LOCUS       NM_001284292            4109 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens NUT midline carcinoma family member 1 (NUTM1),
            transcript variant 1, mRNA.
ACCESSION   NM_001284292 XM_005254276
VERSION     NM_001284292.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4109)
  AUTHORS   Zhuang,X.P., Huang,H.J., Chen,X., Zheng,S.L., Li,B.C. and Sun,H.
  TITLE     [Primary pulmonary NUT carcinoma: a clinicopathological analysis of
            seven cases]
  JOURNAL   Zhonghua Bing Li Xue Za Zhi 52 (12), 1244-1248 (2023)
   PUBMED   38058041
  REMARK    GeneRIF: [Primary pulmonary NUT carcinoma: a clinicopathological
            analysis of seven cases].
REFERENCE   2  (bases 1 to 4109)
  AUTHORS   Charlab,R. and Racz,R.
  TITLE     The expanding universe of NUTM1 fusions in pediatric cancer
  JOURNAL   Clin Transl Sci 16 (8), 1331-1339 (2023)
   PUBMED   37082775
  REMARK    GeneRIF: The expanding universe of NUTM1 fusions in pediatric
            cancer.
            Review article
REFERENCE   3  (bases 1 to 4109)
  AUTHORS   Lemelle,L., Flaadt,T., Fresneau,B., Moya-Plana,A., Timmermann,B.,
            Roganovic,J., Ferrari,A., Fichera,G., Lauer,U.M., Ben-Ami,T.,
            Schneider,D.T., Vokuhl,C., Bolle,S., Fox,E., DuBois,S.G.,
            Rodriguez-Galindo,C., Bisogno,G., Surun,A., Brecht,I.B. and
            Orbach,D.
  TITLE     NUT Carcinoma in Children and Adolescents: The Expert European
            Standard Clinical Practice Harmonized Recommendations
  JOURNAL   J Pediatr Hematol Oncol 45 (4), 165-173 (2023)
   PUBMED   36219702
  REMARK    GeneRIF: NUT Carcinoma in Children and Adolescents: The Expert
            European Standard Clinical Practice Harmonized Recommendations.
REFERENCE   4  (bases 1 to 4109)
  AUTHORS   Yu,D., Liang,Y., Kim,C., Jaganathan,A., Ji,D., Han,X., Yang,X.,
            Jia,Y., Gu,R., Wang,C., Zhang,Q., Cheung,K.L., Zhou,M.M. and
            Zeng,L.
  TITLE     Structural mechanism of BRD4-NUT and p300 bipartite interaction in
            propagating aberrant gene transcription in chromatin in NUT
            carcinoma
  JOURNAL   Nat Commun 14 (1), 378 (2023)
   PUBMED   36690674
  REMARK    GeneRIF: Structural mechanism of BRD4-NUT and p300 bipartite
            interaction in propagating aberrant gene transcription in chromatin
            in NUT carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4109)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   6  (bases 1 to 4109)
  AUTHORS   Stelow,E.B. and French,C.A.
  TITLE     Carcinomas of the upper aerodigestive tract with rearrangement of
            the nuclear protein of the testis (NUT) gene (NUT midline
            carcinomas)
  JOURNAL   Adv Anat Pathol 16 (2), 92-96 (2009)
   PUBMED   19550370
  REMARK    GeneRIF: Some carcinomas of the upper aerodigestive tract have a
            rearrangement of the nuclear protein of the testis (NUT) gene (NUT
            midline carcinomas).
            Review article
REFERENCE   7  (bases 1 to 4109)
  AUTHORS   Stelow,E.B., Bellizzi,A.M., Taneja,K., Mills,S.E., Legallo,R.D.,
            Kutok,J.L., Aster,J.C. and French,C.A.
  TITLE     NUT rearrangement in undifferentiated carcinomas of the upper
            aerodigestive tract
  JOURNAL   Am J Surg Pathol 32 (6), 828-834 (2008)
   PUBMED   18391746
  REMARK    GeneRIF: Approximately, 20% of undifferentiated carcinomas of the
            upper aerodigestive tract not associated with EBV infection were
            found to have rearrangements of NUT by FISH.
REFERENCE   8  (bases 1 to 4109)
  AUTHORS   French,C.A., Ramirez,C.L., Kolmakova,J., Hickman,T.T.,
            Cameron,M.J., Thyne,M.E., Kutok,J.L., Toretsky,J.A.,
            Tadavarthy,A.K., Kees,U.R., Fletcher,J.A. and Aster,J.C.
  TITLE     BRD-NUT oncoproteins: a family of closely related nuclear proteins
            that block epithelial differentiation and maintain the growth of
            carcinoma cells
  JOURNAL   Oncogene 27 (15), 2237-2242 (2008)
   PUBMED   17934517
  REMARK    GeneRIF: BRD-NUT fusion proteins contribute to carcinogenesis by
            associating with chromatin and interfering with epithelial
            differentiation.
REFERENCE   9  (bases 1 to 4109)
  AUTHORS   Haruki,N., Kawaguchi,K.S., Eichenberger,S., Massion,P.P.,
            Gonzalez,A., Gazdar,A.F., Minna,J.D., Carbone,D.P. and Dang,T.P.
  TITLE     Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S
            phase in vitro
  JOURNAL   J Med Genet 42 (7), 558-564 (2005)
   PUBMED   15994877
  REMARK    GeneRIF: Wild type Brd4 inhibits G(1) to S progression and we also
            found that the Brd4-NUT fusion augments the inhibition of
            progression to S phase compared with wild type Brd4.
REFERENCE   10 (bases 1 to 4109)
  AUTHORS   French,C.A., Miyoshi,I., Kubonishi,I., Grier,H.E.,
            Perez-Atayde,A.R. and Fletcher,J.A.
  TITLE     BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma
  JOURNAL   Cancer Res 63 (2), 304-307 (2003)
   PUBMED   12543779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021822.21 and AC025678.7.
            
            On May 17, 2019 this sequence version replaced NM_001284292.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000537011.6/ ENSP00000444896.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-388               AC021822.21        92496-92883
            389-482             AC021822.21        95123-95216
            483-1191            AC025678.7         79587-80295
            1192-1320           AC025678.7         82322-82450
            1321-1457           AC025678.7         85354-85490
            1458-1744           AC025678.7         86064-86350
            1745-1861           AC025678.7         86639-86755
            1862-4109           AC025678.7         87106-89353
FEATURES             Location/Qualifiers
     source          1..4109
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..4109
                     /gene="NUTM1"
                     /gene_synonym="C15orf55; FAM22H; NUT"
                     /note="NUT midline carcinoma family member 1"
                     /db_xref="GeneID:256646"
                     /db_xref="HGNC:HGNC:29919"
                     /db_xref="MIM:608963"
     exon            1..388
                     /gene="NUTM1"
                     /gene_synonym="C15orf55; FAM22H; NUT"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..3865
                     /gene="NUTM1"
                     /gene_synonym="C15orf55; FAM22H; NUT"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear protein in testis; NUT family member 1;
                     NAP1L4/NUTM1D fusion; NAP1L4/NUTM1D fusion protein"
                     /codon_start=1
                     /product="NUT family member 1 isoform 1"
                     /protein_id="NP_001271221.2"
                     /db_xref="CCDS:CCDS61585.1"
                     /db_xref="GeneID:256646"
                     /db_xref="HGNC:HGNC:29919"
                     /db_xref="MIM:608963"
                     /translation="MVVTLGPGPDCLILEASRQPQLVPKPERMASDGASALPGPDMSM
                     KPSAAPSPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFPSSLLVTG
                     DGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEGPAPP
                     FVTASNVKTILPSKAVGVSQEGPPGLPPQPPPPVAQLVPIVPLEKAWPGPHGTTGEGG
                     PVATLSKPSLGDRSKISKDVYENFRQWQRYKALARRHLSQSPDTEALSCFLIPVLRSL
                     ARLKPTMTLEEGLPLAVQEWEHTSNFDRMIFYEMAERFMEFEAEEMQIQNTQLMNGSQ
                     GLSPATPLKLDPLGPLASEVCQQPVYIPKKAASKTRAPRRRQRKAQRPPAPEAPKEIP
                     PEAVKEYVDIMEWLVGTHLATGESDGKQEEEGQQQEEEGMYPDPGLLSYINELCSQKV
                     FVSKVEAVIHPQFLADLLSPEKQRDPLALIEELEQEEGLTLAQLVQKRLMALEEEEDA
                     EAPPSFSGAQLDSSPSGSVEDEDGDGRLRPSPGLQGAGGAACLGKVSSSGKRAREVHG
                     GQEQALDSPRGMHRDGNTLPSPSSWDLQPELAAPQGTPGPLGVERRGSGKVINQVSLH
                     QDGHLGGAGPPGHCLVADRTSEALPLCWQGGFQPESTPSLDAGLAELAPLQGQGLEKQ
                     VLGLQKGQQTGGRGVLPQGKEPLAVPWEGSSGAMWGDDRGTPMAQSYDQNPSPRAAGE
                     RDDVCLSPGVWLSSEMDAVGLELPVQIEEVIESFQVEKCVTEYQEGCQGLGSRGNISL
                     GPGETLVPGDTESSVIPCGGTVAAAALEKRNYCSLPGPLRANSPPLRSKENQEQSCET
                     VGHPSDLWAEGCFPLLESGDSTLGSSKETLPPTCQGNLLIMGTEDASSLPEASQEAGS
                     RGNSFSPLLETIEPVNILDVKDDCGLQLRVSEDTCPLNVHSYDPQGEGRVDPDLSKPK
                     NLAPLQESQESYTTGTPKATSSHQGLGSTLPRRGTRNAIVPRETSVSKTHRSADRAKG
                     KEKKKKEAEEEDEELSNFAYLLASKLSLSPREHPLSPHHASGGQGSQRASHLLPAGAK
                     GPSKLPYPVAKSGKRALAGGPAPTEKTPHSGAQLGVPREKPLALGVVRPSQPRKRRCD
                     SFVTGRRKKRRRSQ"
     exon            389..482
                     /gene="NUTM1"
                     /gene_synonym="C15orf55; FAM22H; NUT"
                     /inference="alignment:Splign:2.1.0"
     exon            483..1191
                     /gene="NUTM1"
                     /gene_synonym="C15orf55; FAM22H; NUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1320
                     /gene="NUTM1"
                     /gene_synonym="C15orf55; FAM22H; NUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1457
                     /gene="NUTM1"
                     /gene_synonym="C15orf55; FAM22H; NUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1744
                     /gene="NUTM1"
                     /gene_synonym="C15orf55; FAM22H; NUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1861
                     /gene="NUTM1"
                     /gene_synonym="C15orf55; FAM22H; NUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..4109
                     /gene="NUTM1"
                     /gene_synonym="C15orf55; FAM22H; NUT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4085..4090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUTM1"
                     /gene_synonym="C15orf55; FAM22H; NUT"
                     /note="hexamer: AATAAA"
     polyA_site      4109
                     /gene="NUTM1"
                     /gene_synonym="C15orf55; FAM22H; NUT"
                     /note="major polyA site"
ORIGIN      
        1 ctactgtgtg ctaggtacac ggcgttagag gggggtaggg atggatgtgg atagaatatt
       61 gacgtataga agcctgtctt tgtctcaaga tacacaccca tttcaggagc agtgagtttt
      121 caatgcctga agaaacaagg gctccaggat tcagagcccc tttaccctag ggaagaaaga
      181 agaggttttc ttccctcccc tcttttacat ccagttcccc tgctccattt caaagcgttg
      241 gcggtaaaga atgcatgttg agtatcaata ttccgtaaag cgaaagagcg taaagttatt
      301 ttatgaaact ggtgaagcat gtttcagcgg tcgaaccaag atttaaagtt aggtccctac
      361 cgcaaattca gcgctctttc ttatggtggt tactctgggt cctggacctg actgcctcat
      421 tctggaggct tccagacagc cacagttagt gcccaaacct gagaggatgg cttcagatgg
      481 agcatctgca ttgccgggac cggatatgag catgaaacct agtgccgccc cgtctccatc
      541 ccctgcactt ccctttctcc caccaacttc tgacccacca gaccacccac ccagggagcc
      601 acctccacag cccatcatgc cttcagtatt ctctccagac aaccctctga tgctctctgc
      661 tttccccagc tcactgttgg tgacagggga tgggggccct tgcctcagtg gggctggggc
      721 tggcaaggtc attgtcaaag tcaagacaga aggggggtca gctgagccct ctcaaactca
      781 gaactttatc cttactcaga ctgccctcaa ttcgactgcc ccgggcactc cctgtggagg
      841 ccttgagggt cctgcacctc catttgtgac agcatctaat gtgaagacca ttctgccctc
      901 taaggctgtt ggtgtcagcc aggagggtcc tccaggcctt ccgcctcagc ctccaccacc
      961 agttgctcaa ctggtcccca ttgtgcccct ggaaaaagct tggccagggc cacatgggac
     1021 aaccggggaa ggaggtcctg tggccactct atccaagcct tccctaggtg accgctccaa
     1081 aatttccaag gacgtttatg agaacttccg tcagtggcag cgttacaaag ccttggcccg
     1141 gaggcaccta tcccagagtc ctgacacaga agctctttcc tgttttctta tcccagtgct
     1201 tcgttccctg gcccggctga agcccactat gaccctggag gagggactgc cattggctgt
     1261 gcaggagtgg gagcacacca gcaactttga ccggatgatc ttttatgaga tggcagaaag
     1321 gttcatggag tttgaggctg aggagatgca gattcagaac acacagctga tgaatgggtc
     1381 tcagggcctg tctcctgcaa cccctttgaa acttgatcct ctagggcccc tggcctctga
     1441 ggtttgccag cagccagtgt acattccgaa gaaggcagcc tccaagacac gggccccccg
     1501 ccggcgtcag cgtaaagccc agagacctcc tgctcctgag gcacccaagg agatcccacc
     1561 agaagctgtg aaggagtatg ttgacatcat ggaatggctg gtggggactc acttggccac
     1621 tggggagtca gatggaaaac aagaggaaga agggcagcag caggaggagg aagggatgta
     1681 tccagatcca ggtctcctga gctacatcaa tgagctgtgt tctcagaagg tctttgtctc
     1741 caaggtggag gctgtcattc accctcaatt tctggcagat ctgctgtccc cagaaaaaca
     1801 gagagatccc ttggccttaa ttgaggagct agagcaagaa gaaggactca ctcttgccca
     1861 gctggtccag aagcgactca tggccttgga agaggaggaa gatgcagagg cgcctccaag
     1921 tttcagtggc gctcagttgg actcaagtcc ttctggttct gttgaggatg aagatgggga
     1981 tgggcggctt cggccctcac ctgggcttca gggggctggg ggcgccgctt gccttggaaa
     2041 ggtttcttct tcaggaaaac gggcaagaga agtgcatggt gggcaggagc aagccctaga
     2101 tagccccaga gggatgcaca gggatgggaa cactctgcca tcccccagca gctgggacct
     2161 gcagccagaa cttgcagctc cacagggaac tccgggaccc ttgggtgtgg agaggagagg
     2221 gtctgggaag gttataaacc aggtatctct acatcaggat ggccatctag gaggcgctgg
     2281 gcctcctggg cactgcctgg tggctgatag gacttcagag gctctgcccc tttgttggca
     2341 gggaggcttc cagcctgaga gcactcccag tttggatgct ggacttgcag agctggctcc
     2401 tctgcaagga caagggttag aaaagcaagt cctgggattg cagaaaggac aacaaacagg
     2461 gggtcgtgga gtgcttcctc aagggaagga gcctttagca gtgccctggg aaggctcttc
     2521 aggagccatg tggggagatg acagaggtac ccccatggct cagagttatg atcagaatcc
     2581 ttcccctaga gcagctgggg agagggacga tgtctgtctc agcccaggag tttggctgag
     2641 cagtgagatg gatgctgtag gcttggagct gcctgtacaa atagaggagg tcatagagag
     2701 cttccaagtt gagaagtgtg taactgagta tcaggaaggc tgccagggac tgggctccag
     2761 gggcaacatt tccctgggtc ctggagaaac cctagtacct ggggatacgg agagcagtgt
     2821 gattccctgt ggaggcacag ttgcggcagc tgccctagaa aagagaaact attgcagctt
     2881 gccaggacct ttgagggcca acagcccacc cttgaggtcc aaagaaaatc aagaacagag
     2941 ctgtgaaacc gtagggcatc ccagtgatct gtgggcagaa ggttgcttcc cattgctaga
     3001 aagtggtgat tccacactgg ggtcttccaa agaaaccctt ccacccacat gccaaggcaa
     3061 tctccttatc atggggactg aggatgcctc ctccttgcct gaagccagtc aagaggcagg
     3121 gagcagaggc aattcctttt ctcctctgtt ggaaaccata gaacctgtca acatactaga
     3181 tgttaaagat gactgtggcc tccaactaag ggtcagcgag gacacctgcc cactgaatgt
     3241 tcattcttat gacccccaag gagaaggcag ggtggatcct gatctgtcca agcctaaaaa
     3301 ccttgctcct ttacaagaga gtcaggagtc ttacacaact gggactccca aagcaacatc
     3361 ttctcaccag ggccttggaa gcactttgcc tagaagggga accaggaatg ccatagttcc
     3421 gagagaaact tctgttagta aaacacacag gtcagcagac agggccaaag gaaaggagaa
     3481 aaagaaaaag gaagcagagg aagaggatga ggaactctcc aactttgctt acctcttggc
     3541 ctctaaactt agcctctcac caagggagca tcccctcagt cctcaccatg cctcaggagg
     3601 tcagggcagc cagagagcat cccacctgct ccctgctgga gcaaaaggcc ccagcaaact
     3661 tccatatcct gttgccaagt ctgggaagcg agctctagct ggaggtccag cccctactga
     3721 aaagacaccc cactcaggag ctcaacttgg ggtccccagg gagaaacccc tagctctggg
     3781 agtagttcga ccctcacagc ctcgtaaaag gcggtgtgac agttttgtca cgggcagaag
     3841 gaagaaacga cgtcgtagcc agtagggagc agcgggacca tctgacccca cttgccagtc
     3901 cctaaaggtg ggtgccccag agtagattcc acccctgctg cccaccaatg gagaatccca
     3961 atgttgaatc tcatcccaat gttgttttgt tgttctgcaa aagtggcaag catggagaga
     4021 gaggtcagac tggctaggct gcagggggaa ttacctttgg aaggagctat atagaaaaaa
     4081 aatgaataaa gtgttttgtt ggaaaatgc
//
