LOCUS       NM_001370446            1629 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens nucleoporin 42 (NUP42), transcript variant 5, mRNA.
ACCESSION   NM_001370446
VERSION     NM_001370446.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1629)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1629)
  AUTHORS   Schwartz,T.U.
  TITLE     The Structure Inventory of the Nuclear Pore Complex
  JOURNAL   J Mol Biol 428 (10 Pt A), 1986-2000 (2016)
   PUBMED   27016207
  REMARK    Review article
REFERENCE   3  (bases 1 to 1629)
  AUTHORS   Bui,K.H., von Appen,A., DiGuilio,A.L., Ori,A., Sparks,L.,
            Mackmull,M.T., Bock,T., Hagen,W., Andres-Pons,A., Glavy,J.S. and
            Beck,M.
  TITLE     Integrated structural analysis of the human nuclear pore complex
            scaffold
  JOURNAL   Cell 155 (6), 1233-1243 (2013)
   PUBMED   24315095
REFERENCE   4  (bases 1 to 1629)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1629)
  AUTHORS   Waldmann,I., Spillner,C. and Kehlenbach,R.H.
  TITLE     The nucleoporin-like protein NLP1 (hCG1) promotes CRM1-dependent
            nuclear protein export
  JOURNAL   J Cell Sci 125 (Pt 1), 144-154 (2012)
   PUBMED   22250199
  REMARK    GeneRIF: NLP1 functions as an accessory factor in CRM1-dependent
            nuclear protein export
REFERENCE   6  (bases 1 to 1629)
  AUTHORS   Shiota,C., Coffey,J., Grimsby,J., Grippo,J.F. and Magnuson,M.A.
  TITLE     Nuclear import of hepatic glucokinase depends upon glucokinase
            regulatory protein, whereas export is due to a nuclear export
            signal sequence in glucokinase
  JOURNAL   J Biol Chem 274 (52), 37125-37130 (1999)
   PUBMED   10601273
REFERENCE   7  (bases 1 to 1629)
  AUTHORS   Farjot,G., Sergeant,A. and Mikaelian,I.
  TITLE     A new nucleoporin-like protein interacts with both HIV-1 Rev
            nuclear export signal and CRM-1
  JOURNAL   J Biol Chem 274 (24), 17309-17317 (1999)
   PUBMED   10358091
REFERENCE   8  (bases 1 to 1629)
  AUTHORS   Katahira,J., Strasser,K., Podtelejnikov,A., Mann,M., Jung,J.U. and
            Hurt,E.
  TITLE     The Mex67p-mediated nuclear mRNA export pathway is conserved from
            yeast to human
  JOURNAL   EMBO J 18 (9), 2593-2609 (1999)
   PUBMED   10228171
REFERENCE   9  (bases 1 to 1629)
  AUTHORS   Fouchier,R.A., Meyer,B.E., Simon,J.H., Fischer,U., Albright,A.V.,
            Gonzalez-Scarano,F. and Malim,M.H.
  TITLE     Interaction of the human immunodeficiency virus type 1 Vpr protein
            with the nuclear pore complex
  JOURNAL   J Virol 72 (7), 6004-6013 (1998)
   PUBMED   9621063
REFERENCE   10 (bases 1 to 1629)
  AUTHORS   Van Laer,L., Van Camp,G., van Zuijlen,D., Green,E.D.,
            Verstreken,M., Schatteman,I., Van de Heyning,P., Balemans,W.,
            Coucke,P., Greinwald,J.H., Smith,R.J., Huizing,E. and Willems,P.
  TITLE     Refined mapping of a gene for autosomal dominant progressive
            sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion
            of a candidate gene that is expressed in the cochlea
  JOURNAL   Eur J Hum Genet 5 (6), 397-405 (1997)
   PUBMED   9450185
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005082.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AC005082.3         18575-18733
            160-388             AC005082.3         21597-21825
            389-483             AC005082.3         23579-23673
            484-560             AC005082.3         32366-32442
            561-647             AC005082.3         33207-33293
            648-705             AC005082.3         33700-33757
            706-790             AC005082.3         35985-36069
            791-1629            AC005082.3         36695-37533
FEATURES             Location/Qualifiers
     source          1..1629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..1629
                     /gene="NUP42"
                     /gene_synonym="CG1; hCG1; NLP-1; NLP1; NLP_1; NUPL2; UIP1"
                     /note="nucleoporin 42"
                     /db_xref="GeneID:11097"
                     /db_xref="HGNC:HGNC:17010"
                     /db_xref="MIM:619998"
     exon            1..159
                     /gene="NUP42"
                     /gene_synonym="CG1; hCG1; NLP-1; NLP1; NLP_1; NUPL2; UIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            160..388
                     /gene="NUP42"
                     /gene_synonym="CG1; hCG1; NLP-1; NLP1; NLP_1; NUPL2; UIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..483
                     /gene="NUP42"
                     /gene_synonym="CG1; hCG1; NLP-1; NLP1; NLP_1; NUPL2; UIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..560
                     /gene="NUP42"
                     /gene_synonym="CG1; hCG1; NLP-1; NLP1; NLP_1; NUPL2; UIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..647
                     /gene="NUP42"
                     /gene_synonym="CG1; hCG1; NLP-1; NLP1; NLP_1; NUPL2; UIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..705
                     /gene="NUP42"
                     /gene_synonym="CG1; hCG1; NLP-1; NLP1; NLP_1; NUPL2; UIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             691..1368
                     /gene="NUP42"
                     /gene_synonym="CG1; hCG1; NLP-1; NLP1; NLP_1; NUPL2; UIP1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     nucleoporin-like protein 1; H_RG271G13.9; nucleoporin-like
                     protein 2; NUP42 homolog; nucleoporin hCG1; nucleoporin
                     like 2; nucleoporin NUP42"
                     /codon_start=1
                     /product="nucleoporin NUP42 isoform 5"
                     /protein_id="NP_001357375.1"
                     /db_xref="GeneID:11097"
                     /db_xref="HGNC:HGNC:17010"
                     /db_xref="MIM:619998"
                     /translation="MVPTVLSDVKDGVNQAAPAFGFGSSQAATFMSPGFPVNNSSSDN
                     AQNFSFKTNSGFAAASSGSPAGFGSSPAFGAAASTSSGISTSAPAFGFGKPEVTSAAS
                     FSFKSPAASSFGSPGFSGLPASLATGPVRAPVAPAFGGGSSVAGFGSPGSHSHTAFSK
                     PSSDTFGNSSISTSLSASSSIIATDNVLFTPRDKLTVEELEQFQSKKFTLGKIPLKPP
                     PLELLNV"
     exon            706..790
                     /gene="NUP42"
                     /gene_synonym="CG1; hCG1; NLP-1; NLP1; NLP_1; NUPL2; UIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1629
                     /gene="NUP42"
                     /gene_synonym="CG1; hCG1; NLP-1; NLP1; NLP_1; NUPL2; UIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1607..1612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP42"
                     /gene_synonym="CG1; hCG1; NLP-1; NLP1; NLP_1; NUPL2; UIP1"
                     /note="hexamer: AATAAA"
     polyA_site      1629
                     /gene="NUP42"
                     /gene_synonym="CG1; hCG1; NLP-1; NLP1; NLP_1; NUPL2; UIP1"
                     /note="major polyA site"
ORIGIN      
        1 gcagactgaa gacgccctcc gtcagcgacg ccgtcgcaat ggccatttgt caattcttcc
       61 ttcaaggccg gtgccgcttt ggagatcggt gctggaacga acatcccggt gctaggggtg
      121 caggaggagg acggcagcaa ccgcagcagc agccttcagg taataataga cgtggatgga
      181 atacaactag ccagagatat tccaatgtca tccagccatc cagtttctcc aaatccacac
      241 catggggggg cagcagagat caagaaaagc catatttcag ttcttttgat tctggagctt
      301 caactaacag gaaggaaggc tttggattgt ctgagaaccc atttgcttca cttagtcctg
      361 atgagcagaa agatgaaaag aaacttctgg aaggaattgt aaaagatatg gaggtttggg
      421 aatcatcagg gcagtggatg ttttctgttt attcaccagt gaaaaagaaa cctaatattt
      481 caggttttac agacatttca ccagaggaat tgaggcttga ataccataac ttcttaacca
      541 gcaataactt acagagttat ctaaattctg tccaacgttt aataaatcaa tggaggaaca
      601 gggtaaatga actgaaaagt ctaaatatat caactaaagt agctttgaaa tgcctttgga
      661 agatatatac ccacctgtct ccaaagatct atggtcccga ctgtgctctc tgatgtaaag
      721 gatggagtaa atcaagcagc acctgcattt ggatttggca gcagtcaagc agcaacattt
      781 atgtcgccag gctttccagt caataacagc agcagtgata atgctcagaa ctttagtttt
      841 aaaacaaact ctggatttgc tgctgcctct tctggaagcc ctgctggttt tgggagttcc
      901 ccagcatttg gagctgcagc ctctaccagt tcaggtatct ctacttctgc tccagctttt
      961 ggatttggga agcctgaagt cacatcggct gcatcatttt cattcaaaag ccctgcagct
     1021 tccagttttg gatcacctgg attttcagga cttccagctt ccttggcaac aggtcctgtc
     1081 agagctccag tggccccagc ctttggaggt ggcagttctg tggctggttt tggtagtccg
     1141 ggctcacatt ctcacactgc tttttctaag ccatccagtg acacttttgg aaatagcagc
     1201 atatccactt ctctgtcagc ctcaagcagc atcattgcaa cagataatgt gttattcaca
     1261 cccagagata aactaacagt agaagaactg gaacaatttc aatccaagaa atttactctg
     1321 ggaaaaattc cattaaagcc tccacctctg gaacttctaa atgtttaaaa gggcaatttt
     1381 aaatacaaaa aagaatgatg tttaaaattg ctttgagtga ttcatacaga gatgtatata
     1441 tgcatacatg tatatattca taaggaatat aagcttccat caatagtgat tttaaatttg
     1501 atttttttct taactctaaa tatttaagta aaaagtaaca aaaactctgc aagcaaggga
     1561 atttttttgt actgtaattt tgaatggaac tgaaaaatta tgcacgaata aagtactttt
     1621 ctcatgcca
//
