LOCUS       NM_001355263            6255 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens NUT family member 2E (NUTM2E), mRNA.
ACCESSION   NM_001355263 XM_024447950
VERSION     NM_001355263.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6255)
  AUTHORS   Gooskens,S.L., Kenny,C., Lazaro,A., O'Meara,E., van Tinteren,H.,
            Spreafico,F., Vujanic,G., Leuschner,I., Coulomb-L'Hermine,A.,
            Perotti,D., de Camargo,B., Bergeron,C., Acha Garcia,T., Tanaka,M.,
            Pieters,R., Pritchard-Jones,K., Graf,N., van den
            Heuvel-Eibrink,M.M. and O'Sullivan,M.J.
  TITLE     The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear
            cell sarcoma of the kidney
  JOURNAL   Genes Chromosomes Cancer 55 (2), 143-147 (2016)
   PUBMED   26542179
  REMARK    GeneRIF: Studies show that patients with clear cell sarcoma of the
            kidney (CCSK) and the fusion YWHAE-NUTM2B/E were relatively young,
            had low tumor volumes, and did not present with stage I disease
            which fail to identify an explicit clinical phenotype.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL135925.10.
            
            On or before Jul 1, 2020 this sequence version replaced
            XM_024447950.1, NM_001355263.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1236840.1,
                                           SRR14038192.2104171.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2155371
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429984.5/ ENSP00000407521.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-619               AL135925.10        25043-25661
            620-897             AL135925.10        36613-36890
            898-1233            AL135925.10        37084-37419
            1234-3728           AL135925.10        37932-40426
            3729-4428           AL135925.10        42477-43176
            4429-4557           AL135925.10        45134-45262
            4558-4697           AL135925.10        46235-46374
            4698-5080           AL135925.10        46817-47199
            5081-5197           AL135925.10        47675-47791
            5198-6255           AL135925.10        48125-49182
FEATURES             Location/Qualifiers
     source          1..6255
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..6255
                     /gene="NUTM2E"
                     /gene_synonym="FAM22E"
                     /note="NUT family member 2E"
                     /db_xref="GeneID:283008"
                     /db_xref="HGNC:HGNC:23448"
     exon            1..619
                     /gene="NUTM2E"
                     /gene_synonym="FAM22E"
                     /inference="alignment:Splign:2.1.0"
     exon            620..897
                     /gene="NUTM2E"
                     /gene_synonym="FAM22E"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1233
                     /gene="NUTM2E"
                     /gene_synonym="FAM22E"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..3728
                     /gene="NUTM2E"
                     /gene_synonym="FAM22E"
                     /inference="alignment:Splign:2.1.0"
     CDS             3347..5983
                     /gene="NUTM2E"
                     /gene_synonym="FAM22E"
                     /note="family with sequence similarity 22, member E"
                     /codon_start=1
                     /product="nUT family member 2E"
                     /protein_id="NP_001342192.1"
                     /db_xref="CCDS:CCDS91285.1"
                     /db_xref="GeneID:283008"
                     /db_xref="HGNC:HGNC:23448"
                     /translation="MEVKGPSGRSFCCESEGQFKSCLKRHTPSLLLPSSWKGNSGSCL
                     MAEALHRTSPTPNSCPLPLPLCRMSGVLCSRNLFTFKFSLFQLDSGASGEPGHSLGLT
                     LGFSYCGNCQTAVVSAQPEGMASNGAYPVLGPGVTANPGTSLSVFTALPFTTPAPGPA
                     HGPLLVTAGAPPGGPLVLSTFPSTPLVTEQDGCSPSGAGASNVFVQMRTEVGPVKAAQ
                     AQTLVLTQAPLVWQAPGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQG
                     LPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGESSLASSQAKAPPDDSCNPRSVYENFR
                     LWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSN
                     FDRMIFYEMAEKFLEFEAEEEMQIQKSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQP
                     VYLPSKAGPKAQTACLPPPRPQRPVTKARRPPPQPHRRAETKARLPPPRPQRPAETKV
                     PEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQREEGKVKQPQEEDWTPPDPGLLSYI
                     DKLCSQKDFVTKVEAVIHPQFLEELLSPDPQMDFLALSQDLEQEEGLTLAQLVEKRLP
                     PLKEKQHSRAAPSRGTARLDSSSSKFAAGQGAERDVPDPQEGVGMETCPPQTTARDSQ
                     GRGRAHTGMARSEDSVVLLGCQDSPGLRAARPTSPPQDHRPTCPGVGTKDALDLPGGS
                     PVRESHGLAQGSSEEEELPSLAFLLGSQHKLLPWWLPQSPVPASGLLSPEKWGPQGTH
                     QSPSAERRGLNLAPSPANKAKKQPLFGSLSPAEKTPHRGPGLRVSGEQSLTWGLGGPS
                     QSQKRKGDPLVSRKEKKQHCSQ"
     exon            3729..4428
                     /gene="NUTM2E"
                     /gene_synonym="FAM22E"
                     /inference="alignment:Splign:2.1.0"
     exon            4429..4557
                     /gene="NUTM2E"
                     /gene_synonym="FAM22E"
                     /inference="alignment:Splign:2.1.0"
     exon            4558..4697
                     /gene="NUTM2E"
                     /gene_synonym="FAM22E"
                     /inference="alignment:Splign:2.1.0"
     exon            4698..5080
                     /gene="NUTM2E"
                     /gene_synonym="FAM22E"
                     /inference="alignment:Splign:2.1.0"
     exon            5081..5197
                     /gene="NUTM2E"
                     /gene_synonym="FAM22E"
                     /inference="alignment:Splign:2.1.0"
     exon            5198..6255
                     /gene="NUTM2E"
                     /gene_synonym="FAM22E"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaaggcca gcgtccctcg ctgggagcag agctagccga gtagggcgcc cggctgtcaa
       61 actggccggc gcagtgcacg ctgggccgcc ccggagcgat cgcagagccc gtcgggagtc
      121 gtagtcccgg acgggcccgc ggcatcgtcc gcgacgcagc tcgggatccg ggtcggggtg
      181 tcggccgggt tgctgccggg caccgtcgag cgttagccac ccagcattga gctgccagcg
      241 gctgttctcc ctaagcaccc tcgctcacgt cgcctcgcct cgcctgaccg gccgcagcct
      301 tggataccag ccttaaatcg agccgactac ggcccagccc cgcccgcggc gaggtgcgcg
      361 gggttcggtg cgagcccctc gcccctggcc gggccagcct cttgatgcac cggggacggg
      421 cgcgcccatc cgactcttcg aggggcggca gggccccatc tgtgtctttc gctctcgagc
      481 ccccagctag agttggcttc agcggaatac ctactgtgcg ggattattca acaagccgat
      541 tgatcacatt cttcagctct agcagtgcaa aggcttcact gaaaaagaac attacaactt
      601 ttttgaaaga aatttggggc tgctcctatc agtgacaaat cagtgtatta gaacatgcat
      661 gctggctgat cattctgatc aagtcaacaa gcttcacaac ttactcaatg aggtcgtccg
      721 tgagaacttc actgttttac gaggacagga gctacttctt tgctgaactg catcacggtt
      781 tcaactgctg aggttttctt caagcttttg cattgtttgg aatgtgaaag gcacggccga
      841 gacacacttt gaggttccca ctgcattgtt acacctcccc cctcacttca gggccaggta
      901 acaccaagaa ggacgccatg agagcgaagg ccgttgggtc accgcccttt gctctcgcgc
      961 tgcgcgtctc cctgccatca accgccgcaa ctggcgctgg gagcggttga gggcggccgg
     1021 cctcgcgctg gaacctcgcc cgcctcaagg ctcctgcggc ggcgcacagg gcaggccagg
     1081 agcccgccct aggagggccc cgctggagat gtggaaatgg agggacgcgg cacctgggtg
     1141 cttcctgggg ccagacaacg ccccctcatt ggaacctcca tgaccgtgcc tctgagaaac
     1201 cagcgcgtcc gcaacgatca ctcctaattt tcggattcct atcatctgtc tccacgtgat
     1261 aacactgaag agccttcaca ttgatgcagg cccagggcct caagtgcaga gtctgagagc
     1321 tctgcaggac acagcatgga gccgccattc ctctactggg tggaggagca tgtgtcctct
     1381 gaacagggga tccaagccct gagatgttct ttctcagctg tcagtgcggc ccaggacttt
     1441 ctgtggggat gctcagacag caggggccgg aggactttta gccaccacct cccatggcca
     1501 gtcttcacaa attacctttg gctaatttga ctgtctctcc tcctggggtc taggacttca
     1561 aacatgtaca gaagcgattg cagaattaag acaagacact tccacaatat attttttgta
     1621 tcactggctc agaaaaagac tcattcaaat cctgtatcaa agccacatgt gagaatcttg
     1681 agaaagcatc agctgactga cttgacaagg gaggaagcaa ccaaaaattc tgcgcttctt
     1741 cagtatctga gtatgatatt ttgcttcaac atccctctta gatgaagtta ttgattgaaa
     1801 atcatttaag tttgccccat ggtaaaagat caagtcctca gaaagatctc caaagtgttt
     1861 acagtttgtt ttgttttggt aagtttacca tgattttgct tgaattgctc tccgttgatc
     1921 ttctcagcta agatggaggt agagttgcac agtggaagag ggctgcatgt aagaaggcag
     1981 ttctgtctca gaggacaaaa ggcctgggag cacccagaca gacagtcact gcatggaggt
     2041 cactcccctc ccagtggcca ctgtggagac atttcacaga aatgcttgct ggaccattca
     2101 ggttcagagt tgggacaaaa ccgagaactc atggggatat tggacaggag ttaggaaatg
     2161 accttctcac acaactgggg cagtggggga gaaccctggg cttgagactt gcaatccacc
     2221 acttgcccct gcccctgccc ctgcagtgtg gccgctgtta cattttcctg caactctgcc
     2281 ttcttgagtc caagtgtctt cgaaagggca aatgcttcgt aagtgccgac agggtgtgtt
     2341 tcagtgaatg tttgcagtgt gcaccggtct ggctgaaggc ctcttccctt ccccaacacc
     2401 ctcccatcgt gcaaaattac cctgcccagc agggagtgat ttgtgtgtct cagaagattt
     2461 tgttgctgtg ctctgagttc tcactcctca tctcctttga ccagtttctt ctaatactcc
     2521 ccttgttcac aacacagaac atgagtgctc tttcctatca ttttgatact aataaacgga
     2581 cagtgattct cagtgtggaa atgagaatga agcttttttt aaagacaggc tacaataatt
     2641 cccatgcaga gaaccacatg ccatgacact ggattccaaa cagcaagaac gtatggtgaa
     2701 gacgaggcca acagtgagct gagagaggcc agccagggtg tgtttcagtg aagatgagaa
     2761 acaatcagat aacacctgtt tcctccagga aagaaaatgt ggccagggaa aagagatggg
     2821 aggaaggctg gtcattgcct attccactgt gcacagtttg aatttggagc catgaaaagt
     2881 attgcttggt taaattaaaa tcattcaaaa gataaaacat aaacatttaa caccagcaca
     2941 atatgctggg aaacaaaatg aaaggatttc tggtctcggt gctgtaggtc acatagccac
     3001 tctttcctgg attgaggctt tccagcaaag gggctgggac gtaaggctgg cctgctggtg
     3061 tggacagaga ttccagcaac atgcatgacc tgggggtaca aggattgctt cctaaacaat
     3121 gataagcaca cagccaccta atagtctgga tcggctgaga ccatcctgat ttcaaacacc
     3181 cagtcccctt gccttcctaa gaacccctgt gtttctcaga ctgaaaatgt gttttgaact
     3241 ttgttcacga agtgaggccg ctgttgaaat tcgtcaagac tgggaaagag ccaaagtggg
     3301 aaggagcatg ggttgattgg cacaaaagta ggtctgctga taaagaatgg aagtaaaggg
     3361 gccatcaggt agaagctttt gctgtgagtc agaaggacaa tttaaaagtt gcctaaagag
     3421 gcacacgcca tctctgctgc tgccttccag ttggaaggga aactcaggtt cttgcctaat
     3481 ggccgaagcc cttcacagaa cgtcccccac ccctaacagc tgcccactgc ccctccccct
     3541 ctgcagaatg tctggggtcc tatgttccag gaacctgttt actttcaaat tttccctgtt
     3601 tcagttggac tcaggagcat ctggtgagcc aggtcactct ctgggtctta cccttggctt
     3661 ttcttattgc ggaaactgcc agacggcggt ggtcagtgcc cagcctgagg ggatggcttc
     3721 gaatggagca tacccagtgc tgggaccggg cgtgaccgcg aaccctggca cctccctgtc
     3781 tgtgttcacg gctctgccct tcaccacacc cgctcccggc ccagcacacg ggccgctcct
     3841 tgtgactgca ggggctcctc caggcggccc tctggtgctg tctaccttcc ccagcacacc
     3901 tctggtgaca gaacaggatg gctgcagccc gagtggggcc ggggcttcca acgtctttgt
     3961 ccagatgagg acagaggtgg ggcctgtgaa ggccgctcag gcgcagacct tggtcctaac
     4021 tcaggccccc ctcgtctggc aggctccagg cgccctctgc ggaggtgttg tgtgtccacc
     4081 tcccctactc ctggcagctg ctcctgtggt gcctgttatg gctgcccagg tggttggggg
     4141 cacccaggcc tgtgagggag gctggtccca gggccttcct cttccaccac caccaccacc
     4201 ggctgcccag ctgcccccca ttgtgtccca agggaatgct gggccatggc cacaaggggc
     4261 tcatggagag agcagcctgg cttcctccca ggccaaggcc ccgccagatg actcctgtaa
     4321 ccccaggagt gtctatgaga acttccgact ctggcagcac tacaagcccc tggcccggag
     4381 gcaccttccc cagagtcctg acaccgaagc gctttcgtgc ttcctcatcc cagttctccg
     4441 atcgctggcc cggcggaagc ccaccatgac cctggaggag ggactgtggc gggccatgcg
     4501 ggaatggcag cacacgagca actttgaccg gatgatcttc tacgagatgg cggaaaagtt
     4561 cctggagttt gaggctgagg aggagatgca gattcagaaa tcgcaatgga tgaaggggcc
     4621 ccagtgcctg cctcctccag ccacaccgag gcttgaacct cgaggacccc cggcccctga
     4681 ggtggtcaag cagccagtgt accttcccag caaggccggc cccaaggccc agactgcctg
     4741 cctgccacca cccagacccc agaggccagt gaccaaggcc cgccggccac caccccagcc
     4801 ccaccggcga gcagagacca aggcccgcct gccaccaccc aggccccaga gaccagcaga
     4861 gaccaaggtc cctgaggaga tccccccaga agtggtgcag gagtatgtgg acatcatgga
     4921 ggagctgctg gggccttccc tcggggccac gggggagccc gagaaacaac gggaagaggg
     4981 caaagtgaag cagccacagg aagaggactg gacgccccca gacccgggcc tcctgagcta
     5041 cattgacaag ctgtgttccc agaaagactt cgtcaccaag gtggaggccg tcattcatcc
     5101 ccaattcctg gaagaattgc tttccccaga tccacagatg gatttcttgg ccctaagcca
     5161 ggacctggag caggaggaag gactcaccct tgcccagcta gtggagaagc gcctcccacc
     5221 cttgaaggag aaacagcatt cgagggcagc ccctagtcgt ggcacagccc ggttggactc
     5281 aagttcttct aagtttgcag ctggccaagg agcagagaga gacgtccctg acccccaaga
     5341 aggggttggc atggaaacct gcccacccca gacgactgcc cgggactctc agggacgagg
     5401 cagagcacac actggcatgg ccaggtccga agactctgtt gtgcttttgg gatgtcagga
     5461 ttcccctggg ctgagggctg cccggccaac ctctcctccc caggaccaca gacccacctg
     5521 ccctggcgtg ggtaccaagg atgccttgga tctccctgga gggtctcctg tcagggagtc
     5581 acatgggctg gctcaggggt caagtgagga ggaggaactc cccagcctgg ccttcctctt
     5641 gggttcccag cacaagcttc tgccctggtg gctaccccag agccctgtcc ctgcctcggg
     5701 ccttctcagc ccagaaaagt ggggacccca gggaactcat cagtccccat ctgctgagag
     5761 aagaggcctc aacctagcac cttctcctgc caacaaggcc aagaagcaac ctctctttgg
     5821 aagcctgtcc cctgctgaaa agacacccca ccgagggcct gggctcaggg tctctgggga
     5881 gcaatccctg acttgggggc tgggtggccc ctcacagtct caaaagagaa agggtgaccc
     5941 cttggtctcc aggaaggaga agaagcagca ttgtagccag taggggcttc tgagcaggct
     6001 ctctggggcc aatccccaag gatggggctc tggcatccga tgccccaaag cggtcaaaag
     6061 cttcttctcc cccagtgctg atcttgctgg gccttagctt tggagggtag gggagggagg
     6121 ggagggagag ggtggctgaa tggggagggc aggaagggag ggtctggggg gaaggggctg
     6181 gggagtgggg gtgggaagca gtgtgttggg ggcctcgtgt gtaagtgtga ataaatgtag
     6241 ttgtcttgga aaatg
//
