LOCUS       NM_002533               2897 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens nuclear VCP like (NVL), transcript variant 1, mRNA.
ACCESSION   NM_002533
VERSION     NM_002533.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2897)
  AUTHORS   Ishida,Y.I., Miyao,S., Saito,M., Hiraishi,N. and Nagahama,M.
  TITLE     Interactome analysis of the Tudor domain-containing protein SPF30
            which associates with the MTR4-exosome RNA-decay machinery under
            the regulation of AAA-ATPase NVL2
  JOURNAL   Int J Biochem Cell Biol 132, 105919 (2021)
   PUBMED   33422691
  REMARK    GeneRIF: Interactome analysis of the Tudor domain-containing
            protein SPF30 which associates with the MTR4-exosome RNA-decay
            machinery under the regulation of AAA-ATPase NVL2.
REFERENCE   2  (bases 1 to 2897)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2897)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2897)
  AUTHORS   Lingaraju,M., Johnsen,D., Schlundt,A., Langer,L.M., Basquin,J.,
            Sattler,M., Heick Jensen,T., Falk,S. and Conti,E.
  TITLE     The MTR4 helicase recruits nuclear adaptors of the human RNA
            exosome using distinct arch-interacting motifs
  JOURNAL   Nat Commun 10 (1), 3393 (2019)
   PUBMED   31358741
  REMARK    GeneRIF: Data show that the nuclear exosome adaptors nuclear
            valosin-containing protein-like (NVL) and zinc finger, CCHC domain
            containing 8 protein (ZCCHC8) bind the Mtr4 exosome RNA helicase
            (MTR4) KOW domain on a surface.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2897)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2897)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2897)
  AUTHORS   Nagahama,M., Yamazoe,T., Hara,Y., Tani,K., Tsuji,A. and Tagaya,M.
  TITLE     The AAA-ATPase NVL2 is a component of pre-ribosomal particles that
            interacts with the DExD/H-box RNA helicase DOB1
  JOURNAL   Biochem Biophys Res Commun 346 (3), 1075-1082 (2006)
   PUBMED   16782053
  REMARK    GeneRIF: Nuclear VCP/p97-like protein 2 might regulate the
            association/dissociation reaction of DOB1 with pre-ribosomal
            particles by acting as a molecular chaperone.
REFERENCE   8  (bases 1 to 2897)
  AUTHORS   Nagahama,M., Hara,Y., Seki,A., Yamazoe,T., Kawate,Y., Shinohara,T.,
            Hatsuzawa,K., Tani,K. and Tagaya,M.
  TITLE     NVL2 is a nucleolar AAA-ATPase that interacts with ribosomal
            protein L5 through its nucleolar localization sequence
  JOURNAL   Mol Biol Cell 15 (12), 5712-5723 (2004)
   PUBMED   15469983
  REMARK    GeneRIF: interaction of NVL2 with ribosomal protein L5 is
            ATP-dependent and likely contributes to the nucleolar translocation
            of NVL2
REFERENCE   9  (bases 1 to 2897)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   10 (bases 1 to 2897)
  AUTHORS   Germain-Lee,E.L., Obie,C. and Valle,D.
  TITLE     NVL: a new member of the AAA family of ATPases localized to the
            nucleus
  JOURNAL   Genomics 44 (1), 22-34 (1997)
   PUBMED   9286697
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP284587.1, AK293923.1,
            U68140.1, AC092809.2 and BU683548.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002533.3.
            
            Summary: This gene encodes a member of the AAA (ATPases associated
            with diverse cellular activities) superfamily. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            Two encoded proteins, described as major and minor isoforms, have
            been localized to distinct regions of the nucleus. The largest
            encoded protein (major isoform) has been localized to the nucleolus
            and shown to participate in ribosome biosynthesis (PMID: 15469983,
            16782053), while the minor isoform has been localized to the
            nucleoplasmin. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1, also known
            as NVL.2 or the major isoform).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U68140.1, SRR1660809.25222.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281701.11/ ENSP00000281701.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BP284587.1         18-49
            33-71               AK293923.1         9-47
            72-500              U68140.1           83-511
            501-501             AC092809.2         135313-135313       c
            502-782             U68140.1           513-793
            783-783             AC092809.2         132207-132207       c
            784-2896            U68140.1           795-2907
            2897-2897           BU683548.1         27-27               c
FEATURES             Location/Qualifiers
     source          1..2897
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.11"
     gene            1..2897
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /note="nuclear VCP like"
                     /db_xref="GeneID:4931"
                     /db_xref="HGNC:HGNC:8070"
                     /db_xref="MIM:602426"
     exon            1..102
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..2616
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /note="isoform 1 is encoded by transcript variant 1; NVLp;
                     nuclear valosin-containing protein-like"
                     /codon_start=1
                     /product="nuclear valosin-containing protein-like isoform
                     1"
                     /protein_id="NP_002524.2"
                     /db_xref="CCDS:CCDS1541.1"
                     /db_xref="GeneID:4931"
                     /db_xref="HGNC:HGNC:8070"
                     /db_xref="MIM:602426"
                     /translation="MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYS
                     IDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSD
                     DDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSI
                     PLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMK
                     RKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKE
                     VCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEI
                     VSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCM
                     DDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRK
                     LRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPS
                     KGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPS
                     AKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPP
                     GCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDE
                     VDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRL
                     DKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVR
                     EASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQESLSR
                     "
     exon            103..176
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            177..229
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            230..329
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            330..387
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            388..660
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            661..793
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            794..870
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1005
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1107
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1225
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1370
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1620
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1839
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1944
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2007
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2127
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2227
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2334
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2411
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2500
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2571
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2897
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2850..2855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /note="hexamer: AATAAA"
     regulatory      2875..2880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /note="hexamer: AATAAA"
     polyA_site      2881
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /note="major polyA site"
     polyA_site      2897
                     /gene="NVL"
                     /gene_synonym="NVL2"
                     /note="major polyA site"
ORIGIN      
        1 gactaggagc tggcggtccg agctgtggct tggaagaccg acgcgatgaa gcccagacct
       61 gcagggttcg tggataataa actcaagcag cgagtcatcc agtaccttac cagtaacaaa
      121 tgtggcaaat atgtggacat tggagtctta gcgtctgatt tacaaagagt gtacagtata
      181 gactatggtc gaagaaaaag aaatgctttt aggattcagg tagaaaaagt atttagcata
      241 attagtagtg agaaggaact taagaattta acagaattag aagatgaaca tttggcaaaa
      301 agggcaagac aaggtgaaga ggataatgag tatactgaaa gctattctga tgatgattca
      361 agtatggaag actacccaga tccacagtca gcaaatcaca tgaacagttc cctgctgtct
      421 ttatatcgga aaggaaatcc tgattctgtt tcaaatactc ctgagatgga gcaaagagaa
      481 accacctctt caacaccacg gataagttcc aaaacaggct ccattccctt gaagacccct
      541 gccaaagatt ctgaaggagg atggtttatt gacaaaaccc caagtgtaaa gaaagacagt
      601 tttttcttgg acctgtcatg tgagaaaagt aatcctaaga agccaataac tgagatacag
      661 gattcaaaag attcttctct tttggagagt gatatgaaac ggaaaggcaa gctaaagaat
      721 aaaggaagca aaaggaagaa agaagatctt caggaagtag atggagaaat tgaagctgtc
      781 ctgcaaaaga aagctaaagc cagggggtta gaattccaga tctccaacgt gaagtttgaa
      841 gatgtgggag gcaatgatat gacattaaaa gaggtctgca agatgctcat acacatgcgt
      901 cacccggagg tgtaccacca cctgggcgtc gtgccccctc gtggagttct ccttcatgga
      961 ccaccaggct gtgggaagac attacttgca catgcaattg ctggggaact tgacctgcca
     1021 attttgaaag tggctgctcc agagattgtg tctggagtat ccggagagtc tgagcagaag
     1081 ctgagagaac tatttgagca agctgtgtca aatgcaccat gtatcatttt cattgatgaa
     1141 attgatgcta ttacccccaa aagagaagtg gcttcaaaag atatggaacg aagaattgta
     1201 gcccaactcc taacctgcat ggatgatctg aataatgtgg ctgctacagc ccgggtccta
     1261 gttattggag ctactaatcg accagactcg ttagaccctg ctttgagacg tgcgggaagg
     1321 ttcgaccgag aaatatgcct aggtatccca gatgaagcat ccagggaaag aatacttcaa
     1381 acattgtgca gaaaactgag gcttcctcaa gcttttgatt tctgtcactt agcacaccta
     1441 actccaggct ttgttggtgc tgatctcatg gcactgtgcc gagaggcagc aatgtgtgca
     1501 gtcaatagag tcttaatgaa gctacaggaa cagcagaaga aaaatcctga aatggaagat
     1561 ttgccatcta aaggagtcca ggaggaaagg ctgggaactg agcccacttc tgaaacacag
     1621 gatgaattac aaaggctgct ggggttgcta agagaccaag atcccctctc agaggagcag
     1681 atgcaaggac tgtgcattga actgaatgat ttcattgttg ctctatcctc agtccaaccc
     1741 tctgccaaaa gggaaggctt tgtcactgtc cctaatgtga catgggcaga tattggtgcc
     1801 ctggaagaca ttagagagga gctcaccatg gcaatattgg caccagtacg caacccagac
     1861 cagttcaaag ctcttggatt ggtgactcca gctggggtcc tccttgctgg tcctcctggc
     1921 tgtgggaaga ctctgctggc gaaggctgtt gcaaatgagt ccggactaaa ttttatatct
     1981 gtcaagggcc ccgaattact aaacatgtat gttggtgaga gtgaacgtgc tgtgcgacaa
     2041 gtttttcaac gagccaagaa ctcagcaccc tgtgtgatat tctttgatga agtggatgct
     2101 ttatgtcctc gaagatcaga ccgagagaca ggggcaagtg tccgagtggt gaatcagcta
     2161 cttacagaga tggatggtct ggaagcacgc cagcaggttt ttattatggc agccactaac
     2221 aggccagata taattgaccc tgcaatcctg cgcccgggcc gcctggacaa aacactgttt
     2281 gtgggtttac cgccccctgc agatcgcctt gccatcttaa aaactatcac aaaaaatggt
     2341 accaaaccac cactggatgc agatgtaaat ttggaagcaa ttgctggtga ccttcgctgt
     2401 gattgctata cgggcgcaga tctctctgct ttggtacgag aagcttctat ctgtgccctg
     2461 agacaggaaa tggcaagaca gaagagtgga aatgaaaaag gtgaactcaa ggttagtcat
     2521 aagcattttg aagaagcttt caagaaagta agatcatcta tatcaaaaaa ggatcaaatc
     2581 atgtatgaac gtttgcagga gtccctcagc cggtgatgtc tccagcagcc ggcttagagg
     2641 agctagccca tcaagccggc agagaatccc ccacacgctc tgaaggaccc actttcagct
     2701 ggacacaggc gcggcctcat gtaaacattt tattttcaaa tgaatgaggc caagctgaag
     2761 ctgaagctga agattcttcc catctggcca gccttgtgtg aaaatgcctt cttcctcttt
     2821 aagaaaaagg acaattttta aactgctgaa ataaaatgac tgttacattt ttcaaataaa
     2881 acttttactt tgaacta
//
