LOCUS       NM_001007525            7764 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens NACHT and WD repeat domain containing 1 (NWD1),
            transcript variant 1, mRNA.
ACCESSION   NM_001007525 XM_211460
VERSION     NM_001007525.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7764)
  AUTHORS   Yang,Q., Huang,Z., Luo,Y., Zheng,F., Hu,Y., Liu,H., Zhu,S., He,M.,
            Xu,D., Li,Y., Yang,M., Yang,Y., Wei,X., Gao,X., Wang,W., Ma,J.,
            Ma,Y., Wang,X. and Wang,Q.
  TITLE     Inhibition of Nwd1 activity attenuates neuronal hyperexcitability
            and GluN2B phosphorylation in the hippocampus
  JOURNAL   EBioMedicine 47, 470-483 (2019)
   PUBMED   31474551
  REMARK    GeneRIF: our study contributes to the understanding of the
            biological role of Nwd1 at the synapse and the characterization of
            the beneficial effects of Nwd1 in the treatment of seizures.
REFERENCE   2  (bases 1 to 7764)
  AUTHORS   Watanabe,Y., Nunokawa,A., Shibuya,M., Ikeda,M., Hishimoto,A.,
            Kondo,K., Egawa,J., Kaneko,N., Muratake,T., Saito,T., Okazaki,S.,
            Shimasaki,A., Igeta,H., Inoue,E., Hoya,S., Sugai,T., Sora,I.,
            Iwata,N. and Someya,T.
  TITLE     Rare truncating variations and risk of schizophrenia: Whole-exome
            sequencing in three families with affected siblings and a
            three-stage follow-up study in a Japanese population
  JOURNAL   Psychiatry Res 235, 13-18 (2016)
   PUBMED   26706132
REFERENCE   3  (bases 1 to 7764)
  AUTHORS   Correa,R.G., Krajewska,M., Ware,C.F., Gerlic,M. and Reed,J.C.
  TITLE     The NLR-related protein NWD1 is associated with prostate cancer and
            modulates androgen receptor signaling
  JOURNAL   Oncotarget 5 (6), 1666-1682 (2014)
   PUBMED   24681825
  REMARK    GeneRIF: Overexpression of NWD1 is associated with prostate cancer.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008737.11, BX489211.1,
            CR749794.1, BC117698.1, AK090685.1 and CB242932.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001007525.4.
            
            Summary: The protein encoded by this gene is thought to be a
            cytosolic protein and predicted to contain a NACHT domain and
            multiple WD40 repeats. Increased expression of this gene was
            observed in some prostate cancer cell lines. Knocking down
            expression of this gene results in decreased androgen receptor
            protein levels, indicating that this gene may be important in
            modulating androgen receptor activity. Alternative splicing results
            in multiple transcript variants encoding different isoforms.
            [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749794.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2153427
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524140.7/ ENSP00000428579.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC008737.11        35582-35710
            130-133             BX489211.1         1-4
            134-594             CR749794.1         1-461
            595-595             AC008737.11        46976-46976
            596-782             CR749794.1         463-649
            783-1202            BC117698.1         302-721
            1203-1203           AC008737.11        65029-65029
            1204-3055           BC117698.1         723-2574
            3056-3056           AC008737.11        88955-88955
            3057-3327           BC117698.1         2576-2846
            3328-3328           AC008737.11        104762-104762
            3329-4838           BC117698.1         2848-4357
            4839-5666           BC117698.1         4464-5291
            5667-5667           AC008737.11        131591-131591
            5668-6537           BC117698.1         5293-6162
            6538-7409           AK090685.1         2133-3004
            7410-7764           CB242932.1         28-382              c
FEATURES             Location/Qualifiers
     source          1..7764
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..7764
                     /gene="NWD1"
                     /note="NACHT and WD repeat domain containing 1"
                     /db_xref="GeneID:284434"
                     /db_xref="HGNC:HGNC:27619"
                     /db_xref="MIM:616250"
     exon            1..447
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..545
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..632
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             552..4850
                     /gene="NWD1"
                     /note="isoform 1 is encoded by transcript variant 1; NACHT
                     and WD repeat domain-containing protein 1; NACHT domain-
                     and WD repeat-containing protein 1"
                     /codon_start=1
                     /product="NACHT domain- and WD repeat-containing protein 1
                     isoform 1"
                     /protein_id="NP_001007526.3"
                     /db_xref="CCDS:CCDS32945.2"
                     /db_xref="GeneID:284434"
                     /db_xref="HGNC:HGNC:27619"
                     /db_xref="MIM:616250"
                     /translation="MQRGKPCRALPTLKCQTFCQRHGLMFEVVDLRWGIRNIEATDHL
                     TTELCLEEVDRCWKTSIGPAFVALIGDQYGPCLIPSRIDEKEWEVLRDHLTARPSDLE
                     LVARYFQRDENAFPPTYVLQAPGTGEACEPEEATLTSVLRSGAQEARRLGLITQEQWQ
                     HYHRSVIEWEIERSLLSSEDREQGATVFLREIQDLHKHILEDCALRMVDRLADGCLDA
                     DAQNLLSSLKSHITDMHPGVLKTHRLPWSRDLVNPKNKTHACYLKELGEQFVVRANHQ
                     VLTRLRELDTAGQELAWLYQEIRHHLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQH
                     TPLVLFGPPGIGKTALMCKLAEQMPRLLGHKTVTVLRLLGTSQMSSDARGLLKSICFQ
                     VCLAYGLPLPPAQVLDAHTRVVQFFHTLLHTVSCRNFESLVLLLDAMDDLDSVRHARR
                     VPWLPLNCPPRVHLILSACSGALGVLDTLQRVLLDPEAYWEVKPLSGNQGQQMIQLLL
                     AAARRTLSPVHTDLLWASLPECGNPGRLRLAFEEARKWASFTVPVPLATTAEEATHQL
                     CTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSLDDEVLQDVYRDWTPPSKELL
                     RFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVVRERYLSGSERAKRHGVLA
                     DFFSGTWSQGTKKLITLPLVGKPLNLDRKVAPQPLWFSHTVANLRKLKELPYHLLHSG
                     RLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCRPAV
                     ELRGMERSLLYTELLARLHFFATSHPALVGQLCQQAQSWFQLCAHPVLVPLGGFLQPP
                     GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVR
                     CVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKV
                     VYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSA
                     TGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVR
                     FLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITG
                     SLDALIQVWSLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFKVWDLSDAHR
                     SRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDTSSEIRCLE
                     VAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARKAINCMSLSKCEDRLAIAYDN
                     IVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAILTDYRVVYSMTNGDLFLYECAT
                     SKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTAPC"
     exon            633..749
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            750..1047
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..2320
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2524
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2684
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2802
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2961
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3159
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3282
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3491
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..3764
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3855
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3856..4010
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..4287
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4288..4838
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4839..7764
                     /gene="NWD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7746..7751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NWD1"
                     /note="hexamer: AATAAA"
     polyA_site      7764
                     /gene="NWD1"
                     /note="major polyA site"
ORIGIN      
        1 agttgctggg agaattgggc aaggagagac ccataaaata cctaagacga aagttactag
       61 gatagccagg ggcttgtctt ccgggtggcg ccgaggccag gaaactgtcc tctctaacct
      121 atttccccag aggagtctaa attggtcgtt caactaccag caaaggctaa agagaggctg
      181 gagcccccag gacagccaga acgctgacac tgcaaagggc ctctgtcctt actggggaag
      241 cccagtcctg ctcagctgtc ttcttcagca acaaacagaa gtccagaaag agaaacagtt
      301 gtggaggaag ctgttgtgat gataatttac tgagcaccta ctatgtgcca ggcacgccag
      361 ccttaccaga caagatcctt gggctcatgg aattcacttt ctcgtgggac agacaaacaa
      421 taacatgtag aaacatatca gctgttgacc atgcggccga tgccctggga gggagaccac
      481 ttgcttaagt cctccaggag ggcgatggag gagccggcat tccaaccagg ctcacggatg
      541 ccaagatatg gatgcagaga gggaagccct gcagagcact gcctaccctg aagtgccaga
      601 ccttctgcca gaggcacggc ttgatgtttg aggtcgttga tctgaggtgg ggtattcgga
      661 acattgaagc cactgaccac ttgaccacag aactctgctt ggaggaggtt gaccggtgtt
      721 ggaaaacatc catagggcca gcttttgttg ccctcatcgg tgatcagtac ggcccctgtc
      781 tgattccctc gcggatcgat gagaaggagt gggaggtatt gagggaccat ctgactgcca
      841 ggccaagtga cctggagctg gtggcacgat acttccagag ggacgagaat gcgtttcctc
      901 ccacctacgt cctgcaggca ccaggtactg gggaggcctg tgaaccagag gaggccacct
      961 taacttctgt cctacgctct ggagcccagg aggcccggag gctggggctc atcacccagg
     1021 agcagtggca gcactaccac cggtcagtca ttgagtggga gatagagcgg agcctgctga
     1081 gctcagagga ccgggaacag ggagccaccg tcttccttag agagatccaa gacctccaca
     1141 aacacatcct tgaagactgc gcccttagga tggtggaccg gctcgcggat ggctgcctgg
     1201 acgctgatgc ccagaacctt ctcagcagcc tcaaaagtca catcactgac atgcacccag
     1261 gggtcctcaa gacccaccgc ctgccgtgga gccgcgactt ggtgaacccc aagaacaaga
     1321 ctcacgcctg ctacctgaag gagctgggtg agcagtttgt ggtgagggcc aatcaccagg
     1381 tcctcacacg cctccgtgag ctggatacgg ccggacagga gttggcgtgg ctctaccaag
     1441 agatccgcca ccacctttgg cagagctcgg aggtcattca gaccttctgc ggacgccagg
     1501 aactcctggc ccggcttggg cagcagctca ggcacgatga cagcaagcag cacacccccc
     1561 tggtactctt tgggccccca ggcattggaa agacagccct gatgtgcaag ctggctgagc
     1621 agatgccaag gctgctgggg cacaagacag tgaccgtcct gcggctgctg gggacgtcac
     1681 aaatgagctc agatgcccgt ggcctgctga agagcatctg cttccaggtg tgcctggcct
     1741 atgggctgcc cttgccccct gcccaggttc tggacgccca caccagggtg gtccagtttt
     1801 tccataccct cctccacact gtctcttgca gaaacttcga gtctctcgtg ctcctgctgg
     1861 atgctatgga tgacctggac tctgtccgcc atgctcggag ggttccctgg ctgcctctca
     1921 actgcccccc gagggtgcac ctcatcctct cagcttgctc gggggcactg ggggttttgg
     1981 acaccttgca gcgggtgctc ctggacccgg aggcctactg ggaggtgaag cccctttccg
     2041 gaaaccaagg ccagcagatg atccaactcc tgctggcagc tgcaaggagg acgctgagcc
     2101 cggtgcacac agatttgctc tgggccagcc tcccagagtg tgggaaccca gggcggctga
     2161 ggctggcgtt tgaggaagcc cggaaatggg cctctttcac cgtgcctgtc ccgctggcca
     2221 ccaccgcaga ggaagccacg caccaactct gcacccgcct ggagcagaca cacgggcagc
     2281 tcctcgtggc ccacgtgctg ggctacattg tgtcttcccg acacggtctc tcggaggcgg
     2341 agctgaagga tgttttgtcc ctggacgacg aggtcctgca ggatgtgtac cgagattgga
     2401 ccccgcccag caaggagctg ctgcgcttcc cgcccctgct gtgggtgcgg cttcgtcggg
     2461 atctgggata ctacttggcc cggcggcccg tggatggctt caccctcctg gccattgccc
     2521 acagacagct ggtcgaggtg gtccgtgagc gctacctgtc aggatccgag agagccaaga
     2581 ggcatggcgt cctggccgac ttcttctcag ggacctggag ccagggtacc aagaagctca
     2641 tcactctgcc acttgtgggg aaaccactga acttggaccg aaaggtggcc ccgcagcctc
     2701 tgtggttctc acatacggtt gcaaacctgc ggaagctgaa ggagttgccc tatcacctgc
     2761 ttcactcggg ccgcctggag gagctgaaac aggaggttct gggcagcatg agctggattt
     2821 cctgccgggg catctctggg ggcattgaag acctgctgga tgactttgac ctgtgtgccc
     2881 ctcacctgga ctcccctgag gttggcctgg tccgtgaagc cctccagctc tgccgccctg
     2941 ctgtggagct ccgaggcatg gagaggagcc tcctgtacac agaactgctg gccagactcc
     3001 atttcttcgc cacctcacat ccagcactgg tgggacagct atgccaacag gcccagagct
     3061 ggttccagtt gtgcgcacac cctgtgctgg tgcccctcgg aggattcctc cagcccccgg
     3121 gaggacccct ccgggcaact ctcagcggct gtcacaaagg catcaccgcc atggcatggg
     3181 gtgtggagga gaagctgctg gtgattggca cccaggatgg catcatggct gtgtgggaca
     3241 tggaagagca gcatgtgatc cacatgctaa ctggacacac aggagaggtg aggtgtgtga
     3301 aaatatttgc caaagggacc ctcgccaact ctgcttcaaa ggattacacg ctgcacttgt
     3361 ggaacttact ctctggccag gagaaattta ccatttggga tggaggctca aaaaatcccg
     3421 ctgaacctca gatctggaac cttcatgtgg atgaggcaca caaagttgtg tattcagcat
     3481 ctggctcaaa gatcaatgct tggaatctgg aaactgcaga gccggtattc catatcctgg
     3541 gagatgcctc tgatccttgg atgtgcatgg ccgtgctggc ctcccaggcc acactgctga
     3601 cagtgtccag ggatggtgtg gtcagtctgt ggagctcagc tacgggaaaa cttcagggga
     3661 agcaacatat gtccagcatc aaagaagaaa cacctacctg tgccgtctca gtccagaagc
     3721 aaggaaagct tgttaccggg tttagcaatg gctccatctc tttggtttcc tccaaagggg
     3781 acagattgct ggagaagctt ccagatgctg tgaggttcct ggtggtctct gaagatgagt
     3841 ccctcctcgc cgcaggcttt ggaagatcgg tgcggatatt cttggcggac tcgaggggct
     3901 ttcgccgatt catggccatg gatctggaac atgaagacat ggtggagacg gctgtttttg
     3961 gtactgagaa caacctgatc atcacggggt cccttgatgc gctcattcag gtgtggagtc
     4021 tgtcagaaca ggggaccctt ctggacatcc tggaaggcgt cggggccccc gtgagcctgc
     4081 tggcccgcgg cggggctttg gtggcatctg cttccccaca gtcctcatct ttcaaggtct
     4141 gggatctcag cgatgctcat aggtcccggg tgcctgcacc atttctggac cgcaccggcc
     4201 tcaccgcagt gtcccacaat ggaagctacg tctacttccc caaaattggg gacaaaaaca
     4261 aagtcactat ttgggacttg gcagaaggcg aggaacaaga ttccctggac acctccagtg
     4321 agatcaggtg tctggaggtt gctgagcagc gcaagctcct atttacgggc ctcgtgtcgg
     4381 gggtcgtcct tgtgttcccc ctgaattcca ggcaggacgt gatatgcatt ccccctcccg
     4441 aggcccggaa agcaatcaac tgcatgtccc tgagcaagtg cgaggaccgc ctggccatcg
     4501 cctatgacaa catcgtcctg gtgctggaca tcacctccgg ggacccctgc ccggtcatcg
     4561 atgggccaag atacaccttt tacactcagc tgcccgagac cctctccagc gtggccattc
     4621 tgacggacta ccgcgtggtc tacagcatga ccaatgggga cctctttctt tacgagtgtg
     4681 caacttccaa agcgtttccc ttggagaccc acaggagccg agttgcctgt gtggaggtca
     4741 gccacaagga gcagctggtg gtcagcgggt ctgaggatgc cctgctgtgt ctctgggacc
     4801 tgcaggcacg caagtggaaa ttcgagatga gctacacggc accctgctga cagtccagtt
     4861 tgtccatgct gtggtaaaca gaatcatccc aaccaccagt ggcttcattg cccccaccag
     4921 gcatggttat ctgatccgag agaatttcca gtgcctttca gcaaaagcct caccgcagga
     4981 ccctcttaag aacttcaaga aggcaatgtg gatggtcaaa tccaggcaga gagaggagct
     5041 agttgcagct gcaggagctc cccaggactt ggagtcagaa agtgcccagg gaaatgaaac
     5101 caaatcaaac aaatgctcac aagtgtgcct gatagtgtaa aaaaataaaa ataaaaaaac
     5161 cctgtggggg tatggggctc cagtgagtta gccccattta atctagttaa agcaaaaaga
     5221 atacgtttgc tggtgtatat ctggacccat ggcttcagat tatggcttca gaccttgtct
     5281 cttctcatct ttccattatt ctttcctctt tttcattttc attctcagac ttgccacccc
     5341 caggttagca acatggtggc caatatgctg ctgtctccaa tttcaataga aaagagagct
     5401 tctctttccc aacagtccta gcctcaactc tactggtccc aattggccca tacgcctagc
     5461 cctaaaccaa ttattatatc tgggagaatg cagagctcta atcggctaga ctgatccaat
     5521 gtccaccact gggactgaga atagaagaga ttactcctga gatgcaaact ggagttctgg
     5581 taccagatga agggggaacg gatgaatgtg agatacagca aatcactgat gtggaccaca
     5641 gaacctcaca gtttataaag ctgtaggtgc tgtcatctga tcctcatcac aactcatact
     5701 ttagggaggg caggagtttc tgtatctatt ttacagatga ggaaactgag ccttgcggaa
     5761 gtagttataa tttgattcag gtcacaagtc caaggtgcaa gagctctgag agtgagcctt
     5821 ctgtcccatt cctgttagac ctcactccaa tttcagtctg cagagcacaa ccatctcttc
     5881 cacaggcacc acactcaaat gctcacagga gctagtgact aatctagaca cttccatgca
     5941 cctgggtgag cagcagggag agacagagac tggacatgtg gaaggcagag attgtgtcta
     6001 gggtgggtat gagcagcctg actgtagccc agaatcacca tggccaaaca agcccactgc
     6061 tgtcagtgct tccagttgta ataagcaaag ccagaaatcc agacttttat gcaaaaatgt
     6121 tctgactttt aaagttggcg attggttgaa tttatatcta tagtgcattt ggcatgtgcg
     6181 tctttggtta atgagctgac ttcaggactc acgctggcag taaaacaatc aacatgttat
     6241 agttcatccc tctctattcc ttggctccca aacttttggg ataaagatgt gggtttttaa
     6301 tcttaaaaac tggaggctct tggaagtaga aagagctgct gatctctccc tgctttgctt
     6361 ttgaactgtc tgccttgtgc aagttcaaca gtcaaactgt tttcattcca cttaagtgga
     6421 tctttcttct ttgcccacag ccttctaaaa gcccttctca gtcttctcag gcttttactt
     6481 taatgctagg atagtctaaa tcttcaaggt ggctatccct tctcccctcc gtggaattcc
     6541 tgatagagtc tcaataaaag caaccttaga aacagaggct tttgagctga acaagaccct
     6601 actgctgtct tattcatcca ttttccaaac cagttttcca aggcaggttt tggtagttct
     6661 gcaaatgtta gtgtcaaatt tcatttaaaa atattttaaa ctgtaatttt aagatgtatg
     6721 cttggatgta ttgggcagca gcttctaagg tgttgaagat tactaaggtt ggtgcaaaaa
     6781 gtaactgtgg ttttcgccat taaaaatatt aaaaataatg gcaaaaactg gctgggcaca
     6841 gtggctcaca cctgtggtcc cagctctttg gaaggccgag gcaggtggat cacctgaggt
     6901 caggagtttg agaccagcct ggacaacatg gtgaaaccct tctctactaa aaatacaaaa
     6961 atcagccagg catggtggtg agtgcctgta atctcagtta ctcaggaggc tgagtcagga
     7021 gaatcacttg aacccgggag gcggaggttg cagtgagctg agattgtgcc actgcactcc
     7081 agcctgggtg acagagcaag actccatctc ataataataa taataatggc aaaagcctcg
     7141 gtggctcacg cctgtaatcc cagcactttg ggaggctgag gcgggtggat cacttgaggc
     7201 caggtgttca agagcagcct ggtcaacatg gtgaaactct gtctctactc aaaaatacaa
     7261 aaattagcct ggtgtggtga cgtacacctg taattccagc tacttgggag gctgaggcag
     7321 gagaatggct tgaacccggg aggcggaggt tgcagtgagc cgagatcgca ccactgcact
     7381 ccagcatgag tgacagagac tctgtctcca aaaaaaaaaa aaaaaaaaag taatggcaaa
     7441 aaccacaatt aattttgcat caacctaata atttaggatt cttctgccat tttcatttaa
     7501 ctgatttaac tgaagagccc aattaaattg tgaagggagc cctgaaaaaa ttagctactc
     7561 tttgccactg cttctctgtg aatcaagggc ttacccaatg cagaaataaa gtagatgttg
     7621 agaccaatta agatttcacc tacaaattct gattttaaat gcctgtgtcc atctccacag
     7681 cctcagtgag aattgattgt tttgtagata aatcctaatt taaacattgg aaatgccttt
     7741 ttactaataa aatgctacaa caaa
//
