LOCUS       NM_017681               1755 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nucleoporin 62 C-terminal like (NUP62CL), transcript
            variant 1, mRNA.
ACCESSION   NM_017681
VERSION     NM_017681.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1755)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1755)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1755)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1755)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 1755)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB448067.1, BC016327.1,
            BF805909.1 and BX105515.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_017681.2.
            
            Summary: This gene encodes a protein containing a domain found in
            nucleoporins which are glycoproteins found in nuclear pore
            complexes. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016327.1, AK000137.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372466.8/ ENSP00000361544.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DB448067.1         8-9
            3-1710              BC016327.1         7-1714
            1711-1728           BF805909.1         8-25                c
            1729-1755           BX105515.1         14-40               c
FEATURES             Location/Qualifiers
     source          1..1755
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.3"
     gene            1..1755
                     /gene="NUP62CL"
                     /note="nucleoporin 62 C-terminal like"
                     /db_xref="GeneID:54830"
                     /db_xref="HGNC:HGNC:25960"
     exon            1..161
                     /gene="NUP62CL"
                     /inference="alignment:Splign:2.1.0"
     exon            162..205
                     /gene="NUP62CL"
                     /inference="alignment:Splign:2.1.0"
     exon            206..310
                     /gene="NUP62CL"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..807
                     /gene="NUP62CL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleoporin-62 C-terminal-like protein; nucleoporin 62kDa
                     C-terminal like"
                     /codon_start=1
                     /product="nucleoporin-62 C-terminal-like protein isoform
                     1"
                     /protein_id="NP_060151.2"
                     /db_xref="CCDS:CCDS14527.1"
                     /db_xref="GeneID:54830"
                     /db_xref="HGNC:HGNC:25960"
                     /translation="MQFTSISNSLTSTAAIGLSFTTSTTTTATFTTNTTTTITSGFTV
                     NQNQLLSRGFENLVPYTSTVSVVATPVMTYGHLEGLINEWNLELEDQEKYFLLQATQV
                     NAWDHTLIENGEMIRILHGEVNKVKLDQKRLEQELDFILSQQQELEFLLTYLEESTRD
                     QSGLHYLQDADEEHVEISTRSAEF"
     exon            311..446
                     /gene="NUP62CL"
                     /inference="alignment:Splign:2.1.0"
     exon            447..597
                     /gene="NUP62CL"
                     /inference="alignment:Splign:2.1.0"
     exon            598..647
                     /gene="NUP62CL"
                     /inference="alignment:Splign:2.1.0"
     exon            648..782
                     /gene="NUP62CL"
                     /inference="alignment:Splign:2.1.0"
     exon            783..849
                     /gene="NUP62CL"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1755
                     /gene="NUP62CL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1732..1737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP62CL"
                     /note="hexamer: ATTAAA"
     polyA_site      1755
                     /gene="NUP62CL"
                     /note="major polyA site"
ORIGIN      
        1 agtctcggtt agcttcactt cagcgggaac ctgcccacta aggaggccga ttctttccgg
       61 ctcgagcagg tccggacccg cccctctggc gtctagcagt ctcggaggcc tgcccgtata
      121 gttcagggcc ggacagcgag cggcggcgac ttgccagtaa gggtttggag tcatcagcag
      181 gtttaatttt ggaggaactt tacaggtttg gctccagcag ctgctgttgc caccaccact
      241 agttcaagca ccatgcagtt tacctcaata tcaaattctt tgacctccac tgctgctatt
      301 gggctctcat ttacaacttc aacgactacc accgccactt tcaccaccaa cactactacc
      361 acaatcacca gtggctttac tgtgaaccaa aaccaactgt tatcaagagg gtttgaaaac
      421 cttgtacctt atacttcaac tgttagtgta gtagcaactc ctgtgatgac atatggtcat
      481 ctggagggtc ttataaatga gtggaacctt gagctggaag atcaagagaa gtactttctt
      541 ctccaggcca ctcaggtcaa tgcttgggac catacattga ttgagaatgg tgagatgatt
      601 cgtattttac atggagaagt gaacaaagtg aaactggatc agaaaagatt ggaacaagaa
      661 ttggatttta tcctgtcaca gcagcaggaa ctagaatttc tgttgactta tttagaggag
      721 tctacgcgtg accagagtgg acttcattat ctgcaggatg cagatgagga gcatgtggag
      781 atctccacca gatctgcaga attctgaatg cccatatgga ctccctgcag tggattgatc
      841 ggaattcagg catgctgcga aggaaggtag aagtggtaac acgggttttc gaggattatc
      901 gtcacgagga gcatgcacac aatgtcaaca ctgcttttta gtgaatgacc atatcttcag
      961 catgtcgttt ctggattatt acctacaaat tctgatgtta aatagagtag tatttatact
     1021 taatatttca tcttgatcat aatgaattgt gcatcctttt tttcatttaa gtattgtact
     1081 gttgagaatt ataccttagt tttgttttta gtattagaaa atcaaaatta tactagcccc
     1141 tttgtccaga cagcaacctc ttagatgctg actctatatg tgtaatttat gtcttactct
     1201 ccctggcatc agtacacatc atccttctca ctccagttga atcatagggt gatgtctgcc
     1261 aaaagtacat gccaacctat atagtgctag atactgtaaa gtctcttctc ctcaaaggaa
     1321 cctactgtct agtttgagat ataattaatg cttgtctgca taaaaacaat atagataata
     1381 taaagaagtg cagtatgaat tatagaaagt gtgttataga gattcagagc agggaggaaa
     1441 agttagggta gattattatt aaagggttaa ggaaaggtaa gtttcaagga atttggttat
     1501 ttttaatgta tggatatact ggcattttat ttggttttag catatgattt atagttggtg
     1561 atttccgtat atttgtttgt ttttcttttt ttttgtttgt ttgttttgtt ttgttttaaa
     1621 taagccttgt tcttaggttt ggaacagtct ggtctcctgt gtttcatgtt tcacctaagt
     1681 cataaataaa ggtaatgtcc taaaaaaaaa catgtaatac tgaaattaac tattaaaagt
     1741 ttttaagtga ctaga
//
