LOCUS       NM_016320               6726 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens nucleoporin 98 and 96 precursor (NUP98), transcript
            variant 1, mRNA.
ACCESSION   NM_016320
VERSION     NM_016320.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6726)
  AUTHORS   Noura,M., Tomita,S., Yasuda,T., Tsuzuki,S., Kiyoi,H. and
            Hayakawa,F.
  TITLE     NUP98-BPTF promotes oncogenic transformation through PIM1
            upregulation
  JOURNAL   Cancer Med 13 (13), e7445 (2024)
   PUBMED   38940430
  REMARK    GeneRIF: NUP98-BPTF promotes oncogenic transformation through PIM1
            upregulation.
REFERENCE   2  (bases 1 to 6726)
  AUTHORS   Guo,Y., Tao,T., Wu,T., Hou,J. and Lin,W.
  TITLE     Nucleoporin Nup98 is an essential factor for ipo4 dependent protein
            import
  JOURNAL   J Cell Biochem 125 (7), e30573 (2024)
   PUBMED   38780165
  REMARK    GeneRIF: Nucleoporin Nup98 is an essential factor for ipo4
            dependent protein import.
REFERENCE   3  (bases 1 to 6726)
  AUTHORS   Gough,S.M., Slape,C.I. and Aplan,P.D.
  TITLE     NUP98 gene fusions and hematopoietic malignancies: common themes
            and new biologic insights
  JOURNAL   Blood 118 (24), 6247-6257 (2011)
   PUBMED   21948299
  REMARK    GeneRIF: Structural chromosomal rearrangements of NUP98, primarily
            balanced translocations and inversions, are associated with wide
            array of hematopoietic malignancies; NUP98 is known to be fused to
            at least 28 different partner genes in patients. [REVIEW]
            Review article
REFERENCE   4  (bases 1 to 6726)
  AUTHORS   Iwamoto,M., Asakawa,H., Hiraoka,Y. and Haraguchi,T.
  TITLE     Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms
  JOURNAL   Genes Cells 15 (7), 661-669 (2010)
   PUBMED   20545767
  REMARK    Review article
REFERENCE   5  (bases 1 to 6726)
  AUTHORS   Hodel,A.E., Hodel,M.R., Griffis,E.R., Hennig,K.A., Ratner,G.A.,
            Xu,S. and Powers,M.A.
  TITLE     The three-dimensional structure of the autoproteolytic, nuclear
            pore-targeting domain of the human nucleoporin Nup98
  JOURNAL   Mol Cell 10 (2), 347-358 (2002)
   PUBMED   12191480
  REMARK    GeneRIF: The three-dimensional structure of the autoproteolytic,
            nuclear pore-targeting domain of the human nucleoporin Nup98.
REFERENCE   6  (bases 1 to 6726)
  AUTHORS   Griffis,E.R., Altan,N., Lippincott-Schwartz,J. and Powers,M.A.
  TITLE     Nup98 is a mobile nucleoporin with transcription-dependent dynamics
  JOURNAL   Mol Biol Cell 13 (4), 1282-1297 (2002)
   PUBMED   11950939
  REMARK    GeneRIF: Nup98 aids in direction of RNAs to the nuclear pore and
            provide the first potential mechanism for the role of a mobile
            nucleoporin.
REFERENCE   7  (bases 1 to 6726)
  AUTHORS   Rosenblum,J.S. and Blobel,G.
  TITLE     Autoproteolysis in nucleoporin biogenesis
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11370-11375 (1999)
   PUBMED   10500183
REFERENCE   8  (bases 1 to 6726)
  AUTHORS   Fontoura,B.M., Blobel,G. and Matunis,M.J.
  TITLE     A conserved biogenesis pathway for nucleoporins: proteolytic
            processing of a 186-kilodalton precursor generates Nup98 and the
            novel nucleoporin, Nup96
  JOURNAL   J Cell Biol 144 (6), 1097-1112 (1999)
   PUBMED   10087256
REFERENCE   9  (bases 1 to 6726)
  AUTHORS   Nakamura,T., Largaespada,D.A., Lee,M.P., Johnson,L.A.,
            Ohyashiki,K., Toyama,K., Chen,S.J., Willman,C.L., Chen,I.M.,
            Feinberg,A.P., Jenkins,N.A., Copeland,N.G. and Shaughnessy,J.D. Jr.
  TITLE     Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome
            translocation t(7;11)(p15;p15) in human myeloid leukaemia
  JOURNAL   Nat Genet 12 (2), 154-158 (1996)
   PUBMED   8563753
REFERENCE   10 (bases 1 to 6726)
  AUTHORS   Radu,A., Moore,M.S. and Blobel,G.
  TITLE     The peptide repeat domain of nucleoporin Nup98 functions as a
            docking site in transport across the nuclear pore complex
  JOURNAL   Cell 81 (2), 215-222 (1995)
   PUBMED   7736573
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB084013.1, AF231130.1,
            AF071076.1 and BC012906.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016320.4.
            
            Summary: Nuclear pore complexes (NPCs) regulate the transport of
            macromolecules between the nucleus and cytoplasm, and are composed
            of many polypeptide subunits, many of which belong to the
            nucleoporin family. This gene belongs to the nucleoporin gene
            family and encodes a 186 kDa precursor protein that undergoes
            autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96
            kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly
            (GLGF) repeat domain and participates in many cellular processes,
            including nuclear import, nuclear export, mitotic progression, and
            regulation of gene expression. The 96 kDa nucleoporin is a scaffold
            component of the NPC. Proteolytic cleavage is important for
            targeting of the proteins to the NPC. Translocations between this
            gene and many other partner genes have been observed in different
            leukemias. Rearrangements typically result in chimeras with the
            N-terminal GLGF domain of this gene to the C-terminus of the
            partner gene. Alternative splicing results in multiple transcript
            variants encoding different isoforms, at least two of which are
            proteolytically processed. Some variants lack the region that
            encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.200264.1, AF231130.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324932.12/ ENSP00000316032.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                DB084013.1         239-277
            40-3005             AF231130.1         1-2966
            3006-3973           AF071076.1         2947-3914
            3974-5865           BC012906.1         648-2539
            5866-6726           AF231130.1         5827-6687
FEATURES             Location/Qualifiers
     source          1..6726
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..6726
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /note="nucleoporin 98 and 96 precursor"
                     /db_xref="GeneID:4928"
                     /db_xref="HGNC:HGNC:8068"
                     /db_xref="MIM:601021"
     exon            1..155
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            156..259
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..5586
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; GLFG-repeat containing nucleoporin;
                     Nup98-Nup96; nucleoporin 98kD; nuclear pore complex
                     protein Nup98-Nup96; nucleoporin 98kDa; nucleoporin 96;
                     NUP98/PHF23 fusion 2 protein"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup98-Nup96 isoform
                     1 precursor"
                     /protein_id="NP_057404.2"
                     /db_xref="CCDS:CCDS7746.1"
                     /db_xref="GeneID:4928"
                     /db_xref="HGNC:HGNC:8068"
                     /db_xref="MIM:601021"
                     /translation="MFNKSFGTPFGGGTGGFGTTSTFGQNTGFGTTSGGAFGTSAFGS
                     SNNTGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGFGTSTGTANTLFGTASTGTSLF
                     SSQNNAFAQNKPTGFGNFGTSTSSGGLFGTTNTTSNPFGSTSGSLFGPSSFTAAPTGT
                     TIKFNPPTGTDTMVKAGVSTNISTKHQCITAMKEYESKSLEELRLEDYQANRKGPQNQ
                     VGAGTTTGLFGSSPATSSATGLFSSSTTNSGFAYGQNKTAFGTSTTGFGTNPGGLFGQ
                     QNQQTTSLFSKPFGQATTTQNTGFSFGNTSTIGQPSTNTMGLFGVTQASQPGGLFGTA
                     TNTSTGTAFGTGTGLFGQTNTGFGAVGSTLFGNNKLTTFGSSTTSAPSFGTTSGGLFG
                     FGTNTSGNSIFGSKPAPGTLGTGLGAGFGTALGAGQASLFGNNQPKIGGPLGTGAFGA
                     PGFNTTTATLGFGAPQAPVALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSD
                     PKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDE
                     PSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPV
                     DENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRN
                     GLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEK
                     GECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGL
                     NRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSW
                     VFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQ
                     SQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSASTHIASSLGINPH
                     VLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGG
                     LLQSKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVP
                     LKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLNGS
                     HELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLEL
                     KLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWTLCEAL
                     WGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSY
                     LTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDER
                     LRIFALLAGKPVWQLSEKKQINVCSQLDWKRSLAIHLWYLLPPTASISRALSMYEEAF
                     QNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDRHYDLNQLLE
                     PRSITADPLDYRLSWHLWEVLRALNYTHLSAQCEGVLQASYAGQLESEGLWEWAIFVL
                     LHIDNSGIREKAVRELLTRHCQLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHME
                     SDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQD
                     WETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKDRLA
                     QSDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQRVPLRLLAPHIGRLPMPEDYAMDEL
                     RSLTQSYLRELAVGSL"
     exon            260..361
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            362..538
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            539..678
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            679..786
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            787..967
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1131
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1269
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1357
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1450
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1591
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1725
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1913
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2030
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2329
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2443
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2582
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2760
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2925
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3108
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3265
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3695
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..3925
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            3926..4192
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            4193..4350
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            4351..4494
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4637
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            4638..4859
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            4860..5101
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            5102..5256
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            5257..5368
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     exon            5369..6726
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5847..5852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /note="hexamer: AATAAA"
     polyA_site      5876
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /note="major polyA site"
     regulatory      6709..6714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /note="hexamer: AATAAA"
     polyA_site      6726
                     /gene="NUP98"
                     /gene_synonym="ADIR2; NUP196; NUP96; Nup98-96"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcgggc cctctgcgcg ctgcgcccga agcggcggtc ggtggcaggg gtggtagcgg
       61 cggcggcgac ggtttcgtgg gggccgcgcg ctgctctgtg agcggcgggt ggcagcaggg
      121 gactcctgac acttcccctt ccccaccgaa ccgcgctttc tgaaacaaag actcattttg
      181 aagatgttta acaaatcatt tggaacaccc tttgggggtg gcacaggtgg ctttggcaca
      241 acttcaacat ttggacagaa tactggcttt ggcactacta gtggaggggc atttggaaca
      301 tctgcatttg gttctagcaa caatactgga ggcctctttg gaaattcaca gactaaacca
      361 ggaggattgt ttggaaccag ttcatttagc cagccagcta cctccacaag cactggcttt
      421 gggtttggta cgtcaacagg aacagcaaat accttgtttg gaactgcaag cacagggacc
      481 agtctcttct catcccaaaa caatgccttt gcacaaaata aaccaactgg ctttggcaat
      541 tttggaacca gtactagcag tggaggactc tttggaacca caaataccac ctctaatcct
      601 tttggcagca catctggctc cctctttggg ccaagtagtt ttacagctgc tcctactggg
      661 actactatta aatttaaccc tccaactggt acagatacta tggtcaaagc tggagttagc
      721 actaacataa gtaccaagca ccagtgtatt actgctatga aagaatatga aagcaagtca
      781 ctagaggaac ttcgtttaga ggattatcag gctaacagga agggcccaca gaaccaggtg
      841 ggagcaggta ccacaactgg cttgtttggg tcttctccag ccacttccag cgcaacagga
      901 ctcttcagct cctccaccac taattcaggc tttgcatatg gtcagaacaa aactgccttt
      961 ggaactagta caactggatt tggaacaaat ccaggtggtc tctttggcca acagaatcag
     1021 cagactacca gcctcttcag caaaccattt ggccaggcta caaccaccca gaacactggc
     1081 ttttcctttg gtaataccag caccatagga cagccaagca ccaacaccat gggattattt
     1141 ggagtaaccc aagcctcaca gcctggaggt ctttttggga cagctacaaa caccagcact
     1201 gggacagcat ttggaacagg aacaggtctc tttgggcaga ccaatactgg atttggtgct
     1261 gttggttcga ccctgtttgg caataacaag cttactacat ttggaagcag cacaaccagt
     1321 gcaccttcat ttggtacaac cagtggcggg ctctttggtt ttggcacaaa taccagtggg
     1381 aatagtattt ttggaagtaa accagcacct gggactcttg gaactgggct tggtgcagga
     1441 tttggaacag ctcttggtgc tggacaggca tctttgtttg ggaacaacca acctaagatt
     1501 ggagggcctc ttggtacagg agcctttggg gcccctggat ttaatactac gacagccact
     1561 ttgggctttg gagcccccca ggccccagta gctttgacag atccaaatgc ttctgctgcc
     1621 cagcaggctg ttctccagca gcacatcaat agtctaacat actcaccttt tggagactct
     1681 cctctcttcc ggaatccgat gtcagaccct aagaagaagg aagagagatt gaaaccaaca
     1741 aatccagcag cccagaaggc tcttactaca cctactcatt ataaactgac accccgccct
     1801 gccactagag tccggccaaa ggctttacaa acaacaggca cagccaagtc acatctcttt
     1861 gatgggctgg atgacgatga accatcccta gccaatggag cattcatgcc caagaagagc
     1921 attaagaagt tggttttgaa gaaccttaat aatagcaatc tcttttctcc tgttaatcgt
     1981 gattcagaaa atctagcttc accatctgaa tatccagaaa atggagagag atttagtttc
     2041 ctaagcaaac ctgttgatga gaatcaccag caggatggag atgaagattc ccttgtttca
     2101 catttttata ctaaccctat tgccaaacct attcctcaaa ccccagaaag tgctggaaat
     2161 aaacacagca acagcaacag tgtggatgat accattgttg cattaaacat gcgtgctgct
     2221 ttgcgaaatg ggctggaagg aagcagtgaa gaaacgtctt ttcatgatga gtcacttcag
     2281 gatgaccgag aagaaataga aaataattct taccatatgc acccagcagg tattattctc
     2341 actaaggttg gttactatac tattccatct atggatgacc ttgctaaaat taccaatgaa
     2401 aaaggagagt gcattgtctc tgatttcact attggtcgga aaggttatgg ttcaatctat
     2461 tttgaaggag atgtgaattt gacaaatcta aatttggatg atattgtgca tatccggagg
     2521 aaagaagtag ttgtctactt agatgataac caaaaaccac ctgtgggtga agggctaaat
     2581 aggaaggctg aagttacatt ggatggagtt tggccaacag ataaaacatc tcgttgttta
     2641 ataaagagcc cagatcgcct tgctgatatc aactatgaag gaagattgga agcagtttca
     2701 aggaaacagg gagctcaatt caaagaatac cggcctgaaa ctggttcttg ggtgtttaag
     2761 gtctcccatt tttctaagta tggccttcag gattctgatg aagaggagga ggagcatccg
     2821 tctaaaacta gtacaaagaa gttgaagact gctcctttgc ctcctgcaag ccagactacg
     2881 cccttgcaga tggctcttaa tggcaaacct gcacctccac ctcagagcca gagcccagag
     2941 gtggagcagt tagggagggt tgtggaactg gacagtgaca tggtagatat cacccaggag
     3001 ccagttttgg ataccatgtt agaagagagc atgcctgagg atcaggaacc tgtgtctgcc
     3061 tcaacacata ttgcatcttc actgggaatt aatccacatg tcttacagat catgaaagca
     3121 tcattgctta ctgatgaaga agatgtagat atggcactgg atcaacgctt cagtcgcctg
     3181 ccttccaaag cagatacttc tcaagaaatc tgttctccca gactccccat ttcagcatcc
     3241 cactcgtcga aaactcgttc actagttggt gggttactac aatcaaaatt tacaagtgga
     3301 gcttttcttt caccaagtgt ctctgtgcaa gaatgtcgta ctcccagagc agcatcttta
     3361 atgaatatcc catccacatc ctcttggtct gtccctccac ccctgacttc tgtgttcaca
     3421 atgcccagcc cagcccctga ggttccgttg aaaacagtgg gtacacgtag gcaactaggc
     3481 ctagtccctc gtgaaaagtc tgtcacctat ggcaagggaa aactcttgat ggacatggcc
     3541 ctattcatgg gacgctcatt tcgtgttggt tggggcccca actggactct tgctaatagt
     3601 ggagaacagc tgaatggctc tcatgaacta gaaaatcatc agattgccga ttccatggag
     3661 tttggattcc tgcccaatcc agtagctgtt aaacccctaa ctgagtcccc attcaaagtt
     3721 cacttagaaa aactcagttt gagacaaaga aagccagatg aagacatgaa attatatcag
     3781 acacctctgg agctcaaatt aaaacacagc actgtccatg tggatgaact gtgtcctctc
     3841 attgtcccca atctgggagt tgctgtcatt catgactatg cagattgggt taaagaagca
     3901 tcaggagact taccagaagc acaaattgtg aagcactgga gcctgacatg gacactatgt
     3961 gaagccctat ggggccacct gaaggagctt gacagccagc taaatgaacc ccgtgaatac
     4021 attcaaattc tggagcgaag aagagctttc tcccgctggc tatcctgtac tgccacacct
     4081 cagattgaag aggaagtctc cttaacccaa aaaaacagcc ctgtggaggc tgtattcagc
     4141 tacctcacag gcaaaaggat cagtgaggcc tgctctctgg cccagcagtc aggggatcat
     4201 cgtcttgctc ttcttttatc tcagtttgtg ggtagccagt cagtccggga gctgctcacc
     4261 atgcagttgg tggactggca tcagctccaa gcagactcct tcatccagga tgagagactg
     4321 cgcatctttg ctctgttggc tggaaaaccg gtgtggcagc tctcagaaaa gaagcaaata
     4381 aacgtgtgct cccagttgga ttggaaacgc tccctggcta tccatctttg gtatttgctt
     4441 ccaccaacag cctccatttc tagggcgctc agcatgtatg aagaagcatt tcagaatacc
     4501 tctgacagtg acagatatgc ctgctcccca cttccttcgt atctggaggg ttctggctgt
     4561 gtgatagcgg aggagcaaaa ctcacagaca ccacttcgag atgtctgctt tcaccttcta
     4621 aaactctaca gtgacagaca ttatgatctc aaccagctgc tggagcctcg aagcataaca
     4681 gcagatcctt tggactaccg cctaagctgg cacttgtggg aagtgctgag ggctcttaac
     4741 tacacccatc tctcagcgca gtgtgaaggt gtgctacagg ccagttacgc tggccagctt
     4801 gaaagtgagg ggctctggga gtgggccatc tttgtcctcc tgcacattga caactcaggc
     4861 atacgtgaga aggctgttcg agagctgctt acccggcact gccagctgtt ggagacccct
     4921 gaatcttggg ctaaagagac tttccttacc cagaagctcc gtgtacctgc caaatggatc
     4981 cacgaggcca aagctgtgcg agcacacatg gaatctgaca agcacttaga ggccctttgc
     5041 ttatttaagg ctgagcactg gaaccgctgc cacaagctca tcatccgaca cttagcttct
     5101 gatgccatca ttaatgagaa ctatgactac ctgaaggggt tcttggaaga cctggcacct
     5161 ccagagcgca gcagcctaat tcaggattgg gaaacatctg ggcttgttta cctggactat
     5221 attagagtca ttgaaatgct ccgccatata cagcaggtgg attgctcagg taatgacctg
     5281 gagcagttac acatcaaagt gacttcactg tgcagtcgga tagagcagat tcagtgttac
     5341 agtgctaaag atcgcctggc tcagtcagac atggccaaac gtgtagccaa cctgctgcgc
     5401 gtggtgctga gtctgcatca tcctcctgat agaacctccg actcaacacc agaccctcag
     5461 cgagtccctt tgcgcctctt ggctccccac attggccggc ttcccatgcc tgaggactat
     5521 gccatggacg aactgcgcag ccttacccag tcctatctgc gagaactggc tgttgggagc
     5581 ctgtgagccc caggcacttt gcatcacagt cacatgccca ttcacaccac acagaggttc
     5641 cctgccttgt ttggattggc actgtttgcc attctctggg ttggctgtgg catctaccct
     5701 ccctccctgc tgccagaagc agcatcctcc acttgttcag ggcttttctt aatactgaac
     5761 gtagcataag ggcttctgga acccagaaga ggagacagtt taccatcctc aagatcattc
     5821 agtgtttttc ctttaaaaaa atggtcaata aagctccttt ggcagaatcc cccaaagaac
     5881 cagggtattc tttttccatc cctagccatt ctggatcttg tgaccctcca tgccaaccag
     5941 cttccctact cctaccctgg cccttttata ctaggactcc ttaggaggag tgagacaggt
     6001 gataatggat ccttaacaga tgaactatcc acagaaggaa gagggatccg tctcttaagt
     6061 aattggttag ttaacactga attttggagg caaaggaggg ttggcctgag ttaggaaaca
     6121 aaatgggatc tttctgacac acttagggca gaagtgaatg cctgtcacgg agggattgat
     6181 cttcagggct gtttttgttc ctgcctttag agttccatga acaccatacc tttgctacta
     6241 ctatgtgcag gaacccttgg tcacatgtga catgtctgtg ggaagctccc agagtttggt
     6301 ttggtccctg gttttcagtc ttgctgagac tctgtctgga tttgcctgca gagtttggat
     6361 aaaaaatggc aggttgggta accctccctg ttcatcccat gttagctcca aagcatttcc
     6421 caccctccat ctaccccttc cagaagcaaa aacaaaccat gactgaggca ggcatggagt
     6481 tgggcgttag gggcaggcag agggcctttg ctacactgct gacagctata gggagcccca
     6541 ggtaatggca tgagatagct ggtgttaggg ctatctcagg caatatggcc acacctgggt
     6601 ctttatgcat gaagataatg taaaggtttt tattaaaaaa tatatatatg tataaataaa
     6661 tgatctagat attttcctct ttttctgaag ctactttctt aaaaaataaa taaaatgttt
     6721 atagca
//
