LOCUS       NM_198887               3831 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens nucleoporin 43 (NUP43), transcript variant 1, mRNA.
ACCESSION   NM_198887
VERSION     NM_198887.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3831)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3831)
  AUTHORS   Tian,C., Zhou,S. and Yi,C.
  TITLE     High NUP43 expression might independently predict poor overall
            survival in luminal A and in HER2+ breast cancer
  JOURNAL   Future Oncol 14 (15), 1431-1442 (2018)
   PUBMED   29402145
  REMARK    GeneRIF: High NUP43 expression was an independent prognostic factor
            of poor overall survival in luminal A subtype and in HER2+ subtype
            breast cancer.
REFERENCE   3  (bases 1 to 3831)
  AUTHORS   Schwartz,T.U.
  TITLE     The Structure Inventory of the Nuclear Pore Complex
  JOURNAL   J Mol Biol 428 (10 Pt A), 1986-2000 (2016)
   PUBMED   27016207
  REMARK    Review article
REFERENCE   4  (bases 1 to 3831)
  AUTHORS   Xu,C., Li,Z., He,H., Wernimont,A., Li,Y., Loppnau,P. and Min,J.
  TITLE     Crystal structure of human nuclear pore complex component NUP43
  JOURNAL   FEBS Lett 589 (21), 3247-3253 (2015)
   PUBMED   26391640
  REMARK    GeneRIF: Data present the crystal structure of full length Nup43
            and show that it adopts a canonical WD40 fold similar to other
            members of the family and interacts with Nup85-Seh1L complex to
            form a ternary complex.
REFERENCE   5  (bases 1 to 3831)
  AUTHORS   Bui,K.H., von Appen,A., DiGuilio,A.L., Ori,A., Sparks,L.,
            Mackmull,M.T., Bock,T., Hagen,W., Andres-Pons,A., Glavy,J.S. and
            Beck,M.
  TITLE     Integrated structural analysis of the human nuclear pore complex
            scaffold
  JOURNAL   Cell 155 (6), 1233-1243 (2013)
   PUBMED   24315095
REFERENCE   6  (bases 1 to 3831)
  AUTHORS   Glavy,J.S., Krutchinsky,A.N., Cristea,I.M., Berke,I.C., Boehmer,T.,
            Blobel,G. and Chait,B.T.
  TITLE     Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160
            subcomplex
  JOURNAL   Proc Natl Acad Sci U S A 104 (10), 3811-3816 (2007)
   PUBMED   17360435
REFERENCE   7  (bases 1 to 3831)
  AUTHORS   Loiodice,I., Alves,A., Rabut,G., Van Overbeek,M., Ellenberg,J.,
            Sibarita,J.B. and Doye,V.
  TITLE     The entire Nup107-160 complex, including three new members, is
            targeted as one entity to kinetochores in mitosis
  JOURNAL   Mol Biol Cell 15 (7), 3333-3344 (2004)
   PUBMED   15146057
REFERENCE   8  (bases 1 to 3831)
  AUTHORS   Le Rouzic,E., Mousnier,A., Rustum,C., Stutz,F., Hallberg,E.,
            Dargemont,C. and Benichou,S.
  TITLE     Docking of HIV-1 Vpr to the nuclear envelope is mediated by the
            interaction with the nucleoporin hCG1
  JOURNAL   J Biol Chem 277 (47), 45091-45098 (2002)
   PUBMED   12228227
REFERENCE   9  (bases 1 to 3831)
  AUTHORS   Cronshaw,J.M., Krutchinsky,A.N., Zhang,W., Chait,B.T. and
            Matunis,M.J.
  TITLE     Proteomic analysis of the mammalian nuclear pore complex
  JOURNAL   J Cell Biol 158 (5), 915-927 (2002)
   PUBMED   12196509
REFERENCE   10 (bases 1 to 3831)
  AUTHORS   Shiota,C., Coffey,J., Grimsby,J., Grippo,J.F. and Magnuson,M.A.
  TITLE     Nuclear import of hepatic glucokinase depends upon glucokinase
            regulatory protein, whereas export is due to a nuclear export
            signal sequence in glucokinase
  JOURNAL   J Biol Chem 274 (52), 37125-37130 (1999)
   PUBMED   10601273
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC324759.1, AF514997.1, BC047539.1, BC046637.1, BG527619.1 and
            AK074311.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198887.2.
            
            Summary: Bidirectional transport of macromolecules between the
            cytoplasm and nucleus occurs through nuclear pore complexes (NPCs)
            embedded in the nuclear envelope. NPCs are composed of
            subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160
            (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the supproted protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.883749.1,
                                           SRR11853565.25494.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340413.7/ ENSP00000342262.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DC324759.1         44-67
            25-1728             AF514997.1         1-1704
            1729-2558           BC047539.1         2681-3510
            2559-2722           BC046637.1         2350-2513
            2723-2795           BG527619.1         33-105              c
            2796-3825           BC046637.1         2587-3616
            3826-3831           AK074311.1         3093-3098
FEATURES             Location/Qualifiers
     source          1..3831
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..3831
                     /gene="NUP43"
                     /gene_synonym="bA350J20.1; p42"
                     /note="nucleoporin 43"
                     /db_xref="GeneID:348995"
                     /db_xref="HGNC:HGNC:21182"
                     /db_xref="MIM:608141"
     exon            1..154
                     /gene="NUP43"
                     /gene_synonym="bA350J20.1; p42"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1177
                     /gene="NUP43"
                     /gene_synonym="bA350J20.1; p42"
                     /note="nup107-160 subcomplex subunit Nup43; nucleoporin
                     43kDa"
                     /codon_start=1
                     /product="nucleoporin Nup43"
                     /protein_id="NP_942590.1"
                     /db_xref="CCDS:CCDS5218.1"
                     /db_xref="GeneID:348995"
                     /db_xref="HGNC:HGNC:21182"
                     /db_xref="MIM:608141"
                     /translation="MEEIYAKFVSQKISKTRWRPLPPGSLQTAETFATGSWDNEENYI
                     SLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVAASSTGCVTVFLH
                     HPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGEDGRINLFRADH
                     KEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQGNEPSQILSLTGDRV
                     PLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEH
                     LFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHSISNQANVHQSVISSWLSTD
                     PAKDRIEITSLLPSRSLSVNTLDVLGPCLVCGTDAEAIYVTRHLFS"
     exon            155..277
                     /gene="NUP43"
                     /gene_synonym="bA350J20.1; p42"
                     /inference="alignment:Splign:2.1.0"
     exon            278..355
                     /gene="NUP43"
                     /gene_synonym="bA350J20.1; p42"
                     /inference="alignment:Splign:2.1.0"
     exon            356..536
                     /gene="NUP43"
                     /gene_synonym="bA350J20.1; p42"
                     /inference="alignment:Splign:2.1.0"
     exon            537..672
                     /gene="NUP43"
                     /gene_synonym="bA350J20.1; p42"
                     /inference="alignment:Splign:2.1.0"
     exon            673..824
                     /gene="NUP43"
                     /gene_synonym="bA350J20.1; p42"
                     /inference="alignment:Splign:2.1.0"
     exon            825..947
                     /gene="NUP43"
                     /gene_synonym="bA350J20.1; p42"
                     /inference="alignment:Splign:2.1.0"
     exon            948..3831
                     /gene="NUP43"
                     /gene_synonym="bA350J20.1; p42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3805..3810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP43"
                     /gene_synonym="bA350J20.1; p42"
                     /note="hexamer: AATGAA"
     polyA_site      3831
                     /gene="NUP43"
                     /gene_synonym="bA350J20.1; p42"
                     /note="major polyA site"
ORIGIN      
        1 gctttttgca gtacctgctg cggccgcttt cggcatggag gaaatttatg cgaagtttgt
       61 gtcccagaaa atcagcaaaa cccgctggcg accgctgcct ccgggaagtt tacagaccgc
      121 ggagacgttc gctacaggat cttgggacaa tgaggaaaat tatatttcac tgtggtctat
      181 tggagatttt ggaaacttgg actctgatgg agggtttgaa ggagaccatc agttattgtg
      241 tgatatcaga caccatggtg atgtaatgga tttacagttt tttgaccagg aaagaattgt
      301 cgctgcttca tcaacaggat gtgtaacagt tttccttcac catccaaata accagactct
      361 gtcagtcaac cagcagtgga ctacagctca ctaccacaca ggccctggca gtccttccta
      421 tagcagtgca ccatgtacag gtgttgtgtg caacaaccca gaaatcgtta cagttggaga
      481 ggatggtcga ataaatctct tcagagctga tcacaaggaa gctgtaagaa ccatagacaa
      541 tgcagatagt agtacactcc atgctgtaac ctttcttcga actcctgaga ttcttactgt
      601 aaattcaatt ggacagttga aaatatggga tttcagacaa caaggaaatg agccttctca
      661 gatattgtca ctgactggtg accgagtgcc actccactgt gttgatagac atcccaacca
      721 acagcatgtt gtagctactg gtggccaaga tggaatgttg agtatttggg atgttagaca
      781 aggtactatg cctgtatctc tgctgaaggc tcatgaagct gaaatgtggg aagttcactt
      841 tcacccatcc aacccagaac atctttttac ctgctctgaa gatggatccc tctggcactg
      901 ggatgcttcc acagatgtac ctgaaaagtc gtcactcttt caccaaggag gaagaagcag
      961 tacttttttg tctcatagca ttagtaacca agctaatgtt caccagtctg tcattagctc
     1021 ctggctcagc actgatcctg caaaagaccg aattgaaatc acaagcttac ttcccagtag
     1081 gtctctgtct gtgaacactt tggatgtttt aggtccttgt cttgtttgtg gaaccgatgc
     1141 agaagcaatt tatgttacta gacatctttt ttcgtagaag tactataatt ataagatttc
     1201 agatagaaca tgcaattagc cttttgaaat ccaacttctg tgcaaaattt tagtatcaga
     1261 aaatacgaga tttgcagggg aaacatcagt aaactaccat taatgtcaat gcccagtttt
     1321 gacttttgtt agcctgacac tcccaaacag ttgtagaatc cgatagatga ctgatggcaa
     1381 aagattgtga acatgtggaa gaaaatcagt gggattctgg tgctgatgaa taggttgcct
     1441 tcagagtatt attgacagac agcttgtgga actaattctt tatttttgat gttgtgggaa
     1501 ttaacacatc aatggtggtt atgggaacta ccaatgggtt cctacaattt ttatcagtag
     1561 tatgtggcat atacaccttc ctagtggcag ttgccaatgt taatgattat tctttttatt
     1621 gcaagtattt cctatgatcc ttccacactt tatttcctta ataataataa actttttcag
     1681 aaagaattga gtagagcaaa aatgacaaag atgtgtagct gtgttcaatt tttttttttt
     1741 tttttttttg aggcagagtc ttgctctgct ggagtgcggt ggtgcaatct cggctcactg
     1801 caacctccac ctcccaggtt caagcaattc tcctgcctca gtctcctgag tagctggaac
     1861 tacaggtgtg cgccaccacg cccagctaat ttttgtaatt ttagtagaga cagagtttca
     1921 ccatgttggc caggatggtc tcgatctctt gacctcatga tccacccgcc tcgacctccc
     1981 aaagtgctgt gattacaggt gtgagccact gcacccggcc tgaaattttt ttaaggtgaa
     2041 aatgttttga caagttcctt tttcagaata ggtttttgag cagaactctt tcagcttgtt
     2101 agacccaact ttgcttttgt ttagcttcac agcatagctg aaagttgcca aactggacat
     2161 tgtgcaataa agtagaattc tatattgata agcaaactat ttccaaacta aaaatgtgat
     2221 agataaaagt gtgattaatc aaatgatatg atcagagtaa agaattttgc cattttgatc
     2281 cttttacttt gttttagcca cctatagtgt taccaaccat ctttatcctt gtctgcaggg
     2341 ataataatga actaatgtag tgttttaaga taatttaatg atactatctt tccaaacttt
     2401 gttagatttt aaatgtatta ttgacctgag accttaatga caaatcactg ctattagaca
     2461 attgaagtgt tcatttactt tgtaattcca ataatcatag ttatggaatt atggtaaggt
     2521 tttgcttttc tgtcctaata aatatatata ttttttgaga tggagttttg ctcttgttgc
     2581 tgaggctgga gtgaaatggc atgatctcag ctcactgcaa cctccgtctc ttaggttcaa
     2641 gcaattctcc tgcctcagcc tcccgagtag ctgggattac aggtgctcac caccacaccc
     2701 agctaatttt tgtattttta gtagagatgg ggtttcactg tgttggccag gctggtcttg
     2761 aactgacctc atgatccacc tgcctcagcc tcccaaaatg ctgggattac aggcttgagc
     2821 cactgctccc ggctgatttt tgtattagta gagacgacag ggtttcacca tgttggccag
     2881 ggctggtctc gaactcctga ccacaggtaa tcagcccgcc tcggcctccc aaagtgctgg
     2941 gattacaggc gtgagccact tagtatttgt aaccataaga gaaagtatat tttaacagca
     3001 ttacatttca tgccaattga caagttttgc caattttaat aagaaactaa gctttatgta
     3061 atgtaacacc gtaatttatg aatttgttca ttgtcactgc ctttattcat gaaactgtca
     3121 aatagagtgt ctttcaaggg ttgcaggatc ttagagatag aaagtacctt ggtgatcatc
     3181 tccagcctaa atttcatcat cccttctatg gtattcccaa caaattatca tccaacctat
     3241 acttaaaaac atatggtggc caggcatggt ggctcacgcc tgtaatgcta gcactttggg
     3301 aggccgaggt gggtgaagca cctgaggtca agagttcgag atcagcctgg ccaacatggc
     3361 gaaaccccgt ctccactaaa aatgcaaaaa aaaaattaac cgggcgtggt ggcaggcatc
     3421 tataatccca gctacttggg aggctgaggc aggagaattg ctcaaacccg ggaggcagag
     3481 gttgcagtga cccaagatcg tgccacttca ctccagcctg ggcaaaagag caaaacgcca
     3541 tctcaaaaaa tatacatata taaggagata aagtttccca ttttccaata cagtttcaca
     3601 tttgaacagc cctaattgat acaactttat ggcagggttt tagtgtgtga gtgggatcca
     3661 aaacactcaa tcctgtaaaa gggtacagtc ctattgtatg ttaacacact gatgatgtga
     3721 gcctgtgaga tgagccaatc accagttgtt atgttcgaat ctgctttgtg ttgggacgct
     3781 ttaatgtcag ggtttcacta aataaatgaa ttttcatata ctgaactgaa a
//
