LOCUS       NP_071335                531 aa            linear   PRI 27-APR-2025
DEFINITION  nuclear RNA export factor 3 [Homo sapiens].
ACCESSION   NP_071335
VERSION     NP_071335.1
DBSOURCE    REFSEQ: accession NM_022052.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 531)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 531)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 531)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 531)
  AUTHORS   Zeng,T., Wang,D., Chen,J., Chen,K., Yu,G., Chen,Q., Liu,Y., Yan,S.,
            Zhu,L., Zhou,H., Huang,A. and Tang,H.
  TITLE     AF119895 regulates NXF3 expression to promote migration and
            invasion of hepatocellular carcinoma through an interaction with
            miR-6508-3p
  JOURNAL   Exp Cell Res 363 (1), 129-139 (2018)
   PUBMED   29274323
  REMARK    GeneRIF: observations collectively demonstrate that AF119895
            modulates the repression of NXF3 by binding to miR-6508-3p
REFERENCE   5  (residues 1 to 531)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   6  (residues 1 to 531)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   7  (residues 1 to 531)
  AUTHORS   Jun,L., Frints,S., Duhamel,H., Herold,A., Abad-Rodrigues,J.,
            Dotti,C., Izaurralde,E., Marynen,P. and Froyen,G.
  TITLE     NXF5, a novel member of the nuclear RNA export factor family, is
            lost in a male patient with a syndromic form of mental retardation
  JOURNAL   Curr Biol 11 (18), 1381-1391 (2001)
   PUBMED   11566096
REFERENCE   8  (residues 1 to 531)
  AUTHORS   Yang,J., Bogerd,H.P., Wang,P.J., Page,D.C. and Cullen,B.R.
  TITLE     Two closely related human nuclear export factors utilize entirely
            distinct export pathways
  JOURNAL   Mol Cell 8 (2), 397-406 (2001)
   PUBMED   11545741
REFERENCE   9  (residues 1 to 531)
  AUTHORS   Herold,A., Suyama,M., Rodrigues,J.P., Braun,I.C., Kutay,U.,
            Carmo-Fonseca,M., Bork,P. and Izaurralde,E.
  TITLE     TAP (NXF1) belongs to a multigene family of putative RNA export
            factors with a conserved modular architecture
  JOURNAL   Mol Cell Biol 20 (23), 8996-9008 (2000)
   PUBMED   11073998
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z75746.1 and AJ277527.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene is one member of a family of nuclear RNA export
            factor genes. Common domain features of this family are a
            noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich
            repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain
            that allows heterodimerization with NTF2-related export protein-1
            (NXT1), and a ubiquitin-associated domain that mediates
            interactions with nucleoporins. The LRRs and NTF2-like domains are
            required for export activity. Alternative splicing seems to be a
            common mechanism in this gene family. The encoded protein of this
            gene has shortened LRR and ubiquitin-associated domains and its RDB
            is unable to bind RNA. It is located in the nucleoplasm but is not
            associated with either the nuclear envelope or the nucleolus.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF346619.1, AJ277527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395065.8/ ENSP00000378504.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     Protein         1..531
                     /product="nuclear RNA export factor 3"
                     /note="TAPL-3; TAP-like protein 3"
                     /calculated_mol_wt=59971
     Region          33..59
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H4D5.1)"
     Region          83..106
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H4D5.1)"
     Region          113..192
                     /region_name="Tap-RNA_bind"
                     /note="Tap, RNA-binding; pfam09162"
                     /db_xref="CDD:462696"
     Region          115..192
                     /region_name="noncanonical RNP-type RNA-binding (RBD)
                     domain"
     Region          193..329
                     /region_name="leucine-rich repeat (LRR) domains"
     Region          218..260
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275382"
     Region          275..305
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275382"
     Region          339..461
                     /region_name="nuclear transport factor 2 (NTF2)-like
                     domain"
     Region          341..496
                     /region_name="NTF2"
                     /note="Nuclear transport factor 2 (NTF2) domain plays an
                     important role in the trafficking of macromolecules, ions
                     and small molecules between the cytoplasm and nucleus.
                     This bi-directional transport of macromolecules across the
                     nuclear envelope requires many...; cd00780"
                     /db_xref="CDD:238403"
     Site            order(369,375,415,440,442..443,452,478,489..491,493,495)
                     /site_type="active"
                     /note="TAP/p15 interaction [active]"
                     /db_xref="CDD:238403"
     Site            order(373,375..376,435..436,440,442..443,450,454..456,460,
                     466..469,472,478,489..491,493..496)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238403"
     Site            order(376..377,427,430,455,457,459..460,466,469,492,494,
                     496)
                     /site_type="active"
                     /note="RanGDP-NTF2 interaction [active]"
                     /db_xref="CDD:238403"
     Region          524..531
                     /region_name="ubiquitin-associated domain"
     CDS             1..531
                     /gene="NXF3"
                     /coded_by="NM_022052.2:121..1716"
                     /db_xref="CCDS:CCDS14503.1"
                     /db_xref="GeneID:56000"
                     /db_xref="HGNC:HGNC:8073"
                     /db_xref="MIM:300316"
ORIGIN      
        1 mslpsghttg htdqvvqrra rcwdiyqrrf ssrsepvnpg mhssshqqqd gdaamhgahm
       61 dspvrytpyt ispynrkgsf rkqdqthvnm ereqkpperr megnmpdgtl gswfkitvpf
      121 gikynekwll nliqnecsvp fvpvefhyen mhasffvena siayalknvs gkiwdednek
      181 isifvnpagi phfvhrelks ekveqiklam nqqcdvsqea ldiqrlpfyp dmvnrdtkma
      241 snprkcmaas ldvheenipt vmsagemdkw kgiepgekca drspvcttfs dtssninsil
      301 elfpkllcld gqqspratlc gteahkrlpt ckgsffgsem lknlvlqflq qyyliydsgd
      361 rqgllsayhd eacfslsipf npedsapssf ckffkdsrni kilkdpylrg ellkhtkldi
      421 vdslsalpkt qhdlssflvd mwyqtewmlc fsvngvfkev egqsqgsvla ftrtfiatpg
      481 sssslcivnd klfvrdtshq gtqsalftlv ptafsssvpa fsqeqqkmlp s
//
