LOCUS       NM_001290355            8522 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens NACHT and WD repeat domain containing 1 (NWD1),
            transcript variant 2, mRNA.
ACCESSION   NM_001290355
VERSION     NM_001290355.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8522)
  AUTHORS   Yang,Q., Huang,Z., Luo,Y., Zheng,F., Hu,Y., Liu,H., Zhu,S., He,M.,
            Xu,D., Li,Y., Yang,M., Yang,Y., Wei,X., Gao,X., Wang,W., Ma,J.,
            Ma,Y., Wang,X. and Wang,Q.
  TITLE     Inhibition of Nwd1 activity attenuates neuronal hyperexcitability
            and GluN2B phosphorylation in the hippocampus
  JOURNAL   EBioMedicine 47, 470-483 (2019)
   PUBMED   31474551
  REMARK    GeneRIF: our study contributes to the understanding of the
            biological role of Nwd1 at the synapse and the characterization of
            the beneficial effects of Nwd1 in the treatment of seizures.
REFERENCE   2  (bases 1 to 8522)
  AUTHORS   Watanabe,Y., Nunokawa,A., Shibuya,M., Ikeda,M., Hishimoto,A.,
            Kondo,K., Egawa,J., Kaneko,N., Muratake,T., Saito,T., Okazaki,S.,
            Shimasaki,A., Igeta,H., Inoue,E., Hoya,S., Sugai,T., Sora,I.,
            Iwata,N. and Someya,T.
  TITLE     Rare truncating variations and risk of schizophrenia: Whole-exome
            sequencing in three families with affected siblings and a
            three-stage follow-up study in a Japanese population
  JOURNAL   Psychiatry Res 235, 13-18 (2016)
   PUBMED   26706132
REFERENCE   3  (bases 1 to 8522)
  AUTHORS   Correa,R.G., Krajewska,M., Ware,C.F., Gerlic,M. and Reed,J.C.
  TITLE     The NLR-related protein NWD1 is associated with prostate cancer and
            modulates androgen receptor signaling
  JOURNAL   Oncotarget 5 (6), 1666-1682 (2014)
   PUBMED   24681825
  REMARK    GeneRIF: Overexpression of NWD1 is associated with prostate cancer.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008737.11, BX648940.1,
            BC117698.1, AK090685.1 and CB242932.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001290355.2.
            
            Summary: The protein encoded by this gene is thought to be a
            cytosolic protein and predicted to contain a NACHT domain and
            multiple WD40 repeats. Increased expression of this gene was
            observed in some prostate cancer cell lines. Knocking down
            expression of this gene results in decreased androgen receptor
            protein levels, indicating that this gene may be important in
            modulating androgen receptor activity. Alternative splicing results
            in multiple transcript variants encoding different isoforms.
            [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, initiates translation at an alternate start codon
            and contains an alternate exon in the 3' coding region, resulting
            in a translational frameshift, compared to variant 1. It encodes
            isoform 2, which is shorter and has distinct N- and C-termini,
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648940.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153427, SAMEA2158569
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC008737.11        35582-35710
            130-447             BX648940.1         1-318
            448-448             AC008737.11        37130-37130
            449-1036            BX648940.1         320-907
            1037-1037           AC008737.11        60220-60220
            1038-1854           BX648940.1         909-1725
            1855-1855           AC008737.11        65029-65029
            1856-3707           BC117698.1         723-2574
            3708-3708           AC008737.11        88955-88955
            3709-3979           BC117698.1         2576-2846
            3980-3980           AC008737.11        104762-104762
            3981-6424           BC117698.1         2848-5291
            6425-6425           AC008737.11        131591-131591
            6426-7295           BC117698.1         5293-6162
            7296-8167           AK090685.1         2133-3004
            8168-8522           CB242932.1         28-382              c
FEATURES             Location/Qualifiers
     source          1..8522
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..8522
                     /gene="NWD1"
                     /note="NACHT and WD repeat domain containing 1"
                     /db_xref="GeneID:284434"
                     /db_xref="HGNC:HGNC:27619"
                     /db_xref="MIM:616250"
     exon            1..447
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..670
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..768
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..855
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..972
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1699
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1609..5898
                     /gene="NWD1"
                     /note="isoform 2 is encoded by transcript variant 2; NACHT
                     and WD repeat domain-containing protein 1; NACHT domain-
                     and WD repeat-containing protein 1"
                     /codon_start=1
                     /product="NACHT domain- and WD repeat-containing protein 1
                     isoform 2"
                     /protein_id="NP_001277284.1"
                     /db_xref="GeneID:284434"
                     /db_xref="HGNC:HGNC:27619"
                     /db_xref="MIM:616250"
                     /translation="MDSQFHMAGEASQSWLKAKEKQRGTSYMVAVIEWEIERSLLSSE
                     DREQGATVFLREIQDLHKHILEDCALRMVDRLADGCLDADAQNLLSSLKSHITDMHPG
                     VLKTHRLPWSRDLVNPKNKTHACYLKELGEQFVVRANHQVLTRLRELDTAGQELAWLY
                     QEIRHHLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCK
                     LAEQMPRLLGHKTVTVLRLLGTSQMSSDARGLLKSICFQVCLAYGLPLPPAQVLDAHT
                     RVVQFFHTLLHTVSCRNFESLVLLLDAMDDLDSVRHARRVPWLPLNCPPRVHLILSAC
                     SGALGVLDTLQRVLLDPEAYWEVKPLSGNQGQQMIQLLLAAARRTLSPVHTDLLWASL
                     PECGNPGRLRLAFEEARKWASFTVPVPLATTAEEATHQLCTRLEQTHGQLLVAHVLGY
                     IVSSRHGLSEAELKDVLSLDDEVLQDVYRDWTPPSKELLRFPPLLWVRLRRDLGYYLA
                     RRPVDGFTLLAIAHRQLVEVVRERYLSGSERAKRHGVLADFFSGTWSQGTKKLITLPL
                     VGKPLNLDRKVAPQPLWFSHTVANLRKLKELPYHLLHSGRLEELKQEVLGSMSWISCR
                     GISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCRPAVELRGMERSLLYTELLARLH
                     FFATSHPALVGQLCQQAQSWFQLCAHPVLVPLGGFLQPPGGPLRATLSGCHKGITAMA
                     WGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYT
                     LHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETAEP
                     VFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPT
                     CAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSV
                     RIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLD
                     ILEGVGAPVSLLARGGALVASASPQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHN
                     GSYVYFPKIGDKNKVTIWDLAEGEEQDSLDTSSEIRCLEVAEQRKLLFTGLVSGVVLV
                     FPLNSRQDVICIPPPEARKAINCMSLSKCEDRLAIAYDNIVLVLDITSGDPCPVIDGP
                     RYTFYTQLPETLSSVAILTDYRVVYSMTNGDLFLYECATSKAFPLETHRSRVACVEVS
                     HKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDR
                     SILVWSVLDGTLLTVQFVHAVVNRIIPTTSGFIAPTRHGYLIRENFQCLSAKASPQDP
                     LKNFKKAMWMVKSRQREELVAAAGAPQDLESESAQGNETKSNKCSQVCLIV"
     exon            1700..2972
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3176
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3336
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3454
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3613
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3811
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3812..3934
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3935..4143
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4144..4416
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4417..4507
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4508..4662
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4663..4939
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4940..5490
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5491..5596
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5597..8522
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8504..8509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NWD1"
                     /note="hexamer: AATAAA"
     polyA_site      8522
                     /gene="NWD1"
                     /note="major polyA site"
ORIGIN      
        1 agttgctggg agaattgggc aaggagagac ccataaaata cctaagacga aagttactag
       61 gatagccagg ggcttgtctt ccgggtggcg ccgaggccag gaaactgtcc tctctaacct
      121 atttccccag aggagtctaa attggtcgtt caactaccag caaaggctaa agagaggctg
      181 gagcccccag gacagccaga acgctgacac tgcaaagggc ctctgtcctt actggggaag
      241 cccagtcctg ctcagctgtc ttcttcagca acaaacagaa gtccagaaag agaaacagtt
      301 gtggaggaag ctgttgtgat gataatttac tgagcaccta ctatgtgcca ggcacgccag
      361 ccttaccaga caagatcctt gggctcatgg aattcacttt ctcgtgggac agacaaacaa
      421 taacatgtag aaacatatca gctgttgcag gcagtaacca agggagcgtg gccaggcgct
      481 gaagtgaatt cgggtccaag gagcctgctg ggacccagga aaacgagaga aggaacagaa
      541 attgtggtgg aggcaaattc aagatcagaa gattggggag gaggtgctaa gagaggtctg
      601 gagagatgct gggacccaga actggggcct cagtgagatc agcaggctgc agctaaactg
      661 tggtatccag accatgcggc cgatgccctg ggagggagac cacttgctta agtcctccag
      721 gagggcgatg gaggagccgg cattccaacc aggctcacgg atgccaagat atggatgcag
      781 agagggaagc cctgcagagc actgcctacc ctgaagtgcc agaccttctg ccagaggcac
      841 ggcttgatgt ttgaggtcgt tgatctgagg tggggtattc ggaacattga agccactgac
      901 cacttgacca cagaactctg cttggaggag gttgaccggt gttggaaaac atccataggg
      961 ccagcttttg ttgccctcat cggtgatcag tacggcccct gtctgattcc ctcgcggatc
     1021 gatgagaagg agtgggaggt attgagggac catctgactg ccaggccaag tgacctggag
     1081 ctggtggcac gatacttcca gagggacgag aatgcgtttc ctcccaccta cgtcctgcag
     1141 gcaccaggta ctggggaggc ctgtgaacca gaggaggcca ccttaacttc tgtcctacgc
     1201 tctggagccc aggaggcccg gaggctgggg ctcatcaccc aggagcagtg gcagcactac
     1261 caccggtcag gtgaggccgc agggactccc ctctggagac ccacaagaaa ctgaccacgt
     1321 gttcagaata tccatcccct gttggcaaaa atgcaacagt ctgcatttct tgcaaatgcc
     1381 aaaccagtca acctctggtc cctcggctct gagaaaggct gttttactga tccaagatag
     1441 ttcagccatg ttcctgatca atcttggtct caggatcttc ctctcctcgc tggctctttc
     1501 ttcttgtctc ccagggaggt tcctggcaca ggggccgtat tagtctgttc tcatgccact
     1561 aataaaggca tacttgaggc tgggtaattt acaaaggaaa gaggtttaat ggactcacaa
     1621 ttccacatgg ctggggaggc ctcacaatca tggctgaagg caaaggagaa gcaaagaggc
     1681 acatcttaca tggtggcagt cattgagtgg gagatagagc ggagcctgct gagctcagag
     1741 gaccgggaac agggagccac cgtcttcctt agagagatcc aagacctcca caaacacatc
     1801 cttgaagact gcgcccttag gatggtggac cggctcgcgg atggctgcct ggacgctgat
     1861 gcccagaacc ttctcagcag cctcaaaagt cacatcactg acatgcaccc aggggtcctc
     1921 aagacccacc gcctgccgtg gagccgcgac ttggtgaacc ccaagaacaa gactcacgcc
     1981 tgctacctga aggagctggg tgagcagttt gtggtgaggg ccaatcacca ggtcctcaca
     2041 cgcctccgtg agctggatac ggccggacag gagttggcgt ggctctacca agagatccgc
     2101 caccaccttt ggcagagctc ggaggtcatt cagaccttct gcggacgcca ggaactcctg
     2161 gcccggcttg ggcagcagct caggcacgat gacagcaagc agcacacccc cctggtactc
     2221 tttgggcccc caggcattgg aaagacagcc ctgatgtgca agctggctga gcagatgcca
     2281 aggctgctgg ggcacaagac agtgaccgtc ctgcggctgc tggggacgtc acaaatgagc
     2341 tcagatgccc gtggcctgct gaagagcatc tgcttccagg tgtgcctggc ctatgggctg
     2401 cccttgcccc ctgcccaggt tctggacgcc cacaccaggg tggtccagtt tttccatacc
     2461 ctcctccaca ctgtctcttg cagaaacttc gagtctctcg tgctcctgct ggatgctatg
     2521 gatgacctgg actctgtccg ccatgctcgg agggttccct ggctgcctct caactgcccc
     2581 ccgagggtgc acctcatcct ctcagcttgc tcgggggcac tgggggtttt ggacaccttg
     2641 cagcgggtgc tcctggaccc ggaggcctac tgggaggtga agcccctttc cggaaaccaa
     2701 ggccagcaga tgatccaact cctgctggca gctgcaagga ggacgctgag cccggtgcac
     2761 acagatttgc tctgggccag cctcccagag tgtgggaacc cagggcggct gaggctggcg
     2821 tttgaggaag cccggaaatg ggcctctttc accgtgcctg tcccgctggc caccaccgca
     2881 gaggaagcca cgcaccaact ctgcacccgc ctggagcaga cacacgggca gctcctcgtg
     2941 gcccacgtgc tgggctacat tgtgtcttcc cgacacggtc tctcggaggc ggagctgaag
     3001 gatgttttgt ccctggacga cgaggtcctg caggatgtgt accgagattg gaccccgccc
     3061 agcaaggagc tgctgcgctt cccgcccctg ctgtgggtgc ggcttcgtcg ggatctggga
     3121 tactacttgg cccggcggcc cgtggatggc ttcaccctcc tggccattgc ccacagacag
     3181 ctggtcgagg tggtccgtga gcgctacctg tcaggatccg agagagccaa gaggcatggc
     3241 gtcctggccg acttcttctc agggacctgg agccagggta ccaagaagct catcactctg
     3301 ccacttgtgg ggaaaccact gaacttggac cgaaaggtgg ccccgcagcc tctgtggttc
     3361 tcacatacgg ttgcaaacct gcggaagctg aaggagttgc cctatcacct gcttcactcg
     3421 ggccgcctgg aggagctgaa acaggaggtt ctgggcagca tgagctggat ttcctgccgg
     3481 ggcatctctg ggggcattga agacctgctg gatgactttg acctgtgtgc ccctcacctg
     3541 gactcccctg aggttggcct ggtccgtgaa gccctccagc tctgccgccc tgctgtggag
     3601 ctccgaggca tggagaggag cctcctgtac acagaactgc tggccagact ccatttcttc
     3661 gccacctcac atccagcact ggtgggacag ctatgccaac aggcccagag ctggttccag
     3721 ttgtgcgcac accctgtgct ggtgcccctc ggaggattcc tccagccccc gggaggaccc
     3781 ctccgggcaa ctctcagcgg ctgtcacaaa ggcatcaccg ccatggcatg gggtgtggag
     3841 gagaagctgc tggtgattgg cacccaggat ggcatcatgg ctgtgtggga catggaagag
     3901 cagcatgtga tccacatgct aactggacac acaggagagg tgaggtgtgt gaaaatattt
     3961 gccaaaggga ccctcgccaa ctctgcttca aaggattaca cgctgcactt gtggaactta
     4021 ctctctggcc aggagaaatt taccatttgg gatggaggct caaaaaatcc cgctgaacct
     4081 cagatctgga accttcatgt ggatgaggca cacaaagttg tgtattcagc atctggctca
     4141 aagatcaatg cttggaatct ggaaactgca gagccggtat tccatatcct gggagatgcc
     4201 tctgatcctt ggatgtgcat ggccgtgctg gcctcccagg ccacactgct gacagtgtcc
     4261 agggatggtg tggtcagtct gtggagctca gctacgggaa aacttcaggg gaagcaacat
     4321 atgtccagca tcaaagaaga aacacctacc tgtgccgtct cagtccagaa gcaaggaaag
     4381 cttgttaccg ggtttagcaa tggctccatc tctttggttt cctccaaagg ggacagattg
     4441 ctggagaagc ttccagatgc tgtgaggttc ctggtggtct ctgaagatga gtccctcctc
     4501 gccgcaggct ttggaagatc ggtgcggata ttcttggcgg actcgagggg ctttcgccga
     4561 ttcatggcca tggatctgga acatgaagac atggtggaga cggctgtttt tggtactgag
     4621 aacaacctga tcatcacggg gtcccttgat gcgctcattc aggtgtggag tctgtcagaa
     4681 caggggaccc ttctggacat cctggaaggc gtcggggccc ccgtgagcct gctggcccgc
     4741 ggcggggctt tggtggcatc tgcttcccca cagtcctcat ctttcaaggt ctgggatctc
     4801 agcgatgctc ataggtcccg ggtgcctgca ccatttctgg accgcaccgg cctcaccgca
     4861 gtgtcccaca atggaagcta cgtctacttc cccaaaattg gggacaaaaa caaagtcact
     4921 atttgggact tggcagaagg cgaggaacaa gattccctgg acacctccag tgagatcagg
     4981 tgtctggagg ttgctgagca gcgcaagctc ctatttacgg gcctcgtgtc gggggtcgtc
     5041 cttgtgttcc ccctgaattc caggcaggac gtgatatgca ttccccctcc cgaggcccgg
     5101 aaagcaatca actgcatgtc cctgagcaag tgcgaggacc gcctggccat cgcctatgac
     5161 aacatcgtcc tggtgctgga catcacctcc ggggacccct gcccggtcat cgatgggcca
     5221 agatacacct tttacactca gctgcccgag accctctcca gcgtggccat tctgacggac
     5281 taccgcgtgg tctacagcat gaccaatggg gacctctttc tttacgagtg tgcaacttcc
     5341 aaagcgtttc ccttggagac ccacaggagc cgagttgcct gtgtggaggt cagccacaag
     5401 gagcagctgg tggtcagcgg gtctgaggat gccctgctgt gtctctggga cctgcaggca
     5461 cgcaagtgga aattcgagat gagctacacg agttcttact gcagaggggt ccaatgtgct
     5521 tgcttctcca aggatgacaa gtatgtgtac gtgggcttaa aggatcgctc tatacttgtt
     5581 tggagtgtgc tggatggcac cctgctgaca gtccagtttg tccatgctgt ggtaaacaga
     5641 atcatcccaa ccaccagtgg cttcattgcc cccaccaggc atggttatct gatccgagag
     5701 aatttccagt gcctttcagc aaaagcctca ccgcaggacc ctcttaagaa cttcaagaag
     5761 gcaatgtgga tggtcaaatc caggcagaga gaggagctag ttgcagctgc aggagctccc
     5821 caggacttgg agtcagaaag tgcccaggga aatgaaacca aatcaaacaa atgctcacaa
     5881 gtgtgcctga tagtgtaaaa aaataaaaat aaaaaaaccc tgtgggggta tggggctcca
     5941 gtgagttagc cccatttaat ctagttaaag caaaaagaat acgtttgctg gtgtatatct
     6001 ggacccatgg cttcagatta tggcttcaga ccttgtctct tctcatcttt ccattattct
     6061 ttcctctttt tcattttcat tctcagactt gccaccccca ggttagcaac atggtggcca
     6121 atatgctgct gtctccaatt tcaatagaaa agagagcttc tctttcccaa cagtcctagc
     6181 ctcaactcta ctggtcccaa ttggcccata cgcctagccc taaaccaatt attatatctg
     6241 ggagaatgca gagctctaat cggctagact gatccaatgt ccaccactgg gactgagaat
     6301 agaagagatt actcctgaga tgcaaactgg agttctggta ccagatgaag ggggaacgga
     6361 tgaatgtgag atacagcaaa tcactgatgt ggaccacaga acctcacagt ttataaagct
     6421 gtaggtgctg tcatctgatc ctcatcacaa ctcatacttt agggagggca ggagtttctg
     6481 tatctatttt acagatgagg aaactgagcc ttgcggaagt agttataatt tgattcaggt
     6541 cacaagtcca aggtgcaaga gctctgagag tgagccttct gtcccattcc tgttagacct
     6601 cactccaatt tcagtctgca gagcacaacc atctcttcca caggcaccac actcaaatgc
     6661 tcacaggagc tagtgactaa tctagacact tccatgcacc tgggtgagca gcagggagag
     6721 acagagactg gacatgtgga aggcagagat tgtgtctagg gtgggtatga gcagcctgac
     6781 tgtagcccag aatcaccatg gccaaacaag cccactgctg tcagtgcttc cagttgtaat
     6841 aagcaaagcc agaaatccag acttttatgc aaaaatgttc tgacttttaa agttggcgat
     6901 tggttgaatt tatatctata gtgcatttgg catgtgcgtc tttggttaat gagctgactt
     6961 caggactcac gctggcagta aaacaatcaa catgttatag ttcatccctc tctattcctt
     7021 ggctcccaaa cttttgggat aaagatgtgg gtttttaatc ttaaaaactg gaggctcttg
     7081 gaagtagaaa gagctgctga tctctccctg ctttgctttt gaactgtctg ccttgtgcaa
     7141 gttcaacagt caaactgttt tcattccact taagtggatc tttcttcttt gcccacagcc
     7201 ttctaaaagc ccttctcagt cttctcaggc ttttacttta atgctaggat agtctaaatc
     7261 ttcaaggtgg ctatcccttc tcccctccgt ggaattcctg atagagtctc aataaaagca
     7321 accttagaaa cagaggcttt tgagctgaac aagaccctac tgctgtctta ttcatccatt
     7381 ttccaaacca gttttccaag gcaggttttg gtagttctgc aaatgttagt gtcaaatttc
     7441 atttaaaaat attttaaact gtaattttaa gatgtatgct tggatgtatt gggcagcagc
     7501 ttctaaggtg ttgaagatta ctaaggttgg tgcaaaaagt aactgtggtt ttcgccatta
     7561 aaaatattaa aaataatggc aaaaactggc tgggcacagt ggctcacacc tgtggtccca
     7621 gctctttgga aggccgaggc aggtggatca cctgaggtca ggagtttgag accagcctgg
     7681 acaacatggt gaaacccttc tctactaaaa atacaaaaat cagccaggca tggtggtgag
     7741 tgcctgtaat ctcagttact caggaggctg agtcaggaga atcacttgaa cccgggaggc
     7801 ggaggttgca gtgagctgag attgtgccac tgcactccag cctgggtgac agagcaagac
     7861 tccatctcat aataataata ataatggcaa aagcctcggt ggctcacgcc tgtaatccca
     7921 gcactttggg aggctgaggc gggtggatca cttgaggcca ggtgttcaag agcagcctgg
     7981 tcaacatggt gaaactctgt ctctactcaa aaatacaaaa attagcctgg tgtggtgacg
     8041 tacacctgta attccagcta cttgggaggc tgaggcagga gaatggcttg aacccgggag
     8101 gcggaggttg cagtgagccg agatcgcacc actgcactcc agcatgagtg acagagactc
     8161 tgtctccaaa aaaaaaaaaa aaaaaaagta atggcaaaaa ccacaattaa ttttgcatca
     8221 acctaataat ttaggattct tctgccattt tcatttaact gatttaactg aagagcccaa
     8281 ttaaattgtg aagggagccc tgaaaaaatt agctactctt tgccactgct tctctgtgaa
     8341 tcaagggctt acccaatgca gaaataaagt agatgttgag accaattaag atttcaccta
     8401 caaattctga ttttaaatgc ctgtgtccat ctccacagcc tcagtgagaa ttgattgttt
     8461 tgtagataaa tcctaattta aacattggaa atgccttttt actaataaaa tgctacaaca
     8521 aa
//
