LOCUS       NM_022053               2336 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens nuclear RNA export factor 2 (NXF2), mRNA.
ACCESSION   NM_022053 XM_936298
VERSION     NM_022053.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2336)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2336)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2336)
  AUTHORS   Viphakone,N., Cumberbatch,M.G., Livingstone,M.J., Heath,P.R.,
            Dickman,M.J., Catto,J.W. and Wilson,S.A.
  TITLE     Luzp4 defines a new mRNA export pathway in cancer cells
  JOURNAL   Nucleic Acids Res 43 (4), 2353-2366 (2015)
   PUBMED   25662211
REFERENCE   4  (bases 1 to 2336)
  AUTHORS   Zhou,J., Li,Y., Yao,Y., Wang,L., Gao,L., Gao,X., Luo,X., Li,J.,
            Jiang,M., Zhou,M., Wang,L. and Yu,L.
  TITLE     The cancer-testis antigen NXF2 is activated by the hypomethylating
            agent decitabine in acute leukemia cells in vitro and in vivo
  JOURNAL   Mol Med Rep 8 (5), 1549-1555 (2013)
   PUBMED   24002123
  REMARK    GeneRIF: Low NXF2 expression is associated with leukemia.
REFERENCE   5  (bases 1 to 2336)
  AUTHORS   Chen,C.P., Su,Y.N., Lin,H.H., Chern,S.R., Tsai,F.J., Wu,P.C.,
            Lee,C.C., Chen,Y.T. and Wang,W.
  TITLE     De novo duplication of Xq22.1-->q24 with a disruption of the NXF
            gene cluster in a mentally retarded woman with short stature and
            premature ovarian failure
  JOURNAL   Taiwan J Obstet Gynecol 50 (3), 339-344 (2011)
   PUBMED   22030050
REFERENCE   6  (bases 1 to 2336)
  AUTHORS   Zhang,M., Wang,Q. and Huang,Y.
  TITLE     Fragile X mental retardation protein FMRP and the RNA export factor
            NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells
  JOURNAL   Proc Natl Acad Sci U S A 104 (24), 10057-10062 (2007)
   PUBMED   17548835
REFERENCE   7  (bases 1 to 2336)
  AUTHORS   Takano,K., Miki,T., Katahira,J. and Yoneda,Y.
  TITLE     NXF2 is involved in cytoplasmic mRNA dynamics through interactions
            with motor proteins
  JOURNAL   Nucleic Acids Res 35 (8), 2513-2521 (2007)
   PUBMED   17403691
REFERENCE   8  (bases 1 to 2336)
  AUTHORS   Loriot,A., Boon,T. and De Smet,C.
  TITLE     Five new human cancer-germline genes identified among 12 genes
            expressed in spermatogonia
  JOURNAL   Int J Cancer 105 (3), 371-376 (2003)
   PUBMED   12704671
REFERENCE   9  (bases 1 to 2336)
  AUTHORS   Jun,L., Frints,S., Duhamel,H., Herold,A., Abad-Rodrigues,J.,
            Dotti,C., Izaurralde,E., Marynen,P. and Froyen,G.
  TITLE     NXF5, a novel member of the nuclear RNA export factor family, is
            lost in a male patient with a syndromic form of mental retardation
  JOURNAL   Curr Biol 11 (18), 1381-1391 (2001)
   PUBMED   11566096
REFERENCE   10 (bases 1 to 2336)
  AUTHORS   Herold,A., Suyama,M., Rodrigues,J.P., Braun,I.C., Kutay,U.,
            Carmo-Fonseca,M., Bork,P. and Izaurralde,E.
  TITLE     TAP (NXF1) belongs to a multigene family of putative RNA export
            factors with a conserved modular architecture
  JOURNAL   Mol Cell Biol 20 (23), 8996-9008 (2000)
   PUBMED   11073998
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC234791.5.
            
            On Dec 4, 2019 this sequence version replaced NM_022053.3.
            
            Summary: This gene encodes a member of a family of nuclear RNA
            export proteins. The encoded protein is associated with the nuclear
            envelope and aids in the export of mRNAs. There is a closely
            related paralog of this gene located adjacent on chromosome X and
            on the opposite strand. [provided by RefSeq, Aug 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015020.1, SRR11853566.29935.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000625106.4/ ENSP00000485586.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC234791.5         76033-76104
            73-194              AC234791.5         77303-77424
            195-290             AC234791.5         135892-135987
            291-480             AC234791.5         145829-146018
            481-631             AC234791.5         146245-146395
            632-715             AC234791.5         146699-146782
            716-820             AC234791.5         146894-146998
            821-901             AC234791.5         147114-147194
            902-971             AC234791.5         147381-147450
            972-1060            AC234791.5         147607-147695
            1061-1168           AC234791.5         147816-147923
            1169-1278           AC234791.5         148103-148212
            1279-1315           AC234791.5         149891-149927
            1316-1384           AC234791.5         150308-150376
            1385-1440           AC234791.5         150463-150518
            1441-1548           AC234791.5         150650-150757
            1549-1607           AC234791.5         150878-150936
            1608-1723           AC234791.5         151075-151190
            1724-1766           AC234791.5         151286-151328
            1767-1839           AC234791.5         151929-152001
            1840-2022           AC234791.5         152536-152718
            2023-2083           AC234791.5         155129-155189
            2084-2336           AC234791.5         155336-155588
FEATURES             Location/Qualifiers
     source          1..2336
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..2336
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /note="nuclear RNA export factor 2"
                     /db_xref="GeneID:56001"
                     /db_xref="HGNC:HGNC:8072"
                     /db_xref="MIM:300315"
     exon            1..72
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            73..194
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            195..290
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..2128
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /note="cancer/testis antigen 39; TAP-like protein 2;
                     t-complex protein 11 homolog"
                     /codon_start=1
                     /product="nuclear RNA export factor 2"
                     /protein_id="NP_071336.1"
                     /db_xref="CCDS:CCDS14497.1"
                     /db_xref="GeneID:56001"
                     /db_xref="HGNC:HGNC:8072"
                     /db_xref="MIM:300315"
                     /translation="MCSTLKKCGTYRTEVAECHDHGSTFQGRKKGGSSFRDNFDKRSC
                     HYEHGGYERPPSHCQENDGSVEMRDVHKDQQLRHTPYSIRCERRMKWHSEDEIRITTW
                     RNRKPPERKMSQNTQDGYTRNWFKVTIPYGIKYDKAWLMNSIQSHCSDRFTPVDFHYV
                     RNRACFFVQDASAASALKDVSYKIYDDENQKICIFVNHSTAPYSVKNKLKPGQMEMLK
                     LTMNKRYNVSQQALDLQNLRFDPDLMGRDIDIILNRRNCMAATLKIIERNFPELLSLN
                     LCNNKLYQLDGLSDITEKAPKVKTLNLSKNKLESAWELGKVKGLKLEELWLEGNPLCS
                     TFSDQSAYVSAIRDCFPKLLRLDGRELSAPVIVDIDSSETMKPCKENFTGSETLKHLV
                     LQFLQQYYSIYDSGDRQGLLGAYHDEACFSLAIPFDPKDSAPSSLCKYFEDSRNMKTL
                     KDPYLKGELLRRTKRDIVDSLSALPKTQHDLSSILVDVWCQTERMLCFSVNGVFKEVE
                     GQSQGSVLAFTRTFIATPGSSSSLCIVNDELFVRDASPQETQSAFSIPVSTLSSSSEP
                     SLSQEQQEMVQAFSAQSGMKLEWSQKCLQDNEWNYTRAGQAFTMLQTEGKIPAEAFKQ
                     IS"
     exon            291..480
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            481..631
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..715
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..820
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            821..901
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..971
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1060
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1168
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1278
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1315
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1384
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1440
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1548
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1607
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1723
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1766
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1839
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2022
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2083
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2336
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2309..2314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /note="hexamer: AATAAA"
     polyA_site      2336
                     /gene="NXF2"
                     /gene_synonym="CT39; TAPL-2; TCP11X2"
                     /note="major polyA site"
ORIGIN      
        1 gcgtcttgtt tgtggcaaga ttctgagggg aagtgtagct cccaggttgg ttccaagtct
       61 tcttccaatt aggatcttat ccaggacgct tcattgcatt tggtcttcat ttctccttag
      121 tctcctccag gctgacattt cctcaatctt tattggtctt ccacagccct gacacttttg
      181 gagataccag tcagcatttc caagttcgtt ctgtgagact gtagtgtcag gacaaagcaa
      241 caacaaaatg tgctctactc taaagaagtg tgggacatac agaactgaag ttgcagaatg
      301 ccatgaccat ggtagcactt ttcaaggaag aaagaaaggt gggagttctt tccgggataa
      361 ttttgacaag aggagctgtc attatgaaca tggtgggtat gagcgcccgc cttcacactg
      421 ccaggagaat gatggaagcg tggagatgag ggatgtccac aaggaccaac aactaagaca
      481 cactccttat agcatccgat gcgaaagaag aatgaaatgg catagtgaag acgaaatccg
      541 tattaccacg tggagaaata gaaaacctcc ggagagaaaa atgagtcaga acacacagga
      601 tggatacaca aggaactggt ttaaggtcac aattccttac gggataaagt atgacaaggc
      661 atggctaatg aattcaatcc agagccattg cagtgaccgc ttcactccgg ttgatttcca
      721 ctacgtccga aatcgggcat gcttctttgt ccaggatgct agcgctgcct ccgcattgaa
      781 ggatgtcagt tataagattt atgatgatga gaaccaaaag atatgtatat ttgtcaatca
      841 ttctactgcg ccctactctg tgaagaataa gttgaagcca ggccaaatgg agatgctaaa
      901 gctgaccatg aacaaacggt acaatgtctc ccagcaagct cttgatctcc agaatctccg
      961 ctttgaccca gacttgatgg gccgtgacat tgatataatc ctgaatcgaa gaaactgcat
     1021 ggctgccacc ctgaagatca ttgaaagaaa tttccctgag ctgttgtctt tgaacttgtg
     1081 caacaacaag ctgtaccagc tggatggcct ttctgacatt acagagaagg ctcccaaagt
     1141 caagaccctg aatctctcca aaaataagct ggagtcggcg tgggagttgg gcaaggtgaa
     1201 agggctgaag ctcgaagagc tatggctaga agggaacccg ttgtgcagca ccttctcgga
     1261 ccagtccgcc tatgtaagtg ccatccggga ttgtttcccc aagttgttac gcctggacgg
     1321 ccgagagtta tccgcaccag tgattgttga cattgacagc tctgagacaa tgaaaccctg
     1381 caaggaaaac tttactggat ctgagaccct aaagcattta gtcctgcaat tcctgcagca
     1441 gtattactcg atctatgact ctggagatcg acagggtctc ctcggtgctt accacgatga
     1501 ggcctgcttc tccttggcta ttcccttcga ccccaaggac tcagccccga gcagcttgtg
     1561 caagtacttt gaggatagca ggaatatgaa aacactcaag gacccctacc tgaaggggga
     1621 actgctgagg cgcacaaaac gtgacattgt ggactccctc agtgcgttgc ccaaaactca
     1681 gcatgacctc agctccatcc tggtggacgt gtggtgccag acggaaagga tgctctgctt
     1741 ttctgtcaat ggggttttca aggaagtgga aggacagtct cagggttctg ttctcgcctt
     1801 cacccggacc ttcattgcta cccctggcag cagttccagt ctgtgcatcg tgaatgacga
     1861 gctgtttgtg agggatgcca gcccccaaga gactcagagt gccttctcca tcccagtgtc
     1921 cacactctcc tccagctctg agccctccct ctcccaggag cagcaggaaa tggtgcaggc
     1981 tttctctgcc cagtctggga tgaaactgga gtggtctcag aagtgccttc aggacaatga
     2041 gtggaactac actagagctg gccaggcctt cactatgctc cagaccgagg gcaagatccc
     2101 cgcggaggcc ttcaagcaaa tctcctaaaa ggagccctcc gatgtcttct ttgtcttcgt
     2161 tcacatcctc tttgtttcct cttttcacca gcctaaggcc tggctgacca ggaagccaac
     2221 gttaacttgc aggccacgtg acataaccac ccaaagagcc agttgctctg tgtattcgcc
     2281 ccactcatga tcaccatttt attttcataa taaagagtga cgttacacgt tgtaca
//
