LOCUS       NM_016553               3361 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens nucleoporin 62 (NUP62), transcript variant 2, mRNA.
ACCESSION   NM_016553
VERSION     NM_016553.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3361)
  AUTHORS   Zarafshani,M., Mahmoodzadeh,H., Soleimani,V., Moosavi,M.A. and
            Rahmati,M.
  TITLE     Expression and Clinical Significance of IRE1-XBP1s, p62, and
            Caspase-3 in Colorectal Cancer Patients
  JOURNAL   Iran J Med Sci 49 (1), 10-21 (2024)
   PUBMED   38322164
  REMARK    GeneRIF: Expression and Clinical Significance of IRE1-XBP1s, p62,
            and Caspase-3 in Colorectal Cancer Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3361)
  AUTHORS   Huang,X., Yao,J., Liu,L., Chen,J., Mei,L., Huangfu,J., Luo,D.,
            Wang,X., Lin,C., Chen,X., Yang,Y., Ouyang,S., Wei,F., Wang,Z.,
            Zhang,S., Xiang,T., Neculai,D., Sun,Q., Kong,E., Tate,E.W. and
            Yang,A.
  TITLE     S-acylation of p62 promotes p62 droplet recruitment into
            autophagosomes in mammalian autophagy
  JOURNAL   Mol Cell 83 (19), 3485-3501 (2023)
   PUBMED   37802024
  REMARK    GeneRIF: S-acylation of p62 promotes p62 droplet recruitment into
            autophagosomes in mammalian autophagy.
REFERENCE   3  (bases 1 to 3361)
  AUTHORS   Feng,R., Liu,J., Yang,Z., Yao,T., Ye,P., Li,X., Zhang,J. and
            Jiang,H.
  TITLE     Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic
            Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to
            Promote Apoptosis
  JOURNAL   Mol Neurobiol 60 (10), 6001-6017 (2023)
   PUBMED   37400749
  REMARK    GeneRIF: Realgar-Induced Neurotoxicity: Crosstalk Between the
            Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62
            Accumulation to Promote Apoptosis.
REFERENCE   4  (bases 1 to 3361)
  AUTHORS   Liang,X., Yao,J., Cui,D., Zheng,W., Liu,Y., Lou,G., Ye,B., Shui,L.,
            Sun,Y., Zhao,Y. and Zheng,M.
  TITLE     The TRAF2-p62 axis promotes proliferation and survival of liver
            cancer by activating mTORC1 pathway
  JOURNAL   Cell Death Differ 30 (6), 1550-1562 (2023)
   PUBMED   37081115
  REMARK    GeneRIF: The TRAF2-p62 axis promotes proliferation and survival of
            liver cancer by activating mTORC1 pathway.
REFERENCE   5  (bases 1 to 3361)
  AUTHORS   Paunovic,V., Vucicevic,L., Misirkic Marjanovic,M., Perovic,V.,
            Ristic,B., Bosnjak,M., Mandic,M., Stevanovic,D.,
            Harhaji-Trajkovic,L., Lalosevic,J., Nikolic,M., Bonaci-Nikolic,B.
            and Trajkovic,V.
  TITLE     Autophagy Receptor p62 Regulates SARS-CoV-2-Induced Inflammation in
            COVID-19
  JOURNAL   Cells 12 (9), 1282 (2023)
   PUBMED   37174682
  REMARK    GeneRIF: Autophagy Receptor p62 Regulates SARS-CoV-2-Induced
            Inflammation in COVID-19.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3361)
  AUTHORS   Hu,T., Guan,T. and Gerace,L.
  TITLE     Molecular and functional characterization of the p62 complex, an
            assembly of nuclear pore complex glycoproteins
  JOURNAL   J Cell Biol 134 (3), 589-601 (1996)
   PUBMED   8707840
REFERENCE   7  (bases 1 to 3361)
  AUTHORS   Guan,T., Muller,S., Klier,G., Pante,N., Blevitt,J.M., Haner,M.,
            Paschal,B., Aebi,U. and Gerace,L.
  TITLE     Structural analysis of the p62 complex, an assembly of O-linked
            glycoproteins that localizes near the central gated channel of the
            nuclear pore complex
  JOURNAL   Mol Biol Cell 6 (11), 1591-1603 (1995)
   PUBMED   8589458
REFERENCE   8  (bases 1 to 3361)
  AUTHORS   Grote,M., Kubitscheck,U., Reichelt,R. and Peters,R.
  TITLE     Mapping of nucleoporins to the center of the nuclear pore complex
            by post-embedding immunogold electron microscopy
  JOURNAL   J Cell Sci 108 (Pt 9), 2963-2972 (1995)
   PUBMED   8537436
REFERENCE   9  (bases 1 to 3361)
  AUTHORS   Paschal,B.M. and Gerace,L.
  TITLE     Identification of NTF2, a cytosolic factor for nuclear import that
            interacts with nuclear pore complex protein p62
  JOURNAL   J Cell Biol 129 (4), 925-937 (1995)
   PUBMED   7744965
REFERENCE   10 (bases 1 to 3361)
  AUTHORS   Carmo-Fonseca,M., Kern,H. and Hurt,E.C.
  TITLE     Human nucleoporin p62 and the essential yeast nuclear pore protein
            NSP1 show sequence homology and a similar domain organization
  JOURNAL   Eur J Cell Biol 55 (1), 17-30 (1991)
   PUBMED   1915414
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA949331.1, BC050717.2,
            BG575286.1, AL162061.1 and BM672281.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_016553.4.
            
            Summary: The nuclear pore complex is a massive structure that
            extends across the nuclear envelope, forming a gateway that
            regulates the flow of macromolecules between the nucleus and the
            cytoplasm. Nucleoporins are the main components of the nuclear pore
            complex in eukaryotic cells. The protein encoded by this gene is a
            member of the FG-repeat containing nucleoporins and is localized to
            the nuclear pore central plug. This protein associates with the
            importin alpha/beta complex which is involved in the import of
            proteins containing nuclear localization signals. Multiple
            transcript variants of this gene encode a single protein isoform.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095410.1, SRR11853563.17316.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA2142680 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352066.8/ ENSP00000305503.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               DA949331.1         228-565
            339-1700            BC050717.2         167-1528
            1701-2018           BG575286.1         147-464
            2019-2648           BC050717.2         1847-2476
            2649-2892           AL162061.1         2475-2718
            2893-3361           BM672281.1         15-483              c
FEATURES             Location/Qualifiers
     source          1..3361
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..3361
                     /gene="NUP62"
                     /gene_synonym="IBSN; p62; SNDI"
                     /note="nucleoporin 62"
                     /db_xref="GeneID:23636"
                     /db_xref="HGNC:HGNC:8066"
                     /db_xref="MIM:605815"
     exon            1..179
                     /gene="NUP62"
                     /gene_synonym="IBSN; p62; SNDI"
                     /inference="alignment:Splign:2.1.0"
     exon            180..301
                     /gene="NUP62"
                     /gene_synonym="IBSN; p62; SNDI"
                     /inference="alignment:Splign:2.1.0"
     exon            302..3361
                     /gene="NUP62"
                     /gene_synonym="IBSN; p62; SNDI"
                     /inference="alignment:Splign:2.1.0"
     CDS             379..1947
                     /gene="NUP62"
                     /gene_synonym="IBSN; p62; SNDI"
                     /note="nucleoporin Nup62; 62 kDa nucleoporin; nucleoporin
                     62kD; nucleoporin 62kDa"
                     /codon_start=1
                     /product="nuclear pore glycoprotein p62"
                     /protein_id="NP_057637.2"
                     /db_xref="CCDS:CCDS12788.1"
                     /db_xref="GeneID:23636"
                     /db_xref="HGNC:HGNC:8066"
                     /db_xref="MIM:605815"
                     /translation="MSGFNFGGTGAPTGGFTFGTAKTATTTPATGFSFSTSGTGGFNF
                     GAPFQPATSTPSTGLFSLATQTPATQTTGFTFGTATLASGGTGFSLGIGASKLNLSNT
                     AATPAMANPSGFGLGSSNLTNAISSTVTSSQGTAPTGFVFGPSTTSVAPATTSGGFSF
                     TGGSTAQPSGFNIGSAGNSAQPTAPATLPFTPATPAATTAGATQPAAPTPTATITSTG
                     PSLFASIATAPTSSATTGLSLCTPVTTAGAPTAGTQGFSLKAPGAASGTSTTTSTAAT
                     ATATTTSSSSTTGFALNLKPLAPAGIPSNTAAAVTAPPGPGAAAGAAASSAMTYAQLE
                     SLINKWSLELEDQERHFLQQATQVNAWDRTLIENGEKITSLHREVEKVKLDQKRLDQE
                     LDFILSQQKELEDLLSPLEELVKEQSGTIYLQHADEEREKTYKLAENIDAQLKRMAQD
                     LKDIIEHLNTSGAPADTSDPLQQICKILNAHMDSLQWIDQNSALLQRKVEEVTKVCEG
                     RRKEQERSFRITFD"
     regulatory      3338..3343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP62"
                     /gene_synonym="IBSN; p62; SNDI"
                     /note="hexamer: AATAAA"
     polyA_site      3361
                     /gene="NUP62"
                     /gene_synonym="IBSN; p62; SNDI"
                     /note="major polyA site"
ORIGIN      
        1 gattccccgc tcgcgactcc ccacccccca gggctcccta aagagggcca cgagctgcga
       61 aagggcggga aaggcagttg gagaagaggt aagcggttac tcactccatg gctgcagcaa
      121 ggagaggcgg cggcggcctc ggctgaagaa agaaggtggg agcggagagc gcaggcgtga
      181 aacccacctt gtcccatcca catcaggaca tcccagctgg agttcaacct tcatcccttc
      241 tgtggcagtt aggagactga atcaaggtcc agagaaggtg gaggaatcct gatactgagc
      301 gaaatcttcc caaggctgca gacaccgacg gatttgcttt gggagccaga gtagctgccg
      361 ccaccagagt ccggagccat gagcgggttt aattttggag gcactggggc ccctacaggc
      421 gggttcacgt ttggcactgc aaagacggca acaaccacac ctgctacagg gttttctttc
      481 tccacctctg gcactggagg gtttaatttt ggggctccct tccaaccagc cacaagtacc
      541 ccttccaccg gcctgttctc acttgccacc cagactccgg ccacacagac gacaggcttc
      601 acttttggaa cagcgactct tgcttcgggg ggaactggat tttctttggg gatcggtgct
      661 tcaaagctca acttgagcaa cacagctgcc accccagcca tggcaaaccc cagcggcttt
      721 gggctgggca gcagcaacct cactaatgcc atatcgagca ccgtcacctc cagccagggc
      781 acagcaccca ccggctttgt gtttggcccc tccaccacct ctgtggctcc agctaccaca
      841 tctggaggct tctcattcac tggtggaagc acggcccaac cctccggttt caacattggc
      901 tcagcaggga attcagccca gcccacggca cctgccacgt tgcccttcac tccggccacg
      961 ccagcagcca ccacagcagg tgccacacag ccagctgctc ccacacccac agccaccatc
     1021 accagcactg ggcccagcct ctttgcgtca atagcaactg ctccaacctc atctgccacc
     1081 actggactct ccctctgtac ccctgtgacc acagcgggcg cccccactgc tgggacacag
     1141 ggcttcagct taaaggcacc tggagcagct tccggcacct ccacaacaac atccaccgct
     1201 gccaccgcca ccgccaccac caccagcagc agcagcacca ccggctttgc cttgaattta
     1261 aaaccactgg cgccagccgg gatccccagc aatacagcag ctgccgtgac cgctccacct
     1321 ggccctggcg cagctgcagg ggcggctgcc agctccgcca tgacctacgc gcagctggag
     1381 agcctgatca acaaatggag cctggagcta gaggaccagg agcggcactt cctccagcag
     1441 gccacccagg tcaacgcctg ggaccgcacg ctgatcgaga atggagaaaa gatcaccagc
     1501 ctgcaccgcg aggtggagaa ggtgaagctg gaccagaaga ggctggacca ggagctcgac
     1561 ttcatcctgt cccagcagaa ggagctggaa gacctgctga gcccactgga ggagttggtc
     1621 aaggagcaga gcgggaccat ctacctgcag cacgcggatg aggagcgtga gaaaacctac
     1681 aagctggctg agaacatcga tgcacagctc aagcgcatgg cccaggatct caaggacatc
     1741 atcgagcacc tgaacacgtc cggggccccc gccgacacca gtgacccact gcagcagatc
     1801 tgcaagatcc tcaatgcgca catggactca ctgcagtgga tcgaccagaa ctcggccctg
     1861 ctgcagagga aggtggagga ggtgaccaag gtgtgcgagg gccggcgcaa ggagcaggag
     1921 cgcagcttcc ggatcacctt tgactgagcg acagcagccc tggggcccgc aggtccctag
     1981 ggagttcatg aggggaatgc gccctgttgt ctgtagtttg gggttgtggc aagatacttg
     2041 tttgtttgtt tctttctttc acatgactgc ccttgacatg atcgctgtgt gctttgcgtt
     2101 tttccattta ggagggtatt ctgggccttc tgcccaggca gcagcctcat gggtgtggct
     2161 tctgtggctt tcatttgagt atctttggcc ccttttcacc tactgcgacc acccacctca
     2221 tcctggctca gcctggtgat ggagaagtgc tgatggtctt ggtcccagcc agggtcgtgg
     2281 gggcagccac tctctccaaa gcatagtcat aggtgtcatg aaaaaatacc aaatgtaaga
     2341 gaacctccaa gtcagggcgc agtggctcac ccctgtaatc tcagcacttt gggtggccaa
     2401 ggcgggcaga tgacttgagg tcaggagttc gagaccagcc tggccaacat ggtgaaaccc
     2461 cgtctctact aaaaatacaa aaattagtca ggtgtggtgg acgcctgtga tctcaatctc
     2521 agctactcgg gaggctgagg caggagaatc acttgaaccc aggaggtgtt gcagtgaacc
     2581 aagatcacac cactgcactc cagcctaggc aacagagact ctgtctcaaa aaaaaaaaaa
     2641 aaaaaaaaga aactcccagg agacagcagc ctagttttcg agtgtgagct tgtgcttgtg
     2701 aaagctaacc atgctaacca ccaaggcaaa gcagcacagt gtgaatagaa cagagcggga
     2761 tcaagaattt cacagaagac aggtcagctg aggggcctgc acacacaggg tgttgaggaa
     2821 ccacagatgg gcgccgagag gcctgccttt tgcctggccc aggctcaccc ccaccttggg
     2881 cctcacctcc tccaggaagc cttcccagct acccgaagct caggtggcct tcttgcaggt
     2941 ccccgtagca ccctgagcct gtaccttggg tggcacttgt tatgctatcc tgtgctagcc
     3001 gtttgtgcct cgtctcgctg ttagattgtg agttcccatg ggcagagacc cactgtcgtt
     3061 ccccgtgtgt ccccagcccg gtccctgtca catttgttaa atgaaagaac aatgaagccc
     3121 agtgtaacgt cagtccacag aaatagccac agcttccagt ggtggccgta gacttggctc
     3181 ggaacttagt ggcaccagag taactctagt cagttacagt aaaatccact gtgtgtggaa
     3241 ggcagaagct agcggttgta tcccaagcat cttttgtatt tgtctttata ctttgctgaa
     3301 ttctctgaaa tacctattac tgtatgttgc ttttctaaat aaatgtattg tgaaaccaaa
     3361 a
//
