LOCUS       NM_001144990            7800 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens NACHT and WD repeat domain containing 2 (NWD2), mRNA.
ACCESSION   NM_001144990 XM_001713967 XM_049078 XM_940885
VERSION     NM_001144990.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7800)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104690.2, AC107400.5 and AC022463.5.
            
            On Nov 24, 2018 this sequence version replaced NM_001144990.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.160477.1,
                                           SRR1803614.153603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145313, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309447.6/ ENSP00000309501.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               AC104690.2         53058-53533
            477-529             AC107400.5         9551-9603
            530-565             AC022463.5         1-36
            566-682             AC022463.5         30378-30494
            683-886             AC022463.5         104584-104787
            887-1031            AC022463.5         107888-108032
            1032-1621           AC022463.5         112813-113402
            1622-7800           AC022463.5         117297-123475
FEATURES             Location/Qualifiers
     source          1..7800
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..7800
                     /gene="NWD2"
                     /gene_synonym="KIAA1239"
                     /note="NACHT and WD repeat domain containing 2"
                     /db_xref="GeneID:57495"
                     /db_xref="HGNC:HGNC:29229"
                     /db_xref="MIM:620172"
     exon            1..476
                     /gene="NWD2"
                     /gene_synonym="KIAA1239"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..5554
                     /gene="NWD2"
                     /gene_synonym="KIAA1239"
                     /codon_start=1
                     /product="NACHT and WD repeat domain-containing protein 2"
                     /protein_id="NP_001138462.1"
                     /db_xref="CCDS:CCDS47040.1"
                     /db_xref="GeneID:57495"
                     /db_xref="HGNC:HGNC:29229"
                     /db_xref="MIM:620172"
                     /translation="MWPAGAGTKLPCPRDSALRRAAFSGNLTALPSHLVPAGRSVRVF
                     ISANPEDTGAERQALRENVYPKLREFCRENYGLEFQVIDLYWGVEEDEWDSPELQKTR
                     MKLLENCLKTSAGPCFVGLLGEKYGNIRIPGEVEASEFEMILDAAIEAKLETKLLEEW
                     YCRDENSVPAAYYLRPKSEMLRSNRNAMQPSTNAENEKTWQEISDEIKKIFKAAVKLL
                     HEKGKMKHSQAKRYLFSAIEDEFDFALGKQTPAFLKKCVCYIRKIANIERFVKIPEMG
                     KYMDITGTEPRIIRDPEAQEKLIKLRDEFIPTIVASSNLRVYTSVTHCDMKLGYSQEI
                     ENHYIEGLGKQFYEDMIDIIQATIQQNFDTETDTLYDEILQHSSLCKTYASFYEYKCE
                     SLNIVHNYILPSKAGHINPLIIYGGPCTGKTLLLAEVAKKAYGWLHEDTGPESDPVVI
                     VRFLGTTDMSSDLRTLLLSVCEQLAVNYRCLVQSYPKKIHDLCDLFINLLNESSLQRP
                     LVIIFDALEQLSENDDARKLWWLPAHLPRFVRIVLSTLPNKHGILQKLRCLIHEEDNY
                     IELIPRDRKMCSQVLKHQLLRVKRKVTSGQQIYVNNALSKCTLPMFVNLTFREVRHWR
                     SHKDVDESSLSVTVHESIEQLFWSLEKKCGQKLVSRALGYITMAKMGLSEMELEDVLA
                     LDNSVMSELKENTRPSNPLRVPYLYIARLKEGLSGYLIERHVKNVTLLVWANRHLQLI
                     AQKLYLQDDNDLREMHTILADYFLGVWSGGRRKAFCLEDPYLNGCLDLENRSLLEEEK
                     HFMEQASFDRQAPDQPWVFQCNPLEPDIFFVNHRKMSELLYHLTRCGKTDDLLYGIIM
                     NFSWLYTMIKIGQFDKVLSDIELAYNYSQEKELKFLANTLRSIKNKVTAFPGSLSAEL
                     QQRLLPVVSSLPKLRHLLLECDKDGPKYCSIVPLHSSMDVTYSPERLPLSSSHLHVTE
                     ILPTCNPSTVLTALENGSISTWDVETRQLLRQITTAQSVILGMKLTSDEKYLVVATTN
                     NTLLIYDNVNSCLLSEVEIKGTKHGSSATYINGFTLSANHALAWLEASKDVTVIDLLY
                     GWPLYQFHCWYEVTCVQCSLDGLYAFCGQYLNTTTIFHLGSGEKLCTVTSEFSGGFVK
                     FLLILDTAQEMVMVDSEGSLSVWNTEDISSPQLTDDFDCRREDSEVVSIELSEDQSAV
                     LICKALSIELLDTGLWKVAEKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFWRRD
                     TGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQ
                     SLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEGIVEHCVLTSTGDIMVTSDDK
                     SSQYVWHTSSGENLFRINGQRISQLLITHNDQFVVSLCEENASRVWRLATGHRVCNIL
                     TTLQNAFITSANTFVVGMTKSKVLAVSLWTGSITKKFCCEDGTTIVNFKLIPDCPDII
                     VFITSAETVNIWSLTDEVICRRVQLPNNFLKNLEDFEISPNGKLGIIARGDENINVLD
                     LYSGKLRVVHASGIIWRQRLSRDGRYLVYICFRNGEEEDENGAIFSLIVMRLADGKNI
                     GACSLYKTPTFLALSQRHLNIIVGFDDGSIGIYTVVDRVDAALKIKIATSNSRQIFNN
                     ATHTSRPKCNSYCFKISVDCLWRESTEVFARDSPITVSDSTESNEATPSKKHNSCYER
                     VCSALEARGHSYAPDN"
     exon            477..565
                     /gene="NWD2"
                     /gene_synonym="KIAA1239"
                     /inference="alignment:Splign:2.1.0"
     exon            566..682
                     /gene="NWD2"
                     /gene_synonym="KIAA1239"
                     /inference="alignment:Splign:2.1.0"
     exon            683..886
                     /gene="NWD2"
                     /gene_synonym="KIAA1239"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1031
                     /gene="NWD2"
                     /gene_synonym="KIAA1239"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1621
                     /gene="NWD2"
                     /gene_synonym="KIAA1239"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..7800
                     /gene="NWD2"
                     /gene_synonym="KIAA1239"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7781..7786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NWD2"
                     /gene_synonym="KIAA1239"
                     /note="hexamer: AATAAA"
     polyA_site      7800
                     /gene="NWD2"
                     /gene_synonym="KIAA1239"
                     /note="major polyA site"
ORIGIN      
        1 aaacgggcgc tgcgcgcgta gccgccgcca cgctgacctc ccgctccagc tggctgctgc
       61 tcggagccct agcagcgggc gaaggcggag gcccagaagg gcaggagacc gccgcgacag
      121 gagcccgagg gtccgtatgg cttctcctcg ccggcgggtg ctgtgcgcca cggagctcgc
      181 caaaggcgct tcgggctcgg agcggctctg agccgcgccg cctgctgaga tcgaccgcct
      241 gctgagccgt tccgtggagc tgcgggcagg aacccgagga gcaggaggtg gcggcggcgg
      301 cagtggctgt tcctcccaga gggcgatgtg gccggccggc gcgggcacca agctgccctg
      361 tccccgagac tctgcgctcc ggcgggcggc tttctctggg aacctcacgg ccctgccctc
      421 tcacctcgtg cccgccggcc gcagcgtccg ggtcttcatc agcgccaacc ctgaagatac
      481 gggagcagaa agacaggcgc taagagaaaa tgtatatcct aaactgagag aattctgcag
      541 agaaaactat ggattggaat ttcaggtcat agatctgtac tggggagtgg aagaagatga
      601 gtgggacagc ccagagctcc agaagacccg catgaagctg ctggagaatt gcttgaaaac
      661 ttctgcaggt ccatgttttg ttggactatt aggtgaaaaa tatgggaata tccgaatccc
      721 tggagaagtt gaagcctcag agtttgaaat gattttggat gccgccatag aggcaaagct
      781 ggagaccaag ttgctggagg agtggtactg tcgagatgag aactcggtgc cagcagccta
      841 ttacctcaga cccaagtcag aaatgctgag aagcaataga aatgcaatgc agccttctac
      901 caatgctgaa aacgagaaga catggcaaga gatatcagat gagatcaaga agatatttaa
      961 ggctgctgta aagctgttac acgaaaaggg taaaatgaaa cacagccagg ctaagaggta
     1021 cctgttctca gctatagagg atgagtttga ctttgctctg ggaaaacaaa ctccagcatt
     1081 tctaaagaag tgtgtttgct acattaggaa aattgctaac attgagcgct ttgtgaaaat
     1141 cccagagatg ggaaaataca tggatataac tggaacagaa ccgaggatta ttcgggaccc
     1201 agaagcccaa gagaagctga taaaactcag ggatgaattt attcctacta ttgttgcatc
     1261 atctaatctg agagtgtaca catctgttac tcattgtgac atgaaactag gctactccca
     1321 agaaatagaa aatcattaca tcgaaggact tggtaaacaa ttttatgagg acatgattga
     1381 tataattcag gcaacgatac aacagaattt tgacactgaa actgatacac tctatgatga
     1441 aatccttcaa cattcatcat tatgtaaaac atacgcctcc ttctatgagt acaaatgtga
     1501 atctctaaac atagtgcata actacattct tccaagcaaa gctggacaca tcaaccctct
     1561 tattatatat ggtgggccat gcactgggaa gacccttctg ctagctgaag tagcaaagaa
     1621 ggcttatggc tggctacatg aggacacagg accagaatct gacccagtag tcatcgtgag
     1681 atttctagga acgacagaca tgagctctga ccttaggact ctccttctaa gtgtttgtga
     1741 acaattggca gttaactacc ggtgtctggt tcaaagctac cctaagaaga tccatgacct
     1801 ctgtgactta tttataaatc ttttgaatga gtcttcactg cagagacctc tagtcataat
     1861 attcgatgca ctagagcagc tctcagagaa tgatgatgcc aggaagcttt ggtggctccc
     1921 agctcacctg ccccgctttg tccggatagt cctttccacg ctgcccaaca aacatgggat
     1981 cttgcagaaa ctaaggtgcc ttatccatga agaagacaac tacatcgagc tgattccccg
     2041 agacaggaag atgtgcagcc aggtcctcaa acaccagctg ctgcgcgtca aaaggaaggt
     2101 cacatcaggc cagcagattt atgtgaacaa tgcattatcc aagtgcacac tgccaatgtt
     2161 tgtgaacctg accttcaggg aggtgaggca ctggagatct cacaaagacg tcgatgaatc
     2221 ctccctctct gtcaccgttc atgaaagtat agagcagtta ttctggtcct tggagaagaa
     2281 gtgtggtcag aaactggtct ctagggctct tggttacatc accatggcca aaatgggtct
     2341 gagtgaaatg gaactggagg atgtgttagc cctagacaac agtgtaatga gtgagctcaa
     2401 agaaaacacc agacccagca atcccctgag agtaccttac ttgtacattg caaggctcaa
     2461 ggagggtctc agtggatacc taatagaaag acatgtgaaa aatgtcacac tcctagtctg
     2521 ggccaacaga cacctgcagc tcatagccca gaagctatat ctgcaggatg acaatgacct
     2581 gcgtgaaatg cacaccatct tagcagatta ttttctgggg gtttggtcag ggggcaggag
     2641 gaaagccttc tgccttgagg acccctactt gaatggctgc cttgacttgg agaacagaag
     2701 tttgctggag gaagaaaagc acttcatgga acaggcttcc tttgacaggc aggctccaga
     2761 ccagccctgg gttttccagt gtaatcccct ggaacctgac atctttttcg ttaatcatcg
     2821 gaaaatgtct gagctgttgt accacttgac gaggtgtgga aaaaccgatg acctgcttta
     2881 cggcatcatc atgaacttca gctggcttta taccatgatc aaaattggcc agtttgacaa
     2941 agtgctttca gacattgagc tggcttacaa ctactcgcaa gagaaggagc tgaagttcct
     3001 ggccaacacc ctccgcagca tcaaaaacaa ggtcactgca tttcccggct ccctttcagc
     3061 agagcttcag caaagactgc tgcctgttgt aagctccctg cccaaactta gacatcttct
     3121 tttagagtgt gataaagatg ggcccaaata ttgctccatt gtaccactgc attcatccat
     3181 ggatgtgaca tacagcccag agcgtcttcc cttatcatcc agtcacctgc atgtcacaga
     3241 gatcctgcct acctgtaacc ccagcactgt cctcacagct ttagaaaatg gttccatcag
     3301 cacctgggat gtagagactc gacagctact caggcaaatc accacagccc agtctgtcat
     3361 cctgggcatg aaactcacca gtgatgaaaa gtaccttgtg gtggctacaa caaataacac
     3421 cttgttgatt tatgacaatg tcaattcttg cctcctgtct gaagtagaaa tcaaggggac
     3481 caagcatgga agcagcgcca cctacatcaa tggatttaca ctgtccgcca accacgccct
     3541 tgcatggctc gaagccagca aagatgtcac tgtcatcgat ctgctgtacg gatggccgct
     3601 ttaccagttc cactgctggt atgaagtgac gtgcgtccag tgctccctgg atggtctgta
     3661 tgctttctgt ggccaatacc tgaacacaac caccatattt catttaggga gtggagaaaa
     3721 gttatgtaca gtgacatcag aattttcagg tggatttgtg aagtttcttc ttatcttgga
     3781 cacagctcag gaaatggtca tggtagacag tgaaggaagt ctttctgttt ggaatactga
     3841 ggacatttcc agcccccagc tgactgatga ctttgattgc cgaagagaag acagtgaggt
     3901 ggtcagcatt gagctttcag aagaccaaag tgcagttctg atctgtaaag ccctcagcat
     3961 tgagctctta gatactggtc tgtggaaggt ggctgaaaag ttcagagcca agcacaacga
     4021 acgctttata tctgccgtgc tgtctaaaaa tggagattgt atcatcgcca ccatggaaaa
     4081 tacctcagct gtgttttttt ggaggcggga cacaggacag tgtatggcaa gcttgcagga
     4141 aatctcaggt tccattgtta agttagtgaa atccagtcac cacaatatgc tactgtcttt
     4201 atcaaccagt ggtgttcttt ccatttggga catagatata atcacagcta tgtccaacat
     4261 agataagact ggaaaaccca tccaaagtct gttgttgcct gctagagggg aaatcattta
     4321 ctccctggat ggatccgatt gtgttcataa gtggaacttc agcagtggct tcatcgaagc
     4381 agtattcaag catgaaggaa tagttgaaca ctgtgtgtta acatccaccg gagatataat
     4441 ggtgacatca gatgacaaaa gcagccagta tgtctggcac accagcagtg gtgaaaacct
     4501 ttttcgaatt aacgggcaga gaatatctca gctgctgatt acacacaatg accagtttgt
     4561 ggtctcgctc tgtgaggaaa atgcctccag ggtttggagg ctcgccacag gccacagggt
     4621 ctgcaacatt ctgaccactt tgcagaatgc ctttattacc tccgcaaata ccttcgtggt
     4681 gggaatgact aaaagcaaag tgttggcagt cagtctttgg acaggaagta tcaccaagaa
     4741 attttgctgt gaagatggga ccaccatcgt gaattttaaa ttaatccctg actgtcctga
     4801 tatcatcgtg tttatcacat cggccgagac tgtgaacatc tggagtctga cagatgaagt
     4861 gatctgtcgg cgcgtgcaac ttccaaacaa cttcttgaaa aatctggagg actttgaaat
     4921 ttctcccaat ggaaagctag gcattatagc caggggagat gaaaacatca atgtgctaga
     4981 tttatacagt ggtaaattgc gggtggttca cgcctctggg atcatctggc ggcagaggtt
     5041 gtctcgggat ggtcgctacc tggtatacat ttgtttccga aatggggagg aggaggatga
     5101 aaatggtgca atattcagtt taattgtaat gagactggca gatggcaaaa atatcggtgc
     5161 ttgttccctt tacaaaacac caactttcct tgcactctcc cagaggcacc tgaacatcat
     5221 tgtgggcttt gatgatggga gtatagggat ctacacggta gtagaccgtg tagatgctgc
     5281 actgaaaatc aaaattgcca cttcaaatag cagacaaatt ttcaacaatg caacacacac
     5341 ctccaggcca aagtgtaaca gttattgttt taaaatatct gtggattgct tatggagaga
     5401 gtccactgag gtctttgcaa gagacagccc catcacagtt agtgactcta ctgagtccaa
     5461 tgaagcaaca ccctccaaga aacacaactc ttgttatgag cgggtatgct cggccctaga
     5521 agccaggggc cacagctatg cccctgataa ctgacaaaat gttttccagc taagcagaaa
     5581 tatgtgatcc acgtacagaa gggaaaaaaa tgtgccccaa atgataaact attcatttat
     5641 taaaaggcag gagcgatgct ggaattccag tgttttatta agatgttcat gaaatggaca
     5701 aataggttag tcttgggtgt ggtctttttg tcaaagtgta tccagaatgt cagaatttct
     5761 agtagtaata tttaaatggt tacttcatct gaaaggcaga ggctaaaagt ttttaaatta
     5821 gctgtgtggt gaggcagcat aatacatccc actggttaag atgagagagg ctagagttat
     5881 atacagatca tttggatggg aattagttct acaaaaatca gctgaaatca tgaagacaaa
     5941 gagctgcttg acttcaaatg attgtgtgat aagtaaacac agccttaatc tctctttaca
     6001 ttttacagtc ctgacaactg tgtacaccta gtctgcagtg aacggtctaa aggtgcaaaa
     6061 tatgtaacaa aaatacccaa gtgtattccc agtttcccga gagatatgac ctgaaacatg
     6121 agactgtgga ctggactggg acaagaacta actaccacta tcatagggct actgaacatg
     6181 gagagtcagt ctttattaaa agacagttgc aacaattgca tgcgagggtt tctgtataac
     6241 agaatatatg atttttaaac tatttcctgg gttgcaaaag aacacattta gtaagaaaca
     6301 acaatctttt cgcatctttt tgaaatgcat atttgtgctg ggtgtaaaga agattacagg
     6361 aagggcatta caaatctggt caaaacacct gtccatttcc atcattgtac taacagaagt
     6421 ctgtactatt tggtcagttt gtatggaagc ataaatattc cctaaattcc tgcagttagt
     6481 cttcatagaa agcaagcttt ctcaacatgc catctctgag atactgatga cgtttgcctt
     6541 actcacattc cttctctttc ctgtgtaaaa tgcagataga tgaccaaata ctctgggata
     6601 aactgaatat gcctgtcttt gtgctaaaat attccataaa tcttaagggt gtccaaaagt
     6661 tctttattgt ccttgtttgt aatcactttc ttacttctac acaccatctg tatgcttctt
     6721 tatctgttac tcttcctgat tgaggactct tctgagcctt ttatagtcct atccatttca
     6781 aagcagaagc tgtggaatgg tattaaatat tttttaaaat taattcacct gtttaaaaga
     6841 aaacattgca tctcaaaagg tgaagatgat tgttctttct tccatatcct ccttacggca
     6901 tgtccttgga taacttttca aaaggtatcc acacttttgg ttgagtttag ttttcttaga
     6961 aagtagagaa gtaacacttt actagaataa tgaacaagga attgatttgc tctaggccca
     7021 gctctgccat aaactcattg tgtattccta gacaggtctt taacttcatc agtgtgttgt
     7081 ttttgtgaag tgcaaaataa agatagtgat agtttctgct gtagccctca tagggacatt
     7141 gggaagcagt ataagaaaaa cttcagcaac atcatgatta ttgatgctaa taggaaaaat
     7201 aaattcatgt aacccataga gaatccaggt caattgtatt tcctcttgga aagcagttta
     7261 acatgtaagc gttcaaagat gtgattcaga taaaaatacc caggtccata gtgaaagatg
     7321 tttttcagta tgttacttat ggtttagcta ctagccaggg aggtggtagc ccagagaagg
     7381 caaaccacat acagatcacc tggagttgat tatatgagtc tatgcttttg agctctttag
     7441 gcaacacatt ctcattcctg tcattatcag ttgaacctcc atgccacaca tttctaagaa
     7501 ttaaatgcct agatggatta aatgtagtat gtgaatgttc tatgtaaaag ccaatagagt
     7561 atacaagtga cttgaatgat ttttcctaac ttgtttgcaa ctgatagctc atattgaatg
     7621 tttttatgta aactttgtat cgttgggaag aattacccaa tcagagattt atattttcat
     7681 aaatgttaca tttagttaaa ttttgttaca gagttgttac actagaaaat tatttcagtc
     7741 ttcaaacaat atacagtctt gtgtatgtat tatttgtatg aataaaagat aaactactta
//
