LOCUS       NM_001099338            3290 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens NUT family member 2A (NUTM2A), mRNA.
ACCESSION   NM_001099338 XM_001127460
VERSION     NM_001099338.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3290)
  AUTHORS   Sugita,S., Arai,Y., Aoyama,T., Asanuma,H., Mukai,W., Hama,N.,
            Emori,M., Shibata,T. and Hasegawa,T.
  TITLE     NUTM2A-CIC fusion small round cell sarcoma: a genetically distinct
            variant of CIC-rearranged sarcoma
  JOURNAL   Hum Pathol 65, 225-230 (2017)
   PUBMED   28188754
  REMARK    GeneRIF: Case Report: genetically distinct variant of
            CIC-rearranged sarcomas with a novel NUTM2A-CIC fusion.
REFERENCE   2  (bases 1 to 3290)
  AUTHORS   Lee,C.H., Marino-Enriquez,A., Ou,W., Zhu,M., Ali,R.H., Chiang,S.,
            Amant,F., Gilks,C.B., van de Rijn,M., Oliva,E., Debiec-Rychter,M.,
            Dal Cin,P., Fletcher,J.A. and Nucci,M.R.
  TITLE     The clinicopathologic features of YWHAE-FAM22 endometrial stromal
            sarcomas: a histologically high-grade and clinically aggressive
            tumor
  JOURNAL   Am J Surg Pathol 36 (5), 641-653 (2012)
   PUBMED   22456610
  REMARK    GeneRIF: Tumors with YWHAE-FAM22 rearrangements constitute a
            distinct group of endometrial stromal sarcoma (ESS), which is
            associated with high-grade morphology and aggressive clinical
            behavior compared to JAZF1 ESS.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC092519.1, AL157893.16, BC033231.1 and EG328792.1.
            
            On May 17, 2019 this sequence version replaced NM_001099338.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092519.1, SRR14038191.2032696.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381707.6/ ENSP00000371126.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-429               BC092519.1         1-429
            430-728             AL157893.16        32328-32626
            729-1300            BC092519.1         725-1296
            1301-1996           BC033231.1         250-945
            1997-2204           EG328792.1         274-481
            2205-2367           BC092519.1         2201-2363
            2368-3241           AL157893.16        40507-41380
            3242-3290           BC092519.1         3238-3286
FEATURES             Location/Qualifiers
     source          1..3290
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.2"
     gene            1..3290
                     /gene="NUTM2A"
                     /gene_synonym="FAM22A"
                     /note="NUT family member 2A"
                     /db_xref="GeneID:728118"
                     /db_xref="HGNC:HGNC:23438"
     exon            1..765
                     /gene="NUTM2A"
                     /gene_synonym="FAM22A"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..3020
                     /gene="NUTM2A"
                     /gene_synonym="FAM22A"
                     /note="protein FAM22A; family with sequence similarity 22,
                     member A"
                     /codon_start=1
                     /product="NUT family member 2A"
                     /protein_id="NP_001092808.1"
                     /db_xref="CCDS:CCDS44452.1"
                     /db_xref="GeneID:728118"
                     /db_xref="HGNC:HGNC:23438"
                     /translation="MEVKGPSGRSFCCESEGQFKSCLKRHTPSLLLPSSWKGNSGSCL
                     MAKALHRMSPTPNSCPLPLPLCRMSGVLCSRNLFTFKFSLFQLDSGASGEPGHSLGLT
                     LGFSHCGNCQTAVVSAQPEGMASNGAYPALGPGVTANPGTSLSVFTALPFTTPAPGPA
                     HGPLLVTAGAPPGGPLVLSTLPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAAQ
                     AQTLVLTQAPLVWQAPGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQG
                     LPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGEGSLASSQAKAPPDDSCNPRSVYENFR
                     LWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSN
                     FDRMIFYEMAEKFLEFEAEEEMQIQKSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQP
                     VYLPSKAGPKAPTACLPPPRPQRPVTKARRPPPRPHRRAETKARLPPPRPQRPAETKV
                     PEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQREEGEVKQPQEEDWTPPDPGLLSYT
                     DKLCSQKDFVTKVEAVIHPQFLEELLSPDPQMDFLALSQELEQEEGLTLAQLVEKRLL
                     PLKEKQHARAAPSRGTARLDSSSSKFAAGQGAERDVPVPQQGVGMETCPPQTTARDSQ
                     GRGRAHTGMARSKDSVVLLGCQDSPGLRAARPTSPPQDHRPTCPGVGTKDALDLPGGS
                     PVRESHGLAQGSSEEEELPSLAFLLGSQHKLLPWWLPQSPVPASGLLSPEKWGPQGTH
                     QFPSAERRGLNLAPSPANKAKKRPLFGSLSPAEKTPHPGPGLRVSGEQSLTWGLGGPS
                     QSQKRKGDPLVSRKEKKQRCSQ"
     exon            766..1465
                     /gene="NUTM2A"
                     /gene_synonym="FAM22A"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1594
                     /gene="NUTM2A"
                     /gene_synonym="FAM22A"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1734
                     /gene="NUTM2A"
                     /gene_synonym="FAM22A"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..2117
                     /gene="NUTM2A"
                     /gene_synonym="FAM22A"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2234
                     /gene="NUTM2A"
                     /gene_synonym="FAM22A"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..3290
                     /gene="NUTM2A"
                     /gene_synonym="FAM22A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatttctgg tctcggtgct gtaggtcaca tagccactct ttcctggatt gaggctttcc
       61 agcaaagggg ctgggacgta aggctggcct gctggtgtgg acagagattc cagcaacatg
      121 catgacctgg gggtacaagg attgcttcct aaacaatgat aagcacacag ccacctaata
      181 gtctggatcg gctgagacca tcctgatttc aaacacccag tccccttgcc ttcctaagaa
      241 cccctgtgtt tctcagactg aaaatgtgtt ttgaactttg ttcacgaagt gaggccgctg
      301 ttgaaattcg tcaagactgg gaaagagcca aagtgggaag gagcatgggt tgattggcac
      361 aaaagtaggt ctgctgataa agaatggaag taaaggggcc atcaggtaga agcttttgct
      421 gtgagtcaga aggacaattt aaaagttgcc taaagaggca cacgccatct ctgctgctgc
      481 cttccagttg gaagggaaac tcaggttctt gcctaatggc caaagccctt cacagaatgt
      541 cccccacccc taacagctgc ccactgcccc tccccctctg cagaatgtct ggggtcctat
      601 gttccaggaa cctgtttact ttcaaatttt ccctgtttca gttggactca ggagcatctg
      661 gtgagccagg tcactctctg ggtcttaccc ttggcttttc tcattgcgga aactgccaga
      721 cagcggtggt cagtgcccag cctgagggga tggcttcaaa tggagcatac ccagcgctgg
      781 gaccgggcgt gaccgcgaac cctggcacct ccctgtctgt gttcacggct ctgcccttca
      841 ccacacccgc tcccggccca gcacacgggc cgctccttgt gactgcaggg gctcctccag
      901 gcggccctct ggtgctgtct accctcccca gcacacctct ggtgacagaa caggatggct
      961 gcggcccgag tggggccggg gcttccaacg tctttgtcca gatgaggaca gaggtggggc
     1021 ctgtgaaggc cgctcaggcg cagaccttgg tcctaactca ggcccccctc gtctggcagg
     1081 ctccaggcgc cctctgcgga ggtgttgtgt gtccacctcc cctactcctg gcagctgctc
     1141 ctgtggtgcc tgttatggct gcccaggtgg ttgggggcac ccaggcctgt gagggaggct
     1201 ggtcccaggg ccttcctctt ccaccaccac caccaccggc tgcccagctg ccccccattg
     1261 tgtcccaagg gaatgctggg ccatggccac aaggggctca cggagagggc agcctggctt
     1321 cctcccaggc caaggccccg ccagatgact cctgtaaccc caggagtgtc tatgagaact
     1381 tccgactctg gcagcactac aagcccctgg cccggaggca ccttccccag agtcctgaca
     1441 ccgaagcgct ttcgtgcttc ctcatcccag ttctccgatc cctggcccgg cggaagccca
     1501 ccatgaccct ggaggaggga ctgtggcggg ccatgcggga atggcagcac acgagcaact
     1561 ttgaccggat gatcttctac gagatggcgg aaaagttcct ggagtttgag gctgaggagg
     1621 agatgcagat tcagaaatcg caatggatga aggggcccca gtgcctgcct cctccagcca
     1681 caccgaggct tgaacctcga ggacccccgg cccctgaggt ggtcaagcag ccagtgtacc
     1741 ttcccagcaa ggccggcccc aaggccccga ctgcctgcct gccaccaccc aggccccaga
     1801 ggccagtgac caaggcccgc cggccaccac cccggcccca ccggcgagca gagaccaagg
     1861 cccgcctgcc accacccagg ccccagagac cagcagagac caaggtccct gaggagatcc
     1921 ccccagaagt ggtgcaggag tatgtggaca tcatggagga gctgctgggg ccttccctcg
     1981 gggccacggg ggagcccgag aaacaacggg aagagggcga agtgaagcag ccacaggaag
     2041 aggactggac gcccccagac ccgggcctcc tgagctacac tgacaagctg tgttcccaga
     2101 aagacttcgt caccaaggtg gaggccgtca ttcatcccca attcctggaa gaattgcttt
     2161 ccccagatcc acagatggat ttcttggccc taagccagga gctggagcag gaggaaggac
     2221 tcacccttgc ccagctagtg gagaagcgcc tcctaccctt gaaggagaaa cagcatgcga
     2281 gggcagcccc tagtcgtggc acagcccggt tggactcaag ttcttctaag tttgcagctg
     2341 gccaaggagc agagagagac gtccctgtcc cccaacaagg ggttggcatg gaaacctgcc
     2401 caccccagac gactgcccgg gactctcagg gacgaggcag agcacacact ggcatggcca
     2461 ggtccaaaga ctctgttgtg cttttgggat gtcaggattc ccctgggctg agggctgccc
     2521 ggccaacctc tcctccccag gaccacagac ccacctgccc tggcgtgggt accaaggatg
     2581 ccttggatct ccctggaggg tctcctgtca gggagtcaca tgggctggct caggggtcaa
     2641 gtgaggagga ggaactcccc agcctggcct tcctcttggg ttcccagcac aagcttctgc
     2701 cctggtggct accccagagc cctgtccctg cctcgggcct tctcagccca gaaaagtggg
     2761 gaccccaggg aactcatcag ttcccatctg ctgagagaag aggcctcaac ctagcacctt
     2821 ctcctgccaa caaggccaag aagcgacctc tctttggaag cctgtcccct gctgaaaaga
     2881 caccccaccc agggcctggg ctcagggtct ctggggagca atccctgact tgggggctgg
     2941 gtggcccctc acagtctcaa aagagaaagg gtgacccctt ggtctccagg aaggagaaga
     3001 agcagcgttg tagccagtag gggcttctga gcaggctctc tggggccgat ccccaaggat
     3061 ggggctctgg catccgatgc cccaaagcgg tcaaaagctt cttctccccc agtgctgatc
     3121 ttgctgggcc ttagctttgg agggtagggg agggagggga gggagagggt ggctgaatgg
     3181 ggagggcagg aagggagggt ctggggggaa ggggctgggg agtgggggtg ggaagcagtg
     3241 cgttgggggc ctcgtgtgta agtgtgaata aatgtagttg tcttggaaaa
//
