119895 regulates NXF3 expression to promote migration and
            invasion of hepatocellular carcinoma through an interaction with
            miR-6508-3p
  JOURNAL   Exp Cell Res 363 (1), 129-139 (2018)
   PUBMED   29274323
  REMARK    GeneRIF: observations collectively demonstrate that AF119895
            modulates the repression of NXF3 by binding to miR-6508-3p
REFERENCE   5  (bases 1 to 1956)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   6  (bases 1 to 1956)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   7  (bases 1 to 1956)
  AUTHORS   Jun,L., Frints,S., Duhamel,H., Herold,A., Abad-Rodrigues,J.,
            Dotti,C., Izaurralde,E., Marynen,P. and Froyen,G.
  TITLE     NXF5, a novel member of the nuclear RNA export factor family, is
            lost in a male patient with a syndromic form of mental retardation
  JOURNAL   Curr Biol 11 (18), 1381-1391 (2001)
   PUBMED   11566096
REFERENCE   8  (bases 1 to 1956)
  AUTHORS   Yang,J., Bogerd,H.P., Wang,P.J., Page,D.C. and Cullen,B.R.
  TITLE     Two closely related human nuclear export factors utilize entirely
            distinct export pathways
  JOURNAL   Mol Cell 8 (2), 397-406 (2001)
   PUBMED   11545741
REFERENCE   9  (bases 1 to 1956)
  AUTHORS   Herold,A., Suyama,M., Rodrigues,J.P., Braun,I.C., Kutay,U.,
            Carmo-Fonseca,M., Bork,P. and Izaurralde,E.
  TITLE     TAP (NXF1) belongs to a multigene family of putative RNA export
            factors with a conserved modular architecture
  JOURNAL   Mol Cell Biol 20 (23), 8996-9008 (2000)
   PUBMED   11073998
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z75746.1 and AJ277527.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022052.1.
            
            Summary: This gene is one member of a family of nuclear RNA export
            factor genes. Common domain features of this family are a
            noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich
            repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain
            that allows heterodimerization with NTF2-related export protein-1
            (NXT1), and a ubiquitin-associated domain that mediates
            interactions with nucleoporins. The LRRs and NTF2-like domains are
            required for export activity. Alternative splicing seems to be a
            common mechanism in this gene family. The encoded protein of this
            gene has shortened LRR and ubiquitin-associated domains and its RDB
            is unable to bind RNA. It is located in the nucleoplasm but is not
            associated with either the nuclear envelope or the nucleolus.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF346619.1, AJ277527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395065.8/ ENSP00000378504.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                Z75746.1           19152-19200
            50-1945             AJ277527.1         1-1896
            1946-1956           Z75746.1           36475-36485
FEATURES             Location/Qualifiers
     source          1..1956
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..1956
                     /gene="NXF3"
                     /note="nuclear RNA export factor 3"
                     /db_xref="GeneID:56000"
                     /db_xref="HGNC:HGNC:8073"
                     /db_xref="MIM:300316"
     exon            1..148
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1716
                     /gene="NXF3"
                     /note="TAPL-3; TAP-like protein 3"
                     /codon_start=1
                     /product="nuclear RNA export factor 3"
                     /protein_id="NP_071335.1"
                     /db_xref="CCDS:CCDS14503.1"
                     /db_xref="GeneID:56000"
                     /db_xref="HGNC:HGNC:8073"
                     /db_xref="MIM:300316"
                     /translation="MSLPSGHTTGHTDQVVQRRARCWDIYQRRFSSRSEPVNPGMHSS
                     SHQQQDGDAAMHGAHMDSPVRYTPYTISPYNRKGSFRKQDQTHVNMEREQKPPERRME
                     GNMPDGTLGSWFKITVPFGIKYNEKWLLNLIQNECSVPFVPVEFHYENMHASFFVENA
                     SIAYALKNVSGKIWDEDNEKISIFVNPAGIPHFVHRELKSEKVEQIKLAMNQQCDVSQ
                     EALDIQRLPFYPDMVNRDTKMASNPRKCMAASLDVHEENIPTVMSAGEMDKWKGIEPG
                     EKCADRSPVCTTFSDTSSNINSILELFPKLLCLDGQQSPRATLCGTEAHKRLPTCKGS
                     FFGSEMLKNLVLQFLQQYYLIYDSGDRQGLLSAYHDEACFSLSIPFNPEDSAPSSFCK
                     FFKDSRNIKILKDPYLRGELLKHTKLDIVDSLSALPKTQHDLSSFLVDMWYQTEWMLC
                     FSVNGVFKEVEGQSQGSVLAFTRTFIATPGSSSSLCIVNDKLFVRDTSHQGTQSALFT
                     LVPTAFSSSVPAFSQEQQKMLPS"
     exon            149..317
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            318..471
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            472..555
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            556..660
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            661..741
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            742..811
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            812..900
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1010
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1047
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1116
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1172
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1280
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1339
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1455
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1498
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1571
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1704
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1765
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1956
                     /gene="NXF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1917..1922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXF3"
                     /note="hexamer: AATAAA"
     polyA_site      1956
                     /gene="NXF3"
                     /note="major polyA site"
ORIGIN      
        1 gtaagcaagg cttgaggctt gctctcgcct tcgtcagcag ccctcctcaa tcttctccaa
       61 actcccgtcc ccaggccaca cagattctcc tcaagagagc cctataagga cattggtaaa
      121 atgtcactgc cttcaggaca cactacgggt cacactgatc aagttgttca aagaagagca
      181 agatgttggg atatttacca aaggagattt agcagtaggt ctgaacctgt caatcctggc
      241 atgcattctt catcccatca gcagcaagat ggagatgcag caatgcatgg tgcccacatg
      301 gactctccag taagatacac tccctatact atttcaccct ataatcggaa aggcagtttt
      361 cgtaaacaag accaaaccca cgttaacatg gagagagagc aaaaacctcc agagagaaga
      421 atggagggga acatgccgga tgggacctta gggagctggt tcaagatcac agttcccttt
      481 ggcataaaat acaatgagaa gtggctgctg aatttgattc agaatgaatg cagtgtaccc
      541 ttcgtcccag ttgagtttca ctatgaaaac atgcatgcca gcttctttgt ggagaatgcc
      601 agcatcgcct atgcactgaa gaatgtcagt ggcaagattt gggatgagga taatgaaaag
      661 atatcaatct ttgtcaaccc tgctggcata ccccactttg tgcacaggga gctgaagtca
      721 gaaaaggtgg agcagataaa gctggccatg aaccaacagt gtgatgtctc ccaggaagct
      781 cttgatatcc agagactccc attttaccca gacatggtga accgtgatac taagatggca
      841 tcgaatccta gaaagtgcat ggctgcctcc ctggacgtcc atgaagagaa catacctaca
      901 gtgatgtctg caggggagat ggacaagtgg aaagggatag agccaggaga gaagtgtgcg
      961 gacagaagcc cagtgtgcac gaccttctcg gatacctcca gcaacataaa ctccatcctg
     1021 gaattgttcc ccaaattatt atgcctggat ggccagcagt cacccagagc aactttatgt
     1081 ggtactgaag cccacaagag gttaccaacc tgtaagggaa gcttctttgg atctgagatg
     1141 ttgaagaatc tggtcctgca attcctgcag cagtattact tgatctatga ctctggagat
     1201 cgacagggtc tccttagtgc ttaccacgat gaggcctgct tctccctgag cattcccttc
     1261 aatcctgagg actcagcccc gagcagcttc tgcaagttct tcaaggatag caggaatata
     1321 aaaattctca aggaccccta ccttcggggg gagctgctga agcacacaaa acttgatatt
     1381 gtggactccc tcagtgcgtt gcctaaaact cagcatgacc tcagctcctt cctggtggac
     1441 atgtggtacc agacggaatg gatgctctgc ttttctgtca acggggtgtt caaggaagtg
     1501 gaaggacagt ctcagggttc tgttctcgcc ttcacccgga ccttcattgc tacccctggc
     1561 agcagttcca gtctgtgcat cgtgaatgac aagctctttg tgcgggatac cagccaccaa
     1621 gggacccaga gtgccttgtt caccctagtg cccacagcct tctccagctc cgtgcctgcc
     1681 ttctcccagg agcagcagaa aatgctgcct tcgtaacaac cagtgtgact acgtcagagc
     1741 tcctcatgtt cttgcatggc ccaagatgta tttccctgtg actgaaccag gagatctggc
     1801 tggggctaag aagccgaagc ccaactcaca gggctgactc tcatccttcc aaaggggcca
     1861 gttgttctgt gcacttgtcc acccctgtta cccccaggat ctctgttcct tttcacaata
     1921 aagtatggtg tcttgttatg tcaaatccct gcaaaa
//
