LOCUS       NM_001042483            5345 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens nuclear protein 1, transcriptional regulator (NUPR1),
            transcript variant 1, mRNA.
ACCESSION   NM_001042483
VERSION     NM_001042483.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5345)
  AUTHORS   Li,Y., Sun,Y., Jia,B., Ma,Z. and Zhou,R.
  TITLE     MED23 depletion induces premature senescence in NSCLC cells by
            interacting with BCLAF1 and then suppressing NUPR1 expression
  JOURNAL   Biochem Biophys Res Commun 734, 150754 (2024)
   PUBMED   39366174
  REMARK    GeneRIF: MED23 depletion induces premature senescence in NSCLC
            cells by interacting with BCLAF1 and then suppressing NUPR1
            expression.
REFERENCE   2  (bases 1 to 5345)
  AUTHORS   Ren,S., Chen,Y., Wang,Q., Song,L., Xin,Z., Shi,M. and Liu,X.
  TITLE     NUPR1 induces autophagy and promotes the progression of Esophageal
            squamous cell carcinoma via the MAPK-mTOR pathway
  JOURNAL   Pathol Res Pract 257, 155323 (2024)
   PUBMED   38653091
  REMARK    GeneRIF: NUPR1 induces autophagy and promotes the progression of
            Esophageal squamous cell carcinoma via the MAPK-mTOR pathway.
REFERENCE   3  (bases 1 to 5345)
  AUTHORS   Wang,C., Wang,T., Li,K.J., Hu,L.H., Li,Y., Yu,Y.Z., Xie,T., Zhu,S.,
            Fu,D.J., Wang,Y., Zeng,X.Z., Liu,F.P., Chen,H., Chen,Z.S.,
            Feng,N.H., Liu,J., Jiang,Y. and Zhao,S.C.
  TITLE     SETD4 inhibits prostate cancer development by promoting
            H3K27me3-mediated NUPR1 transcriptional repression and cell cycle
            arrest
  JOURNAL   Cancer Lett 579, 216464 (2023)
   PUBMED   37879429
  REMARK    GeneRIF: SETD4 inhibits prostate cancer development by promoting
            H3K27me3-mediated NUPR1 transcriptional repression and cell cycle
            arrest.
REFERENCE   4  (bases 1 to 5345)
  AUTHORS   Liu,Y.C., Wu,Z.L., Ge,L.Y., DU,T., Wu,Y.Q., Song,Y.M., Liu,C. and
            Ma,L.L.
  TITLE     [Mechanism of nuclear protein 1 in the resistance to axitinib in
            clear cell renal cell carcinoma]
  JOURNAL   Beijing Da Xue Xue Bao Yi Xue Ban 55 (5), 781-792 (2023)
   PUBMED   37807730
  REMARK    GeneRIF: [Mechanism of nuclear protein 1 in the resistance to
            axitinib in clear cell renal cell carcinoma].
REFERENCE   5  (bases 1 to 5345)
  AUTHORS   Tan,L., Armstrong,A.R., Rosas,S., Patel,C.M., Vander Wiele,S.S.,
            Willey,J.S., Carlson,C.S. and Yammani,R.R.
  TITLE     Nuclear protein-1 is the common link for pathways activated by
            aging and obesity in chondrocytes: A potential therapeutic target
            for osteoarthritis
  JOURNAL   FASEB J 37 (9), e23133 (2023)
   PUBMED   37566478
  REMARK    GeneRIF: Nuclear protein-1 is the common link for pathways
            activated by aging and obesity in chondrocytes: A potential
            therapeutic target for osteoarthritis.
REFERENCE   6  (bases 1 to 5345)
  AUTHORS   Encinar,J.A., Mallo,G.V., Mizyrycki,C., Giono,L.,
            Gonzalez-Ros,J.M., Rico,M., Canepa,E., Moreno,S., Neira,J.L. and
            Iovanna,J.L.
  TITLE     Human p8 is a HMG-I/Y-like protein with DNA binding activity
            enhanced by phosphorylation
  JOURNAL   J Biol Chem 276 (4), 2742-2751 (2001)
   PUBMED   11056169
REFERENCE   7  (bases 1 to 5345)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
REFERENCE   8  (bases 1 to 5345)
  AUTHORS   Ree,A.H., Tvermyr,M., Engebraaten,O., Rooman,M., Rosok,O.,
            Hovig,E., Meza-Zepeda,L.A., Bruland,O.S. and Fodstad,O.
  TITLE     Expression of a novel factor in human breast cancer cells with
            metastatic potential
  JOURNAL   Cancer Res 59 (18), 4675-4680 (1999)
   PUBMED   10493524
REFERENCE   9  (bases 1 to 5345)
  AUTHORS   Vasseur,S., Vidal Mallo,G., Fiedler,F., Bodeker,H., Canepa,E.,
            Moreno,S. and Iovanna,J.L.
  TITLE     Cloning and expression of the human p8, a nuclear protein with
            mitogenic activity
  JOURNAL   Eur J Biochem 259 (3), 670-675 (1999)
   PUBMED   10092851
REFERENCE   10 (bases 1 to 5345)
  AUTHORS   Mallo,G.V., Fiedler,F., Calvo,E.L., Ortiz,E.M., Vasseur,S.,
            Keim,V., Morisset,J. and Iovanna,J.L.
  TITLE     Cloning and expression of the rat p8 cDNA, a new gene activated in
            pancreas during the acute phase of pancreatitis, pancreatic
            development, and regeneration, and which promotes cellular growth
  JOURNAL   J Biol Chem 272 (51), 32360-32369 (1997)
   PUBMED   9405444
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP214401.1, BF965595.1, AF069073.1 and AC020765.8.
            
            On Jun 2, 2019 this sequence version replaced NM_001042483.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU689422.1, SRR7346977.198413.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BP214401.1         201-218
            19-473              BF965595.1         1-455
            474-712             AF069073.1         455-693
            713-5345            AC020765.8         71175-75807         c
FEATURES             Location/Qualifiers
     source          1..5345
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..5345
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /note="nuclear protein 1, transcriptional regulator"
                     /db_xref="GeneID:26471"
                     /db_xref="HGNC:HGNC:29990"
                     /db_xref="MIM:614812"
     exon            1..179
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..370
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /note="isoform a is encoded by transcript variant 1;
                     candidate of metastasis 1; protein p8; nuclear protein,
                     transcriptional regulator, 1; nuclear transcriptional
                     regulator protein 1"
                     /codon_start=1
                     /product="nuclear protein 1 isoform a"
                     /protein_id="NP_001035948.1"
                     /db_xref="CCDS:CCDS42137.1"
                     /db_xref="GeneID:26471"
                     /db_xref="HGNC:HGNC:29990"
                     /db_xref="MIM:614812"
                     /translation="MATFPPATSAPQQPPGPEDEDSSLDESDLYSLAHSYLGPLIMPM
                     PTSPLTPALVTGGGGRKGRTKREAAANTNRPSPGGHERKLVTKLQNSERKKRGARR"
     exon            180..383
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /inference="alignment:Splign:2.1.0"
     exon            384..5345
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      661..666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /note="hexamer: AATAAA"
     regulatory      665..670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /note="hexamer: AATAGA"
     polyA_site      681
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /note="major polyA site"
     polyA_site      710
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
     regulatory      5320..5325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
                     /note="hexamer: AATGAA"
     polyA_site      5345
                     /gene="NUPR1"
                     /gene_synonym="COM1; P8"
ORIGIN      
        1 gccaggaaag cagagacaga caaagcgtta ggagaagaag agaggcaggg aagacaagcc
       61 aggcacgatg gccaccttcc caccagcaac cagcgccccc cagcagcccc caggcccgga
      121 ggacgaggac tccagcctgg atgaatctga cctctatagc ctggcccatt cctacctcgg
      181 gcctctcatc atgcctatgc ccacttcacc tctgactcct gccttggtta caggaggtgg
      241 aggccggaaa ggtcgcacca agagagaagc tgctgccaac accaaccgcc ccagccctgg
      301 cgggcacgag aggaaactgg tgaccaagct gcagaattca gagaggaaga agcgaggggc
      361 acggcgctga gacagagctg gagatgaggc cagaccatgg acactacacc cagcaataga
      421 gacgggactg cggaggaagg aggacccagg acaggatcca ggccggcttg ccacaccccc
      481 cacccctagg acttattccc gctgactgag tctctgaggg gctaccagga aagcgcctcc
      541 aaccctagca aaagtgcaag atggggagtg agaggctggg aatggagggg cagagccagg
      601 aagatccccc agaaaagaaa gctacagaag aaactggggc tcctccaggg tggcagcaac
      661 aataaataga cacgcacggc agccacagct tgggtgtgtg ttcatccttg ttctttgtgt
      721 gtttttgttc gggcatgtgt gtgcttgcct gtgcctgcac attcatgagc ctgagagagc
      781 atctttgatg tgtatttgtg tttggtgtat gtatctgggg cagggagtgt tcctgctctt
      841 gcagggtcta cgctgtgaat gcagcttttg gtttgtttgc ttttgcttgc atatatttta
      901 gtgcatacat ttctgtgggc tcctacgtag tggaaaggaa tttcttctgc ttttttgcga
      961 tactgcccat gaaacacggc cctccccagc acctgttttt gttgattgtg tcctgttcat
     1021 agacgggaac gctacttatg agtgccatct aaaagtcaga gaaaactgag atttaaaata
     1081 ttaaaagcca gggccggggg cagtggctca cgcctgtaat cccagcactt tgggaggccg
     1141 aggtgggtgg atcacaaagt caggagttca agaccagcct gaccaacatg gtgaaacccc
     1201 atctccacta aaaataccaa aaattagcca agcatggtgg caggtgcctg taatcccagc
     1261 tgctcaggag gctgaggcag tagaatcgct tgaacccagg aggtagaggt tgcagtgagc
     1321 cgacatcgtg ccattgcact ccagcctggg tgacagaggg agactctgtc tcaaaacaaa
     1381 caaacaaaca aaaactaaag tctgggagca gtggctcatg cctgtaatca cagcagttta
     1441 ggaggccgaa gtgggaggat tacttgagcc taggagtttg agaccagcct gagcatcata
     1501 gtaagacccc atctctacaa tttttttttt gagacagagt ctcactctgt tgctcaggtt
     1561 agagtgcagt ggcaccatct tggctcactg caacctctgc ctcccgggtt caagcaattc
     1621 tcgtgcctac gccccctgag tagctgggat tacaggtgag caccaccacg cctggctaat
     1681 ttttgttttt ttgttttttt gatacagagt ctcactctgt tgctcaggct ggagtgcagt
     1741 ggcatgatcg cagctcactg caacctccgc ctcctgggtt caagctattc tcctgcttca
     1801 gcctcctgag tagctgggac tacaggcacc tgccaccatg cctggctaat ttttgtattt
     1861 ttagtagaaa cagagtttca ccatgttggc caggatggtc tcaatctctt gacctcatga
     1921 tccacccacc ttggcctccc aaagtgctgg gattacaggc gtcagccacc acgcctggcc
     1981 aatttttgta tttttagtag agatggggtt tcatcatgtt ggccaggctg gtctcaaact
     2041 cctggcctca aatgatctgc ccacctcagc cttccagcct ttgggaggcc aaggagggag
     2101 gatcgcttga ggccaggagt tcgagaccag cctaggcaac ataccaaggc cctgtctcta
     2161 caaaaattta aaaattagca aagcatggtg gctcatgcct gtagtcctag ttgctcagag
     2221 gctgaagttg gaggatccct tgaacccagt tggaggctac agtaagccat gatggtgcca
     2281 ctgcactgca gcctgagcaa tagagtgaaa ccatgtattg aaaaagaaag aaagaaagaa
     2341 agagaaaaag aaggaaggaa ggaaaagaaa ggaaggaaga aagaaaagaa agagagaaag
     2401 gagagaaaaa gaagaaagag agagaaagag aagaaagaaa gaaagaaaga aagaaagaaa
     2461 gaaagaaaga aagaaagaaa ggaaggaagg aaagaaagaa agaaagaagg aaagaaagaa
     2521 agaaagaaag aaagaaagaa agaaagaaaa gagcgagccc cggcacagtg gctcacacct
     2581 gtaatcccag cactttggga ggccaaggca ggcggatcac ctgaggtcag tagttcgagt
     2641 tcgaggcaga agttgtggtg agccaagatc acgccattgc actccagcct gggcaacaag
     2701 agcaaaactc catctcaaaa aaagaaaaag agagagaaag aaagagagaa ggagggaaag
     2761 aaagaggaag gaaaggaggg agggaaggag ggaaggagga aaggagggaa ggaaatatta
     2821 agggatttgc cctagctcac tcagggctca tattcaggga tcttattgtc ttcagatatg
     2881 aggtgggtcc ccaggccaag ggggctgtgg gacagggttc tgggaagtga gatgggggag
     2941 ggagattctt attcagtgct atgtctcagg accagagttg aagaaaaata tggggcaaac
     3001 aggaagtgtg gttggagctg agattatttg ttgattgaga tacaggtttg ggttgctatt
     3061 atgaagaatc aaaacaggat acaaagttac tcctctctta cttagcccca agtcctcctg
     3121 ggttcaaatg gcagctccat tgtgttgagg attccagcta tttttactca ctgttctgcc
     3181 acacccaaaa catggcttcc actttgaggc ccaaaatagc tactccaata cctgccatca
     3241 cgtttgcatc tcagcctgtg gaaagagtgt ggaagagaca gaggaggcca cacctcttca
     3301 attttagggc ataatctaaa agtagaacac atcacatctg ctccgaatgt ggctacatgg
     3361 ccacacccaa ctacgagaga ggttgggaaa tgtagcattg agctgcttag ccacgtggta
     3421 gccaaaactt gggcaacagc agggttttat gatgaaaggg aaccagagag agtgaataca
     3481 cgaagaagct agcaagaaac attgcccaca tgcagactca acagatgtcg ggggagaaaa
     3541 ctctgagatt gggccccggg cagagcctgt ttccttttcc cctgtccctt tcacataagc
     3601 cccacactgc agaacttgga gtcagtggtt catggggacc caaggacatc cacagaagac
     3661 cgaagtacct gatagagcag gaacagatgc acgtcagact acgaccagct tgaacccttg
     3721 gggacctgta tccatcccct tcccttgagt ccagcctaat cacagccaca gaatgaatcc
     3781 atgacccgga aggacattta aggacctctg gcccaactct ccccacgcaa cagtgggatt
     3841 gcctctgctt gtttgaatac cactatggag ggggaacttg ctacatttaa aggttgctga
     3901 atttttttgt tttgttttgg gagatggagt ctctctctgt cgcccaggct ggagtgcagt
     3961 ggtgtgatct cgacccactg caacctccgc ttcctgggtt caagcgattt tcatgcctca
     4021 gcctccctag tagctgggac tacaggtgtg ggccaccaca cctggctaat ttttgtattt
     4081 ttagtagaga cggggtttca ccatgttgcc caggctggtc tcaaactccc gacctcaggt
     4141 gatctgcctg ccttggcctc ccaaagtgtt gggattacag gcttgagcca caccacccgg
     4201 caaaggttgc ctaattctat ctcagggcaa gtctgttcat gtgggctgaa atctgtctct
     4261 catacctgcc cttaaataag cttctgtttt tctggtcctt tctgtctgag atgactttaa
     4321 ttcctccccc gaccccatct catgaggctc agcttagatg tttccttctc ttcctccctg
     4381 atggctgcgt gcagaagctc atacctgcaa tcccagcact ttgggaggcc gaggtgggag
     4441 gattgcttgg gcccaggagt tctaggccag cctagcaaca cagcaagacc ctctctctac
     4501 aaaaaattaa aaattagcca ggtgtggtgg cttgtgcctg tgggcccacc tactcaggag
     4561 gctgaggtga gaggatctct tgagtctggg aggtggaggc tgcagtgagc catgatctca
     4621 ctccagcctg ggcgtcagag tgagacctgt ctcaaaaaaa caaaaaccaa agttttcctt
     4681 aacttgcaat cctccaccca tctcctgacc tccaccccag gccgaccctc ctctgggatc
     4741 acacggaagc ctgggcccag aatcttacag tctaccttgg aaatccttca gattttgcct
     4801 ccaactcctc tttccataca agttacatat taactcaatc aatgcttatt ggatgccttc
     4861 tgagttacca ggatgctgct ggaggcctgt gctgctgaga gggacaaata gaatcctgat
     4921 atgactggaa ccaggaatag ggccaccatc agctctagaa cccagggagc aaatggcagg
     4981 agcaacacca ggcagtcggc cctcagccca gcacagacct ggtgtgttgg cttcagaaaa
     5041 tcctggaaac atctctgctg tgtttggagc tcctattctg tgagaagtgt tttataggct
     5101 ttgctccatt taatccttac gataacccaa taggacatac tattaatgat cccctttttt
     5161 tcagaccgga aaactgaggt tcggagacat taagtaattt gcctaaagtc acacagccac
     5221 atcctgtagg acttggaatt atgaactcag gtctatctga attttaaagc ctggattttt
     5281 ccccctttgc tacatgcctg ggaagaacca tgtattgaca atgaagaatc ctaaactctc
     5341 gttaa
//
