LOCUS       NM_014669               8234 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens nucleoporin 93 (NUP93), transcript variant 1, mRNA.
ACCESSION   NM_014669
VERSION     NM_014669.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8234)
  AUTHORS   Zhang,G., Wei,W., Li,S. and Yang,J.
  TITLE     Transcription Factor yin-Yang 1 augments nucleoporin 93 oncogene
            activity and modulates bladder Cancer malignancy
  JOURNAL   Toxicol In Vitro 99, 105875 (2024)
   PUBMED   38857852
  REMARK    GeneRIF: Transcription Factor yin-Yang 1 augments nucleoporin 93
            oncogene activity and modulates bladder Cancer malignancy.
REFERENCE   2  (bases 1 to 8234)
  AUTHORS   Han,Y., Sha,H., Yang,Y., Yu,Z., Zhou,L., Wang,Y., Yang,F., Qiu,L.,
            Zhang,Y. and Zhou,J.
  TITLE     Mutations in the NUP93, NUP107 and NUP160 genes cause
            steroid-resistant nephrotic syndrome in Chinese children
  JOURNAL   Ital J Pediatr 50 (1), 81 (2024)
   PUBMED   38650033
  REMARK    GeneRIF: Mutations in the NUP93, NUP107 and NUP160 genes cause
            steroid-resistant nephrotic syndrome in Chinese children.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8234)
  AUTHORS   Nguyen,T.D., Rao,M.K., Dhyani,S.P., Banks,J.M., Winek,M.A.,
            Michalkiewicz,J. and Lee,M.Y.
  TITLE     Nucleoporin93 limits Yap activity to prevent endothelial cell
            senescence
  JOURNAL   Aging Cell 23 (4), e14095 (2024)
   PUBMED   38348753
  REMARK    GeneRIF: Nucleoporin93 limits Yap activity to prevent endothelial
            cell senescence.
REFERENCE   4  (bases 1 to 8234)
  AUTHORS   Zhang,J., Xin,Y., Ling,X., Liang,H., Zhang,L., Fang,C. and Ma,J.
  TITLE     Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase
            HECTD1, promotes esophageal squamous cell carcinoma progression
  JOURNAL   Hum Cell 37 (1), 245-257 (2024)
   PUBMED   37993750
  REMARK    GeneRIF: Nucleoporin 93, a new substrate of the E3 ubiquitin
            protein ligase HECTD1, promotes esophageal squamous cell carcinoma
            progression.
REFERENCE   5  (bases 1 to 8234)
  AUTHORS   Bierzynska,A., Bull,K., Miellet,S., Dean,P., Neal,C., Colby,E.,
            McCarthy,H.J., Hegde,S., Sinha,M.D., Bugarin Diz,C., Stirrups,K.,
            Megy,K., Mapeta,R., Penkett,C., Marsh,S., Forrester,N., Afzal,M.,
            Stark,H., BioResource,N., Williams,M., Welsh,G.I., Koziell,A.B.,
            Hartley,P.S. and Saleem,M.A.
  TITLE     Exploring the relevance of NUP93 variants in steroid-resistant
            nephrotic syndrome using next generation sequencing and a fly
            kidney model
  JOURNAL   Pediatr Nephrol 37 (11), 2643-2656 (2022)
   PUBMED   35211795
  REMARK    GeneRIF: Exploring the relevance of NUP93 variants in
            steroid-resistant nephrotic syndrome using next generation
            sequencing and a fly kidney model.
REFERENCE   6  (bases 1 to 8234)
  AUTHORS   Hase,M.E. and Cordes,V.C.
  TITLE     Direct interaction with nup153 mediates binding of Tpr to the
            periphery of the nuclear pore complex
  JOURNAL   Mol Biol Cell 14 (5), 1923-1940 (2003)
   PUBMED   12802065
  REMARK    Erratum:[Mol Biol Cell. 2003 Aug;14(8):preceding Table of Contents]
REFERENCE   7  (bases 1 to 8234)
  AUTHORS   Le Rouzic,E., Mousnier,A., Rustum,C., Stutz,F., Hallberg,E.,
            Dargemont,C. and Benichou,S.
  TITLE     Docking of HIV-1 Vpr to the nuclear envelope is mediated by the
            interaction with the nucleoporin hCG1
  JOURNAL   J Biol Chem 277 (47), 45091-45098 (2002)
   PUBMED   12228227
REFERENCE   8  (bases 1 to 8234)
  AUTHORS   Shiota,C., Coffey,J., Grimsby,J., Grippo,J.F. and Magnuson,M.A.
  TITLE     Nuclear import of hepatic glucokinase depends upon glucokinase
            regulatory protein, whereas export is due to a nuclear export
            signal sequence in glucokinase
  JOURNAL   J Biol Chem 274 (52), 37125-37130 (1999)
   PUBMED   10601273
REFERENCE   9  (bases 1 to 8234)
  AUTHORS   Shah,S., Tugendreich,S. and Forbes,D.
  TITLE     Major binding sites for the nuclear import receptor are the
            internal nucleoporin Nup153 and the adjacent nuclear filament
            protein Tpr
  JOURNAL   J Cell Biol 141 (1), 31-49 (1998)
   PUBMED   9531546
REFERENCE   10 (bases 1 to 8234)
  AUTHORS   Grandi,P., Dang,T., Pane,N., Shevchenko,A., Mann,M., Forbes,D. and
            Hurt,E.
  TITLE     Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with
            a novel 205-kDa protein and is required for correct nuclear pore
            assembly
  JOURNAL   Mol Biol Cell 8 (10), 2017-2038 (1997)
   PUBMED   9348540
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA587787.1, BC034346.1,
            AK294176.1, DA495676.1 and AC012181.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014669.4.
            
            Summary: The nuclear pore complex is a massive structure that
            extends across the nuclear envelope, forming a gateway that
            regulates the flow of macromolecules between the nucleus and the
            cytoplasm. Nucleoporins are the main components of the nuclear pore
            complex in eukaryotic cells. This gene encodes a nucleoporin
            protein that localizes both to the basket of the pore and to the
            nuclear entry of the central gated channel of the pore. The encoded
            protein is a target of caspase cysteine proteases that play a
            central role in programmed cell death by apoptosis. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.237711.1,
                                           SRR1803611.100073.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308159.10/ ENSP00000310668.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                DA587787.1         25-90
            67-1623             BC034346.1         1-1557
            1624-2833           AK294176.1         1647-2856
            2834-2898           DA495676.1         172-236
            2899-8234           AC012181.8         117606-122941       c
FEATURES             Location/Qualifiers
     source          1..8234
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..8234
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /note="nucleoporin 93"
                     /db_xref="GeneID:9688"
                     /db_xref="HGNC:HGNC:28958"
                     /db_xref="MIM:614351"
     exon            1..83
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            84..276
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2557
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear pore complex protein Nup93; nucleoporin Nup93; 93
                     kDa nucleoporin; nucleoporin 93kDa"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup93 isoform 1"
                     /protein_id="NP_055484.3"
                     /db_xref="CCDS:CCDS10769.1"
                     /db_xref="GeneID:9688"
                     /db_xref="HGNC:HGNC:28958"
                     /db_xref="MIM:614351"
                     /translation="MDTEGFGELLQQAEQLAAETEGISELPHVERNLQEIQQAGERLR
                     SRTLTRTSQETADVKASVLLGSRGLDISHISQRLESLSAATTFEPLEPVKDTDIQGFL
                     KNEKDNALLSAIEESRKRTFGMAEEYHRESMLVEWEQVKQRILHTLLASGEDALDFTQ
                     ESEPSYISDVGPPGRSSLDNIEMAYARQIYIYNEKIVNGHLQPNLVDLCASVAELDDK
                     SISDMWTMVKQMTDVLLTPATDALKNRSSVEVRMEFVRQALAYLEQSYKNYTLVTVFG
                     NLHQAQLGGVPGTYQLVRSFLNIKLPAPLPGLQDGEVEGHPVWALIYYCMRCGDLLAA
                     SQVVNRAQHQLGEFKTWFQEYMNSKDRRLSPATENKLRLHYRRALRNNTDPYKRAVYC
                     IIGRCDVTDNQSEVADKTEDYLWLKLNQVCFDDDGTSSPQDRLTLSQFQKQLLEDYGE
                     SHFTVNQQPFLYFQVLFLTAQFEAAVAFLFRMERLRCHAVHVALVLFELKLLLKSSGQ
                     SAQLLSHEPGDPPCLRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKDSQGENMF
                     LRCVSELVIESREFDMILGKLENDGSRKPGVIDKFTSDTKPIINKVASVAENKGLFEE
                     AAKLYDLAKNADKVLELMNKLLSPVVPQISAPQSNKERLKNMALSIAERYRAQGISAN
                     KFVDSTFYLLLDLITFFDEYHSGHIDRAFDIIERLKLVPLNQESVEERVAAFRNFSDE
                     IRHNLSEVLLATMNILFTQFKRLKGTSPSSSSRPQRVIEDRDSQLRSQARTLITFAGM
                     IPYRTSGDTNARLVQMEVLMN"
     exon            277..394
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            395..457
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            458..586
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            587..661
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            662..751
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            752..891
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1024
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1182
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1348
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1442
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1634
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1761
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1834
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1879
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1996
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2115
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2233
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2317
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2446
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..8234
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2693..2698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /note="hexamer: AATAAA"
     polyA_site      2713
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /note="major polyA site"
     regulatory      2868..2873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /note="hexamer: ATTAAA"
     polyA_site      2898
                     /gene="NUP93"
                     /gene_synonym="NIC96"
     regulatory      8215..8220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP93"
                     /gene_synonym="NIC96"
                     /note="hexamer: AGTAAA"
     polyA_site      8234
                     /gene="NUP93"
                     /gene_synonym="NIC96"
ORIGIN      
        1 aggaagcggg ggagagcggc gcgagaagcg gcggccgcgt cctcaagccg gcacctgagc
       61 ggcggagacg gctgtagcac aaggatctgc atctccaatg gatactgagg ggtttggtga
      121 gctccttcag caagctgaac agcttgctgc tgagactgag ggcatctcag agcttcccca
      181 tgtggaacgg aacttacagg agatccagca ggcgggagag cgcctgcgtt cccgtaccct
      241 aacacgcacg tcccaggaga cggcagatgt caaggcgtca gttctcctcg ggtctcgggg
      301 acttgacata tcccacatct cccagcgatt ggagagtctg agtgcagcca ccacctttga
      361 gcctcttgag cctgtgaagg acactgacat tcagggcttc ctgaagaatg agaaggacaa
      421 tgccctgctg tctgccatcg aagagtcccg gaagaggacc ttcggcatgg ctgaggagta
      481 ccatcgggag tcaatgttgg ttgagtggga gcaagtgaaa cagcgaattc tgcacacact
      541 gctggcatca ggagaagacg cccttgactt tactcaagaa agcgagccaa gctacatcag
      601 tgatgtggga ccccctggtc gaagctctct ggataacatc gagatggcct atgcgcggca
      661 aatttatatc tataatgaga aaattgtaaa tggacacctg cagcctaacc tggtggacct
      721 ttgtgcttcc gtcgcagagc tcgatgataa gagcatttcc gacatgtgga ccatggtaaa
      781 acaaatgaca gacgtgttgt tgacaccggc aacggatgcc ctgaagaacc gcagcagcgt
      841 ggaagtgcgc atggagtttg tcaggcaggc cttggcgtac cttgagcaga gttataagaa
      901 ttacaccctt gtgactgtct ttggaaattt gcatcaggcc cagctgggcg gggtgcctgg
      961 gacttaccaa ttggttcgaa gtttcctgaa cattaaactg ccagctccct tgcctggact
     1021 acaggatgga gaggtggaag gccatcctgt gtgggcgcta atttactact gcatgcgctg
     1081 tggagacctg cttgccgctt cacaggtagt taatcgagcc cagcaccagc tgggagagtt
     1141 taaaacctgg ttccaggagt acatgaacag caaggacaga agattgtccc cagctacgga
     1201 aaacaagctc cggctgcatt accgtagggc cctcaggaac aatacagatc cctacaagcg
     1261 ggccgtgtac tgtatcattg gcagatgtga cgtcaccgac aaccagagtg aagtggcgga
     1321 caaaactgag gattacctgt ggctgaagtt gaaccaagtg tgttttgacg acgatggcac
     1381 cagctcccca caagacaggc tcactctctc acagttccag aagcagttgt tggaagacta
     1441 tggcgagtcc cactttacgg tgaaccagca acccttcctc tacttccaag tcctgttcct
     1501 gacagcgcag tttgaagcag cagttgcctt tcttttccgc atggagcggc tgcgctgcca
     1561 tgctgtccat gtagcactgg tgctgtttga gctgaagctg cttttaaagt cctctggaca
     1621 gagtgctcag ctcctcagcc acgagcctgg tgaccctcct tgcttgcggc ggctgaactt
     1681 cgtgcggctc ctcatgctgt acacccggaa gtttgagtcc acggacccaa gggaggccct
     1741 ccagtacttc tatttcctca gggatgagaa agatagtcaa ggagaaaaca tgtttctgcg
     1801 ctgtgtgagt gagcttgtga ttgaaagccg agagttcgat atgattcttg ggaaactaga
     1861 gaatgacgga agtagaaagc ctggagtcat agataagttt actagtgaca caaagcctat
     1921 tatcaacaaa gttgcttctg tggcagaaaa taaaggactg tttgaagagg cagcaaagct
     1981 gtatgacctt gccaagaatg ctgacaaggt actggagctg atgaacaaac tgctgagccc
     2041 tgtcgtcccc cagatcagtg ccccgcaatc caacaaggag aggctgaaga acatggcact
     2101 ctccattgcc gaacggtata gggctcaagg aataagcgca aataaatttg tggactccac
     2161 gttctatctt cttttggact tgatcacctt ttttgacgag tatcatagtg gtcatattga
     2221 tagagctttt gatatcattg agcgcttgaa gctggtgccc ctgaatcagg aaagtgtgga
     2281 agagagagtg gctgccttca gaaatttcag tgatgaaatc aggcacaacc tctcagaagt
     2341 gcttcttgcc accatgaaca tcttgttcac acagtttaag aggctcaagg ggacaagtcc
     2401 atcctcgtca tccaggcccc agcgagtcat cgaggaccgc gactctcaac tccgaagtca
     2461 agcccgcact ctgattacct ttgctggaat gataccatac cgaacgtctg gggacaccaa
     2521 tgcgaggctg gtgcagatgg aggtcctcat gaattaagtg ccatgctttg tgggagtctg
     2581 ggtcggcaca ctgtcagtac atcaggcaca tgggcccact aggctggggt ttctggtttt
     2641 gtttctgttg tgttttgttt tggtttctgt attatgtatt tttgtcaacg ccaataaatt
     2701 tctttgattt gtatttcttt tcaacattct tttattttct tttttttttt ctttgaaatt
     2761 ttgtttacat ttttatttgt gtaatgggaa ataccgtcac tagctcttgg gccagggaat
     2821 gagaggctat gtagatattc attatttggt taaattgacc ttaattaatt aaaaatctac
     2881 ccaaaatgag ccaggaaaca aagcctttgg gagttacttt tatttagata taatattcca
     2941 tatagcagag tcacgattca ttttcacatt tttatttgaa tgtgaaagtc aacctcagcc
     3001 ttagaagatg taagatttgt gtgtgaaata tcaagcactc catgtcctcc tctagagagt
     3061 gtgacttaag tccagatggt ccaagaccat cccccaaatc atcagctctg attgcaggat
     3121 tcatcagttt gccgttctgt tgcaatccca gtggagataa aagcatagac ctagaaaaag
     3181 ccttaagaag gaaggttgca agtgccccca gcttgcactt gaggaagggg taaaccttgc
     3241 cactgcactc ctctgtagct gctccactgt gagttgactg ctcggccttg tacacacccc
     3301 tcctagaaag acgtttaagc ccctatttcc cttctctggt ggtcagttcc tctgctcaga
     3361 cgaccccctt ccccactcat taaggtaatt ggccaggcag gctcatgggt cacgtgctga
     3421 gtctgcaatg tacagaatcc agaccaccac atggcatcag caccatgggt gtttgctccc
     3481 tgagcagtag ttgtcaccca tcatttgctc tgtttccccc accatcagtc ccaaagccct
     3541 agactaaacc agagagcaaa ttaggtcgtg tttgttcctg aatgggccaa ctggagcctt
     3601 gagacagtgg gcagtggtct gctctgctgg tttgatggac ggctccctga ggtagactct
     3661 ttcccagcag aatgttaaga tccccaaagg gtccccaaag gtgcctttgc ttgtagggag
     3721 aagtttctgt cttgtcacag ggtgtggtca tccccactgt ctcccagttg ttaaaataat
     3781 tgttaccttt tcttttggga agaaataatc tgtagataat ggaaccaact gctgcttatc
     3841 ggtaggattc catgttccag gaaggatgcg gcctgagggt cagtggagct gtgttctgcc
     3901 ttcctcctct agtcccatct tgtcaccctg gaggactgtc ttcaattgag ctttactaga
     3961 aagtcttgaa acatgagccc tgcagaggcc ttgatttagc aagttgtgcc ctgcttatat
     4021 gtgctgattt aagctaatca aatgatttaa tagtgctttt taaaaaagag tactcctggc
     4081 cgggtggggt ggctcacacc tgtaatccta gcactttggg aggccaaggc aggtgatcac
     4141 ctgagatcag gagttcaaga ccagcctggc caacattgtg acaccccgtc tatactaaaa
     4201 atacaaaaat tagccgggca tggtggcagg cacctgtaat cccagctaca caggaagctg
     4261 agacagaatt gcttgaaccc gggaggcgaa ggttgcagtg atctgagatc atgccactgc
     4321 actccagcct gggtgaaaga gcgatactcc gtctcaaaaa aataaagagt actctggccg
     4381 agtgcagtgg ctcacgcctg taaccccagc actttgggag gccaaggcag gcagttcgct
     4441 tgaggtaagg ggtttgagac cagtctggcc aacatgggga aaccccgttt ctactaaaaa
     4501 tacaaaaatc agctgggcat ggtggcaggc gcctgtaatc ccagctactc gggaggctga
     4561 ggcaggagaa tcacttgaac ccaagaggcg gaggttgcag tgagccgagc ttatgccact
     4621 gcactccagc ctaggcgatg gagtgaggct ctgattcaaa aataaaaata agagtactct
     4681 gtggactttt cataaagtgc aacttagtgc tttgtttttc taatactaga ttttacttgc
     4741 agatagaaat ataacaatgc cacaaatgag aaggctcaag ttgtttaaat acatgtttgc
     4801 tcctggctta cctcttcttc actatcccat gagaatcgtg gatttgcctt tccttgcatc
     4861 ctgcagttct acttgtctca gagagaactg cacaccagcc ctgcatccag gggatgaggt
     4921 tctttgacct gtagatgggt cctaaaatga gaagggagag aagcagccag accttgagct
     4981 gctctgctag gggagctgtg agttgggaga aaagtggtca ctggttggca gttaaggact
     5041 tgctgagaga gacatttgta ggagaaagaa gataagtagg ttcataccag aagggccagg
     5101 actcggatgg agcaaatccc agttcttgtc ctacaagctg attgtgcgat tgagcacagg
     5161 cctctggaat tgtgcagaga tgagaaacag gctgaatttg caaggccaca acatcaggtt
     5221 gtcatgtacc catcattaca gcttatgccc agaagtcctg accctgtgac aggttattat
     5281 cttaaaaact catcttcagc ccactttttc agagaactaa ctctttcctt agatgttggg
     5341 ccaggatttc actatttacc cagagaaact aagagaaagt ggcactaggc gtcttgtctt
     5401 ccagatgtga gatttcgatc tttctaatga aattgggggc actttgagac tgtcagggtt
     5461 tgttcctgtc tcagaatggc tcataataaa ctcactgaaa cactcaaagg aaagtactga
     5521 cttgatctgg atccttttca gaggcctgga gatttaattt cacagattct cttcttttgg
     5581 ctcaacaaca acagcaacaa aaaactcttt gactccccaa cttcagaggg aaaactgaag
     5641 cgaaactggt gagctctgcc acggcagatg ccttcctttt tcactcacga gctgggcggg
     5701 ctcatcaaag agcaggaagt gcccatttta cactggggcc aggatgcaga cccagctcct
     5761 gtcctccgcg aacttacagt ctaattagag cctcttaagg acaatttggc agccactgtt
     5821 aactcttgat gcatcattta aatcctagaa caggcagctt taaagcaaag aactacagac
     5881 ttttccgcag tgtccagcat ttgctgacca aaaaaaacct gagggtgatt tttctctctt
     5941 tgaattttta cccttgcctg cacctagcca gaacccttaa tactaaattt gcagttatat
     6001 gcagctctgc caacgccttc ctgctttaga ctggatctct actatccttt ttctctacta
     6061 ggcaccagaa cctttgtcta gttcattagg tggttcacat cacttgccaa atttccagca
     6121 tgccactcag gaagtgactt gagcatgctg aatgctgagt cagaaaatga acccctgggc
     6181 tggcgggttg acccaggcct gacaaagtct tggcagtccc cacactgact gcgaactctc
     6241 ccttagcctc agtcagctgg gaaaggaatt gagccctgtg tcagcaaatt gggagaaagt
     6301 gttacatata aaattcttga tggaaatgtg tgttttatat cagaattgag cttttgttcc
     6361 tgcatctcag aaataccagg aagaagtcag catctcatta aacaggagtt gtctaaactg
     6421 tggaagaaaa tatcccccat tctttatcct acgctgaatc cacaagtctt cccatcttcc
     6481 accatcttct gacagttcca taatatattg gtatccctca cagggcaggg acaggaagga
     6541 aataaatctt tctgccactt gtttccaacc gaaaaggaaa aaagttaaaa attactaaag
     6601 tgttctgaaa agagatttca agtggtctgt gctgcttttt tgccttgtta cgcacataac
     6661 ttgtgactgg ctagataggc cacgtgtatt tatcagccaa gattccattg cagcagatga
     6721 tttcaaaacc tctttgtgtg ctgggccgtg ctaggtagct ggaatatctg aggtaaatta
     6781 agcactgatt tgttcccaga gttgtgcata attctttaaa agtaggctcg tttttttcgt
     6841 ttttttgtcc aggatcacct aagtgaagta ctcgtggttc taagttgcta acccagggaa
     6901 agaggatatt ttcctgtcct aaccttggtt tttgaaatat gcttctcctg tgtgccctct
     6961 ctggggtatc tggcccacag tagattgctc agcagatatt tgaatgagca gatgctttgc
     7021 tttgtcctcc tgtgccaggc tcctccccac atcctctgga tcagctccac gtgcctagat
     7081 tcagactccg tgattcaccg tgggggccct taataggcat tcagtctgaa agaaggtgga
     7141 ggagaataat gtctcccagg atcaaatgag actcagggct gttccttcaa agacagaaac
     7201 ttgcagagct gcacagcagc agggaaacat tgagaagggg gtggaaattt gatgtactgt
     7261 gaataatgaa ggccggatct ttaaaaagaa aaagggacgg ggtgctggca gaaacccagc
     7321 tctgcgctag cacaatctgt acacctggct gcctttgccc ttgagcttct atttcttggg
     7381 gatggggagg gcaaaaaagt ttgccccaga cactggcttc tgtttgaaca ggaagtgggg
     7441 agtcagtgat cccagagggg acttcagcat caggacatat gctttggtgg cctcagcaga
     7501 cctggcctag gcaggctttc aggtggcacc caggggcttt atggcctgca ggtaaggccc
     7561 cttcatccgg gtcagactta gcaaataaaa atataggaca ctcaattaag tttgcatttt
     7621 ggataaacag tgaagaagtt cctagtgtaa gtatgtccca gttctatgtg gctgccctac
     7681 ctgggcttgc ctctgctggt actagctgcc cagagacctt caggcctgcc acgggctgcc
     7741 gggagctctc tagtggaatt ggattaccct gattttgtgc attgtttgtg cttttgtggg
     7801 catcggaaat gactgagata cgcagttttg aagagctagg caggcagctg agcgggataa
     7861 tgtgggcccc agttgacctc agtggctgtc atctactgtg tttttcaacc aggaatttca
     7921 aatactgtgt attttagaaa gaaaggaaag agccaaagta cagccttttc tcacttgatc
     7981 agtaacttgt gttagaaact cagtggggga gaattctttg cgtttttcag ttgactgatt
     8041 attttccttt ttttcttttt tgcttttctc gagtcactct gtgtggtgct tgtgggagaa
     8101 gggagagggt gggagagcgt tggtggatgt gttctgcatg ttcctttctg tacagtaact
     8161 tctgcattta ctctgtttag gatggttcct tcaccactat ccctgtctgt agccagtaaa
     8221 tttctggaat attc
//
