LOCUS       NM_002532               3611 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nucleoporin 88 (NUP88), transcript variant 2, mRNA.
ACCESSION   NM_002532
VERSION     NM_002532.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3611)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3611)
  AUTHORS   Makise,M., Uchimura,R., Higashi,K., Mashiki,Y., Shiraishi,R.,
            Shutoku,Y. and Kuniyasu,A.
  TITLE     Overexpression of the nucleoporin Nup88 stimulates migration and
            invasion of HeLa cells
  JOURNAL   Histochem Cell Biol 156 (5), 409-421 (2021)
   PUBMED   34331103
  REMARK    GeneRIF: Overexpression of the nucleoporin Nup88 stimulates
            migration and invasion of HeLa cells.
REFERENCE   3  (bases 1 to 3611)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3611)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3611)
  AUTHORS   Kindermann,B., Valkova,C., Kramer,A., Perner,B., Engelmann,C.,
            Behrendt,L., Kritsch,D., Jungnickel,B., Kehlenbach,R.H., Oswald,F.,
            Englert,C. and Kaether,C.
  TITLE     The nuclear pore proteins Nup88/214 and T-cell acute lymphatic
            leukemia-associated NUP214 fusion proteins regulate Notch signaling
  JOURNAL   J Biol Chem 294 (31), 11741-11750 (2019)
   PUBMED   31186352
  REMARK    GeneRIF: Loss of Nup88 inhibited nuclear export of recombination
            signal-binding protein for immunoglobulin kappaJ region (RBP-J),
            the DNA-binding component of the Notch pathway.
REFERENCE   6  (bases 1 to 3611)
  AUTHORS   Martinez,N., Alonso,A., Moragues,M.D., Ponton,J. and Schneider,J.
  TITLE     The nuclear pore complex protein Nup88 is overexpressed in tumor
            cells
  JOURNAL   Cancer Res 59 (21), 5408-5411 (1999)
   PUBMED   10554006
REFERENCE   7  (bases 1 to 3611)
  AUTHORS   Stoffler,D., Fahrenkrog,B. and Aebi,U.
  TITLE     The nuclear pore complex: from molecular architecture to functional
            dynamics
  JOURNAL   Curr Opin Cell Biol 11 (3), 391-401 (1999)
   PUBMED   10395558
  REMARK    Review article
REFERENCE   8  (bases 1 to 3611)
  AUTHORS   Boer,J., Bonten-Surtel,J. and Grosveld,G.
  TITLE     Overexpression of the nucleoporin CAN/NUP214 induces growth arrest,
            nucleocytoplasmic transport defects, and apoptosis
  JOURNAL   Mol Cell Biol 18 (3), 1236-1247 (1998)
   PUBMED   9488438
REFERENCE   9  (bases 1 to 3611)
  AUTHORS   Fornerod,M., van Baal,S., Valentine,V., Shapiro,D.N. and
            Grosveld,G.
  TITLE     Chromosomal localization of genes encoding CAN/Nup214-interacting
            proteins--human CRM1 localizes to 2p16, whereas Nup88 localizes to
            17p13 and is physically linked to SF2p32
  JOURNAL   Genomics 42 (3), 538-540 (1997)
   PUBMED   9205132
REFERENCE   10 (bases 1 to 3611)
  AUTHORS   Fornerod,M., van Deursen,J., van Baal,S., Reynolds,A., Davis,D.,
            Murti,K.G., Fransen,J. and Grosveld,G.
  TITLE     The human homologue of yeast CRM1 is in a dynamic subcomplex with
            CAN/Nup214 and a novel nuclear pore component Nup88
  JOURNAL   EMBO J 16 (4), 807-816 (1997)
   PUBMED   9049309
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX956129.1, BC000335.2,
            CX870338.1, AC004148.1, BQ937933.1 and AW089098.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002532.5.
            
            Summary: The nuclear pore complex is a massive structure that
            extends across the nuclear envelope, forming a gateway that
            regulates the flow of macromolecules between the nucleus and the
            cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the
            main components of the nuclear pore complex in eukaryotic cells.
            The protein encoded by this gene belongs to the nucleoporin family
            and is associated with the oncogenic nucleoporin CAN/Nup214 in a
            dynamic subcomplex. This protein is also overexpressed in a large
            number of malignant neoplasms and precancerous dysplasias.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.305859.1,
                                           SRR1803616.17552.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000573584.6/ ENSP00000458954.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BX956129.1         78-87
            11-2344             BC000335.2         1-2334
            2345-2673           CX870338.1         505-833
            2674-2816           AC004148.1         13167-13309         c
            2817-3553           BQ937933.1         1-737
            3554-3611           AW089098.1         6-63                c
FEATURES             Location/Qualifiers
     source          1..3611
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..3611
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /note="nucleoporin 88"
                     /db_xref="GeneID:4927"
                     /db_xref="HGNC:HGNC:8067"
                     /db_xref="MIM:602552"
     exon            1..309
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..2238
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nuclear pore complex protein 88; karyoporin; nucleoporin
                     88kDa; nuclear pore complex protein Nup88; nucleoporin
                     Nup88"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup88 isoform 2"
                     /protein_id="NP_002523.2"
                     /db_xref="CCDS:CCDS11070.1"
                     /db_xref="GeneID:4927"
                     /db_xref="HGNC:HGNC:8067"
                     /db_xref="MIM:602552"
                     /translation="MAAAEGPVGDGELWQTWLPNHVVFLRLREGLKNQSPTEAEKPAS
                     SSLPSSPPPQLLTRNVVFGLGGELFLWDGEDSSFLVVRLRGPSGGGEEPALSQYQRLL
                     CINPPLFEIYQVLLSPTQHHVALIGIKGLMVLELPKRWGKNSEFEGGKSTVNCSTTPV
                     AERFFTSSTSLTLKHAAWYPSEILDPHVVLLTSDNVIRIYSLREPQTPTNVIILSEAE
                     EESLVLNKGRAYTASLGETAVAFDFGPLAAVPKTLFGQNGKDEVVAYPLYILYENGET
                     FLTYISLLHSPGNIGKLLGPLPMHPAAEDNYGYDACAVLCLPCVPNILVIATESGMLY
                     HCVVLEGEEEDDHTSEKSWDSRIDLIPSLYVFECVELELALKLASGEDDPFDSDFSCP
                     VKLHRDPKCPSRYHCTHEAGVHSVGLTWIHKLHKFLGSDEEDKDSLQELSTEQKCFVE
                     HILCTKPLPCRQPAPIRGFWIVPDILGPTMICITSTYECLIWPLLSTVHPASPPLLCT
                     REDVEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLS
                     RATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLAD
                     KYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQV
                     TMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEGEHIREMVKQINDIRNHVN
                     F"
     exon            310..479
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            480..605
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            606..692
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            693..869
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1056
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1204
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1303
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1394
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1496
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1655
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1781
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1847
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1928
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2055
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2174
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..3611
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2323..2328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /note="hexamer: TATAAA"
     polyA_site      2343
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /note="major polyA site"
     regulatory      2391..2396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /note="hexamer: AGTAAA"
     polyA_site      2411
                     /gene="NUP88"
                     /gene_synonym="FADS4"
     regulatory      3590..3595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP88"
                     /gene_synonym="FADS4"
                     /note="hexamer: AATAAA"
     polyA_site      3611
                     /gene="NUP88"
                     /gene_synonym="FADS4"
ORIGIN      
        1 agttgggcca agatggcggc cgccgaggga ccggtgggcg acggcgagct gtggcagacc
       61 tggcttccta accacgtcgt gttcttgcgg ctccgggagg gactgaaaaa ccagagtcca
      121 accgaagctg agaaaccagc ttcttcgtcg ttgccttcgt cgccgccgcc gcagttgctg
      181 acgagaaacg tggtctttgg cctcggcgga gagcttttcc tgtgggacgg agaagacagc
      241 tccttcttag tcgttcgcct tcggggcccc agcggcggcg gcgaagagcc cgccctgtcc
      301 cagtaccaga gattgctttg cataaatcca cccctgtttg aaatctatca agtcttgtta
      361 agcccaacac aacatcatgt agcacttata ggaataaaag gacttatggt attagaatta
      421 cctaaaagat gggggaagaa ttctgaattt gaaggtggaa aatcaacagt gaattgtagt
      481 accactccag ttgcggagag atttttcacc agttccacct ctctgactct aaagcatgct
      541 gcatggtatc caagtgaaat cctggatccc cacgtagtgc tgttaacatc agacaacgta
      601 atcagaattt actcactacg tgagccgcag acacccacta acgtgataat actttcagaa
      661 gccgaagagg aaagtctagt actcaataaa ggaagggcgt ataccgcatc tctaggagag
      721 acagcagttg catttgactt tgggccattg gcagcagtcc caaagactct atttggacaa
      781 aacggcaaag atgaagtagt ggcataccca ctgtacatct tatatgaaaa tggagagact
      841 ttcctgacat acatcagtct gttacacagc cctggaaata ttggaaagct gttgggtcca
      901 ttgcccatgc atcctgcggc tgaagataac tatggttatg atgcgtgtgc tgtactctgc
      961 ttaccctgtg tccccaatat cttagtgatc gctactgaat caggaatgct gtatcactgt
     1021 gtcgtgctag aaggggaaga agaagatgac cacacgtcag aaaagtcctg ggattccagg
     1081 attgacctca ttccttctct gtatgtgttt gaatgtgttg agttggagct tgctttgaaa
     1141 ctggcatctg gagaggatga cccttttgat tctgactttt cttgtccagt caaacttcat
     1201 agagatccca agtgtccttc aagatatcac tgtactcatg aagctggtgt acatagtgtt
     1261 gggctaactt ggattcataa acttcacaaa tttcttggat cagatgaaga agataaggat
     1321 agtttacagg aactctctac agaacagaaa tgctttgttg aacacatcct ttgtacgaag
     1381 ccattgccct gcaggcagcc agctccaatt cgaggatttt ggattgtacc tgacattctg
     1441 ggacccacga tgatctgcat caccagtacc tatgaatgcc tcatatggcc gttattaagt
     1501 acagtccatc cagcgtctcc tcccctgctt tgtactcgag aagatgttga agtggcagag
     1561 tctcccctcc gtgttctggc tgaaacccca gattcctttg aaaagcatat tagaagcatt
     1621 ttgcaacgta gtgttgccaa tccagcattt ttgaaagctt ctgaaaagga catagcccct
     1681 cctcctgaag aatgccttca gctcctcagc agagccaccc aggtgttcag agagcagtac
     1741 attctcaaac aggacttggc aaaggaggag attcagcgga gggtcaaatt attatgtgac
     1801 caaaaaaaga aacaactaga agatctcagt tattgtcgag aagagaggaa aagtctgcgg
     1861 gaaatggctg agcgtttagc tgacaaatat gaggaagcta aagaaaaaca agaggatatc
     1921 atgaacagga tgaaaaaact acttcacagt tttcactctg agctcccagt tctctctgat
     1981 agtgagcgag acatgaagaa agaattacag ctgatacctg atcaacttcg acatttgggc
     2041 aatgccatca aacaggttac tatgaaaaag gattatcaac agcaaaagat ggagaaggtg
     2101 ttgagtcttc caaaacccac cattattctc agtgcctacc agcgaaagtg cattcagtcc
     2161 atcctgaaag aggagggtga acatataagg gaaatggtga agcaaatcaa tgatatccgc
     2221 aatcatgtaa acttctgaca ccaccaggag ctgactcaca cctgaactga acaccattga
     2281 aggcttaaac ccatattgta aaacaggtag aattatctaa tttataaaaa ggtgttttga
     2341 tgacctttgg tgtggttcat ctttttaaat atgttgtttt ataataattg agtaaatgct
     2401 tttatttaaa atttggaatg tgctttataa ctcaagccta cagttgtgtt cagcaaggac
     2461 tcaggattat ttcacactgc acactgccag aacctccctg aaccctattg agttttctcc
     2521 atatttgagc aagttagtta ttcttgtgag ctgtgtttta aagtagcagc accagaaaca
     2581 tgactctgaa gagggataga accctaggat tcaaaggaga agaccacaca gtgtacttgg
     2641 cagcagcttt tttaatttga acactttctt cttgaggaca caccttcagt acagttaaca
     2701 aatggttaca cctgaaatct gctgagagca gagctcaaga tccacaattg caaaggccac
     2761 tgctggctca cttcctcaca agctgtatta cctttcagag ctgagtgagg ctgtgctcta
     2821 cgtcccaata cttgttactg agtggacatg aggtgcaagt ttagcacctt aaagggagaa
     2881 aaaaataggt tagtatgcag aatgtgattt tgtcctcact tcaccttaag tcatcttttt
     2941 acacttgcca atgtgagttc tgaaaggtac tactatatct gcttagaaat ggctgagtga
     3001 ctgtcaatta aaagccacat gataaggtag gttacaggta agaggtaaat caggttagac
     3061 atgcatgaga acatgtaggc acagactgaa tataagcaca ggaacactcg tgaaacccaa
     3121 ctgagctttt cttttgccta gaagggctaa atcctgcctt ctacatcagt tcccatttat
     3181 gctgaaaacc cagttgaaag aattgtttcc tacctggaca gtgacacagt agtttgtttc
     3241 ataccagaaa cacattgcta aacaaaactt aagagtctca gtttgggttt ttctacaata
     3301 aagtgaattc caacagttgg catttgccac agtagagacc actaaccatt ccctaattgt
     3361 gatgatttta ttacccagca ccatcttctg gagaaaaata tctgtaaggt gctcagtctc
     3421 agcagaacac ttcactgcaa gctctagttc agtcagttca gaaaggctgt gaattgccca
     3481 ccctgattta cagcactaat tttaataatc tgaagacaaa ttcgcttggg gcttatccaa
     3541 gggactagtc ttaaacctac gtaatttaaa ttgattgcat tttataatta ataaaatccc
     3601 ctgtaactca a
//
