LOCUS       NM_006362               2290 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens nuclear RNA export factor 1 (NXF1), transcript variant
            1, mRNA.
ACCESSION   NM_006362
VERSION     NM_006362.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2290)
  AUTHORS   Ebara,S., Yoshida,M., Yamakawa,H., Shimokawa,K., Inoue,Y.,
            Tauchi,H. and Morishita,D.
  TITLE     Interaction of CDK12 with NXF1 is a new node for the linking
            mechanism between transcription and transportation of mRNA
  JOURNAL   Biochem Biophys Res Commun 735, 150608 (2024)
   PUBMED   39270556
  REMARK    GeneRIF: Interaction of CDK12 with NXF1 is a new node for the
            linking mechanism between transcription and transportation of mRNA.
REFERENCE   2  (bases 1 to 2290)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2290)
  AUTHORS   Jin,T., Yang,L., Chang,C., Luo,H., Wang,R., Gan,Y., Sun,Y., Guo,Y.,
            Tang,R., Chen,S., Meng,D., Dai,P. and Liu,M.
  TITLE     HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via
            ALYREF/NXF1 Complex to Foster Breast Cancer Development
  JOURNAL   Adv Sci (Weinh) 11 (24), e2307639 (2024)
   PUBMED   38626369
  REMARK    GeneRIF: HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective
            Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development.
REFERENCE   4  (bases 1 to 2290)
  AUTHORS   Luo,F., Zou,P., Liao,Y., Luo,J., Luo,D., Hu,K., Zhang,K. and
            Wang,B.
  TITLE     Association between TAP gene polymorphisms and tuberculosis
            susceptibility in a Han Chinese population in Guangdong
  JOURNAL   Mol Genet Genomics 297 (3), 779-790 (2022)
   PUBMED   35325275
  REMARK    GeneRIF: Association between TAP gene polymorphisms and
            tuberculosis susceptibility in a Han Chinese population in
            Guangdong.
REFERENCE   5  (bases 1 to 2290)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2290)
  AUTHORS   Li,Y., Bor,Y.C., Misawa,Y., Xue,Y., Rekosh,D. and Hammarskjold,M.L.
  TITLE     An intron with a constitutive transport element is retained in a
            Tap messenger RNA
  JOURNAL   Nature 443 (7108), 234-237 (2006)
   PUBMED   16971948
  REMARK    GeneRIF: results indicate that Tap regulates expression of its own
            intron-containing RNA through a CTE (constitutive transport
            element)-mediated mechanism
REFERENCE   7  (bases 1 to 2290)
  AUTHORS   Wilson,K.F., Fortes,P., Singh,U.S., Ohno,M., Mattaj,I.W. and
            Cerione,R.A.
  TITLE     The nuclear cap-binding complex is a novel target of growth factor
            receptor-coupled signal transduction
  JOURNAL   J Biol Chem 274 (7), 4166-4173 (1999)
   PUBMED   9933612
REFERENCE   8  (bases 1 to 2290)
  AUTHORS   Gruter,P., Tabernero,C., von Kobbe,C., Schmitt,C., Saavedra,C.,
            Bachi,A., Wilm,M., Felber,B.K. and Izaurralde,E.
  TITLE     TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export
            from the nucleus
  JOURNAL   Mol Cell 1 (5), 649-659 (1998)
   PUBMED   9660949
REFERENCE   9  (bases 1 to 2290)
  AUTHORS   Arai,Y., Hosoda,F., Kobayashi,H., Arai,K., Hayashi,Y., Kamada,N.,
            Kaneko,Y. and Ohki,M.
  TITLE     The inv(11)(p15q22) chromosome translocation of de novo and
            therapy-related myeloid malignancies results in fusion of the
            nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10
  JOURNAL   Blood 89 (11), 3936-3944 (1997)
   PUBMED   9166830
REFERENCE   10 (bases 1 to 2290)
  AUTHORS   Yoon,D.W., Lee,H., Seol,W., DeMaria,M., Rosenzweig,M. and Jung,J.U.
  TITLE     Tap: a novel cellular protein that interacts with tip of
            herpesvirus saimiri and induces lymphocyte aggregation
  JOURNAL   Immunity 6 (5), 571-582 (1997)
   PUBMED   9175835
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001160.4, BC004904.2 and
            BC028041.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006362.4.
            
            Summary: This gene is one member of a family of nuclear RNA export
            factor genes. Common domain features of this family are a
            noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich
            repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain
            that allows heterodimerization with NTF2-related export protein-1
            (NXT1), and a ubiquitin-associated domain that mediates
            interactions with nucleoporins. The LRRs and NTF2-like domains are
            required for export activity. Alternative splicing seems to be a
            common mechanism in this gene family. The encoded protein of this
            gene shuttles between the nucleus and the cytoplasm and binds in
            vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast
            protein Mex67p. The encoded protein overcomes the mRNA export block
            caused by the presence of saturating amounts of CTE (constitutive
            transport element) RNA of type D retroviruses. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028041.1, AF112880.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294172.7/ ENSP00000294172.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AP001160.4         82675-82741         c
            68-2249             BC004904.2         57-2238
            2250-2290           BC028041.1         2232-2272
FEATURES             Location/Qualifiers
     source          1..2290
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..2290
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /note="nuclear RNA export factor 1"
                     /db_xref="GeneID:10482"
                     /db_xref="HGNC:HGNC:8071"
                     /db_xref="MIM:602647"
     exon            1..112
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1944
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /note="isoform 1 is encoded by transcript variant 1; tip
                     associating protein; mRNA export factor TAP;
                     tip-associated protein"
                     /codon_start=1
                     /product="nuclear RNA export factor 1 isoform 1"
                     /protein_id="NP_006353.2"
                     /db_xref="CCDS:CCDS8037.1"
                     /db_xref="GeneID:10482"
                     /db_xref="HGNC:HGNC:8071"
                     /db_xref="MIM:602647"
                     /translation="MADEGKSYSEHDDERVNFPQRKKKGRGPFRWKYGEGNRRSGRGG
                     SGIRSSRLEEDDGDVAMSDAQDGPRVRYNPYTTRPNRRGDTWHDRDRIHVTVRRDRAP
                     PERGGAGTSQDGTSKNWFKITIPYGRKYDKAWLLSMIQSKCSVPFTPIEFHYENTRAQ
                     FFVEDASTASALKAVNYKILDRENRRISIIINSSAPPHTILNELKPEQVEQLKLIMSK
                     RYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPELLSLNLSNNR
                     LYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELWLDGNSLCDTFRDQ
                     STYISAIRERFPKLLRLDGHELPPPIAFDVEAPTTLPPCKGSYFGTENLKSLVLHFLQ
                     QYYAIYDSGDRQGLLDAYHDGACCSLSIPFIPQNPARSSLAEYFKDSRNVKKLKDPTL
                     RFRLLKHTRLNVVAFLNELPKTQHDVNSFVVDISAQTSTLLCFSVNGVFKEVDGKSRD
                     SLRAFTRTFIAVPASNSGLCIVNDELFVRNASSEEIQRAFAMPAPTPSSSPVPTLSPE
                     QQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAFMK"
     exon            113..299
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            300..453
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            454..537
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            538..642
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            643..723
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            724..793
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            794..882
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            883..990
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1100
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1137
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1206
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1262
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1370
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1429
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1545
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1588
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1661
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1844
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1905
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2290
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2231..2236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /note="hexamer: TATAAA"
     polyA_site      2249
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /note="major polyA site"
     regulatory      2272..2277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /note="hexamer: TATAAA"
     polyA_site      2290
                     /gene="NXF1"
                     /gene_synonym="MEX67; TAP"
                     /note="major polyA site"
ORIGIN      
        1 acttcggtcc tgagcgcttg ggagttaggt tgtttgccgg cgtagcggcc agcgcctgag
       61 cccgcccttg atcttcgctg tggcatggcg gacgagggga agtcgtacag cgaacacgat
      121 gatgaacgcg ttaatttccc tcaaagaaag aagaaaggcc ggggtccctt ccggtggaaa
      181 tatggtgaag gaaaccgtag gtctggaaga ggcggttctg gtattcggtc ttcccgcctt
      241 gaggaagatg atggagatgt ggcaatgagt gatgcccagg atggtccccg agtacgatac
      301 aacccctata ccacccgacc taaccgtcgg ggtgatactt ggcatgatcg agatcgcatt
      361 catgttactg tgcggagaga cagagctcct ccagagagag gaggggctgg caccagccag
      421 gatgggacct caaagaactg gttcaagatt acaattcctt atggcagaaa gtatgacaag
      481 gcatggctcc tgagcatgat tcagagcaag tgcagtgtgc ccttcacccc tattgagttt
      541 cactatgaga atacacgggc ccagttcttc gttgaagacg ccagtactgc ctctgcattg
      601 aaggctgtca actataagat tttggatcgg gagaaccgaa ggatatctat catcatcaac
      661 tcttctgctc caccccacac tatactgaat gaactgaagc cagaacaagt agaacagcta
      721 aagctgatca tgagcaaacg atacgatggc tcccaacaag cccttgacct caaaggcctc
      781 cgttcagacc cagatttggt ggcccagaac attgacgttg tcctgaatcg cagaagctgt
      841 atggcagcta ccctgaggat cattgaagag aacatccctg agctattgtc cttgaacttg
      901 agcaacaaca ggctgtacag gctggatgac atgtctagca ttgttcagaa ggcacccaac
      961 ctgaagatcc taaacctttc tggaaatgaa ttgaagtctg agcgggaatt ggacaagata
     1021 aaggggctga agctagaaga gctctggctc gatggaaact ccctgtgtga caccttccga
     1081 gaccagtcca cctacatcag cgccattcgc gaacgatttc ccaagttact acgcctggat
     1141 ggccatgagc tacccccacc aattgccttt gatgttgaag cccccacgac gttaccgccc
     1201 tgcaagggaa gctattttgg aacagaaaac ttgaagagtc tggtcttgca cttcctgcaa
     1261 cagtactatg caatttacga ctctggagac cgacaagggc tcctggatgc ctaccatgat
     1321 ggggcctgct gttccctgag cattcctttc attcctcaga accctgcccg aagcagctta
     1381 gccgagtatt tcaaggatag cagaaatgtg aagaagctta aagaccctac cttgcggttc
     1441 cggctgctga agcacacgcg tctcaacgtt gttgccttcc tcaatgagtt gcccaaaacc
     1501 cagcacgacg tcaattcctt cgtggtagac ataagcgccc agacaagcac attgctgtgt
     1561 ttttctgtca atggagtctt caaggaagtg gacggaaagt cccgggattc tttgcgagcc
     1621 ttcacccgga cattcattgc tgttcctgct agcaattcag ggctatgtat tgtaaatgat
     1681 gagctatttg tgcggaatgc cagttctgaa gagatccaaa gagccttcgc tatgcctgca
     1741 cccacgcctt cctccagccc ggtgcccacc ctctctccag agcagcagga aatgttgcaa
     1801 gcattctcta cccagtctgg catgaacctc gagtggtccc agaagtgcct tcaggacaac
     1861 aactgggact acaccagatc tgcccaggcc ttcactcatc tcaaggccaa gggcgagatc
     1921 ccagaagtgg cattcatgaa gtgatcgtag tcatgcctca gaagcagtcc cccctgtaaa
     1981 tagtccttgg atattaccgt ctggttgtcg tctgtcatct cctcctgtct ggcccgaggc
     2041 cgccccgtga ctgtgaccga gggagggagg gctgcctgat ccctctcctc gcctgccttc
     2101 tggaagactt cagaagattg agcctcactg gtgccaggaa gccaaagctt actttgtaga
     2161 actgacacta aactacccga aggacttagg tgctttgtgt acttaacccc aggacctcct
     2221 tactttttaa tataaagagt gatgttgtat ttcgtgttct gcacttttta atataaagag
     2281 tgatgttgta
//
