LOCUS       NP_076962                326 aa            linear   PRI 27-APR-2025
DEFINITION  nucleoporin Nup37 [Homo sapiens].
ACCESSION   NP_076962 XP_005269201
VERSION     NP_076962.2
DBSOURCE    REFSEQ: accession NM_024057.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 326)
  AUTHORS   Liu,Z., Hu,Q., Luo,Q., Zhang,G., Yang,W., Cao,K., Fang,R., Wang,R.,
            Shi,H. and Zhang,B.
  TITLE     NUP37 accumulation mediated by TRIM28 enhances lipid synthesis to
            accelerate HCC progression
  JOURNAL   Oncogene 43 (44), 3255-3267 (2024)
   PUBMED   39294431
  REMARK    GeneRIF: NUP37 accumulation mediated by TRIM28 enhances lipid
            synthesis to accelerate HCC progression.
REFERENCE   2  (residues 1 to 326)
  AUTHORS   Xiong,H., Li,Y. and Liu,M.
  TITLE     DEPDC1B is involved in the proliferation, metastasis, cell cycle
            arrest and apoptosis of colon cancer cells by regulating NUP37
  JOURNAL   Mol Med Rep 27 (6) (2023)
   PUBMED   37203403
  REMARK    GeneRIF: DEPDC1B is involved in the proliferation, metastasis, cell
            cycle arrest and apoptosis of colon cancer cells by regulating
            NUP37.
REFERENCE   3  (residues 1 to 326)
  AUTHORS   Peng,Y., Shen,J., Gao,Y., Dai,W., Liang,S., Chen,J., Gao,L.,
            Lin,Y., Cai,L., Qin,L., Cui,Y., Liu,J. and Diao,F.
  TITLE     Nucleoporin37 may play a role in early embryo development in human
            and mice
  JOURNAL   Mol Hum Reprod 28 (6) (2022)
   PUBMED   35583302
  REMARK    GeneRIF: Nucleoporin37 may play a role in early embryo development
            in human and mice.
REFERENCE   4  (residues 1 to 326)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (residues 1 to 326)
  AUTHORS   Tang,Z., Yang,Y., Chen,W., Li,E. and Liang,T.
  TITLE     Demethylation at enhancer upregulates MCM2 and NUP37 expression
            predicting poor survival in hepatocellular carcinoma patients
  JOURNAL   J Transl Med 20 (1), 49 (2022)
   PUBMED   35093119
  REMARK    GeneRIF: Demethylation at enhancer upregulates MCM2 and NUP37
            expression predicting poor survival in hepatocellular carcinoma
            patients.
            Erratum:[J Transl Med. 2022 Dec 13;20(1):594. doi:
            10.1186/s12967-022-03766-0. PMID: 36514057]
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 326)
  AUTHORS   Bui,K.H., von Appen,A., DiGuilio,A.L., Ori,A., Sparks,L.,
            Mackmull,M.T., Bock,T., Hagen,W., Andres-Pons,A., Glavy,J.S. and
            Beck,M.
  TITLE     Integrated structural analysis of the human nuclear pore complex
            scaffold
  JOURNAL   Cell 155 (6), 1233-1243 (2013)
   PUBMED   24315095
REFERENCE   7  (residues 1 to 326)
  AUTHORS   Zuccolo,M., Alves,A., Galy,V., Bolhy,S., Formstecher,E., Racine,V.,
            Sibarita,J.B., Fukagawa,T., Shiekhattar,R., Yen,T. and Doye,V.
  TITLE     The human Nup107-160 nuclear pore subcomplex contributes to proper
            kinetochore functions
  JOURNAL   EMBO J 26 (7), 1853-1864 (2007)
   PUBMED   17363900
REFERENCE   8  (residues 1 to 326)
  AUTHORS   Glavy,J.S., Krutchinsky,A.N., Cristea,I.M., Berke,I.C., Boehmer,T.,
            Blobel,G. and Chait,B.T.
  TITLE     Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160
            subcomplex
  JOURNAL   Proc Natl Acad Sci U S A 104 (10), 3811-3816 (2007)
   PUBMED   17360435
REFERENCE   9  (residues 1 to 326)
  AUTHORS   Loiodice,I., Alves,A., Rabut,G., Van Overbeek,M., Ellenberg,J.,
            Sibarita,J.B. and Doye,V.
  TITLE     The entire Nup107-160 complex, including three new members, is
            targeted as one entity to kinetochores in mitosis
  JOURNAL   Mol Biol Cell 15 (7), 3333-3344 (2004)
   PUBMED   15146057
REFERENCE   10 (residues 1 to 326)
  AUTHORS   Cronshaw,J.M., Krutchinsky,A.N., Zhang,W., Chait,B.T. and
            Matunis,M.J.
  TITLE     Proteomic analysis of the mammalian nuclear pore complex
  JOURNAL   J Cell Biol 158 (5), 915-927 (2002)
   PUBMED   12196509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC420994.1, BC000861.2,
            BM995521.1 and AC079907.25.
            
            On or before Dec 12, 2015 this sequence version replaced
            XP_005269201.1, NP_076962.1.
            
            Summary: Nuclear pore complexes (NPCs) are used for transporting
            macromolecules between the cytoplasm and the nucleus. NPCs consist
            of multiple copies of 30 distinct proteins (nucleoporins), which
            assemble into biochemically-separable subcomplexes. The protein
            encoded by this gene is part of a subcomplex (Nup107-160) that is
            required for proper NPC function as well as for normal
            kinetochore-microtubule interaction and mitosis. [provided by
            RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.4225.1,
                                           SRR1660807.178350.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000552283.6/ ENSP00000448054.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.2"
     Protein         1..326
                     /product="nucleoporin Nup37"
                     /note="nup107-160 subcomplex subunit Nup37; nucleoporin
                     37kDa"
                     /calculated_mol_wt=36577
     Region          6..54
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NFH4.1)"
     Region          <16..216
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          22..70
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          61..109
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NFH4.1)"
     Region          76..122
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          115..154
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NFH4.1)"
     Region          127..163
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          159..195
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NFH4.1)"
     Region          170..205
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          199..237
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NFH4.1)"
     Region          211..248
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          242..282
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NFH4.1)"
     Region          287..324
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NFH4.1)"
     Region          291..322
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..326
                     /gene="NUP37"
                     /gene_synonym="MCPH24; p37"
                     /coded_by="NM_024057.4:131..1111"
                     /db_xref="CCDS:CCDS9089.1"
                     /db_xref="GeneID:79023"
                     /db_xref="HGNC:HGNC:29929"
                     /db_xref="MIM:609264"
ORIGIN      
        1 mkqdasrnaa ytvdcedyvh vvefnpfeng dsgnliaygg nnyvvigtct fqeeeadveg
       61 iqyktlrtfh hgvrvdgiaw spetrldslp pvikfctsaa dmkirlftsd lqdkneykvl
      121 eghtdfingl vfdpkegqei asvsddhtcr iwnlegvqta hfvlhspgms vcwhpeetfk
      181 lmvaekngti rfydllaqqa ilsleseqvp lmsahwclkn tfkvgavagn dwliwditrs
      241 sypqnkrpvh mdraclfrws tisenlfatt gypgkmasqf qihhlghpqp ilmgsvavgs
      301 glswhrtlpl cviggdhkll fwvtev
//
