LOCUS       NM_014089               4236 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nucleoporin 58 (NUP58), transcript variant 1, mRNA.
ACCESSION   NM_014089
VERSION     NM_014089.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4236)
  AUTHORS   Targa,A., Larrimore,K.E., Wong,C.K., Chong,Y.L., Fung,R., Lee,J.,
            Choi,H. and Rancati,G.
  TITLE     Non-genetic and genetic rewiring underlie adaptation to hypomorphic
            alleles of an essential gene
  JOURNAL   EMBO J 40 (21), e107839 (2021)
   PUBMED   34528284
  REMARK    GeneRIF: Non-genetic and genetic rewiring underlie adaptation to
            hypomorphic alleles of an essential gene.
REFERENCE   2  (bases 1 to 4236)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4236)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4236)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4236)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4236)
  AUTHORS   Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
            Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
            Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
            Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
            Hughes,R.E.
  TITLE     Huntingtin interacting proteins are genetic modifiers of
            neurodegeneration
  JOURNAL   PLoS Genet 3 (5), e82 (2007)
   PUBMED   17500595
REFERENCE   7  (bases 1 to 4236)
  AUTHORS   Le Rouzic,E., Mousnier,A., Rustum,C., Stutz,F., Hallberg,E.,
            Dargemont,C. and Benichou,S.
  TITLE     Docking of HIV-1 Vpr to the nuclear envelope is mediated by the
            interaction with the nucleoporin hCG1
  JOURNAL   J Biol Chem 277 (47), 45091-45098 (2002)
   PUBMED   12228227
REFERENCE   8  (bases 1 to 4236)
  AUTHORS   Ben-Efraim,I. and Gerace,L.
  TITLE     Gradient of increasing affinity of importin beta for nucleoporins
            along the pathway of nuclear import
  JOURNAL   J Cell Biol 152 (2), 411-417 (2001)
   PUBMED   11266456
REFERENCE   9  (bases 1 to 4236)
  AUTHORS   Shiota,C., Coffey,J., Grimsby,J., Grippo,J.F. and Magnuson,M.A.
  TITLE     Nuclear import of hepatic glucokinase depends upon glucokinase
            regulatory protein, whereas export is due to a nuclear export
            signal sequence in glucokinase
  JOURNAL   J Biol Chem 274 (52), 37125-37130 (1999)
   PUBMED   10601273
REFERENCE   10 (bases 1 to 4236)
  AUTHORS   Buss,F. and Stewart,M.
  TITLE     Macromolecular interactions in the nucleoporin p62 complex of rat
            nuclear pores: binding of nucleoporin p54 to the rod domain of p62
  JOURNAL   J Cell Biol 128 (3), 251-261 (1995)
   PUBMED   7531196
  REMARK    GeneRIF: The human gene NUPL1 shares 87% sequence identity with rat
            nucleoporin p58.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP249090.1, BC001104.2,
            AK025800.1, AF113020.1 and AL138958.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014089.3.
            
            Summary: This gene encodes a member of the nucleoporin family that
            shares 87% sequence identity with rat nucleoporin p58. The protein
            is localized to the nuclear rim and is a component of the nuclear
            pore complex (NPC). All molecules entering or leaving the nucleus
            either diffuse through or are actively transported by the NPC.
            Alternate transcriptional splice variants, encoding different
            isoforms, have been characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.234691.1,
                                           SRR1660805.40241.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381736.8/ ENSP00000371155.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BP249090.1         98-128
            32-2739             BC001104.2         1-2708
            2740-3735           AK025800.1         743-1738
            3736-4221           AF113020.1         780-1265
            4222-4236           AL138958.18        5097-5111
FEATURES             Location/Qualifiers
     source          1..4236
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.13"
     gene            1..4236
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /note="nucleoporin 58"
                     /db_xref="GeneID:9818"
                     /db_xref="HGNC:HGNC:20261"
                     /db_xref="MIM:607615"
     exon            1..256
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1949
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /note="isoform a is encoded by transcript variant 1;
                     nucleoporin p58/p45; nucleoporin-like protein 1;
                     nucleoporin like 1; 58 kDa nucleoporin; nucleoporin 58kDa"
                     /codon_start=1
                     /product="nucleoporin p58/p45 isoform a"
                     /protein_id="NP_054808.1"
                     /db_xref="CCDS:CCDS9314.1"
                     /db_xref="GeneID:9818"
                     /db_xref="HGNC:HGNC:20261"
                     /db_xref="MIM:607615"
                     /translation="MSTGFSFGSGTLGSTTVAAGGTSTGGVFSFGTGASSNPSVGLNF
                     GNLGSTSTPATTSAPSSGFGTGLFGSKPATGFTLGGTNTGIATTITTGLTLGTPATTS
                     AATTGFSLGFNKPAASATPFALPITSTSASGLTLSSALTSTPAASTGFTLNNLGGTTA
                     TTTTASTGLSLGGALAGLGGSLFQSTNTGTSGLGQNALGLTLGTTAATSTAGNEGLGG
                     IDFSSSSDKKSDKTGTRPEDSKALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMS
                     SKAMLKVQEDIKALKQLLSLAANGIQRNTLNIDKLKIETAQELKNAEIALRTQKTPPG
                     LQHEYAAPADYFRILVQQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKI
                     YQTFVALAAQLQSIHENVKVLKEQYLGYRKMFLGDAVDVFETRRAEAKKWQNTPRVTT
                     GPTPFSTMPNAAAVAMAATLTQQQQPATGPQPSLGVSFGTPFGSGIGTGLQSSGLGSS
                     NLGGFGTSSGFGCSTTGASTFGFGTTNKPSGSLSAGFGSSSTSGFNFSNPGITASAGL
                     TFGVSNPASAGFGTGGQLLQLKKPPAGNKRGKR"
     exon            257..399
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     exon            400..435
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     exon            436..585
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     exon            586..723
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     exon            724..834
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     exon            835..859
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     exon            860..925
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1100
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1180
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1299
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1382
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1584
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1683
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1779
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..4236
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4203..4208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /note="hexamer: AATAAA"
     polyA_site      4236
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /note="major polyA site"
ORIGIN      
        1 agccttgcct tcgccgccgt tggggctgga agttcccgcc aggtccgtgc cgggcgagag
       61 agatgctgcc cggcccgcct cggctttgag gcgagagaag tgtcccagac ccatttcgcc
      121 ttgctgacgg cgtcgagccc tggccagaca tgtccacagg gttctccttc gggtccggga
      181 ctctgggctc caccaccgtg gccgccggcg ggaccagcac aggcggcgtt ttctccttcg
      241 gaacgggagc gtctagcaac ccttctgtgg ggctcaattt tggaaatctt ggaagtactt
      301 caactccagc aactacatct gctccttcaa gtggttttgg aaccgggctc tttggatcta
      361 aacctgccac tgggttcact ctaggaggaa caaatacagg aatagcaaca actataacta
      421 caggattaac tctgggaacg ccagccacta catctgcagc tacaacaggc ttcagtttag
      481 gattcaataa acctgcagca tctgccacac catttgctct acctattacc tctacctcag
      541 ctagcggtct gactctttcg tctgctctga catcaactcc agcagcatcc acaggattta
      601 ctctaaataa tttgggtggg acaacagcca caactacaac tgcatcaaca ggcctctctt
      661 tagggggagc cttagctggt ttgggaggtt cacttttcca gagtacaaac acaggaacat
      721 caggacttgg acagaatgct ttagggttga ctttgggaac tacagcagct acttcaactg
      781 caggcaatga aggccttggt ggtatagatt tcagtagctc ctcagataaa aagagtgata
      841 aaacgggaac aagaccagag gatagtaaag ctctgaagga tgaaaatcta cctcctgtca
      901 tctgccagga tgttgaaaat ctccagaaat ttgtgaagga gcagaaacaa gttcaagaag
      961 aaattagtag aatgtcttca aaagcaatgc ttaaggtaca agaagatatt aaagctctga
     1021 agcagctcct gtcgttggct gccaatggaa tacagagaaa cactctcaac attgacaaat
     1081 tgaaaataga aactgctcag gagttgaaga atgctgaaat agctttaaga acccagaaga
     1141 caccacctgg acttcaacat gaatatgcag ctcctgctga ctacttcaga atcttggttc
     1201 agcaatttga ggtacagctt cagcagtaca ggcagcagat tgaagaacta gaaaaccatc
     1261 ttgccactca agcaaataat tcacatataa cccctcaaga tttgtcaatg gctatgcaga
     1321 aaatttatca aacatttgta gctttagcgg cacaacttca gtctattcat gaaaatgtaa
     1381 aggttctgaa agaacagtac cttggctaca ggaaaatgtt cttgggagat gctgttgatg
     1441 tgtttgaaac aaggcgagca gaagccaaga agtggcagaa cacacccaga gttactactg
     1501 gacccactcc tttcagcacc atgccaaacg cagcagccgt tgccatggct gcaacactta
     1561 cacagcagca acagcctgct acagggccac agccatctct gggagttagt tttggaacgc
     1621 cattcggctc aggtattggc actggcttgc aatcaagtgg cttaggttct tcaaaccttg
     1681 gaggatttgg aactagctct ggttttggat gcagcaccac aggggcctcc acatttggat
     1741 ttggaacaac aaataaaccc tcaggaagtc ttagtgcagg ctttggcagc tcaagtacat
     1801 ctgggtttaa cttcagcaat cctggcatca cggcatcagc tggtttgact tttggggtgt
     1861 ccaatcctgc ctctgcaggt tttggaacag gaggacaact ccttcagttg aagaaacctc
     1921 cagctggaaa caaaagagga aaaagataaa catgggttga tgtgttgaga gaatccatag
     1981 cagcaccgtt cattctatga gtctattttt ctaatgatgc agtaattaaa ttgcatccca
     2041 ggagatttat aaagttttga tatttttccc tactctggaa tttgaacttt cttcatgttt
     2101 gccatactga acatcttttt tcttgtggaa tttaaagtcc agctgtgttt tctttttaat
     2161 ttgattctca gtgtaagaaa tgttctgatt acatcactga ttggtaatgg ttagaaacca
     2221 ttaacctaaa acttactatt taacctagtg tttttgttga tgaggtttac attatgtgaa
     2281 tacatgcaca tttgtttctt atacaggtgg tgtgaactct agggcctata ctagaatcaa
     2341 tttgttcctt gttaaaggcc ttttgaatta tactgcaggg catcttgtga atatgtatgt
     2401 aaatatatac agaataatac acacagttgt gtgtgcatat aaaatacata tttacgccag
     2461 gcgtggtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcagg cggatcacct
     2521 gaggtcagga gtttgagacc agcctgacat ggtgaaaccc catctctacg aaaaatacaa
     2581 aaattagctg ggcatagtgg cgggtaccta taatcccagc tactcgggag gctgaggcac
     2641 gagaatcact tgaagccggg aggtgggggt tgcagtgagc cgagatcaca ccactgcact
     2701 ccagcctggg caacaagagc aaaactccgt ctcaaaaaag atgaaaataa aataaaatat
     2761 atatttacag gcctacaact tttgcctcag actgttcccc ttttctaagg gtattcaagt
     2821 tttcaccttt taagcttcat atcctcagtg cttgtagaat gatgagctta gaggtaccag
     2881 gtcattgcag ttgtttgctt aaagacttat tgaaatggtt actggcgtaa atacttggcc
     2941 aactcaactt tattgcccct gatcttttcc atttttgttt ccaccttaac ctatagcagc
     3001 tcctccaaat gaggaatgct gtaagtaaga ctcatcaaac agattttaac cattttatta
     3061 tcctgtgtgt ccttacattg cttctgtgag atgttttttt cttatctgag atgaactttc
     3121 aggagcctat ttgaactcca gactggtgtt ctggggcaaa gagctattag ccaaactgat
     3181 tctatgcagg tgaaggatgc actaaagttc tcactttagt gagaactttt ctagctattc
     3241 caatacagag ttctttctta tagggctatt gatattgaca ccaaatggag tggcttctca
     3301 gcctcttaat gtcttaagta agtgcttaat ttggaataga gaaaccagta tattttaaaa
     3361 aagaaaaata ttctttgtag caactgtaaa ttctcccatt ataacagtga acagagctcc
     3421 aggtaataac gcataggcat gtcaggttgc atctgtatat ttgactacat tagtattagt
     3481 gacatcaggt ggatataaaa gaaaaccctt ggaaagagaa ctgccttagc catgatttcg
     3541 ttagtagacc tatttatgat tcaattgcaa ttttcagata ggatgtgaac atggaatttc
     3601 attgaaaata gtttaatttt ttatataaaa ggttttgtat ataatgtgtg tcagtgacta
     3661 ttttcaaaat cattttcatc aagacacctt ttttctaaaa taggcattgc atacacatat
     3721 gcacacgtat gtgcatgtgc cacacatttt ttgtataatg ttgggtttga ttataaaagt
     3781 gttgtcaaat gttttattta tctgcatata gcagtggttg gcttttttga attgaaattt
     3841 ttgcgcattg atgcattgaa ataaggaaaa ttatttatct ctgagcacta aacttatttt
     3901 tgcatatttc tgtaatattg cagtccccag atccagaaca tgggaagtta gggaaaatgt
     3961 gtgattttgt gttttgaatt actgtcagaa ttacatacac aattacaaca aacttttttt
     4021 aaaagacatt tcattgtact gcaaaaatct gaatatttat atttcttgtt tttttcttta
     4081 tatgttttgc attttaatat gttgagccac tggaaatttg taacagatta atttgttata
     4141 ggagtttaaa tgtgttgtca ttgtctccat tgtctttgtc cagagcctat tattatggaa
     4201 acaataaaat ttattgtgtc agttgctttg attctt
//
