LOCUS       NM_005796               2120 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens nuclear transport factor 2 (NUTF2), transcript variant
            1, mRNA.
ACCESSION   NM_005796
VERSION     NM_005796.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2120)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2120)
  AUTHORS   Vukovic,L.D., Chen,P., Mishra,S., White,K.H., Gigley,J.P. and
            Levy,D.L.
  TITLE     Nuclear Transport Factor 2 (NTF2) suppresses WM983B metastatic
            melanoma by modifying cell migration, metastasis, and gene
            expression
  JOURNAL   Sci Rep 11 (1), 23586 (2021)
   PUBMED   34880267
  REMARK    GeneRIF: Nuclear Transport Factor 2 (NTF2) suppresses WM983B
            metastatic melanoma by modifying cell migration, metastasis, and
            gene expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2120)
  AUTHORS   Shen,Q., Tian,T., Xiong,Q., Ellis Fisher,P.D., Xiong,Y.,
            Melia,T.J., Lusk,C.P. and Lin,C.
  TITLE     DNA-Origami NanoTrap for Studying the Selective Barriers Formed by
            Phenylalanine-Glycine-Rich Nucleoporins
  JOURNAL   J Am Chem Soc 143 (31), 12294-12303 (2021)
   PUBMED   34324340
  REMARK    GeneRIF: DNA-Origami NanoTrap for Studying the Selective Barriers
            Formed by Phenylalanine-Glycine-Rich Nucleoporins.
REFERENCE   4  (bases 1 to 2120)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2120)
  AUTHORS   Stewart,M., Kent,H.M. and McCoy,A.J.
  TITLE     Structural basis for molecular recognition between nuclear
            transport factor 2 (NTF2) and the GDP-bound form of the Ras-family
            GTPase Ran
  JOURNAL   J Mol Biol 277 (3), 635-646 (1998)
   PUBMED   9533885
REFERENCE   6  (bases 1 to 2120)
  AUTHORS   Clarkson,W.D., Corbett,A.H., Paschal,B.M., Kent,H.M., McCoy,A.J.,
            Gerace,L., Silver,P.A. and Stewart,M.
  TITLE     Nuclear protein import is decreased by engineered mutants of
            nuclear transport factor 2 (NTF2) that do not bind GDP-Ran
  JOURNAL   J Mol Biol 272 (5), 716-730 (1997)
   PUBMED   9368653
REFERENCE   7  (bases 1 to 2120)
  AUTHORS   Hu,T., Guan,T. and Gerace,L.
  TITLE     Molecular and functional characterization of the p62 complex, an
            assembly of nuclear pore complex glycoproteins
  JOURNAL   J Cell Biol 134 (3), 589-601 (1996)
   PUBMED   8707840
REFERENCE   8  (bases 1 to 2120)
  AUTHORS   Bullock,T.L., Clarkson,W.D., Kent,H.M. and Stewart,M.
  TITLE     The 1.6 angstroms resolution crystal structure of nuclear transport
            factor 2 (NTF2)
  JOURNAL   J Mol Biol 260 (3), 422-431 (1996)
   PUBMED   8757804
REFERENCE   9  (bases 1 to 2120)
  AUTHORS   Paschal,B.M. and Gerace,L.
  TITLE     Identification of NTF2, a cytosolic factor for nuclear import that
            interacts with nuclear pore complex protein p62
  JOURNAL   J Cell Biol 129 (4), 925-937 (1995)
   PUBMED   7744965
REFERENCE   10 (bases 1 to 2120)
  AUTHORS   Grundmann,U., Nerlich,C., Rein,T., Lottspeich,F. and Kupper,H.A.
  TITLE     Isolation of cDNA coding for the placental protein 15 (PP15)
  JOURNAL   Nucleic Acids Res 16 (10), 4721 (1988)
   PUBMED   3380696
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X07315.1 and BX647782.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005796.2.
            
            Summary: This gene encodes a cytosolic factor that facilitates
            protein transport into the nucleus. The encoded protein is required
            for nuclear import of the small Ras-like GTPase, Ran which is
            involved in numerous cellular processes. This protein also
            interacts with the nuclear pore complex glycoprotein p62. [provided
            by RefSeq, Apr 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1105906.1,
                                           SRR3476690.653232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219169.9/ ENSP00000219169.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-869               X07315.1           18-886
            870-2120            BX647782.1         1358-2608
FEATURES             Location/Qualifiers
     source          1..2120
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2120
                     /gene="NUTF2"
                     /gene_synonym="NTF-2; NTF2; PP15"
                     /note="nuclear transport factor 2"
                     /db_xref="GeneID:10204"
                     /db_xref="HGNC:HGNC:13722"
                     /db_xref="MIM:605813"
     exon            1..53
                     /gene="NUTF2"
                     /gene_synonym="NTF-2; NTF2; PP15"
                     /inference="alignment:Splign:2.1.0"
     exon            54..181
                     /gene="NUTF2"
                     /gene_synonym="NTF-2; NTF2; PP15"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..466
                     /gene="NUTF2"
                     /gene_synonym="NTF-2; NTF2; PP15"
                     /note="placental protein 15"
                     /codon_start=1
                     /product="nuclear transport factor 2"
                     /protein_id="NP_005787.1"
                     /db_xref="CCDS:CCDS10848.1"
                     /db_xref="GeneID:10204"
                     /db_xref="HGNC:HGNC:13722"
                     /db_xref="MIM:605813"
                     /translation="MGDKPIWEQIGSSFIQHYYQLFDNDRTQLGAIYIDASCLTWEGQ
                     QFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQM
                     FLLKNINDAWVCTNDMFRLALHNFG"
     exon            182..253
                     /gene="NUTF2"
                     /gene_synonym="NTF-2; NTF2; PP15"
                     /inference="alignment:Splign:2.1.0"
     exon            254..352
                     /gene="NUTF2"
                     /gene_synonym="NTF-2; NTF2; PP15"
                     /inference="alignment:Splign:2.1.0"
     exon            353..2120
                     /gene="NUTF2"
                     /gene_synonym="NTF-2; NTF2; PP15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      843..848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUTF2"
                     /gene_synonym="NTF-2; NTF2; PP15"
                     /note="hexamer: AATAAA"
     polyA_site      869
                     /gene="NUTF2"
                     /gene_synonym="NTF-2; NTF2; PP15"
                     /note="major polyA site"
     regulatory      2101..2106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUTF2"
                     /gene_synonym="NTF-2; NTF2; PP15"
                     /note="hexamer: AATAAA"
     polyA_site      2120
                     /gene="NUTF2"
                     /gene_synonym="NTF-2; NTF2; PP15"
ORIGIN      
        1 gcagaccgcg ctgggttgcc gctgccgctg ccgccatcgt gccagcccct cgggtctccg
       61 tgaggccggg tgacgctcca gaatgggaga caagccaatt tgggagcaga ttggatccag
      121 cttcattcaa cattactacc agttatttga taatgataga acccaactag gcgcaattta
      181 cattgacgcg tcatgcctta cgtgggaagg acaacagttc caggggaaag ctgccattgt
      241 ggagaagttg tctagccttc cgttccagaa aattcagcac agcatcaccg cgcaggacca
      301 tcagcccact ccagatagct gcatcatcag catggttgtg ggccagctta aggcggatga
      361 agaccccatc atggggttcc accagatgtt cctattaaag aacatcaacg atgcttgggt
      421 ttgcaccaat gacatgttca ggctcgccct gcacaacttt ggctgacctc ctctcagcta
      481 ggcactcacg ctgtttcctc ctccctcctc ttcccaatac tattcccact cctccagatg
      541 ctccaaatat catgcacaaa tgagcagggc cgcggtggga gtgggcgcag tgcgctgctg
      601 ccactgaggt gttgtgcatg atgtttggat gctagactag ttgcatctga cgggagaagt
      661 ttgtgttgta ccagcgcatg ccttggaaag acttaagtaa tgcaaaaggt tgtccttttt
      721 tttttttttt tttttttaat ctactgacaa gttgctctag taacccaaag aagtgaagga
      781 gaaagcagct gcctcaccgc ccagacattg atttgttcag atgtttcaat gcctcatgat
      841 acaataaaac cacaaaaatt ttcttaacag tttaaattgt tttaattagt ttactagttg
      901 gctgggcatc agaagctacc cagacccgtt gtctctctca tgtttcaccc tcccacttct
      961 gccccaactc tgaatacctg ttgcagggag aaactgctga agcagcactc ccagctagcc
     1021 tctcagaagc cgtgtagggc agttctctcc cactccacag ggcgactggt ctttggaaag
     1081 caggcaggaa gagctcaggt ctggcctgaa gcttctctca ctgaagcctg tgcagtcagt
     1141 tctgatacct cctgtgactt ctgctctggg taggttcagg gccctagtag caggagagat
     1201 gatcctgaat cctgttgaag ctggagaggc cttggcaaaa tggctcatca cgttcaggcc
     1261 ctccgggctg agttgtcagc agtatcaagg gaggggcctg ctctatcccc agaaggatca
     1321 ggatcatatc caggatgccc cacatacacc aagccaggca gagggcagct cagctcctgt
     1381 cccatctgct ttggatatct ttacccaaag gcaggtaacc cgaagagcca gcctccactg
     1441 cccacagagc caggcccagt tgtgttggag tataggtcag gagctgtgga aggaggcagt
     1501 ctgtgaggga ctcatgcttt aggagtcctc acccctcaga ctgctgcagg acattgccag
     1561 gcctctctcc acttccttcc tcagcataca gacttcatgc tatcttccaa ttccggggag
     1621 tcttagctat tagggcagtt tctgcttctc cattttgggg acaaaggcct tgcccagtac
     1681 aaatctagcc ccttgtccca cagacttctg gatggtataa acctagtggc aatgtagcaa
     1741 ccataggcta gaaccaaacc caagatttgg gtcagtgccc tgttaagggt tttaggattg
     1801 gtaaggacac cacagctaaa tctgacatgt aaaaggatac ccttcccctg tcccactacg
     1861 ggtggaggct aaggacctcc tcagatccca cagattgcct ggtgacattg ggcacagggc
     1921 tggatggtgt gctgtttgag aggacagcat gctcaggaga tttcagtggg aatgatctct
     1981 aggctgatgt gtatttgggg aagtgggggt ggggaagagg taggtgcctg ctgcctcaaa
     2041 ccaccttgtg taaaatctgc aatacggctt cttccatgta cctgtgcctg aactgtctgc
     2101 aataaagaag aatttgtaaa
//
