LOCUS       NM_012385               5291 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens nuclear protein 1, transcriptional regulator (NUPR1),
            transcript variant 2, mRNA.
ACCESSION   NM_012385
VERSION     NM_012385.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5291)
  AUTHORS   Li,Y., Sun,Y., Jia,B., Ma,Z. and Zhou,R.
  TITLE     MED23 depletion induces premature senescence in NSCLC cells by
            interacting with BCLAF1 and then suppressing NUPR1 expression
  JOURNAL   Biochem Biophys Res Commun 734, 150754 (2024)
   PUBMED   39366174
  REMARK    GeneRIF: MED23 depletion induces premature senescence in NSCLC
            cells by interacting with BCLAF1 and then suppressing NUPR1
            expression.
REFERENCE   2  (bases 1 to 5291)
  AUTHORS   Ren,S., Chen,Y., Wang,Q., Song,L., Xin,Z., Shi,M. and Liu,X.
  TITLE     NUPR1 induces autophagy and promotes the progression of Esophageal
            squamous cell carcinoma via the MAPK-mTOR pathway
  JOURNAL   Pathol Res Pract 257, 155323 (2024)
   PUBMED   38653091
  REMARK    GeneRIF: NUPR1 induces autophagy and promotes the progression of
            Esophageal squamous cell carcinoma via the MAPK-mTOR pathway.
REFERENCE   3  (bases 1 to 5291)
  AUTHORS   Wang,C., Wang,T., Li,K.J., Hu,L.H., Li,Y., Yu,Y.Z., Xie,T., Zhu,S.,
            Fu,D.J., Wang,Y., Zeng,X.Z., Liu,F.P., Chen,H., Chen,Z.S.,
            Feng,N.H., Liu,J., Jiang,Y. and Zhao,S.C.
  TITLE     SETD4 inhibits prostate cancer development by promoting
            H3K27me3-mediated NUPR1 transcriptional repression and cell cycle
            arrest
  JOURNAL   Cancer Lett 579, 216464 (2023)
   PUBMED   37879429
  REMARK    GeneRIF: SETD4 inhibits prostate cancer development by promoting
            H3K27me3-mediated NUPR1 transcriptional repression and cell cycle
            arrest.
REFERENCE   4  (bases 1 to 5291)
  AUTHORS   Liu,Y.C., Wu,Z.L., Ge,L.Y., DU,T., Wu,Y.Q., Song,Y.M., Liu,C. and
            Ma,L.L.
  TITLE     [Mechanism of nuclear protein 1 in the resistance to axitinib in
            clear cell renal cell carcinoma]
  JOURNAL   Beijing Da Xue Xue Bao Yi Xue Ban 55 (5), 781-792 (2023)
   PUBMED   37807730
  REMARK    GeneRIF: [Mechanism of nuclear protein 1 in the resistance to
            axitinib in clear cell renal cell carcinoma].
REFERENCE   5  (bases 1 to 5291)
  AUTHORS   Tan,L., Armstrong,A.R., Rosas,S., Patel,C.M., Vander Wiele,S.S.,
            Willey,J.S., Carlson,C.S. and Yammani,R.R.
  TITLE     Nuclear protein-1 is the common link for pathways activated by
            aging and obesity in chondrocytes: A potential therapeutic target
            for osteoarthritis
  JOURNAL   FASEB J 37 (9), e23133 (2023)
   PUBMED   37566478
  REMARK    GeneRIF: Nuclear protein-1 is the common link for pathways
            activated by aging and obesity in chondrocytes: A potential
            therapeutic target for osteoarthritis.
REFERENCE   6  (bases 1 to 5291)
  AUTHORS   Encinar,J.A., Mallo,G.V., Mizyrycki,C., Giono,L.,
            Gonzalez-Ros,J.M., Rico,M., Canepa,E., Moreno,S., Neira,J.L. and
            Iovanna,J.L.
  TITLE     Human p8 is a HMG-I/Y-like protein with DNA binding activity
            enhanced by phosphorylation
  JOURNAL   J Biol Chem 276 (4), 2742-2751 (2001)
   PUBMED   11056169
REFERENCE   7  (bases 1 to 5291)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
REFERENCE   8  (bases 1 to 5291)
  AUTHORS   Ree,A.H., Tvermyr,M., Engebraaten,O., Rooman,M., Rosok,O.,
            Hovig,E., Meza-Zepeda,L.A., Bruland,O.S. and Fodstad,O.
  TITLE     Expression of a novel factor in human breast cancer cells with
            metastatic potential
  JOURNAL   Cancer Res 59 (18), 4675-4680 (1999)
   PUBMED   10493524
REFERENCE   9  (bases 1 to 5291)
  AUTHORS   Vasseur,S., Vidal Mallo,G., Fiedler,F., Bodeker,H., Canepa,E.,
            Moreno,S. and Iovanna,J.L.
  TITLE     Cloning and expression of the human p8, a nuclear protein with
            mitogenic activity
  JOURNAL   Eur J Biochem 259 (3), 670-675 (1999)
   PUBMED   10092851
REFERENCE   10 (bases 1 to 5291)
  AUTHORS   Mallo,G.V., Fiedler,F., Calvo,E.L., Ortiz,E.M., Vasseur,S.,
            Keim,V., Morisset,J. and Iovanna,J.L.
  TITLE     Cloning and expression of the rat p8 cDNA, a new gene activated in
            pancreas during the acute phase of pancreatitis, pancreatic
            development, and regeneration, and which promotes cellular growth
  JOURNAL   J Biol Chem 272 (51), 32360-32369 (1997)
   PUBMED   9405444
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF069073.1 and AC020765.8.
            
            On Jun 3, 2019 this sequence version replaced NM_012385.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform b), compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1075112.1,
                                           SRR7346977.1273103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324873.8/ ENSP00000315559.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-658               AF069073.1         36-693
            659-5291            AC020765.8         71175-75807         c
FEATURES             Location/Qualifiers
     source          1..5291
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..5291
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /note="nuclear protein 1, transcriptional regulator"
                     /db_xref="GeneID:26471"
                     /db_xref="HGNC:HGNC:29990"
                     /db_xref="MIM:614812"
     exon            1..179
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..316
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /note="isoform b is encoded by transcript variant 2;
                     candidate of metastasis 1; protein p8; nuclear protein,
                     transcriptional regulator, 1; nuclear transcriptional
                     regulator protein 1"
                     /codon_start=1
                     /product="nuclear protein 1 isoform b"
                     /protein_id="NP_036517.1"
                     /db_xref="CCDS:CCDS10634.1"
                     /db_xref="GeneID:26471"
                     /db_xref="HGNC:HGNC:29990"
                     /db_xref="MIM:614812"
                     /translation="MATFPPATSAPQQPPGPEDEDSSLDESDLYSLAHSYLGGGGRKG
                     RTKREAAANTNRPSPGGHERKLVTKLQNSERKKRGARR"
     exon            180..329
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /inference="alignment:Splign:2.1.0"
     exon            330..5291
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      607..612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /note="hexamer: AATAAA"
     regulatory      611..616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /note="hexamer: AATAGA"
     polyA_site      627
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /note="major polyA site"
     polyA_site      656
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
     regulatory      5266..5271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /note="hexamer: AATGAA"
     polyA_site      5291
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
ORIGIN      
        1 gccaggaaag cagagacaga caaagcgtta ggagaagaag agaggcaggg aagacaagcc
       61 aggcacgatg gccaccttcc caccagcaac cagcgccccc cagcagcccc caggcccgga
      121 ggacgaggac tccagcctgg atgaatctga cctctatagc ctggcccatt cctacctcgg
      181 aggtggaggc cggaaaggtc gcaccaagag agaagctgct gccaacacca accgccccag
      241 ccctggcggg cacgagagga aactggtgac caagctgcag aattcagaga ggaagaagcg
      301 aggggcacgg cgctgagaca gagctggaga tgaggccaga ccatggacac tacacccagc
      361 aatagagacg ggactgcgga ggaaggagga cccaggacag gatccaggcc ggcttgccac
      421 accccccacc cctaggactt attcccgctg actgagtctc tgaggggcta ccaggaaagc
      481 gcctccaacc ctagcaaaag tgcaagatgg ggagtgagag gctgggaatg gaggggcaga
      541 gccaggaaga tcccccagaa aagaaagcta cagaagaaac tggggctcct ccagggtggc
      601 agcaacaata aatagacacg cacggcagcc acagcttggg tgtgtgttca tccttgttct
      661 ttgtgtgttt ttgttcgggc atgtgtgtgc ttgcctgtgc ctgcacattc atgagcctga
      721 gagagcatct ttgatgtgta tttgtgtttg gtgtatgtat ctggggcagg gagtgttcct
      781 gctcttgcag ggtctacgct gtgaatgcag cttttggttt gtttgctttt gcttgcatat
      841 attttagtgc atacatttct gtgggctcct acgtagtgga aaggaatttc ttctgctttt
      901 ttgcgatact gcccatgaaa cacggccctc cccagcacct gtttttgttg attgtgtcct
      961 gttcatagac gggaacgcta cttatgagtg ccatctaaaa gtcagagaaa actgagattt
     1021 aaaatattaa aagccagggc cgggggcagt ggctcacgcc tgtaatccca gcactttggg
     1081 aggccgaggt gggtggatca caaagtcagg agttcaagac cagcctgacc aacatggtga
     1141 aaccccatct ccactaaaaa taccaaaaat tagccaagca tggtggcagg tgcctgtaat
     1201 cccagctgct caggaggctg aggcagtaga atcgcttgaa cccaggaggt agaggttgca
     1261 gtgagccgac atcgtgccat tgcactccag cctgggtgac agagggagac tctgtctcaa
     1321 aacaaacaaa caaacaaaaa ctaaagtctg ggagcagtgg ctcatgcctg taatcacagc
     1381 agtttaggag gccgaagtgg gaggattact tgagcctagg agtttgagac cagcctgagc
     1441 atcatagtaa gaccccatct ctacaatttt ttttttgaga cagagtctca ctctgttgct
     1501 caggttagag tgcagtggca ccatcttggc tcactgcaac ctctgcctcc cgggttcaag
     1561 caattctcgt gcctacgccc cctgagtagc tgggattaca ggtgagcacc accacgcctg
     1621 gctaattttt gtttttttgt ttttttgata cagagtctca ctctgttgct caggctggag
     1681 tgcagtggca tgatcgcagc tcactgcaac ctccgcctcc tgggttcaag ctattctcct
     1741 gcttcagcct cctgagtagc tgggactaca ggcacctgcc accatgcctg gctaattttt
     1801 gtatttttag tagaaacaga gtttcaccat gttggccagg atggtctcaa tctcttgacc
     1861 tcatgatcca cccaccttgg cctcccaaag tgctgggatt acaggcgtca gccaccacgc
     1921 ctggccaatt tttgtatttt tagtagagat ggggtttcat catgttggcc aggctggtct
     1981 caaactcctg gcctcaaatg atctgcccac ctcagccttc cagcctttgg gaggccaagg
     2041 agggaggatc gcttgaggcc aggagttcga gaccagccta ggcaacatac caaggccctg
     2101 tctctacaaa aatttaaaaa ttagcaaagc atggtggctc atgcctgtag tcctagttgc
     2161 tcagaggctg aagttggagg atcccttgaa cccagttgga ggctacagta agccatgatg
     2221 gtgccactgc actgcagcct gagcaataga gtgaaaccat gtattgaaaa agaaagaaag
     2281 aaagaaagag aaaaagaagg aaggaaggaa aagaaaggaa ggaagaaaga aaagaaagag
     2341 agaaaggaga gaaaaagaag aaagagagag aaagagaaga aagaaagaaa gaaagaaaga
     2401 aagaaagaaa gaaagaaaga aagaaaggaa ggaaggaaag aaagaaagaa agaaggaaag
     2461 aaagaaagaa agaaagaaag aaagaaagaa agaaaagagc gagccccggc acagtggctc
     2521 acacctgtaa tcccagcact ttgggaggcc aaggcaggcg gatcacctga ggtcagtagt
     2581 tcgagttcga ggcagaagtt gtggtgagcc aagatcacgc cattgcactc cagcctgggc
     2641 aacaagagca aaactccatc tcaaaaaaag aaaaagagag agaaagaaag agagaaggag
     2701 ggaaagaaag aggaaggaaa ggagggaggg aaggagggaa ggaggaaagg agggaaggaa
     2761 atattaaggg atttgcccta gctcactcag ggctcatatt cagggatctt attgtcttca
     2821 gatatgaggt gggtccccag gccaaggggg ctgtgggaca gggttctggg aagtgagatg
     2881 ggggagggag attcttattc agtgctatgt ctcaggacca gagttgaaga aaaatatggg
     2941 gcaaacagga agtgtggttg gagctgagat tatttgttga ttgagataca ggtttgggtt
     3001 gctattatga agaatcaaaa caggatacaa agttactcct ctcttactta gccccaagtc
     3061 ctcctgggtt caaatggcag ctccattgtg ttgaggattc cagctatttt tactcactgt
     3121 tctgccacac ccaaaacatg gcttccactt tgaggcccaa aatagctact ccaatacctg
     3181 ccatcacgtt tgcatctcag cctgtggaaa gagtgtggaa gagacagagg aggccacacc
     3241 tcttcaattt tagggcataa tctaaaagta gaacacatca catctgctcc gaatgtggct
     3301 acatggccac acccaactac gagagaggtt gggaaatgta gcattgagct gcttagccac
     3361 gtggtagcca aaacttgggc aacagcaggg ttttatgatg aaagggaacc agagagagtg
     3421 aatacacgaa gaagctagca agaaacattg cccacatgca gactcaacag atgtcggggg
     3481 agaaaactct gagattgggc cccgggcaga gcctgtttcc ttttcccctg tccctttcac
     3541 ataagcccca cactgcagaa cttggagtca gtggttcatg gggacccaag gacatccaca
     3601 gaagaccgaa gtacctgata gagcaggaac agatgcacgt cagactacga ccagcttgaa
     3661 cccttgggga cctgtatcca tccccttccc ttgagtccag cctaatcaca gccacagaat
     3721 gaatccatga cccggaagga catttaagga cctctggccc aactctcccc acgcaacagt
     3781 gggattgcct ctgcttgttt gaataccact atggaggggg aacttgctac atttaaaggt
     3841 tgctgaattt ttttgttttg ttttgggaga tggagtctct ctctgtcgcc caggctggag
     3901 tgcagtggtg tgatctcgac ccactgcaac ctccgcttcc tgggttcaag cgattttcat
     3961 gcctcagcct ccctagtagc tgggactaca ggtgtgggcc accacacctg gctaattttt
     4021 gtatttttag tagagacggg gtttcaccat gttgcccagg ctggtctcaa actcccgacc
     4081 tcaggtgatc tgcctgcctt ggcctcccaa agtgttggga ttacaggctt gagccacacc
     4141 acccggcaaa ggttgcctaa ttctatctca gggcaagtct gttcatgtgg gctgaaatct
     4201 gtctctcata cctgccctta aataagcttc tgtttttctg gtcctttctg tctgagatga
     4261 ctttaattcc tcccccgacc ccatctcatg aggctcagct tagatgtttc cttctcttcc
     4321 tccctgatgg ctgcgtgcag aagctcatac ctgcaatccc agcactttgg gaggccgagg
     4381 tgggaggatt gcttgggccc aggagttcta ggccagccta gcaacacagc aagaccctct
     4441 ctctacaaaa aattaaaaat tagccaggtg tggtggcttg tgcctgtggg cccacctact
     4501 caggaggctg aggtgagagg atctcttgag tctgggaggt ggaggctgca gtgagccatg
     4561 atctcactcc agcctgggcg tcagagtgag acctgtctca aaaaaacaaa aaccaaagtt
     4621 ttccttaact tgcaatcctc cacccatctc ctgacctcca ccccaggccg accctcctct
     4681 gggatcacac ggaagcctgg gcccagaatc ttacagtcta ccttggaaat ccttcagatt
     4741 ttgcctccaa ctcctctttc catacaagtt acatattaac tcaatcaatg cttattggat
     4801 gccttctgag ttaccaggat gctgctggag gcctgtgctg ctgagaggga caaatagaat
     4861 cctgatatga ctggaaccag gaatagggcc accatcagct ctagaaccca gggagcaaat
     4921 ggcaggagca acaccaggca gtcggccctc agcccagcac agacctggtg tgttggcttc
     4981 agaaaatcct ggaaacatct ctgctgtgtt tggagctcct attctgtgag aagtgtttta
     5041 taggctttgc tccatttaat ccttacgata acccaatagg acatactatt aatgatcccc
     5101 tttttttcag accggaaaac tgaggttcgg agacattaag taatttgcct aaagtcacac
     5161 agccacatcc tgtaggactt ggaattatga actcaggtct atctgaattt taaagcctgg
     5221 atttttcccc ctttgctaca tgcctgggaa gaaccatgta ttgacaatga agaatcctaa
     5281 actctcgtta a
//
