LOCUS       NM_024057               2362 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens nucleoporin 37 (NUP37), mRNA.
ACCESSION   NM_024057 XM_005269144
VERSION     NM_024057.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2362)
  AUTHORS   Liu,Z., Hu,Q., Luo,Q., Zhang,G., Yang,W., Cao,K., Fang,R., Wang,R.,
            Shi,H. and Zhang,B.
  TITLE     NUP37 accumulation mediated by TRIM28 enhances lipid synthesis to
            accelerate HCC progression
  JOURNAL   Oncogene 43 (44), 3255-3267 (2024)
   PUBMED   39294431
  REMARK    GeneRIF: NUP37 accumulation mediated by TRIM28 enhances lipid
            synthesis to accelerate HCC progression.
REFERENCE   2  (bases 1 to 2362)
  AUTHORS   Xiong,H., Li,Y. and Liu,M.
  TITLE     DEPDC1B is involved in the proliferation, metastasis, cell cycle
            arrest and apoptosis of colon cancer cells by regulating NUP37
  JOURNAL   Mol Med Rep 27 (6) (2023)
   PUBMED   37203403
  REMARK    GeneRIF: DEPDC1B is involved in the proliferation, metastasis, cell
            cycle arrest and apoptosis of colon cancer cells by regulating
            NUP37.
REFERENCE   3  (bases 1 to 2362)
  AUTHORS   Peng,Y., Shen,J., Gao,Y., Dai,W., Liang,S., Chen,J., Gao,L.,
            Lin,Y., Cai,L., Qin,L., Cui,Y., Liu,J. and Diao,F.
  TITLE     Nucleoporin37 may play a role in early embryo development in human
            and mice
  JOURNAL   Mol Hum Reprod 28 (6) (2022)
   PUBMED   35583302
  REMARK    GeneRIF: Nucleoporin37 may play a role in early embryo development
            in human and mice.
REFERENCE   4  (bases 1 to 2362)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2362)
  AUTHORS   Tang,Z., Yang,Y., Chen,W., Li,E. and Liang,T.
  TITLE     Demethylation at enhancer upregulates MCM2 and NUP37 expression
            predicting poor survival in hepatocellular carcinoma patients
  JOURNAL   J Transl Med 20 (1), 49 (2022)
   PUBMED   35093119
  REMARK    GeneRIF: Demethylation at enhancer upregulates MCM2 and NUP37
            expression predicting poor survival in hepatocellular carcinoma
            patients.
            Erratum:[J Transl Med. 2022 Dec 13;20(1):594. doi:
            10.1186/s12967-022-03766-0.. PMID: 36514057]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2362)
  AUTHORS   Bui,K.H., von Appen,A., DiGuilio,A.L., Ori,A., Sparks,L.,
            Mackmull,M.T., Bock,T., Hagen,W., Andres-Pons,A., Glavy,J.S. and
            Beck,M.
  TITLE     Integrated structural analysis of the human nuclear pore complex
            scaffold
  JOURNAL   Cell 155 (6), 1233-1243 (2013)
   PUBMED   24315095
REFERENCE   7  (bases 1 to 2362)
  AUTHORS   Zuccolo,M., Alves,A., Galy,V., Bolhy,S., Formstecher,E., Racine,V.,
            Sibarita,J.B., Fukagawa,T., Shiekhattar,R., Yen,T. and Doye,V.
  TITLE     The human Nup107-160 nuclear pore subcomplex contributes to proper
            kinetochore functions
  JOURNAL   EMBO J 26 (7), 1853-1864 (2007)
   PUBMED   17363900
REFERENCE   8  (bases 1 to 2362)
  AUTHORS   Glavy,J.S., Krutchinsky,A.N., Cristea,I.M., Berke,I.C., Boehmer,T.,
            Blobel,G. and Chait,B.T.
  TITLE     Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160
            subcomplex
  JOURNAL   Proc Natl Acad Sci U S A 104 (10), 3811-3816 (2007)
   PUBMED   17360435
REFERENCE   9  (bases 1 to 2362)
  AUTHORS   Loiodice,I., Alves,A., Rabut,G., Van Overbeek,M., Ellenberg,J.,
            Sibarita,J.B. and Doye,V.
  TITLE     The entire Nup107-160 complex, including three new members, is
            targeted as one entity to kinetochores in mitosis
  JOURNAL   Mol Biol Cell 15 (7), 3333-3344 (2004)
   PUBMED   15146057
REFERENCE   10 (bases 1 to 2362)
  AUTHORS   Cronshaw,J.M., Krutchinsky,A.N., Zhang,W., Chait,B.T. and
            Matunis,M.J.
  TITLE     Proteomic analysis of the mammalian nuclear pore complex
  JOURNAL   J Cell Biol 158 (5), 915-927 (2002)
   PUBMED   12196509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC420994.1, BC000861.2,
            BM995521.1 and AC079907.25.
            
            On Nov 23, 2018 this sequence version replaced NM_024057.3.
            
            Summary: Nuclear pore complexes (NPCs) are used for transporting
            macromolecules between the cytoplasm and the nucleus. NPCs consist
            of multiple copies of 30 distinct proteins (nucleoporins), which
            assemble into biochemically-separable subcomplexes. The protein
            encoded by this gene is part of a subcomplex (Nup107-160) that is
            required for proper NPC function as well as for normal
            kinetochore-microtubule interaction and mitosis. [provided by
            RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.4225.1,
                                           SRR1660807.178350.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000552283.6/ ENSP00000448054.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                DC420994.1         18-82
            66-1273             BC000861.2         1-1208
            1274-1276           BM995521.1         18-20               c
            1277-2362           AC079907.25        46598-47683
FEATURES             Location/Qualifiers
     source          1..2362
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.2"
     gene            1..2362
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /note="nucleoporin 37"
                     /db_xref="GeneID:79023"
                     /db_xref="HGNC:HGNC:29929"
                     /db_xref="MIM:609264"
     exon            1..65
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            66..286
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1111
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /note="nup107-160 subcomplex subunit Nup37; nucleoporin
                     37kDa"
                     /codon_start=1
                     /product="nucleoporin Nup37"
                     /protein_id="NP_076962.2"
                     /db_xref="CCDS:CCDS9089.1"
                     /db_xref="GeneID:79023"
                     /db_xref="HGNC:HGNC:29929"
                     /db_xref="MIM:609264"
                     /translation="MKQDASRNAAYTVDCEDYVHVVEFNPFENGDSGNLIAYGGNNYV
                     VIGTCTFQEEEADVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADM
                     KIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTA
                     HFVLHSPGMSVCWHPEETFKLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCL
                     KNTFKVGAVAGNDWLIWDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKM
                     ASQFQIHHLGHPQPILMGSVAVGSGLSWHRTLPLCVIGGDHKLLFWVTEV"
     exon            287..411
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            412..484
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            485..579
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            580..670
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            671..852
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            853..903
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            904..997
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            998..2362
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1249..1254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /note="hexamer: AATAAA"
     polyA_site      1276
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /note="major polyA site"
     regulatory      2343..2348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /note="hexamer: AATAAA"
     polyA_site      2362
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
ORIGIN      
        1 acagcgcgtc gcggcagccc ccaaggaaga ccagcctgcc tctggtcggt tcctggcgct
       61 ctgcgtttcg tgaccttgtc cagtagaagg ctatttaatt ttcacaactg cttgaatttt
      121 gacatacaag atgaagcaag atgcctcaag aaatgctgcc tacactgtgg attgtgaaga
      181 ttatgtgcat gtggtagaat ttaatccctt tgagaatggg gattcaggaa acctaattgc
      241 atatggtggc aataattatg tggtcattgg cacgtgtacg tttcaggaag aagaagcaga
      301 cgttgaaggc attcagtata aaacacttcg aacatttcac catggagtca gggttgatgg
      361 catagcttgg agcccagaga ctagacttga ttcattgcct ccagtaatca aattttgtac
      421 ttcagctgct gatatgaaaa ttagattatt tacttcagat cttcaggata aaaatgaata
      481 taaggtttta gagggccata ccgatttcat taatggtttg gtgtttgatc ccaaagaagg
      541 ccaagaaatt gcaagtgtga gtgacgatca cacctgcagg atttggaact tggaaggagt
      601 gcaaacagct cattttgttc ttcattctcc tggcatgagt gtgtgctggc atcctgagga
      661 gacttttaag ctaatggttg cagagaagaa tggaacaatc cggttttatg atcttttggc
      721 ccaacaggct attttatctc ttgaatcaga acaagtgcca ttaatgtcag cacactggtg
      781 cttaaaaaac accttcaaag ttggagccgt tgcaggaaat gattggttaa tttgggatat
      841 tactcggtcc agttatcctc aaaataagag acctgttcac atggatcgag cctgcttatt
      901 caggtggtcc acaattagtg aaaatctgtt tgcaaccact ggttatcctg gcaaaatggc
      961 aagccagttt caaattcatc atttaggaca ccctcagccc atcctcatgg gttctgtagc
     1021 cgttggatct ggactgtcct ggcatcgaac tctccctctg tgtgtaattg gaggagacca
     1081 caagctgttg ttttgggtga ctgaagtata aagtgttttc tgtaccttag attcacaaac
     1141 tttgtatttt tagtacatat tttgaagaat ttctatagta catattttga agaattttta
     1201 tatcaaatat accgtatact ttagaaaatg tctcagttgc ttttattaaa taaaatgttg
     1261 atggtttgaa aaattatttt tctactctgt tctctgtgtg tgtatatata tatattttta
     1321 atcttacaaa atcatattga ctcagcagct cacctccaga gaagagatga ctaaggaaaa
     1381 ataatgcttt tgagtttatc aaaaaaggag tatttgaagt gtatcctgtt ttctatactt
     1441 tgagtatatg ctgtttttct aattctcagg gacacattta tcaaaagaga aaaaaaggcc
     1501 aggtacaatg gctcacactt gtaatcccaa cactttggga ggctgaaggg agtggatcac
     1561 ttgaggtgag gagttcaaga ccaacctggc caacatggtg aaaccctatc tctactaaaa
     1621 aaataaaaat aaaaaaaatt agccaagcat ggtttggaag actgaggcag gagaatcact
     1681 tgaacctgga aggcagaggt tacagtgagc caagatcgtg ccacttcact gcagcctggg
     1741 cgacagagcg agactatctc aaaagaaaaa aaatccaagg agaaaaaaat atcttagggt
     1801 attctggaag tggttgttga gtatatatat gtgtatgtgt actcaattta atgtaaaaaa
     1861 ttgttttcag tttcttaaat atgtgattga ttatattgct caaccctgtt tattatacgc
     1921 agattccttt ggacgaggtg ttctaacagt cttagaacat ctgatatatg ggatcaaaag
     1981 ttaccttgaa aaatgacttc tagtgtatac ctttaacagc ctcctttttg tgaattttca
     2041 ctgttcttac caagaaactt aagtgttttt gagatgggac ctgttggcaa tggaactgtg
     2101 ttcaccctct caaagatcat taaaatcaac gttatctaag acagctgtat cacatttttg
     2161 ggatacatca tggtacagtc agaagcatat aaaattatgg ttctgcttgt cagtcacata
     2221 cagaatccaa tacattttga caaactgccc attcctgcaa gttaatgccc tttttgaagc
     2281 ttcatttcct cttgtaaagt acagatagga atcattattt tgtggagttg ctgtaaagat
     2341 taaataaagg tgaatgaaaa ta
//
